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Membrane Transporter/Ion Channel

Membrane Transporter/Ion Channel

Membrane transporter and ion channel inhibitors are compounds that block the function of proteins responsible for the transport of ions, nutrients, and other molecules across cell membranes. These inhibitors are crucial for studying the regulation of cellular homeostasis, signal transduction, and neurotransmission. Membrane transporter and ion channel inhibitors are also important in developing treatments for disorders such as epilepsy, cardiovascular diseases, and metabolic syndromes. At CymitQuimica, we provide a diverse selection of high-quality membrane transporter and ion channel inhibitors to support your research in physiology, neuroscience, and pharmacology.

Subcategories of "Membrane Transporter/Ion Channel"

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Found 2280 products of "Membrane Transporter/Ion Channel"

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  • Leptomycin A
    Targetmol
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    Leptomycin A

    CAS:
    <p>Leptomycin A from Streptomyces inhibits CRM1, reducing HIV-1 replication, less potent than Leptomycin B, blocks protein nuclear export.</p>
    Formula:C32H46O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:526.7

    Ref: TM-T11837

  • A-317567
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    A-317567

    CAS:
    A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM, and it has antidepressant and antinociception effects[1][2].
    Formula:C27H31N3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:397.56

    Ref: TM-T14070

  • Oleoyl-D-lysine
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    Oleoyl-D-lysine

    CAS:
    <p>Oleoyl-D-lysine: lipid-based GlyT2 inhibitor, eases neuropathic pain in mice, safe, non-sedative, no respiratory depression.</p>
    Formula:C24H46N2O3
    Color and Shape:Solid
    Molecular weight:410.63

    Ref: TM-T74739

  • ω-Conotoxin GVIA
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    ω-Conotoxin GVIA

    CAS:
    <p>Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo.</p>
    Formula:C120H182N38O43S6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3037

    Ref: TM-TP2062

  • BKCa activator-1
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    BKCa activator-1

    <p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>
    Formula:C22H23F7N2O3
    Color and Shape:Solid
    Molecular weight:496.418

    Ref: TM-T205564

  • Nipecotic acid
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    Nipecotic acid

    CAS:
    <p>Compound PDK0243, with CAS No. 498-95-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0243 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>
    Formula:C6H11NO2
    Color and Shape:Off-White To Pale Yellow-Beige Powder
    Molecular weight:129.16

    Ref: TM-PDK0243

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    ABCB1-IN-1

    <p>ABCB1-IN-1 (compound 3) is a potent inhibitor of ABCB1 that promotes cell apoptosis.</p>
    Formula:C36H33F3FeN2O4PS
    Color and Shape:Solid
    Molecular weight:733.54

    Ref: TM-T78763

  • Tiludronate disodium hemihydrate
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    Tiludronate disodium hemihydrate

    CAS:
    <p>Tiludronate: an oral bisphosphonate for bone disorder research; inhibits osteoclasts and reduces inflammation.</p>
    Formula:C14H16Cl2Na4O13P4S2
    Color and Shape:Solid
    Molecular weight:743.16

    Ref: TM-T39037

  • GSK2332255B
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    GSK2332255B

    CAS:
    <p>GSK2332255B: potent TRPC3/6 antagonist; IC50 5 nM (TRPC3), 4 nM (TRPC6); over 100-fold selectivity vs other Ca2+ channels.</p>
    Formula:C18H19ClFN3O3S
    Color and Shape:Solid
    Molecular weight:411.88

    Ref: TM-T38780

  • N-Oleoyl Glutamine
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    N-Oleoyl Glutamine

    CAS:
    <p>N-Oleoyl Glutamine (Oleoyl-L-glutamine) antagonizes TRPV1 of the transient receptor potential (TRP) calcium channel.</p>
    Formula:C23H42N2O4
    Purity:99.61%
    Color and Shape:Solid
    Molecular weight:410.59

    Ref: TM-T36064

  • LTGO-33
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    LTGO-33

    CAS:
    <p>LTGO-33 is a voltage-gated sodium channel NaV1.8 inhibitor that inhibits NaV1.8, NaV1.1-NaV1.7, and NaV1.9.</p>
    Formula:C21H17F4N3O3S
    Purity:97.6%
    Color and Shape:Soild
    Molecular weight:467.44

