MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
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PLK1/p38γ-IN-1
CAS:2418614-81-8
PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively …
Formula:
C21H26ClN3O2
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
387.9
Ref: TM-T81441
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 18 Feb 2025
B-Raf IN 16
CAS:2304746-24-3
B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used …
Formula:
C20H19N5O3S
Purity:
98.59% - 99.56%
Color and Shape:
Liquid
Molecular weight:
409.46
Ref: TM-T79830
| 1mg | 182.00 € | ||
| 5mg | 451.00 € | ||
| 10mg | 646.00 € | ||
| 25mg | 1,007.00 € | ||
| 50mg | 1,390.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
ERK1/2 inhibitor 9
CAS:2169302-75-2
ERK1/2 Inhibitor 9 (Probe 1), a covalent antagonist of ERK1/2, exhibits sub-micromolar efficacy in cellular …
Formula:
C31H32ClN7O3
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
586.08
Ref: TM-T78190
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 18 Feb 2025
KRAS G12C inhibitor 13
CAS:2241719-75-3
KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .
Formula:
C40H46F3N7O4
Purity:
98%
Color and Shape:
Solid
Molecular weight:
745.83
Ref: TM-T11767
| 25mg | 1,967.00 € | ||
| 50mg | 2,600.00 € | ||
| 100mg | 3,460.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
BI-2493
CAS:2937344-16-4
BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity …
Formula:
C24H27N7OS
Purity:
97.03% - 99.49%
Color and Shape:
Soild
Molecular weight:
461.58
Ref: TM-T72061
| 1mg | 587.00 € | ||
| 5mg | 1,444.00 € | ||
| 10mg | 2,300.00 € | ||
| 25mg | 3,413.00 € | ||
| 50mg | 4,545.00 € | ||
| 100mg | 6,149.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
AY 77
CAS:1835734-92-3
AY 77: Potent, selective PAR2 agonist, favors Ca2+ (ec50=40nM) & ERK1/2 (ec50=2μM), boosts breast cancer …
Formula:
C21H32N4O4
Purity:
99.7%
Color and Shape:
Solid
Molecular weight:
404.5
Ref: TM-T41190
| 1mg | 637.00 € | ||
| 5mg | 1,375.00 € | ||
| 10mg | 1,854.00 € | ||
| 25mg | 2,747.00 € | ||
| 50mg | 3,720.00 € | ||
| 100mg | 5,001.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
JWG-071
CAS:2250323-50-1
JWG-071: First ERK5 kinase probe, BET inhibitor, 1 μM BRD4 IC, boosts ERK5 function and …
Formula:
C34H44N8O3
Purity:
98.33%
Color and Shape:
Solid
Molecular weight:
612.77
Ref: TM-T14547
| 1mg | 69.00 € | ||
| 5mg | 149.00 € | ||
| 10mg | 182.00 € | ||
| 25mg | 276.00 € | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 197.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
KRAS G12D modulator-1
CAS:2883034-05-5
KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging …
Formula:
C30H36FN5O4
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
549.64
Ref: TM-T79072
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 18 Feb 2025
Kras4B G12D-IN-1
CAS:2042365-85-3
Kras4B G12D-IN-1 is an inhibitor of Kras4B G12D with anticancer activity.Kras4B G12D-IN-1 inhibits Kras protein …
Formula:
C16H21ClN2O4S
Purity:
99.75%
Color and Shape:
Liquid
Molecular weight:
372.87
Ref: TM-T78170
| 2mg | 96.00 € | ||
| 5mg | 150.00 € | ||
| 10mg | 238.00 € | ||
| 25mg | 483.00 € | ||
| 50mg | 772.00 € | ||
| 100mg | 1,175.00 € | ||
| 500mg | 2,359.00 € | ||
| 1mL*10mM (DMSO) | 169.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
(R)-VX-11e
CAS:1680187-43-2
'(R)-VX-11e (Compound 1) functions as an inhibitor of ERK2 [1].'
