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Membrane Transporter/Ion Channel

Membrane Transporter/Ion Channel

Membrane transporter and ion channel inhibitors are compounds that block the function of proteins responsible for the transport of ions, nutrients, and other molecules across cell membranes. These inhibitors are crucial for studying the regulation of cellular homeostasis, signal transduction, and neurotransmission. Membrane transporter and ion channel inhibitors are also important in developing treatments for disorders such as epilepsy, cardiovascular diseases, and metabolic syndromes. At CymitQuimica, we provide a diverse selection of high-quality membrane transporter and ion channel inhibitors to support your research in physiology, neuroscience, and pharmacology.

Subcategories of "Membrane Transporter/Ion Channel"

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Found 2290 products of "Membrane Transporter/Ion Channel"

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  • CymitQuimica logo
    Targetmol
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    Antimalarial agent 7

    <p>Antimalarial agent 7 is a potent and effective inhibitor of PfATP4. Antimalarial agent 7 has potential for the study of the human plasmodium falciparum.</p>
    Formula:C23H22F2N4O3
    Color and Shape:Solid
    Molecular weight:440.44

    Ref: TM-T62537

  • Olisutrigine bromide
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    Olisutrigine bromide

    CAS:
    <p>Olisutrigine bromide is a sodium channel blocker used as an analgesic.</p>
    Formula:C25H35BrN2
    Color and Shape:Solid
    Molecular weight:443.463

    Ref: TM-T205479

  • ErSO-TFPy
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    ErSO-TFPy

    CAS:
    <p>ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.</p>
    Formula:C19H13F7N2O2
    Color and Shape:Solid
    Molecular weight:434.307

    Ref: TM-T205320

  • Moxetomidate
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    Moxetomidate

    CAS:
    <p>Moxetomidate is a GABAA receptor (GABAA receptor) agonist with hypnotic properties.</p>
    Formula:C15H18N2O3
    Color and Shape:Solid
    Molecular weight:274.315

    Ref: TM-T205308

  • LY3130481
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    LY3130481

    CAS:
    LY3130481: TARP γ-8 dependent AMPA receptor blocker; selectively targets AMPA/TARP γ-8 with 65 nM IC50.
    Formula:C19H18N4O3S
    Color and Shape:Solid
    Molecular weight:382.44

    Ref: TM-T15814

  • Crinecerfont tosylate
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    Crinecerfont tosylate

    CAS:
    <p>Crinecerfont tosylate is an effective oral CRF1 receptor antagonist. It is applicable to studies involving congenital adrenal hyperplasia (CAH).</p>
    Formula:C34H36ClFN2O4S2
    Color and Shape:Solid
    Molecular weight:655.242

    Ref: TM-T205414

  • (3S,6R)-NML
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    (3S,6R)-NML

    CAS:
    <p>(3S,6R)-NML is an NMDA receptor antagonist with pIC50 values of 4.8 [GluN1-GluN2A], 4.6 [GluN1-GluN2B], 5.0 [GluN1-GluN2C], and 5.0 [GluN1-GluN2D]. It is applicable in the study of depression.</p>
    Formula:C20H27NO
    Color and Shape:Solid
    Molecular weight:297.435

    Ref: TM-T205321

  • PDE2 inhibitor 6
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    PDE2 inhibitor 6

    CAS:
    <p>PDE2 inhibitor6 (Compound 1) is an orally active phosphodiesterase (PDE) inhibitor, effectively inhibiting PDE2A, PDE3B, and PDE10A2 with IC50 values of 0.95 nM, 6.17 μM (pIC50=5.21), and 87.1 nM (pIC50=7.06), respectively. It modulates AMPA receptor activity, enhances synaptic plasticity, and improves learning and memory in rat models. Furthermore, PDE2 inhibitor6 possesses blood-brain barrier permeability.</p>
    Formula:C20H22F2N6O
    Color and Shape:Solid
    Molecular weight:400.425

    Ref: TM-T206498

  • TTA-P1
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    TTA-P1

    CAS:
    <p>TTA-P1: potent T-type calcium channel inhibitor; impacts neuron firing, hormone secretion, cell growth; potential in absence epilepsy research.</p>
    Formula:C19H27Cl2FN2O
    Color and Shape:Solid
    Molecular weight:389.33

    Ref: TM-T61747

  • SGE-516
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    SGE-516

    CAS:
    <p>SGE516: neuroactive steroid, enhances GABAA, lowers neuronal activity, protects from seizures.</p>
    Formula:C23H35N3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:385.54