    Ref: TM-T84298

  • 5-Hydroxy-2′,3,4′,7-tetramethoxyflavone
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    5-Hydroxy-2′,3,4′,7-tetramethoxyflavone

    CAS:
    <p>5-Hydroxy-2′,3,4′,7-tetramethoxyflavone shows weak ABCG2 inhibitory potency with IC50s of 3.27 and 3.89 µM in the Hoechst 33342 and pheophorbide A assays.</p>
    Formula:C19H18O7
    Purity:98%
    Color and Shape:Soild
    Molecular weight:358.34

    Ref: TM-TN7124

  • S-Sulfo-L-cysteine sodium salt
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    S-Sulfo-L-cysteine sodium salt

    CAS:
    <p>S-Sulfo-L-cysteine sodium salt shows a weak affinity for mGluR1α and mGluR5a at high concentrations and has potential antioxidant activity.</p>
    Formula:C3H6NNaO5S2
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:223.2

    Ref: TM-T23303

  • NF864
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    NF864

    CAS:
    NF864, a suramin analog, is a P2X1 receptor inhibitor.
    Formula:C57H28N6Na12O41S12
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2113.5

    Ref: TM-T25863

  • 18β-Glycyrrhetyl-3-O-sulfate
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    18β-Glycyrrhetyl-3-O-sulfate

    CAS:
    <p>18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)), a major metabolite of Glycyrrhetinic acid (GA), serves as a potent inhibitor of type 2</p>
    Formula:C30H46O7S
    Color and Shape:Solid
    Molecular weight:550.75

    Ref: TM-T74729

  • Phrixotoxin 3
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    Phrixotoxin 3

    CAS:
    <p>Potent NaV blocker: IC50 - 0.6 nM (NaV1.2), 42 nM (NaV1.3), 72 nM (NaV1.5); voltage-dependent inhibition.</p>
    Formula:C176H269N51O48S6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4059.74

    Ref: TM-TP1967

  • TRPA1-IN-1
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    TRPA1-IN-1

    CAS:
    <p>TRPA1-IN-1 is a potent, selective antagonist of the TRPA1 channel, demonstrating significant oral bioavailability as a small molecule.</p>
    Formula:C19H17ClN6O3
    Color and Shape:Solid
    Molecular weight:412.83

    Ref: TM-T39935

  • 17α-Hydroxywithanolide D
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    17α-Hydroxywithanolide D

    <p>17alpha-Hydroxywithanolide D is an allosteric modulator of the NMDA receptor, with an IC50 of 44.24 nM. This compound exhibits neuroprotective properties and can be utilized in Alzheimer's disease research.</p>
    Formula:C28H46O7
    Color and Shape:Solid
    Molecular weight:494.661

    Ref: TM-T204406

  • Apamin acetate
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    Apamin acetate

    <p>Apamin acetate: Selective Ca2+-activated K+ channel blocker, 18-amino acid bee venom peptide, promotes synapse repair, anti-inflammatory.</p>
    Purity:96.97%
    Color and Shape:Solid

    Ref: TM-TP1223L

  • CymitQuimica logo
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    Conantokin G TFA

    <p>Conantokin G TFA, a 17-aa peptide, blocks NMDA receptors with 480 nM IC50 and is neuroprotective.</p>
    Formula:C90H139F3N26O46
    Color and Shape:Solid
    Molecular weight:2378.21

    Ref: TM-T75890

  • GS-9191 PM
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    GS-9191 PM

    <p>GS-9191 PM: novel antitumorviral bis-amide prodrug, inhibits MDR1/BCRP, has antiproliferative activity.</p>
    Formula:C11H16N6O
    Purity:99.79%
    Color and Shape:Soild
    Molecular weight:248.28

    Ref: TM-T67821

  • LY-466195
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    LY-466195

    CAS:
    <p>LY-466195 is a competitive antagonist of GLUK5 receptor.</p>
    Formula:C16H24F2N2O4
    Color and Shape:Solid
    Molecular weight:346.37

    Ref: TM-T27958

  • ProTx II
    Targetmol
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    ProTx II

    CAS:
    <p>Selective NaV1.7 inhibitor, alters activation, reduces current, 100x more selective for 1.7 over other Na+ channels.</p>
    Formula:C168H250N46O41S8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3826.59

