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Membrane Transporter/Ion Channel

Membrane Transporter/Ion Channel

Membrane transporter and ion channel inhibitors are compounds that block the function of proteins responsible for the transport of ions, nutrients, and other molecules across cell membranes. These inhibitors are crucial for studying the regulation of cellular homeostasis, signal transduction, and neurotransmission. Membrane transporter and ion channel inhibitors are also important in developing treatments for disorders such as epilepsy, cardiovascular diseases, and metabolic syndromes. At CymitQuimica, we provide a diverse selection of high-quality membrane transporter and ion channel inhibitors to support your research in physiology, neuroscience, and pharmacology.

Subcategories of "Membrane Transporter/Ion Channel"

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Found 2290 products of "Membrane Transporter/Ion Channel"

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  • ATP synthase inhibitor 2
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    ATP synthase inhibitor 2

    CAS:
    <p>ATP synthase inhibitor 2 blocks P. aeruginosa ATP synthase; IC50=10 μg/mL, fully inhibits at 128 μg/mL.</p>
    Formula:C21H22N2O3S
    Color and Shape:Solid
    Molecular weight:382.48

    Ref: TM-T61649

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    T-Type calcium channel inhibitor 2

    <p>Compound 6g inhibits T-type Ca channels (IC50: Cav3.1-31μM, Cav3.2-83μM), cytotoxic to A549 (IC50: 5μM) &amp; HCT-116 cells (IC50: 6.4μM).</p>
    Formula:C36H39FN4OS
    Color and Shape:Solid
    Molecular weight:594.78

    Ref: TM-T64203

  • Gabaculine HCl
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    Gabaculine HCl

    CAS:
    <p>Gabaculine, an irreversible GABA-T inhibitor (Ki: 2.9 μM), impacts plastid development and affects DPOR/GluTR levels.</p>
    Formula:C7H10ClNO2
    Color and Shape:Solid
    Molecular weight:175.61

    Ref: TM-T24080

  • SR 33805 oxalate
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    SR 33805 oxalate

    CAS:
    <p>Ca2+ channel antagonist</p>
    Formula:C34H42N2O9S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:654.77

    Ref: TM-T23391

  • Kv7.2/Kv7.3 modulator-1
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    Kv7.2/Kv7.3 modulator-1

    CAS:
    <p>Kv7.2/Kv7.3 modulator-1 (compound 6a) acts as a modulator for Kv7.2/Kv7.3 channels, with a pEC50 value of 7.96 for opening these channels. Kv7.2/Kv7.3 modulator-1 is applicable in research related to epilepsy, depression, brain injury, and pain.</p>
    Formula:C20H21F4N3O3
    Color and Shape:Solid
    Molecular weight:427.393

    Ref: TM-T206950

  • RO-275
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    RO-275

    CAS:
    <p>RO-275 is an HCN1 inhibitor that also inhibits HCN2, HCN3, and HCN4, improving working memory deficits and being used in research on cognitive disorders.</p>
    Formula:C18H14ClN5O
    Purity:98.12% - 98.3%
    Color and Shape:Solid
    Molecular weight:351.79

    Ref: TM-T87339

  • EMD-95885
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    EMD-95885

    CAS:
    <p>EMD-95885 is a selective antagonist of NMDA receptors containing NR2B subunits, with an IC50 of 3.9 nM. It does not interact with other sites on the NMDA receptor.</p>
    Formula:C22H23FN2O3
    Color and Shape:Solid
    Molecular weight:382.428

    Ref: TM-T205291

  • MSK-195
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    MSK-195

    CAS:
    <p>MSK-195 is an effective TRPV1 agonist.</p>
    Formula:C28H40N2O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:484.63

    Ref: TM-T24504

  • Olorigliflozin
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    Olorigliflozin

    CAS:
    <p>Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.</p>
    Formula:C23H27ClO7
    Color and Shape:Solid
    Molecular weight:450.909

    Ref: TM-T205428

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    Cav 3.2 inhibitor 2

    <p>Cav 3.2 inhibitor 2 blocks T-type Ca2+ channels (IC50=0.09339 μM) and reduces mouse somatic/visceral pain. Used for intractable pain studies.</p>
    Formula:C32H37F2N3O
    Color and Shape:Solid
    Molecular weight:517.65

