CymitQuimica logo
JAK

JAK

JAK (Janus kinase) inhibitors are compounds that target the JAK-STAT signaling pathway, which is involved in cell growth, immune response, and angiogenesis. By inhibiting JAK, these compounds can reduce the signaling that leads to the formation of new blood vessels in tumors, thereby inhibiting tumor growth. JAK inhibitors are important in the treatment of cancers and inflammatory diseases. At CymitQuimica, we offer a diverse range of high-quality JAK inhibitors to support your research in oncology, immunology, and angiogenesis.

Found 245 products of "JAK"

Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
products per page.
  • Baricitinib
    Targetmol
    + Info

    Baricitinib

    CAS:
    <p>Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.</p>
    Formula:C16H17N7O2S
    Purity:99% - >99.99%
    Color and Shape:Solid
    Molecular weight:371.42

    Ref: TM-T2485

  • JAK3-IN-6
    Targetmol
    + Info

    JAK3-IN-6

    CAS:
    <p>JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM</p>
    Formula:C19H18N4O3
    Purity:99.94% - 99.94%
    Color and Shape:Solid
    Molecular weight:350.37

    Ref: TM-T5492

  • Ruxolitinib (S enantiomer)
    Targetmol
    + Info

    Ruxolitinib (S enantiomer)

    CAS:
    <p>Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.</p>
    Formula:C17H18N6
    Purity:99.37% - 99.79%
    Color and Shape:Solid
    Molecular weight:306.36

    Ref: TM-T6156

  • WHI-P97 HCl
    Targetmol
    + Info

    WHI-P97 HCl

    <p>WHI-P97 HCl is a potent and selective JAK-3 inhibitor.</p>
    Formula:C16H14Br2ClN3O3
    Purity:99.49%
    Color and Shape:Solid
    Molecular weight:491.56

    Ref: TM-T4657L

  • Fedratinib
    Targetmol
    + Info

    Fedratinib

    CAS:
    <p>Fedratinib (TG-101348) (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.</p>
    Formula:C27H36N6O3S
    Purity:97.31% - 99.96%
    Color and Shape:Solid
    Molecular weight:524.68

    Ref: TM-T1995

  • RO495
    Targetmol
    + Info

    RO495

    CAS:
    <p>RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays</p>
    Formula:C17H14Cl2N6O
    Purity:97.94%
    Color and Shape:Solid
    Molecular weight:389.24

    Ref: TM-T22416

  • WP1066
    Targetmol
    + Info

    WP1066

    CAS:
    <p>WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.</p>
    Formula:C17H14BrN3O
    Purity:98.92% - 99.73%
    Color and Shape:Solid
    Molecular weight:356.22

    Ref: TM-T2156

  • Momelotinib HCl
    Targetmol
    + Info

    Momelotinib HCl

    CAS:
    <p>Momelotinib HCl is a JAK1/2 inhibitor, reducing anemia in myelofibrosis (MF) patients.</p>
    Formula:C23H24Cl2N6O2
    Color and Shape:Solid
    Molecular weight:487.38

    Ref: TM-T70823

  • RGB-286638 free base
    Targetmol
    + Info

    RGB-286638 free base

    CAS:
    <p>RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.</p>
    Formula:C29H35N7O4
    Purity:98% - 99.91%
    Color and Shape:Solid
    Molecular weight:545.63

    Ref: TM-T2378

  • SC99
    Targetmol
    + Info

    SC99

    CAS:
    <p>SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.</p>
    Formula:C15H8Cl2FN3O
    Purity:99.56%
    Color and Shape:Solid
    Molecular weight:336.15

    Ref: TM-T8719

  • Pyridone 6
    Targetmol
    + Info

    Pyridone 6

    CAS:
    <p>Pyridone 6, a selective JAK1/2/3 and Tyk2 inhibitor with IC50s: JAK1=15 nM, JAK2=1 nM, JAK3 (Ki=5 nM), Tyk2=1 nM; weakly binds other kinases (130 nM-10 μM).</p>
    Formula:C18H16FN3O
    Purity:97.1% - 98.74%
    Color and Shape:Solid
    Molecular weight:309.34

    Ref: TM-T3080

  • NVP-BSK805 trihydrochloride
    Targetmol
    + Info

    NVP-BSK805 trihydrochloride

    CAS:
    <p>NVP-BSK805 trihydrochloride inhibits JAK2 (0.48 nM IC50); also affects JAK1, JAK3, TYK2.</p>
    Formula:C27H31Cl3F2N6O
    Color and Shape:Solid
    Molecular weight:599.93

    Ref: TM-T39858

  • Ritlecitinib
    Targetmol
    + Info

    Ritlecitinib

    CAS:
    <p>Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.</p>
    Formula:C15H19N5O
    Purity:98.82% - 99.92%
    Color and Shape:Solid
    Molecular weight:285.34

    Ref: TM-T5382

  • (E/Z)-Zotiraciclib
    Targetmol
    + Info

    (E/Z)-Zotiraciclib

    CAS:
    <p>(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.</p>
    Formula:C23H24N4O
    Purity:97.75% - 99.92%
    Color and Shape:Solid
    Molecular weight:372.46

    Ref: TM-T21503

  • Deucravacitinib
    Targetmol
    + Info

    Deucravacitinib

    CAS:
    <p>Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor.Cost-effective and quality-assured.</p>
    Formula:C20H19D3N8O3
    Purity:98.52% - >99.99%
    Color and Shape:Solid
    Molecular weight:425.46

    Ref: TM-T14687

  • WDR5-0103 hydrochloride[890190-22-4(free base)]
    Targetmol
    + Info

    WDR5-0103 hydrochloride[890190-22-4(free base)]

    <p>WDR5-0103 hydrochloride[890190-22-4(free base)] (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd:</p>
    Formula:C21H26ClN3O4
    Purity:99.66%
    Color and Shape:Solid
    Molecular weight:419.9

    Ref: TM-T5140

  • XL019
    Targetmol
    + Info

    XL019

    CAS:
    <p>XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.</p>
    Formula:C25H28N6O2
    Purity:99.19%
    Color and Shape:Solid
    Molecular weight:444.53

    Ref: TM-T3072

  • TG101209
    Targetmol
    + Info

    TG101209

    CAS:
    <p>TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.</p>
    Formula:C26H35N7O2S
    Purity:99% - >99.99%
    Color and Shape:Solid
    Molecular weight:509.67

    Ref: TM-T3065

  • Brevilin A
    Targetmol
    + Info

    Brevilin A

    CAS:
    <p>Brevilin A, a sesquiterpene from Centipeda minima, hinders JAK and blocks STAT3 (IC50=10.6μM), inducing apoptosis and autophagy in cancer cells.</p>
    Formula:C20H26O5
    Purity:99.97% - >99.99%
    Color and Shape:Solid
    Molecular weight:346.42

    Ref: TM-T4672

  • FM-381
    Targetmol
    + Info

    FM-381

    CAS:
    <p>FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.</p>
    Formula:C24H24N6O2
    Purity:98.44%
    Color and Shape:Solid
    Molecular weight:428.49

    Ref: TM-T5091