MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 893 products of "MAPK"
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PLX8394
CAS:Plixorafenib (PLX8394) is an orally active inhibitor of the serine/threonine protein kinase B-Raf (BRAF) protein.Cost-effective and quality-assured.Formula:C25H21F3N6O3SPurity:98.75% - >99.99%Color and Shape:SolidMolecular weight:542.53S6K-18
CAS:S6K-18, a highly selective S6K1 inhibitor, inhibits S6K1 with IC50 of 52nM.Formula:C17H18N4O3SPurity:98.99%Color and Shape:SolidMolecular weight:358.41Ref: TM-T22422
1mg39.00€5mg92.00€10mg138.00€25mg304.00€50mg424.00€100mg587.00€200mg792.00€1mL*10mM (DMSO)105.00€KO-947
CAS:KO-947 is a potent and specific inhibitor of ERK1/2 kinases.
Formula:C21H17N5OPurity:97.84%Color and Shape:SolidMolecular weight:355.39(S)-AMG-510
CAS:(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.Formula:C30H30F2N6O3Purity:99.05% - 99.76%Color and Shape:SolidMolecular weight:560.594Ref: TM-T22258
2mg34.00€5mg50.00€10mg80.00€25mg147.00€50mg259.00€100mg404.00€500mg888.00€1mL*10mM (DMSO)73.00€Bentamapimod
CAS:Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK.Formula:C25H23N5O2SPurity:97.04% - 99.92%Color and Shape:SolidMolecular weight:457.55Ref: TM-T2675
1g1,972.00€2g2,655.00€2mg43.00€5mg63.00€10mg94.00€25mg154.00€50mg187.00€100mg333.00€500mg1,089.00€Tizoxanide
CAS:Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.Formula:C10H7N3O4SPurity:98.89% - 99.28%Color and Shape:SolidMolecular weight:265.25β-Glycerophosphate disodium salt pentahydrate
CAS:β-Glycerophosphate disodium salt pentahydrate is a protein phosphatase inhibitor.Formula:C3H7O6PH2ONaPurity:98.94% - ≥98%Color and Shape:SolidMolecular weight:306.11APS6-45
CAS:APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.Formula:C23H16F8N4O3Purity:99.39%Color and Shape:SolidMolecular weight:548.39Ref: TM-T8843
2mg37.00€5mg84.00€10mg120.00€25mg236.00€50mg380.00€100mg583.00€200mg785.00€1mL*10mM (DMSO)92.00€B-Raf IN 1
CAS:B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.Formula:C29H24F3N5OPurity:97.22% - 99.27%Color and Shape:SolidMolecular weight:515.53Ref: TM-T1845
1mg87.00€2mg113.00€5mg177.00€10mg313.00€25mg530.00€50mg757.00€100mg1,044.00€1mL*10mM (DMSO)210.00€GW 284543 hydrochloride
CAS:GW 284543 hydrochloride is a selective inhibitor of MEK5 .Formula:C23H21ClN2O3Purity:99.73%Color and Shape:SolidMolecular weight:408.87Pimasertib
CAS:Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.Formula:C15H15FIN3O3Purity:98.25% - 99.57%Color and Shape:SolidMolecular weight:431.2Ref: TM-T6131
2mg34.00€5mg50.00€10mg58.00€25mg96.00€50mg140.00€100mg207.00€200mg270.00€1mL*10mM (DMSO)52.00€ERK5-IN-2
CAS:ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.Formula:C17H11BrFN3O2Purity:99.01%Color and Shape:SolidMolecular weight:388.19Ref: TM-T5535
1mg46.00€5mg90.00€10mg160.00€25mg268.00€50mg401.00€100mg580.00€200mg798.00€1mL*10mM (DMSO)101.00€SLV-2436
CAS:SLV-2436 (SEL201-88) is a novel effective and ATP-competitive inhibitor of MNK1 and MNK2 (IC50: 10.8/5.4 nM).Formula:C19H15ClN4OPurity:98.56%Color and Shape:SolidMolecular weight:350.8Ref: TM-T4424
1mg77.00€2mg101.00€5mg166.00€10mg260.00€25mg462.00€50mg677.00€100mg888.00€200mg1,234.00€1mL*10mM (DMSO)178.00€ASP2453
CAS:ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.Formula:C40H48F3N7O4Purity:99.71%Color and Shape:SolidMolecular weight:747.85NG25 trihydrochloride
CAS:NG25 trihydrochloride: kinase inhibitor for MAP4K2, TAK1, Src, LYN, Abl, CSK, FER, p38α; blocks TNF-α signals; impedes IFN secretion; anti-cancer properties.Formula:C29H33Cl3F3N5O2Color and Shape:SolidMolecular weight:646.96Maohuoside A
CAS:Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.Formula:C27H32O12Purity:98.91% - 99.57%Color and Shape:SolidMolecular weight:548.54Ref: TM-TN2081
1mg52.00€5mg116.00€10mg172.00€25mg266.00€50mg353.00€100mg803.00€200mg1,063.00€1mL*10mM (DMSO)142.00€IQ-3
CAS:IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and reduces TNF-α/IL-6 production.
