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Membrane Transporter/Ion Channel

Membrane Transporter/Ion Channel

Membrane transporter and ion channel inhibitors are compounds that block the function of proteins responsible for the transport of ions, nutrients, and other molecules across cell membranes. These inhibitors are crucial for studying the regulation of cellular homeostasis, signal transduction, and neurotransmission. Membrane transporter and ion channel inhibitors are also important in developing treatments for disorders such as epilepsy, cardiovascular diseases, and metabolic syndromes. At CymitQuimica, we provide a diverse selection of high-quality membrane transporter and ion channel inhibitors to support your research in physiology, neuroscience, and pharmacology.

Subcategories of "Membrane Transporter/Ion Channel"

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Found 2280 products of "Membrane Transporter/Ion Channel"

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  • P2X4 antagonist-4
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    P2X4 antagonist-4

    <p>P2X4 antagonist-4 (compound 64) is a potent P2X4R antagonist with an IC50 value of 8 µM. It can inhibit ATP-induced activation of the NLRP3 inflammasome and the subsequent release of IL-1β.</p>
    Formula:C27H22FN3O4S
    Color and Shape:Solid
    Molecular weight:503.545

    Ref: TM-T204441

  • BKCa activator-1
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    BKCa activator-1

    <p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>
    Formula:C22H23F7N2O3
    Color and Shape:Solid
    Molecular weight:496.418

    Ref: TM-T205564

  • D-GsMTx4
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    D-GsMTx4

    <p>TRPC1/6 &amp; Piezo2 inhibitor; mimics GsMTx4; blocks ~70% mechanosensitive currents; aids in mouse heart attack models; protease-resistant.</p>
    Color and Shape:Soild

    Ref: TM-T37697

  • ω-Agatoxin IVA
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    ω-Agatoxin IVA

    CAS:
    <p>Selective blocker of P-type calcium channels (IC50 &lt; 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations.</p>
    Formula:C217H360N68O60S10
    Purity:98%
    Color and Shape:Solid
    Molecular weight:5202.25

    Ref: TM-TP2087

  • GX 201
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    GX 201

    CAS:
    <p>GX 201 is a selective NaV1.7 inhibitor, IC50 of &lt; 3.2 nM for hNaV1.7.</p>
    Formula:C25H27ClF4N2O4S
    Purity:99.81%
    Color and Shape:Solid
    Molecular weight:563

    Ref: TM-T9647

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    ABCB1-IN-1

    <p>ABCB1-IN-1 (compound 3) is a potent inhibitor of ABCB1 that promotes cell apoptosis.</p>
    Formula:C36H33F3FeN2O4PS
    Color and Shape:Solid
    Molecular weight:733.54

    Ref: TM-T78763

  • α5-GABAA receptor modulator 1
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    α5-GABAA receptor modulator 1

    <p>α5-GABAA receptor modulator 1 (Compound A-4) is a selective silent allosteric modulator (SAM) targeting the α5 subunit of GABAA receptors, useful for research into central nervous system (CNS) disorders.</p>
    Formula:C21H20FN3O4
    Color and Shape:Solid
    Molecular weight:397.4

    Ref: TM-T205217

  • Tacrine hydrochloride
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    Tacrine hydrochloride

    CAS:
    <p>Tacrine: a cholinergic agonist, anticholinesterase; inhibits AChE/BChE with IC50s of 31/25.6 nM.</p>
    Formula:C13H15ClN2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:234.73

    Ref: TM-T22435

  • Agitoxin-2
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    Agitoxin-2

    CAS:
    Potent Shaker K+ channel blocker (Ki = 0.64 nM). Also inhibits Kv1.3, Kv1.6 and Kv1.1 K+ channels (Ki values are 4, 37 and 44 pM respectively).
    Formula:C169H278N54O48S8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4090.87

    Ref: TM-TP2089

  • Levamlodipine besylate Hemipentahydrate
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    Levamlodipine besylate Hemipentahydrate

    CAS:
    <p>Levamlodipine besylate hemipentahydrate is the besylate hemipentahydrate salt form of Levamlodipine. It is an orally effective calcium channel blocker with antioxidative and vasodilatory properties. This compound can reduce serum malondialdehyde (MDA) levels, enhance the activity of superoxide dismutase (SOD), and alleviate oxidative stress. Levamlodipine besylate hemipentahydrate is relevant for research in vascular dementia, hypertension, and cerebrovascular diseases.</p>
    Formula:C20H25ClN2O5·C6H6O3SH2O
    Color and Shape:Solid
    Molecular weight:1224.18

