MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

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products per page. 536 products on this category.

Brand	Product data	Purity	Price range	Estimated delivery
	XMU-MP-9 REF: TM-T200189CAS: 2251130-41-1	- - -	To inquire	Mon 17 Mar 25
	NHTD REF: TM-T200095CAS: 2540915-70-4	- - -	To inquire	Mon 17 Mar 25
	Emprumapimod REF: TM-T63067CAS: 765914-60-1	100% - 99.21%	246.00 €~2,162.00 €	Mon 17 Mar 25
	JNK-1-IN-4 REF: TM-T200667CAS: 3047795-60-5	- - -	To inquire	Mon 17 Mar 25
	Refametinib R enantiomer REF: TM-T12697CAS: 923032-38-6	99.43%	91.00 €~2,037.00 €	Mon 17 Mar 25
	SJ-C1044 REF: TM-T200357CAS: 2121503-76-0	- - -	To inquire	Mon 17 Mar 25
	ERK-IN-2 REF: TM-T11225CAS: 2743576-56-7	98%	907.00 €~2,337.00 €	Mon 17 Mar 25
	SKLB646 REF: TM-T200104CAS: 1970149-05-3	- - -	To inquire	Mon 17 Mar 25
	Anti-osteoporosis agent-11 REF: TM-T200650CAS: 2869099-50-1	- - -	To inquire	Mon 17 Mar 25
	LSN3074753 REF: TM-T89906CAS: 1455031-68-1	- - -	To inquire	Mon 17 Mar 25
	KRAS inhibitor-35 REF: TM-T200557CAS: 3030078-96-4	- - -	To inquire	Mon 17 Mar 25
	IHMT-RAF-128 REF: TM-T89984CAS: 2479289-15-9	- - -	To inquire	Mon 17 Mar 25
	Rineterkib REF: TM-T11224CAS: 1715025-32-3	98.4%	96.00 €~1,170.00 €	Mon 31 Mar 25
	Garsorasib REF: TM-T40186CAS: 2559761-14-5	98.99%	- - -	Discontinued product
	I-37 free base( 2359690-13-2(free base)) REF: TM-T8721L	99.75%	- - -	Discontinued product
	I-37 REF: TM-T8721CAS: 2359690-13-2	98%	- - -	Discontinued product

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XMU-MP-9

CAS:2251130-41-1

XMU-MP-9, a bifunctional compound, targets the C2 domain of Nedd4-1 and the allosteric site of …

Formula:

C₁₉H₁₃ClFN₃OS

Color and Shape:

Liquid

Molecular weight:

385.84

Ref: TM-T200189

10mg		To inquire
50mg		To inquire

Estimated delivery in United States, on Monday 17 Mar 2025

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NHTD

CAS:2540915-70-4

NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, …

Formula:

C₂₄H₂₆N₂O₅

Color and Shape:

Liquid

Molecular weight:

422.47

Ref: TM-T200095

10mg		To inquire
50mg		To inquire

Estimated delivery in United States, on Monday 17 Mar 2025

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Emprumapimod

CAS:765914-60-1

Emprumapimod, an oral p38α MAPK inhibitor, targets RPMI-8226 cells, curbs LPS-induced IL-6; IC50: 100 pM; …

Formula:

C₂₄H₂₉F₂N₅O₃

Purity:

100% - 99.21%

Color and Shape:

Liquid

Molecular weight:

473.52

Ref: TM-T63067

1mg		246.00 €
5mg		502.00 €
10mg		801.00 €
50mg		1,603.00 €
100mg		2,162.00 €

Estimated delivery in United States, on Monday 17 Mar 2025

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JNK-1-IN-4

CAS:3047795-60-5

JNK-1-IN-4 (Compound E1) is an inhibitor of JNK, targeting JNK-1, JNK-2, and JNK-3 with IC50 …

Formula:

C₂₂H₂₅BrN₆O₃

Color and Shape:

Liquid

Molecular weight:

501.38

Ref: TM-T200667

10mg		To inquire
50mg		To inquire

Estimated delivery in United States, on Monday 17 Mar 2025

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Refametinib R enantiomer

Refametinib R enantiomer

CAS:923032-38-6

Refametinib R enantiomer (RDEA119 R enantiomer) is an MEK inhibitor with an EC50 of 2.0-15 …

Formula:

C₁₉H₂₀F₃IN₂O₅S

Purity:

99.43%

Color and Shape:

Solid

Molecular weight:

572.34

Ref: TM-T12697

1mg		91.00 €
5mg		195.00 €
10mg		289.00 €
25mg		544.00 €
50mg		729.00 €
100mg		1,016.00 €
500mg		2,037.00 €

Estimated delivery in United States, on Monday 17 Mar 2025

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SJ-C1044

CAS:2121503-76-0

SJ-C1044 is an orally effective pan-RAF inhibitor demonstrating immunomodulatory and antitumor activities. It targets wild-type …

Formula:

C₂₅H₁₄F₇N₇O

Color and Shape:

Liquid

Molecular weight:

561.41

Ref: TM-T200357

10mg		To inquire
50mg		To inquire

Estimated delivery in United States, on Monday 17 Mar 2025

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ERK-IN-2

CAS:2743576-56-7

ERK-IN-2, an ERK2 inhibitor, exhibits an IC50 value of 1.8 nM. At doses greater than …

Formula:

C₁₆H₁₈ClN₅O₂

Purity:

98%

Color and Shape:

Solid

Molecular weight:

347.8

Ref: TM-T11225

25mg		1,410.00 €
50mg		1,851.00 €
100mg		2,337.00 €

Estimated delivery in United States, on Monday 17 Mar 2025

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SKLB646

CAS:1970149-05-3

SKLB646 is an orally active multitarget kinase inhibitor that exhibits potent suppression of several kinases. …

Formula:

C₂₈H₂₆F₃N₇O

Color and Shape:

Liquid

Molecular weight:

533.55

Ref: TM-T200104

10mg		To inquire
50mg		To inquire

Estimated delivery in United States, on Monday 17 Mar 2025

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Anti-osteoporosis agent-11

Anti-osteoporosis agent-11

CAS:2869099-50-1

Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. It exhibits its most prominent …

Formula:

C₂₃H₁₇NO₂Se₂

Color and Shape:

Liquid

Molecular weight:

497.31

Ref: TM-T200650

10mg		To inquire
50mg		To inquire

Estimated delivery in United States, on Monday 17 Mar 2025

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LSN3074753

CAS:1455031-68-1

LSN3074753, a derivative of LY3009120, acts as a pan-RAF and Raf dimer inhibitor. This compound …

Formula:

C₂₄H₃₀FN₅O₂

Color and Shape:

Liquid

Molecular weight:

439.53

Ref: TM-T89906

10mg		To inquire
50mg		To inquire

Estimated delivery in United States, on Monday 17 Mar 2025

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KRAS inhibitor-35

KRAS inhibitor-35

CAS:3030078-96-4

KRAS inhibitor-35 (compound 72) is a KRAS inhibitor with an IC50 of 2 nM, utilized …

Formula:

C₃₈H₃₂F₄N₆O₃S

Color and Shape:

Liquid

Molecular weight:

728.76

Ref: TM-T200557

10mg		To inquire
50mg		To inquire

Estimated delivery in United States, on Monday 17 Mar 2025

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IHMT-RAF-128

CAS:2479289-15-9

IHMT-RAF-128 is a potent pan-RAF inhibitor that demonstrates robust antitumor activity in xenograft mouse tumor …

Formula:

C₂₇H₂₄F₃N₅O₂

Color and Shape:

Liquid

Molecular weight:

507.51

Ref: TM-T89984

10mg		To inquire
50mg		To inquire

Estimated delivery in United States, on Monday 17 Mar 2025

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Rineterkib

CAS:1715025-32-3

Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.

Formula:

C₂₆H₂₇BrF₃N₅O₂

Purity:

98.4%

Color and Shape:

Solid

Molecular weight:

578.42

Ref: TM-T11224

1mg		96.00 €
5mg		190.00 €
10mg		357.00 €
25mg		604.00 €
50mg		860.00 €
100mg		1,170.00 €
1mL*10mM (DMSO)		252.00 €

Estimated delivery in United States, on Monday 31 Mar 2025

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Garsorasib

CAS:2559761-14-5

Garsorasib is an effective KRAS G12C inhibitor (IC50 = 10 nM) and can be used …

Formula:

C₃₂H₃₂F₂N₈O₂

Purity:

98.99%

Color and Shape:

Solid

Molecular weight:

598.65

Ref: TM-T40186

1mg		Discontinued	Request information
2mg		Discontinued	Request information
5mg		Discontinued	Request information
10mg		Discontinued	Request information
25mg		Discontinued	Request information
50mg		Discontinued	Request information
100mg		Discontinued	Request information
1ml*10 (DMSO)		Discontinued	Request information
1mL*10mM (DMSO)		Discontinued	Request information

Discontinued product

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I-37 free base( 2359690-13-2(free base))

I-37 free base( 2359690-13-2(free base))

I-37 free base is a novel benzylamino substituted pyridopyrimidinone as SOS1 inhibitor.

Formula:

C₂₂H₂₄ClF₃N₄O

Purity:

99.75%

Color and Shape:

Solid

Molecular weight:

452.9

Ref: TM-T8721L

1mg		Discontinued	Request information
1ml		Discontinued	Request information
5mg		Discontinued	Request information
10mg		Discontinued	Request information
25mg		Discontinued	Request information
50mg		Discontinued	Request information
100mg		Discontinued	Request information
1ml*10 (DMSO)		Discontinued	Request information

Discontinued product

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I-37

CAS:2359690-13-2

I-37 (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-6-(1-methylcyclopropyl)-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-) is a novel benzylamino

Formula:

C₂₂H₂₃F₃N₄O

Purity:

98%

Color and Shape:

Solid

Molecular weight:

416.44

Ref: TM-T8721

5mg		Discontinued	Request information
10mg		Discontinued	Request information
25mg		Discontinued	Request information
50mg		Discontinued	Request information
100mg		Discontinued	Request information

Discontinued product

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