    Ref: TM-T28766

  • CymitQuimica logo
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    IAB15

    CAS:
    <p>IAB15 is a potent inhibitor of T-type calcium channel that can be used in the research of epilepsy [1].</p>
    Formula:C15H14F3NO2
    Color and Shape:Solid
    Molecular weight:297.27

    Ref: TM-T60648

  • Quinacainol dihydrochloride
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    Quinacainol dihydrochloride

    CAS:
    <p>Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.</p>
    Formula:C21H32Cl2N2O
    Color and Shape:Solid
    Molecular weight:399.398

    Ref: TM-T204878

  • CymitQuimica logo
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    URAT1 inhibitor 2

    <p>URAT1 inhibitor 2: oral URAT1/CYP blocker, IC50 of 1.36μM (URAT1), 16.97μM (CYP1A2), 5.22μM (CYP2C9); potential gout treatment.</p>
    Formula:C21H18BrN3O2S
    Color and Shape:Solid
    Molecular weight:456.36

    Ref: TM-T62825

  • Ro-51
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    Ro-51

    CAS:
    <p>dual P2X3 and P2X2/3 antagonist</p>
    Formula:C17H23IN4O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:474.29

    Ref: TM-T23245

  • CymitQuimica logo
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    Cav 2.2/3.2 blocker 1

    <p>Compound 9e is a Cav 2.2/3.2 blocker; IC50: 1.22 μM &amp; 80 μM, respectively; penetrates CNS.</p>
    Formula:C28H30N2O3
    Color and Shape:Solid
    Molecular weight:442.55

    Ref: TM-T62586

  • Insecticidal agent 21
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    Insecticidal agent 21

    CAS:
    <p>Insecticidal agent 21 (Compound 6) is an insecticide targeting Culex pipiens larvae with an LC50 of 0.4 μg/mL. It achieves multi-target neurotoxicity by inhibiting acetylcholinesterase (AChE) and simultaneously targeting other neural receptors, including nicotinic acetylcholine receptors (nAChR), voltage-gated sodium channels (VGSC), and γ-aminobutyric acid receptors (GABAAR). Insecticidal agent 21 shows potent insecticidal activity and can be utilized in the development of new insecticides to combat mosquito resistance to conventional agents.</p>
    Formula:C37H40ClN3O2
    Color and Shape:Solid
    Molecular weight:594.185

    Ref: TM-T206704

  • ATPase-IN-5
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    ATPase-IN-5

    CAS:
    <p>ATPase-IN-5 (Compound 11) is an antifungal Pma1p (H+ -ATPase) inhibitor (IC50 = 12.7 μM) that inhibits the growth of Candida albicans and Saccharomyces cerevisiae.</p>
    Formula:C10H10N4O3S
    Purity:99.19%
    Color and Shape:Solid
    Molecular weight:266.28

    Ref: TM-T204943

  • Lu AF90103
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    Lu AF90103

    CAS:
    <p>Lu AF90103 (Compound 42e) is the methyl ester prodrug of compound 42d, capable of crossing the blood-brain barrier. Compound 42d acts as a partial agonist of the GluN1/GluN2B complex, with an efficacy of 24% and an EC50 value of 78 nM. Lu AF90103 plays a significant role in neuropsychiatric disorder research.</p>
    Formula:C13H15N3O3S
    Color and Shape:Solid
    Molecular weight:293.342

    Ref: TM-T204820

  • Cyazofamid
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    Cyazofamid

    CAS:
    <p>Cyazofamid functions as a fungicide by impairing the production of ATP. It inhibits Organic Cation Transporter 3 (OCT3) and OAT1 with IC50 values of 1.54 and 17.3 μM, respectively.</p>
    Formula:C13H13ClN4O2S
    Color and Shape:Solid
    Molecular weight:324.79

    Ref: TM-T201605

  • cis-KV1.3-IN-1
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    cis-KV1.3-IN-1

    CAS:
    <p>cis-KV1.3-IN-1, also known as Compound cis-18, is the cis-isomer of KV1.3-IN-1 and functions as an inhibitor of the KV1.3 channel. In Xenopus laevis oocytes expressing human hKV1.3, cis-KV1.3-IN-1 (10 μM) achieves an inhibition rate of 25.53% against KV1.3.</p>
    Formula:C23H30N2O4S
    Color and Shape:Solid
    Molecular weight:430.56

    Ref: TM-T201783