    Ref: TM-T204904

  • Ouabagenin
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    Ouabagenin

    CAS:
    <p>Ouabagenin, a naturally occurring LXR ligand with selective agonist activity, functions as an EC 3.6.3.9 (Na(+)/K(+)-transport ATPase) inhibitor [1] [2].</p>
    Formula:C23H34O8
    Color and Shape:Solid
    Molecular weight:438.51

    Ref: TM-TN7752

  • GS-9191 PM
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    GS-9191 PM

    <p>GS-9191 PM: novel antitumorviral bis-amide prodrug, inhibits MDR1/BCRP, has antiproliferative activity.</p>
    Formula:C11H16N6O
    Purity:99.79%
    Color and Shape:Soild
    Molecular weight:248.28

    Ref: TM-T67821

  • AQP3-IN-1
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    AQP3-IN-1

    CAS:
    <p>AQP3-IN-1 (compounds 3), an AQP3 inhibitor, exhibits an IC 50 of 8.91 μM and effectively inhibits melanoma cell proliferation [1].</p>
    Formula:C11H9AuCl2N2
    Color and Shape:Solid
    Molecular weight:437.08

    Ref: TM-T85716

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    Anticonvulsant agent 9

    <p>Anticonvulsant agent 9 (compound 4f) is an activator of the α1β2γ2GABA_A receptor, with an EC50 value of 1.24 μM. It inhibits the inactivation of Nav1.2 channels and exhibits significant anticonvulsant activity.</p>
    Formula:C22H24N4O2
    Color and Shape:Solid
    Molecular weight:376.45

    Ref: TM-T205256

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    PptT-IN-4

    <p>PptT-IN-4 (Compound 3a) is a PptT inhibitor exhibiting an IC50 of 0.71 μM.</p>
    Formula:C17H23N3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:269.38

    Ref: TM-T78714

  • Elgodipine
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    Elgodipine

    CAS:
    <p>Elgodipine decreases angina severity, inhibits muscle growth, and is voltage-sensitive, showing promise for angina treatment.</p>
    Formula:C29H33FN2O6
    Purity:98.95% - 99.50%
    Color and Shape:Solid
    Molecular weight:524.58

    Ref: TM-T68060

  • 5-Tridecanol
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    5-Tridecanol

    CAS:
    <p>5-Tridecanol blocks ion flux in sodium channels.</p>
    Formula:C13H28O
    Purity:97.87%
    Color and Shape:Solid
    Molecular weight:200.36

    Ref: TM-T84115

  • 17(R)-Resolvin D1
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    17(R)-Resolvin D1

    CAS:
    <p>Resolvins are anti-inflammatory lipids from EPA and DHA. Resolvin D1, made from DHA, and its aspirin-triggered epimer 17(R)-RvD1, inhibit acute inflammation.</p>
    Formula:C22H32O5
    Color and Shape:Solid
    Molecular weight:376.493

    Ref: TM-T35946

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    P-gp inhibitor 15

    <p>P-gp Inhibitor 15 (compound 7a), a nonsubstrate inhibitor of P-glycoprotein (Pgp), inhibits Pgp-ATPase activity and interferes with Pgp-mediated Rhodamine123</p>
    Formula:C35H60N2O4
    Color and Shape:Solid
    Molecular weight:572.86

    Ref: TM-T79261

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    Crofelemer

    CAS:
    <p>Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.</p>
    Color and Shape:Solid

    Ref: TM-T205474

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    Analgesic/antidepressant agent-1

    <p>Analgesic/antidepressant agent-1 (Compound k1) is an orally active N-acetylamino chloro ketone derivative capable of crossing the blood-brain barrier. It exhibits high affinity for NMDA receptors and demonstrates analgesic, anti-inflammatory, and antidepressant properties, with low psychotomimetic activity.</p>
    Formula:C22H25ClN2O2
    Color and Shape:Solid
    Molecular weight:384.9

    Ref: TM-T205604

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    AQP4 (201-220) TFA

    <p>AQP4 (201-220) TFA is an encephalitogenic epitope of AQP-4. This compound can induce experimental autoimmune encephalomyelitis (EAE), characterized by midline brain lesions, retinal abnormalities, and lesions at the grey/white matter boundary of the spinal cord. AQP-4 is the target antigen in neuromyelitis optica.</p>
    Color and Shape:Odour Solid

    Ref: TM-TP3208

  • Calcium Ionophore I
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    Calcium Ionophore I

    CAS:
    <p>Calcium Ionophore I has a wide range of applications in life science related research.</p>
    Formula:C38H72N2O8
    Color and Shape:Solid
    Molecular weight:685.0