Formula:C20H11N3O3Purity:≥98%Color and Shape:SolidMolecular weight:341.32B-Raf IN 11
CAS:B-Raf IN 11 is a novel selective inhibitor.Formula:C17H14BrF2N3O3SPurity:99.947%Color and Shape:SolidMolecular weight:458.28ERK-IN-4
CAS:ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.Formula:C14H17ClN2O3SPurity:98.92% - 99.84%Color and Shape:SolidMolecular weight:328.814Ref: TM-T36675
1mg46.00€2mg57.00€5mg93.00€10mg137.00€25mg219.00€50mg324.00€100mg484.00€1mL*10mM (DMSO)99.00€Raf inhibitor 1
CAS:B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.Formula:C26H19ClN8Purity:99.91%Color and Shape:SolidMolecular weight:478.94SHP389
CAS:SHP389 is a highly effective allosteric inhibitor of SHP2, inhibiting SHP2 and p-ERK, used in cancer research.Formula:C23H29ClN8O2Purity:98.24%Color and Shape:SolidMolecular weight:484.98GW284543
CAS:GW284543 (UNC10225170) is a selective inhibitor of MEK5 .Formula:C23H20N2O3Purity:99.75%Color and Shape:SolidMolecular weight:372.42Ulixertinib hydrochloride
CAS:Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosisFormula:C21H23Cl3N4O2Purity:99.85%Color and Shape:SolidMolecular weight:469.79TBAP-001
CAS:TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.Formula:C27H23F2N7O3Purity:99.58%Color and Shape:SolidMolecular weight:531.51Ref: TM-T9693
1mg46.00€5mg92.00€10mg147.00€25mg258.00€50mg386.00€100mg537.00€200mg710.00€1mL*10mM (DMSO)107.00€NCB-0846
CAS:NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).Formula:C21H21N5O2Purity:97.04% - 99.89%Color and Shape:SolidMolecular weight:375.42Trametiglue
CAS:Trametiglue, a potent Trametinib derivative, selectively targets KSR-MEK and RAF-MEK through unique binding.Formula:C25H24FIN6O5SColor and Shape:SolidMolecular weight:666.46AZD0022
CAS:AZD0022 is a selective, reversible, and orally active KRAS G12D inhibitor, exhibits tumour marker inhibition in PDAC and NSCLC models.Formula:C34H30F4N6OPurity:98.73%Color and Shape:SoildMolecular weight:614.64ASK1-IN-6
CAS:ASK1-IN-6 (Compound 32), a selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor, exhibits an IC50 of 25 nM. This compound readily crosses the blood-brain barrier, as evidenced by rat pharmacokinetics showing a clearance/unchanged clearance rate of 1.6/56 L/h/kg and an unbound partition coefficient (Kp,uu) of 0.46. Additionally, ASK1-IN-6 demonstrates anti-inflammatory activity and effectively improves symptoms in the Alzheimer's Disease Tg4510 mouse model.Formula:C17H14F4N6O2Molecular weight:410.33AMG410
CAS:AMG410 is a non-covalent, dual-modality KRAS inhibitor effective against both GDP (OFF) and GTP (ON) binding independently of the cell cycle and other mutants,Formula:C31H32ClF2N7O5Purity:98.01% - 99.84%Color and Shape:SoildMolecular weight:656.086H05
CAS:6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).Formula:C20H30ClN3O2S3Purity:98%Color and Shape:SolidMolecular weight:476.12Deltarasin
CAS:Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.Formula:C40H37N5OPurity:99.4%Color and Shape:SolidMolecular weight:603.75FMK
CAS:FMK 是一种不可逆的 RSK2 抑制剂，能够共价修饰 RSK 的 C 末端区域。Formula:C18H19FN4O2Purity:99.71%Color and Shape:SolidMolecular weight:342.37Ref: TM-TQ0310
1mg74.00€2mg96.00€5mg168.00€10mg301.00€25mg512.00€50mg738.00€100mg1,035.00€500mg2,062.00€1mL*10mM (DMSO)187.00€Cephradine monohydrate
CAS:Cephradine monohydrate is a β-lactam cephalosporin antibiotic exhibiting broad-spectrum activity against Gram-positive and Gram-negative pathogens.Formula:C16H21N3O5SPurity:99.91%Color and Shape:SolidMolecular weight:367.42SC-68376
