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JAK

JAK

JAK (Janus kinase) inhibitors are compounds that target the JAK-STAT signaling pathway, which is involved in cell growth, immune response, and angiogenesis. By inhibiting JAK, these compounds can reduce the signaling that leads to the formation of new blood vessels in tumors, thereby inhibiting tumor growth. JAK inhibitors are important in the treatment of cancers and inflammatory diseases. At CymitQuimica, we offer a diverse range of high-quality JAK inhibitors to support your research in oncology, immunology, and angiogenesis.

Found 245 products of "JAK"

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  • FDA-Approved Kinase Inhibitor Library
    Targetmol
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    FDA-Approved Kinase Inhibitor Library

    <p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>
    Color and Shape:Liquid

    Ref: TM-L1610

  • CymitQuimica logo
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    JAK3-IN-15

    <p>JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200631

  • S-Ruxolitinib
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    S-Ruxolitinib

    CAS:
    <p>S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.</p>
    Formula:C17H18N6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:306.37

    Ref: TM-T3066

  • JAK1/TYK2-IN-1
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    JAK1/TYK2-IN-1

    CAS:
    <p>JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).</p>
    Formula:C18H20F3N7O
    Color and Shape:Solid
    Molecular weight:407.401

    Ref: TM-T39314

  • JAK-2/3-IN-1
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    JAK-2/3-IN-1

    CAS:
    <p>JAK-2/3-IN-1 inhibits JAK-2/3 isoforms with sub-250 nM Ki; from US patent US8163732B2.</p>
    Formula:C20H12ClN3O
    Color and Shape:Solid
    Molecular weight:345.79

    Ref: TM-T38436

  • CymitQuimica logo
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    DBL-6-13

    <p>DBL-6-13 is an inhibitor of WDR5, displaying moderate binding affinity with dissociation constants (Kd) of 6.8 μM and 9.1 μM as determined by microscale thermophoresis analysis and fluorescence polarization analysis, respectively.</p>
    Formula:C25H38N4O3
    Color and Shape:Solid
    Molecular weight:442.59

    Ref: TM-T203576

  • Axltide
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    Axltide

    CAS:
    <p>Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.</p>
    Formula:C63H107N19O20S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1514.77

    Ref: TM-TP1713

  • SJ1008030
    Targetmol
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    SJ1008030

    CAS:
    <p>SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.</p>
    Formula:C42H43N13O7S
    Color and Shape:Solid
    Molecular weight:873.94

    Ref: TM-T74580

  • CymitQuimica logo
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    HAT-SIL-TG-1&AT

    <p>HAT-SIL-TG-1&amp;AT: a hypoxia-activated JAK inhibitor that curbs HEL cell growth &amp; STAT3/5 phosphorylation in tumors.</p>
    Formula:C60H69N17O11S
    Color and Shape:Solid
    Molecular weight:1236.36

    Ref: TM-T74800

  • CymitQuimica logo
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    JAK1/STAT3-IN-1

    <p>JAK1/STAT3-IN-1 (compound 4f) functions as an anti-atopic dermatitis (AD) agent by inhibiting the JAK1/STAT3 signaling pathway. It has an IC50 value of 2.17 μM for inhibiting NO production. Additionally, JAK1/STAT3-IN-1 improves skin conditions in AD-like mice by reducing inflammatory infiltration, suppressing the expression of p-JAK1/JAK1 and p-STAT3/STAT3, and alleviating the hyperimmune response induced by MC903 (Calcipotriol).</p>
    Formula:C30H33FN4O3S
    Color and Shape:Solid
    Molecular weight:548.67

    Ref: TM-T205385

  • Atinvicitinib
    Targetmol
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    Atinvicitinib

    CAS:
    <p>Atinvicitinib, a selective JAK1 inhibitor, blocks cytokine signaling, modulating itch, allergy, and inflammatory responses, immune and therapeutic studies.</p>
    Formula:C16H17FN6O3
    Purity:99.36%
    Color and Shape:Solid
    Molecular weight:360.35

    Ref: TM-T39646

  • Itacitinib adipate
    Targetmol
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    Itacitinib adipate

    CAS:
    <p>Itacitinib adipate: oral JAK1 inhibitor, tested in phase II myelofibrosis trial.</p>
    Formula:C32H33F4N9O5
    Color and Shape:Solid
    Molecular weight:699.66

    Ref: TM-T11687

  • DTP3
    Targetmol
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    DTP3

    CAS:
    <p>DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.</p>
    Formula:C26H35N7O5
    Color and Shape:Solid
    Molecular weight:525.6

    Ref: TM-T22319

  • Ifidancitinib
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    Ifidancitinib

    CAS:
    <p>Ifidancitinib (ATI-50002) is a JAK kinase 1/3 inhibitor used to study autoimmune diseases.</p>
    Formula:C20H18FN5O3
    Purity:98.05%
    Color and Shape:Solid
    Molecular weight:395.39

    Ref: TM-T38623

  • WHI-P154
    TCI
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    WHI-P154

    CAS:
    Formula:C16H14BrN3O3
    Purity:>98.0%(HPLC)
    Color and Shape:White to Yellow to Orange powder to crystal
    Molecular weight:376.21

    Ref: 3B-W0013

    10mg
    70.00€
    50mg
    238.00€
  • WHI-P180 Hydrochloride
    TCI
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    WHI-P180 Hydrochloride

    CAS:
    Formula:C16H15N3O3·HCl
    Purity:>97.0%(T)(HPLC)
    Color and Shape:White to Light gray to Light yellow powder to crystal
    Molecular weight:333.77

    Ref: 3B-W0021

    25mg
    169.00€
  • CHZ868
    Targetmol
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    CHZ868

    CAS:
    <p>CHZ868 is a type II JAK inhibitor with potential antitumor activity that reverses the persistence of type I JAK inhibitors and can be used to study leukemia.</p>
    Formula:C22H19F2N5O2
    Purity:99.38%
    Color and Shape:Solid
    Molecular weight:423.42

    Ref: TM-TQ0061

  • Ilunocitinib
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    Ilunocitinib

    CAS:
    <p>Ilunocitinib is a non-selective and orally active Janus kinase (JAK) inhibitor for pruritus and atopic dermatitis caused by atopic dermatitis in dogs.</p>
    Formula:C17H17N7O2S
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:383.43

    Ref: TM-T38571

  • Fedratinib hydrochloride hydrate
    Targetmol
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    Fedratinib hydrochloride hydrate

    CAS:
    <p>Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.</p>
    Formula:C27H40Cl2N6O4S
    Purity:98.96% - 99.87%
    Color and Shape:Solid
    Molecular weight:615.61

    Ref: TM-T9251

  • AG490
    Targetmol
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    AG490

    CAS:
    <p>AG490 inhibits EGFR (0.1 μM IC50), 135x &gt; selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.</p>
    Formula:C17H14N2O3
    Purity:98.6% - 99.39%
    Color and Shape:Yellow Solid
    Molecular weight:294.3

    Ref: TM-T2600