    Ref: TM-T21663

  • Charybdotoxin
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    Charybdotoxin

    CAS:
    <p>Specific inhibitor of the big conductance Ca2+-activated K+ channel.</p>
    Formula:C176H277N57O55S7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4295.95

    Ref: TM-TP2059

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    ATP synthase inhibitor 2 TFA

    <p>ATP Synthase Inhibitor 2 (Compound 22) TFA is a potent inhibitor of Pseudomonas aeruginosa ATP synthase with an IC50 value of 10 μg/mL.</p>
    Formula:C23H23F3N2O5S
    Color and Shape:Solid
    Molecular weight:496.5

    Ref: TM-T79004

  • JAMI1001A
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    JAMI1001A

    CAS:
    <p>JAMI1001A enhances AMPA receptor signaling, slows deactivation/desensitization for flip/flop isoforms.</p>
    Formula:C16H17F3N4O3S
    Color and Shape:Solid
    Molecular weight:402.39

    Ref: TM-T38392

  • Phe-Met-Arg-Phe, amide
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    Phe-Met-Arg-Phe, amide

    CAS:
    <p>Phe-Met-Arg-Phe amide activates K+ current in neurons (ED50=23 nM), co-localizes with neuropeptide Y in brain regions.</p>
    Formula:C29H42N8O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:598.76

    Ref: TM-TP1858

  • Tariquidar dimesylate
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    Tariquidar dimesylate

    CAS:
    <p>Tariquidar, a non-competitive P-glycoprotein inhibitor, may help combat cancer drug resistance.</p>
    Formula:C80H94N8O25S4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1695.9

    Ref: TM-T6287L

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    L-Palmitoylcarnitine TFA

    <p>L-Palmitoylcarnitine TFA: long-chain fat metabolite that disrupts membranes in ischaemia &amp; inhibits KATP channels via Kir6.2 interaction.</p>
    Formula:C25H46F3NO6
    Color and Shape:Solid
    Molecular weight:513.63

    Ref: TM-T73764

  • Apamin acetate
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    Apamin acetate

    <p>Apamin acetate: Selective Ca2+-activated K+ channel blocker, 18-amino acid bee venom peptide, promotes synapse repair, anti-inflammatory.</p>
    Purity:96.97%
    Color and Shape:Solid

    Ref: TM-TP1223L

  • Roquefortine C
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    Roquefortine C

    CAS:
    <p>Roquefortine C is a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins</p>
    Formula:C22H23N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:389.45

    Ref: TM-T13872

  • SLC26A3-IN-2
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    SLC26A3-IN-2

    CAS:
    <p>Vilobelimab (CaCP-29) is a human-mouse chimeric IgG antibody targeting human complement component 5a, a C5a inhibitor that inhibits neutrophil activation.</p>
    Formula:C19H13ClN2O2S
    Purity:99.86%
    Color and Shape:Solid
    Molecular weight:368.84

    Ref: TM-T74815

  • P-gp inhibitor 14
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    P-gp inhibitor 14

    CAS:
    <p>Compound 8a, also known as P-gp inhibitor 14, demonstrates high affinity as a P-gp inhibitor and effectively reverses P-gp-mediated multidrug resistance (EC 50 = 48.74 nM). Additionally, this compound exhibits a weak inhibitory effect on CYP3A4 activity [1].</p>
    Formula:C37H38N2O8
    Color and Shape:Solid
    Molecular weight:638.71

    Ref: TM-T87137

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    MS7710

    <p>MS7710 is a brain-penetrant inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. It reduces Ih current by inhibiting HCN channels, thereby decreasing the activity of dopamine neurons in the ventral tegmental area (VTA). MS7710 effectively improves social interaction deficits and reward-related cognitive flexibility in mouse models of chronic social defeat stress (CSDS) and shows promise for depression research.</p>
    Color and Shape:Odour Solid

    Ref: TM-T207039

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    ATP Synthesis-IN-2

    <p>ATP Synthesis-IN-2 (Compound 5) serves as a potent inhibitor of ATP synthesis activity, displaying significant antibacterial properties with an IC50 value of 0.</p>
    Color and Shape:Odour Solid

    Ref: TM-T82944

  • Way 125971
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    Way 125971

    CAS:
    <p>Way 125971 is a bioactive chemcial.</p>
    Formula:C22H28N4O5S2
    Color and Shape:Solid
    Molecular weight:492.61

    Ref: TM-T35111

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    Chlorotoxin TFA

    <p>Chlorotoxin TFA, a scorpion venom peptide, blocks chloride channels and has anti-cancer properties.</p>
    Formula:C160H250F3N53O49S11
    Color and Shape:Solid
    Molecular weight:4109.74