Formula:
C24H20Cl2FN5O2
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
500.35
Ref: TM-T78143
| 2mg | 73.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
Glycinexylidide
CAS:18865-38-8
Glycinexylidide (GX), the active metabolite of the local anesthetic Lidocaine, exhibits properties significant in inhibiting …
Formula:
C10H14N2O
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
178.23
Ref: TM-T80638
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 18 Feb 2025
Raf inhibitor 3
CAS:1662682-11-2
Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 …
Formula:
C18H19FN8O2S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
430.46
Ref: TM-T79813
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 18 Feb 2025
AZD4747
CAS:2489226-14-2
AZD4747 is an inhibitor of the mutant GTPase KRASG12C that hasial antitumor activity for the …
Formula:
C24H22ClFN2O3
Purity:
99.36%
Color and Shape:
Liquid
Molecular weight:
440.89
Ref: TM-T79213
| 1mg | 248.00 € | ||
| 5mg | 606.00 € | ||
| 10mg | 918.00 € | ||
| 25mg | 2,026.00 € | ||
| 50mg | 3,243.00 € | ||
| 100mg | 5,222.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
BI-0474
CAS:2750570-55-7
BI-0474: KRASG12C inhibitor, IC50=7.0 nM, blocks GDP-KRAS/SOS1, anti-tumor in NCI-H358 cells & lung cancer model, …
Formula:
C30H37N9O2S
Purity:
100%
Color and Shape:
Liquid
Molecular weight:
587.74
Ref: TM-T69529
| 1mg | 360.00 € | ||
| 5mg | 759.00 € | ||
| 10mg | 1,141.00 € | ||
| 25mg | 1,846.00 € | ||
| 50mg | 2,545.00 € | ||
| 1mL*10mM (DMSO) | 728.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
p38 MAPK-IN-1
CAS:1006378-90-0
p38 MAPK-IN-1: selective p38 MAPK inhibitor, IC50 68 nM, good bioavailability, sustained, low clearance.
Formula:
C21H14F2N2O
Purity:
98%
Color and Shape:
Solid
Molecular weight:
348.35
Ref: TM-T16424
| 2mg | 186.00 € | ||
| 5mg | 325.00 € | ||
| 25mg | 1,058.00 € | ||
| 50mg | 1,385.00 € | ||
| 100mg | 1,884.00 € | ||
| 1mL*10mM (DMSO) | 361.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
KRAS G12C inhibitor 14
CAS:2349393-95-7
KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor with an IC 50 of …
Formula:
C24H19ClF2N4O3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
484.88
Ref: TM-T11768
| 10mg | 893.00 € | ||
| 25mg | 1,767.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
Cobimetinib racemate
CAS:934662-91-6
Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also …
Formula:
C21H21F3IN3O2
Purity:
98.00% - 99.71%
Color and Shape:
Solid
Molecular weight:
531.31
Ref: TM-T22677
| 2mg | 185.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
δ-Tocotrienol
CAS:25612-59-3
δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor.
Formula:
C27H40O2
Purity:
97.38%
Color and Shape:
Solid
Molecular weight:
396.61
Ref: TM-TMA2474
| 1mg | 47.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 150.00 € | ||
| 25mg | 291.00 € | ||
| 50mg | 436.00 € | ||
| 100mg | 645.00 € | ||
| 1mL*10mM (DMSO) | 104.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
Uplarafenib
CAS:1425485-87-5
Uplarafenib (B-Raf IN 10), a potent BRAF inhibitor (IC50: 50-100 nM), exhibits antitumor effects on …
Formula:
C22H21F3N4O4S
Purity:
99.85%
Color and Shape:
Liquid
Molecular weight:
494.49
Ref: TM-T63333
| 1mg | 94.00 € | ||
| 5mg | 199.00 € | ||
| 10mg | 291.00 € | ||
| 25mg | 618.00 € | ||
| 50mg | 930.00 € | ||
| 100mg | 1,613.00 € | ||
| 500mg | 3,232.00 € | ||
| 1mL*10mM (DMSO) | 220.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
pan-KRAS-IN-2
CAS:2882825-14-9
Pan-KRAS-IN-2 (compound 6) is a broad-spectrum KRAS inhibitor exhibiting potent activity with IC50 values of …
Formula:
C34H34F2N4O3
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
584.66
Ref: TM-T79800
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 18 Feb 2025
