JAK
JAK (Janus kinase) inhibitors are compounds that target the JAK-STAT signaling pathway, which is involved in cell growth, immune response, and angiogenesis. By inhibiting JAK, these compounds can reduce the signaling that leads to the formation of new blood vessels in tumors, thereby inhibiting tumor growth. JAK inhibitors are important in the treatment of cancers and inflammatory diseases. At CymitQuimica, we offer a diverse range of high-quality JAK inhibitors to support your research in oncology, immunology, and angiogenesis.
Found 244 products of "JAK"
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CHZ868
CAS:CHZ868 is a type II JAK inhibitor with potential antitumor activity that reverses the persistence of type I JAK inhibitors and can be used to study leukemia.Formula:C22H19F2N5O2Purity:99.38%Color and Shape:SolidMolecular weight:423.42RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formula:C29H35N7O4Purity:98% - 99.91%Color and Shape:SolidMolecular weight:545.63Filgotinib
CAS:Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.Formula:C21H23N5O3SPurity:98.03% - ≥95%Color and Shape:SolidMolecular weight:425.5AMG-47a
CAS:AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.Formula:C29H28F3N5O2Purity:98%Color and Shape:SolidMolecular weight:535.56Pacritinib
CAS:Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).Formula:C28H32N4O3Purity:99.25% - 99.49%Color and Shape:SolidMolecular weight:472.58WHI-P154
CAS:WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.Formula:C16H14BrN3O3Purity:98% - 99.67%Color and Shape:SolidMolecular weight:376.2Fedratinib hydrochloride hydrate
CAS:Fedratinib hydrochloride hydrate (SAR 302503 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.Formula:C27H40Cl2N6O4SPurity:98.96% - 99.87%Color and Shape:SolidMolecular weight:615.61Abrocitinib
CAS:Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).Formula:C14H21N5O2SPurity:99.09% - 99.91%Color and Shape:SolidMolecular weight:323.41Decernotinib
CAS:Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.Formula:C18H19F3N6OPurity:99.28% - >99.99%Color and Shape:SolidMolecular weight:392.38Ref: TM-T2636
1mg34.00€2mg48.00€5mg71.00€10mg99.00€25mg197.00€50mg295.00€100mg447.00€1mL*10mM (DMSO)79.00€AG490
CAS:AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formula:C17H14N2O3Purity:98.6% - 99.85%Color and Shape:Yellow SolidMolecular weight:294.3SHR0302
CAS:SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,Formula:C18H22N8O2SPurity:99.11%Color and Shape:SolidMolecular weight:414.48Ref: TM-T9195
1mg80.00€5mg183.00€10mg298.00€25mg512.00€50mg817.00€100mg1,311.00€1mL*10mM (DMSO)167.00€Brevilin A
CAS:Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.Formula:C20H26O5Purity:99.97% - >99.99%Color and Shape:SolidMolecular weight:346.42Ref: TM-T4672
1mg90.00€5mg203.00€10mg350.00€25mg578.00€50mg797.00€100mg1,071.00€500mg2,187.00€1mL*10mM (DMSO)224.00€CEP-33779
CAS:CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.Formula:C24H26N6O2SPurity:98.24% - ≥95%Color and Shape:SolidMolecular weight:462.57Ref: TM-T6122
1mg43.00€2mg56.00€5mg93.00€10mg137.00€25mg231.00€50mg356.00€100mg530.00€500mg1,153.00€1mL*10mM (DMSO)92.00€JAK3-IN-6
CAS:JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nMFormula:C19H18N4O3Purity:99.94% - 99.94%Color and Shape:SolidMolecular weight:350.37G5-7
CAS:G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Formula:C22H19F2NO3Purity:97.3%Color and Shape:SolidMolecular weight:383.39Ref: TM-T8742
1mg35.00€5mg71.00€10mg96.00€25mg172.00€50mg248.00€100mg348.00€200mg470.00€1mL*10mM (DMSO)78.00€FLLL32
CAS:FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Formula:C28H32O6Purity:97% - 97.90%Color and Shape:SolidMolecular weight:464.55Ref: TM-T6838
2mg43.00€5mg63.00€10mg88.00€25mg117.00€50mg187.00€100mg333.00€500mg797.00€1mL*10mM (DMSO)69.00€NVP-BSK805 trihydrochloride
CAS:NVP-BSK805 trihydrochloride inhibits JAK2 (0.48 nM IC50); also affects JAK1, JAK3, TYK2.Formula:C27H31Cl3F2N6OColor and Shape:SolidMolecular weight:599.93Gandotinib
CAS:LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).Formula:C23H25ClFN7OPurity:99.33% - 99.86%Color and Shape:SolidMolecular weight:469.94AZ960
CAS:AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).Formula:C18H16F2N6Purity:96.02% - 99.88%Color and Shape:SolidMolecular weight:354.36