CAS:SC-68376 is a potent, reversible, cell-permeable, ATP-competitive, and selective inhibitor of p38 MAP kinase.Formula:C15H12N2OPurity:98%Color and Shape:SolidMolecular weight:236.27ETC-168
CAS:ETC-168 is a selective, orally active MNK inhibitor with IC50 values of 23 nM for MNK1 and 43 nM for MNK2. It demonstrates antiproliferative efficacy both in vivo and in vitro [1].Formula:C24H19N5O2Color and Shape:SolidMolecular weight:409.44Sulindac sulfide
CAS:Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid metabolite.Formula:C20H17FO2SPurity:99.35%Color and Shape:SolidMolecular weight:340.41Cot inhibitor-2
CAS:Cot inhibitor-2: Potent, selective Tpl2/MAP3K8 blocker. IC50: 1.6 nM; hampers LPS-induced TNF-α, IC50: 0.3 μM. Orally active.Formula:C26H25Cl2FN8Purity:99.85%Color and Shape:SolidMolecular weight:539.43Ref: TM-T10866
1mg69.00€5mg149.00€10mg230.00€25mg485.00€50mg713.00€100mg1,018.00€200mg1,369.00€1mL*10mM (DMSO)172.00€PLX7904
CAS:PLX7904 (PB04), a selective RAF inhibitor, blocks ERK1/2 in mutant BRAF melanoma without activating it in RAS mutants.Formula:C24H22F2N6O3SPurity:99.51% - 99.66%Color and Shape:SolidMolecular weight:512.53KRAS inhibitor-7
CAS:KRAS inhibitor-7 is a potent KRAS G12C inhibitor.Formula:C26H27ClF2N6O2Purity:98%Color and Shape:SolidMolecular weight:528.98MCP110
CAS:MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.Formula:C33H36N2O3Purity:97.23%Color and Shape:OilMolecular weight:508.65Ref: TM-T24437
1mg34.00€5mg92.00€10mg160.00€25mg276.00€50mg400.00€100mg532.00€500mg1,063.00€1mL*10mM (DMSO)103.00€GABAB receptor antagonist 1
CAS:(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selectiveFormula:C18H24O4Purity:98%Color and Shape:SolidMolecular weight:304.38JNK3 inhibitor-2
CAS:JNK3 inhibitor-2: selectively inhibits JNK3 (IC50 = 0.25 μM); less effective on JNK1/JNK2 (>100 μM); targets DDR1 and EGFR mutations.Formula:C20H14N2O2Color and Shape:SolidMolecular weight:314.34RAS inhibitor Abd-7
CAS:Abd-7: potent RAS inhibitor (Kd=51 nM) that blocks RAS-effector PPI, disrupting KRAS, NRAS Q61H, HRAS G12V signaling.Formula:C23H25N3O3Color and Shape:SolidMolecular weight:391.46VU0424465
CAS:VU0424465 is a mGlu5-selective allosteric agonist.Formula:C19H19FN2O2Color and Shape:SolidMolecular weight:326.36RAF-IN-1
CAS:RAF-IN-1: strong b/cRAF inhibitor; cRAF IC50=3.8 nM; bRAFwt IC50=36 nM; bRAFV600E IC50=29.4 nM; A375/H358 bRAFV600E GI50=3.4/2.9 nM.Formula:C26H22F3N3O4Color and Shape:SolidMolecular weight:497.47KRAS inhibitor-4
CAS:KRAS inhibitor-4 developed as anticancer agents, is a potent KRAS inhibitor.Formula:C30H39ClN8OPurity:98%Color and Shape:SolidMolecular weight:563.14Anti-inflammatory agent 33
CAS:Agent 33: potent p38α inhibitor, reduces NO, iNOS, COX-2, p-p38α, p-MK2; shows anti-inflammatory effects.Formula:C22H15N3O5SColor and Shape:SolidMolecular weight:433.44RSK2-IN-3
CAS:RSK2-IN-3 (Compound 26) is a covalent, reversible inhibitor of RPS6KA3 (RSK2) kinase.Formula:C24H26N4O5Color and Shape:SolidMolecular weight:450.49MLKL-IN-5
CAS:MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis .Formula:C18H20N6O4SColor and Shape:SolidMolecular weight:416.45ZINC09659342
CAS:ZINC09659342 (compound 13) is an inhibitor of Lbc-RhoA interaction (IC50: 3.6 μM).Formula:C23H15F3N2O4Color and Shape:SolidMolecular weight:440.37
