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MAPK

MAPK

MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.

Found 887 products of "MAPK"

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  • 6-T-GDP
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    6-T-GDP

    CAS:
    <p>6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.</p>
    Formula:C10H15N5O10P2S
    Color and Shape:Solid
    Molecular weight:459.27

    Ref: TM-T88704

  • GDC-0879
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    GDC-0879

    CAS:
    <p>GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.</p>
    Formula:C19H18N4O2
    Purity:99.62%
    Color and Shape:Solid
    Molecular weight:334.37

    Ref: TM-T6320

  • Tpl2-IN-I
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    Tpl2-IN-I

    CAS:
    <p>Tpl2-IN-I is an inhibitor of tumour progression locus 2 (Tpl2) kinase.</p>
    Formula:C21H14ClFN6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:404.83

    Ref: TM-T26284

  • NSC1011
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    NSC1011

    CAS:
    <p>NSC1011 is an inhibitor of ras converting enzyme 1 (Rce1).</p>
    Formula:C23H18N2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:370.4

    Ref: TM-T28201

  • AZD6703 free base
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    AZD6703 free base

    CAS:
    <p>AZD6703 is a potent, selective and reversible orally bioavailable inhibitor of p38 mitogen-activated protein kinase 14 (MAPK14).</p>
    Formula:C24H27N5O2
    Color and Shape:Solid
    Molecular weight:417.5

    Ref: TM-T26721

  • Kobe2601
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    Kobe2601

    CAS:
    <p>Kobe2601 is a Kobe0065 and Kobe02602 water-soluble analog. It displays inhibitory activity towards Ras-Raf binding.</p>
    Formula:C13H10FN5O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:351.31

    Ref: TM-T24267

  • GSK329
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    GSK329

    CAS:
    <p>GSK329 selectively inhibits TNNI3K, showing cardioprotection in ischemic heart models.</p>
    Formula:C19H14Cl2F3N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:472.25

    Ref: TM-T24109

  • HCI-2184
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    HCI-2184

    CAS:
    <p>HCI-2184 is an inhibitor of AXL kinase and Nek2 that acts by successfully mitigating drug resistance in bortezomib-resistant multiple myeloma.</p>
    Formula:C23H28ClN7O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:502.03

    Ref: TM-T24130

  • GSK649A
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    GSK649A

    CAS:
    <p>GSK649A is a novel activator of Satellite Cell Proliferation, it could enhance repair of Damaged Muscle.</p>
    Formula:C15H12ClFN6OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:378.81

    Ref: TM-T27486

  • CP-281384
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    CP-281384

    CAS:
    <p>CP-281384 is a potent, p38alpha-selective inhibitor.</p>
    Formula:C18H14F2N4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:340.33

    Ref: TM-T27062

  • RBC6
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    RBC6

    CAS:
    <p>RBC6 is an inhibitor of the binding of Ral to its effector RALBP1.</p>
    Formula:C16H14Cl2N4O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:365.21

    Ref: TM-T24707

  • CP-944629
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    CP-944629

    CAS:
    <p>CP-944629 is a novel, potent, and selective inhibitor of p38alpha.</p>
    Formula:C19H15F3N4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:372.34

    Ref: TM-T27067

  • BNC-1
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    BNC-1

    CAS:
    <p>BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.</p>
    Formula:C16H14N2O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:282.29

    Ref: TM-T26879

  • (2Z,3Z)-U0126
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    (2Z,3Z)-U0126

    CAS:
    U0126 selectively inhibits MEK1/2, blocks MAPK/ERK signaling, and suppresses Ki-ras-induced cell growth, with IC50s of 72 nM and 58 nM for MEK1/2.
    Formula:C18H16N6S2
    Color and Shape:Solid
    Molecular weight:380.49

    Ref: TM-T69826

  • Migoprotafib
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    Migoprotafib

    CAS:
    Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.
    Formula:C25H26N8O
    Color and Shape:Solid
    Molecular weight:454.53

    Ref: TM-T62798

  • BSJ-04-122
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    BSJ-04-122

    CAS:
    <p>BSJ-04-122: MKK4/7 inhibitor with IC50s of 4 nM &amp; 181 nM, used in cancer research.</p>
    Formula:C15H12ClN5O
    Purity:97.61%
    Color and Shape:Solid
    Molecular weight:313.74

    Ref: TM-T73182

  • CK1-IN-2
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    CK1-IN-2

    CAS:
    <p>CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor p38a, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.</p>
    Formula:C17H12FN3O2
    Purity:99.31%
    Color and Shape:Solid
    Molecular weight:309.29

    Ref: TM-T79145

  • SR-3306
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    SR-3306

    CAS:
    <p>SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values ​​of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.</p>
    Formula:C28H26N8O
    Purity:99.38% - 99.71%
    Color and Shape:Solid
    Molecular weight:490.56

    Ref: TM-T16927

  • GNE-1858
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    GNE-1858

    CAS:
    <p>GNE-1858 inhibits HPK1; IC50: 1.9 nM for wild-type, 1.9 nM (HPK1-TSEE), 4.5 nM (HPK1-SA).</p>
    Formula:C21H26F2N8
    Purity:99.36%
    Color and Shape:Solid
    Molecular weight:428.48

    Ref: TM-T11438

  • J30-8
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    J30-8

    CAS:
    <p>J30-8 is a JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity and can be used to study neurodegenerative diseases such as Alzheimer's disease.</p>
    Formula:C17H9ClFN3O2S
    Purity:99.90%
    Color and Shape:Solid
    Molecular weight:373.79

    Ref: TM-T11702