    Ref: TM-T63606

  • ARN23765
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    ARN23765

    CAS:
    <p>ARN23765 is an F508del-CFTR corrector with an EC50 of 38 pM in human bronchial epithelial cells. It enhances the maturation and function of F508del-CFTR at the cell membrane, influencing ion transport and secretion, thereby addressing the pathological mechanisms of cystic fibrosis (CF).</p>
    Formula:C30H22F5N3O6
    Color and Shape:Solid
    Molecular weight:615.504

    Ref: TM-T205032

  • Pyrimidinone 8
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    Pyrimidinone 8

    CAS:
    <p>Pyrimidinone 8 is a reversible, linear non-competitive inhibitor of divalent metal transporter 1 (DMT1) with a Ki of 20 μM (hDMT1). It does not affect the surface expression of hDMT1 and is not influenced by extracellular pH. Pyrimidinone 8 inhibits hDMT1-mediated iron uptake, with an IC50 of 13.8 μM.</p>
    Formula:C10H12N4O
    Color and Shape:Solid
    Molecular weight:204.229

    Ref: TM-T205042

  • GABA-IN-4
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    GABA-IN-4

    CAS:
    <p>GABA-IN-4 (Compound 17) is a derivative of N-(indol-3-ylglyoxylyl)benzylamine. It exhibits high affinity for the benzodiazepine receptor (BzR), the binding site within the GABAA receptor complex, with a Ki value of 67 nM. Benzodiazepines are widely used as anxiolytic, sedative-hypnotic, and anticonvulsant agents.</p>
    Formula:C17H13ClN2O2
    Color and Shape:Solid
    Molecular weight:312.75

    Ref: TM-T205501

  • Zilvetrigine
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    Zilvetrigine

    CAS:
    <p>Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.</p>
    Formula:C20H20ClN3O2
    Color and Shape:Solid
    Molecular weight:369.845

    Ref: TM-T205304

  • NMDA agonist 1
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    NMDA agonist 1

    CAS:
    <p>NMDA agonist 1 (compound 42d) is a potent NMDA agonist with a Ki value of 96 nM. It acts as a partial agonist of the GluN1/GluN2B complex, exhibiting an EC50 value of 78 nM.</p>
    Formula:C12H13N3O3S
    Color and Shape:Solid
    Molecular weight:279.315

    Ref: TM-T204880

  • Antidepressant agent 9
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    Antidepressant agent 9

    CAS:
    <p>Antidepressant agent 9 (Compound 24) is an orally active inhibitor of NMDAR and SERT, with IC50 values of 3.50 μM and 1044 nM, respectively. It exhibits good metabolic stability and plasma exposure, and demonstrates antidepressant-like effects in the forced swim test in mice.</p>
    Formula:C17H24N2
    Color and Shape:Solid
    Molecular weight:256.386

    Ref: TM-T205640

  • SGC-CAMKK2-1
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    SGC-CAMKK2-1

    CAS:
    <p>SGC-CAMKK2-1 is a selective inhibitor of calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) with an IC50 of 30 nM. It effectively inhibits AMPK phosphorylation in C4-2 cells, exhibiting an IC50 value of 1.6 µM.</p>
    Formula:C26H23NO3
    Color and Shape:Solid
    Molecular weight:397.466

    Ref: TM-T205037

  • O4I4
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    O4I4

    CAS:
    <p>O4I4 is an OCT4-inducing compound capable of activating endogenous OCT4 and its associated signaling pathways, shown anti-aging effects.</p>
    Formula:C15H20N2S
    Purity:99.74%
    Color and Shape:Solid
    Molecular weight:260.4

    Ref: TM-T87051

  • Antidepressant agent 8
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    Antidepressant agent 8

    CAS:
    <p>Antidepressant agent 8 (Compound 1f) acts as a selective antagonist for the NMDA receptor GluN1/2A (NMDA receptorGluN1/2A), with an IC50 of 2.94 μmol/L. In a hydrocortisone-induced zebrafish depression model, it demonstrates antidepressant-like effects and shows good blood-brain barrier penetration.</p>
    Formula:C18H23FN4OS2
    Color and Shape:Solid
    Molecular weight:394.53

    Ref: TM-T205232

  • LY503430
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    LY503430

    CAS:
    <p>LY503430: Oral AMPA enhancer with nootropic, neuroprotective properties, mitigates 6-OHDA/MPTP brain damage.</p>
    Formula:C20H25FN2O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:392.49

    Ref: TM-T27959