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JAK

JAK

JAK (Janus kinase) inhibitors are compounds that target the JAK-STAT signaling pathway, which is involved in cell growth, immune response, and angiogenesis. By inhibiting JAK, these compounds can reduce the signaling that leads to the formation of new blood vessels in tumors, thereby inhibiting tumor growth. JAK inhibitors are important in the treatment of cancers and inflammatory diseases. At CymitQuimica, we offer a diverse range of high-quality JAK inhibitors to support your research in oncology, immunology, and angiogenesis.

Found 245 products of "JAK"

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  • AG490
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    AG490

    CAS:
    <p>AG490 inhibits EGFR (0.1 μM IC50), 135x &gt; selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.</p>
    Formula:C17H14N2O3
    Purity:98.6% - 99.39%
    Color and Shape:Yellow Solid
    Molecular weight:294.3

    Ref: TM-T2600

  • Abrocitinib
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    Abrocitinib

    CAS:
    <p>Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).</p>
    Formula:C14H21N5O2S
    Purity:99.09% - 99.91%
    Color and Shape:Solid
    Molecular weight:323.41

    Ref: TM-TQ0037

  • CEP-33779
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    CEP-33779

    CAS:
    <p>CEP-33779 is a novel and selective inhibitor of JAK2 with an IC50 of 1.8±0.6 nM.</p>
    Formula:C24H26N6O2S
    Purity:98.24% - ≥95%
    Color and Shape:Solid
    Molecular weight:462.57

    Ref: TM-T6122

  • WDR5-0103 hydrochloride[890190-22-4(free base)]
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    WDR5-0103 hydrochloride[890190-22-4(free base)]

    <p>WDR5-0103 hydrochloride[890190-22-4(free base)] (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd:</p>
    Formula:C21H26ClN3O4
    Purity:99.66%
    Color and Shape:Solid
    Molecular weight:419.9

    Ref: TM-T5140

  • SHR0302
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    SHR0302

    CAS:
    <p>SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3,</p>
    Formula:C18H22N8O2S
    Purity:99.11%
    Color and Shape:Solid
    Molecular weight:414.48

    Ref: TM-T9195

  • Brevilin A
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    Brevilin A

    CAS:
    <p>Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.</p>
    Formula:C20H26O5
    Purity:99.97% - >99.99%
    Color and Shape:Solid
    Molecular weight:346.42

    Ref: TM-T4672

  • JAK3-IN-6
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    JAK3-IN-6

    CAS:
    <p>JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM</p>
    Formula:C19H18N4O3
    Purity:99.94% - 99.94%
    Color and Shape:Solid
    Molecular weight:350.37

    Ref: TM-T5492

  • Cucurbitacin I
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    Cucurbitacin I

    CAS:
    <p>Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.</p>
    Formula:C30H42O7
    Purity:96.69% - 99.8%
    Color and Shape:Solid
    Molecular weight:514.65

    Ref: TM-TQ0196

  • Gandotinib
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    Gandotinib

    CAS:
    <p>LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).</p>
    Formula:C23H25ClFN7O
    Purity:99.33% - 99.86%
    Color and Shape:Solid
    Molecular weight:469.94

    Ref: TM-T2638

  • NVP-BSK805 trihydrochloride
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    NVP-BSK805 trihydrochloride

    CAS:
    <p>NVP-BSK805 trihydrochloride inhibits JAK2 (0.48 nM IC50); also affects JAK1, JAK3, TYK2.</p>
    Formula:C27H31Cl3F2N6O
    Color and Shape:Solid
    Molecular weight:599.93

    Ref: TM-T39858

  • AT9283
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    AT9283

    CAS:
    <p>AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).</p>
    Formula:C19H23N7O2
    Purity:99.83% - 99.98%
    Color and Shape:Solid
    Molecular weight:381.43

    Ref: TM-T3068

  • Curculigoside
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    Curculigoside

    CAS:
    <p>1.</p>
    Formula:C22H26O11
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:466.44

    Ref: TM-T6S1966

  • AMG-47a
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    AMG-47a

    CAS:
    <p>AMG-47a inhibits Lck, T cell growth, and degrades KRAS oncoprotein, affecting EGFP-KRASG12V but not EGFP.</p>
    Formula:C29H28F3N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:535.56

    Ref: TM-T7123

  • Decernotinib
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    Decernotinib

    CAS:
    <p>Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.</p>
    Formula:C18H19F3N6O
    Purity:99.28% - >99.99%
    Color and Shape:Solid
    Molecular weight:392.38

    Ref: TM-T2636

  • Ritlecitinib
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    Ritlecitinib

    CAS:
    <p>Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.</p>
    Formula:C15H19N5O
    Purity:98.82% - 99.92%
    Color and Shape:Solid
    Molecular weight:285.34

    Ref: TM-T5382

  • Momelotinib HCl
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    Momelotinib HCl

    CAS:
    <p>Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.</p>
    Formula:C23H24Cl2N6O2
    Color and Shape:Solid
    Molecular weight:487.38

    Ref: TM-T70823

  • AZ960
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    AZ960

    CAS:
    <p>AZ960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: &lt;3 nM and0.45 nM).</p>
    Formula:C18H16F2N6
    Purity:96.02% - 98.51%
    Color and Shape:Solid
    Molecular weight:354.36

    Ref: TM-T6309

  • WHI-P97 HCl
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    WHI-P97 HCl

    <p>WHI-P97 HCl is a potent and selective JAK-3 inhibitor.</p>
    Formula:C16H14Br2ClN3O3
    Purity:99.49%
    Color and Shape:Solid
    Molecular weight:491.56

    Ref: TM-T4657L

  • RO495
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    RO495

    CAS:
    <p>RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays</p>
    Formula:C17H14Cl2N6O
    Purity:97.94%
    Color and Shape:Solid
    Molecular weight:389.24

    Ref: TM-T22416

  • WP1066
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    WP1066

    CAS:
    <p>WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.</p>
    Formula:C17H14BrN3O
    Purity:98.92% - 99.73%
    Color and Shape:Solid
    Molecular weight:356.22

    Ref: TM-T2156