    Ref: TM-T75722

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    AQP4 (205-215) TFA

    <p>AQP4 (205-215) TFA is a fragment of the water channel protein-4 (AQP4). AQP4 acts as an autoimmune antigen in neuromyelitis optica, upregulating and presenting in B cells upon binding with CD40. AQP4 is associated with neuromyelitis optica (NMO), an autoimmune inflammatory disease of the central nervous system (CNS).</p>
    Color and Shape:Odour Solid

    Ref: TM-TP3237

  • Homocarnosine
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    Homocarnosine

    CAS:
    <p>Homocarnosine is an endogenous dipeptide in cerebral regions and cerebrospinal fluid.</p>
    Formula:C10H16N4O3
    Color and Shape:Solid
    Molecular weight:240.26

    Ref: TM-T32098

  • Quinine hemisulfate hydrate
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    Quinine hemisulfate hydrate

    CAS:
    <p>Quinine hemisulfate hydrate: anti-malaria, derived from cinchona bark, inhibits mouse Slo3 channels with IC50 169 μM.</p>
    Formula:C20H26N2O3H2O4S·H2O
    Color and Shape:Solid
    Molecular weight:391.47

    Ref: TM-T75333

  • S-Sulfo-L-cysteine sodium salt
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    S-Sulfo-L-cysteine sodium salt

    CAS:
    <p>S-Sulfo-L-cysteine sodium salt shows a weak affinity for mGluR1α and mGluR5a at high concentrations and has potential antioxidant activity.</p>
    Formula:C3H6NNaO5S2
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:223.2

    Ref: TM-T23303

  • LY-466195
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    LY-466195

    CAS:
    <p>LY-466195 is a competitive antagonist of GLUK5 receptor.</p>
    Formula:C16H24F2N2O4
    Color and Shape:Solid
    Molecular weight:346.37

    Ref: TM-T27958

  • Trans (2,3)-Dihydrotetrabenazine
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    Trans (2,3)-Dihydrotetrabenazine

    CAS:
    <p>Trans (2,3)-Dihydrotetrabenazine is a Tetrabenazine metabolite, shows inhibition activity on vesicular monoamine transporter (VMAT2).</p>
    Formula:C19H29NO3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:319.44

    Ref: TM-T12190

  • MMK 1
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    MMK 1

    CAS:
    <p>Potent hFPR2 agonist; EC50: 1 nM (mFPR2), 2 nM (hFPR2), &gt;10,000 nM (hFPR1). Induces monocyte/neutrophil migration, boosts IL-1β/IL-6, activates NADPH-oxidase.</p>
    Formula:C75H123N19O18S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1610.97

    Ref: TM-TP1891

  • TP-050
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    TP-050

    CAS:
    <p>TP-050: potent, selective NMDAR agonist, EC50 0.51 µM (GluN2A), 9.6 µM (GluN2D), BBB permeable, boosts hippocampal LTP.</p>
    Formula:C16H15ClF2N6O
    Color and Shape:Solid
    Molecular weight:380.78

    Ref: TM-T73491

  • RuBi-GABA
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    RuBi-GABA

    CAS:
    <p>Ruthenium-bipyridine-triphenylphosphine caged GABA</p>
    Formula:C42H39F6N5O2P2Ru
    Purity:98%
    Color and Shape:Solid
    Molecular weight:922.8

    Ref: TM-T23277

  • AHN-683
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    AHN-683

    CAS:
    <p>AHN-683 is a fluorescent ligand. It was used for peripheral-type benzodiazepine receptors.</p>
    Formula:C42H32FN3O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:709.72

    Ref: TM-T23675

  • NF864
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    NF864

    CAS:
    NF864, a suramin analog, is a P2X1 receptor inhibitor.
    Formula:C57H28N6Na12O41S12
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2113.5

    Ref: TM-T25863

  • BeKm-1
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    BeKm-1

    CAS:
    <p>Potent, selective hERG (KV11.1) blocker; doesn't affect 14 other K+ channels; extends QTc in rabbit heart dose-dependently.</p>
    Formula:C174H261N51O52S6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4091.65

    Ref: TM-TP2072

  • Spongionellol A
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    Spongionellol A

    <p>Spongionellol A inhibits MDR1, selectively kills prostate cancer through caspase-induced apoptosis, and aids cancer research.</p>
    Formula:C27H40O9
    Color and Shape:Solid
    Molecular weight:508.6

    Ref: TM-T72802