MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Found 924 products for "MAPK".
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CST905
CAS:CST905 is an efficient PROTAC BRAF-V600E degrader with a DC50 of 18 nM, suitable for cancer research.Formula:C51H58F2N10O7S2Molecular weight:1025.20KRAS G12C inhibitor 18
CAS:KRAS G12C inhibitor 18 is a potent, orally active compound that inhibits KRAS G12C and exhibits anti-tumor activities.Formula:C25H20ClFN4O3SColor and Shape:SolidMolecular weight:510.97Endothelin-1 (1-31) (Human)
CAS:Endothelin-1 (1-31) is a human-derived vasoconstrictor and hypertensive formed by chymase hydrolysis of big ET-1.Formula:C162H236N38O47S5Molecular weight:3628.16BI1701963
BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.Formula:C47H62N8O4SColor and Shape:SolidMolecular weight:835.11MS432
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.Formula:C50H65F3IN7O6SPurity:98%Color and Shape:SolidMolecular weight:1076.06KRASG12C IN-14
KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.Formula:C51H65F4N9O9S2Color and Shape:SolidMolecular weight:1088.24JNK3 inhibitor-8
JNK3 inhibitor-8: potent, selective, oral, BBB-penetrating, IC50: JNK3=21 nM, JNK2=2203 nM, JNK1>10,000 nM; potential in Alzheimer's research.Formula:C32H30FN7O3Color and Shape:SolidMolecular weight:579.62PROTAC MLKL Degrader-1
PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%.Formula:C46H55F2N9O9SColor and Shape:SolidMolecular weight:948.05NecroX-2
CAS:NecroX-2 is a cell-permeable necrosis inhibitor with antioxidant properties. NecroX-2 selectively suppresses necrotic cell death triggered by oxidative stress. NecroX-2 does not confer protection against apoptosis induced by staurosporine or etoposide but shows protective effects under conditions such as cold shock, hypoxia, and oxidative stress in vitro.Formula:C25H32N4O4S2Purity:97.12%Color and Shape:SolidMolecular weight:516.68AM-001
CAS:AM-001 is a non-competitive Epac1 inhibitor that blocks Rap1 activation and is used in heart disease research.Formula:C24H16FN3OS2Purity:99.92%Color and Shape:Yellow SolidMolecular weight:445.532Anticancer agent 207
Anticanceragent 207 (compound 10b) is an effective anticancer agent. It binds to NRAS rG4 with a KD value of 2.31 µM. It exhibits cytotoxicity and reduces NRAS protein expression, demonstrating antitumor activity.Formula:C29H39FN4O2Molecular weight:494.3057SOS1-IN-24
SOS1-IN-24 (Compound 15) is an SOS1 inhibitor with an IC50 of 0.398 μM, effectively blocking the interaction of SOS1::KRAS12D. It is applicable in research on cancers such as pancreatic and colorectal cancer.RTIL 13
CAS:RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).Formula:C30H55BrN2O3Color and Shape:SolidMolecular weight:571.685JNK-IN-15, Cell-Permeable, Negative Control
JNK-IN-15, Cell-Permeable, Negative Control serves as the negative control for JNK-IN-15, Cell-Permeable. JNK-IN-15, Cell-Permeable functions as an inhibitor of JNK.Formula:C191H336N70O48SColor and Shape:SolidMolecular weight:4410.57236SMU-L11
SMU-L11 is a specific TLR7 agonist (EC50=0.024 μM) that recruits the MyD88 adaptor protein, activating downstream NF-κB and MAPK signaling pathways. In mouse models, SMU-L11 significantly enhances immune cell activation and boosts CD4+ T and CD8+ T cell proliferation, leading to direct tumor cell destruction and inhibition of tumor growth. This compound has applications in cancer research and potential in studying immune system disorders.Formula:C19H24N4OMolecular weight:324.19501ADT-007
CAS:ADT-007 is a pan-RAS inhibitor with potent anticancer activity.Formula:C26H24FNO5Purity:98.82%Color and Shape:Yellow SolidMolecular weight:449.47L-JNKI-1
L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK, it has been shown to effectively inhibit JNK activity in in vivo studies.Formula:C164H286N66O40Purity:98%Color and Shape:SolidMolecular weight:3822.44FAM49B (190-198) mouse
CAS:FAM49B (190-198) mouse represents a peptide fragment of the mitochondria-localized protein FAM49B, which is instrumental in regulating mitochondrial fission, function, and integrity, in addition to influencing tumor progression. Beyond its role in mitochondrial dynamics, FAM49B serves as a negative regulator of T cell activation by inhibiting GTPase Rac activity and affecting cytoskeleton reorganization.Formula:C49H71N9O14SColor and Shape:SolidMolecular weight:1042.2PPARγ agonist-21
PPARγagonist-21 (Compound 9a) is a PPARγ agonist with an EC50 of 3.12 μM. It inhibits NF-κB by activating PPAR-γ and reduces the assembly of the NLRP3 inflammasome. PPARγagonist-21 blocks interactions between NLRP3-ASC and NLRP3-NEK7, alleviating the severity of gouty arthritis.(S,R,S)-AHPC-Me-C10-Br
CAS:(S,R,S)-AHPC-Me-C10-Br is a chemically synthesized conjugate and ligand-linker for E3 ligase, MS432 for MEK1/2 inhibitors and a VHL E3 ligase linker.Formula:C34H51BrN4O4SPurity:98.89%Color and Shape:SolidMolecular weight:691.762