    Ref: TM-TP1680

  • Conantokin G
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    Conantokin G

    CAS:
    <p>GluN2B-specific NMDA receptor blocker; IC50=480 nM in neurons, ~300 nM in oocytes; neuroprotective.</p>
    Formula:C88H138N26O44
    Purity:98%
    Color and Shape:White Lyophilised Solid
    Molecular weight:2264.21

    Ref: TM-TP2060

  • NSC265473
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    NSC265473

    CAS:
    <p>NSC265473 is an ABCG2 substrate.</p>
    Formula:C21H35N3O4S
    Color and Shape:Solid
    Molecular weight:425.58

    Ref: TM-T33753

  • Linoleic Acid Amide
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    Linoleic Acid Amide

    CAS:
    <p>Linoleic Acid Amide (Linoleamide) is derived from linoleic acid and regulates Ca2+ flux by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase.</p>
    Formula:C18H33NO
    Purity:98%
    Color and Shape:Solid
    Molecular weight:279.46

    Ref: TM-T36812

  • α,β-Methylene-ATP dilithium
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    α,β-Methylene-ATP dilithium

    CAS:
    <p>α,β-Methylene ATP dilithium, a phosphonic analog of ATP, serves as a ligand for P2X3 and P2X7 receptors.</p>
    Formula:C11H16Li2N5O12P3
    Color and Shape:Solid
    Molecular weight:517.07

    Ref: TM-T38444

  • MIDD0301
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    MIDD0301

    CAS:
    <p>MIDD0301 is a potent positive allosteric α5β3γ selective GABAA receptor (GABAAR) ligand with EC50 of 17 nM.</p>
    Formula:C19H13BrFN3O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:414.23

    Ref: TM-T9946

  • Anisatin
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    Anisatin

    <p>Anisatin is a useful organic compound for research related to life sciences and the catalog number is T124719.</p>
    Formula:C15H20O8
    Color and Shape:Solid
    Molecular weight:328.317

    Ref: TM-T124719

  • Lyso-Globotriaosylceramide (d18:1)
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    Lyso-Globotriaosylceramide (d18:1)

    CAS:
    <p>Lyso-Gb3, lacking fatty acyl, binds Stx1 with cholesterol and phosphatidylcholine, not Stx2; lowers neutrophil viability; accumulates in Fabry disease.</p>
    Formula:C36H67NO17
    Color and Shape:Solid
    Molecular weight:785.922

    Ref: TM-T37291

  • 4-oxo-2-Nonenal
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    4-oxo-2-Nonenal

    CAS:
    <p>4-Hydroxy Nonenal and 4-oxo-2-Nonenal are lipid peroxidation byproducts, signaling oxidative stress and possibly causing mutagenesis.</p>
    Formula:C9H14O2
    Color and Shape:Solid
    Molecular weight:154.209

    Ref: TM-T35646

  • Mesoridazine free base
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    Mesoridazine free base

    CAS:
    <p>Mesoridazine (thioridazine EP impurity B) is a phenothiazine antipsychotic with effects similar to chlorpromazine.</p>
    Formula:C21H26N2OS2
    Color and Shape:Solid
    Molecular weight:386.57

    Ref: TM-T3086L

  • Furosemide sodium
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    Furosemide sodium

    CAS:
    <p>Furosemide sodium: potent NKCC inhibitor, loop diuretic, treats heart failure, hypertension, edema, selective GABAA antagonist.</p>
    Formula:C12H10ClN2NaO5S
    Purity:99.52% - >99.99%
    Color and Shape:Solid
    Molecular weight:352.73

    Ref: TM-T35336

  • Resolvin D2 methyl ester
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    Resolvin D2 methyl ester

    CAS:
    <p>RvD2 is an anti-inflammatory lipid made from docosahexaenoic acid by 15- and 5-lipoxygenase. Its methyl ester may serve as a prodrug.</p>
    Formula:C23H34O5
    Color and Shape:Solid
    Molecular weight:390.52

    Ref: TM-T37169

  • (+)-Lycoctonine
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    (+)-Lycoctonine

    CAS:
    <p>Compound TJS1874 is a useful organic compound for research related to life sciences. The catalog number is TJS1874 and the CAS number is 26000-17-9.</p>
    Formula:C25H41NO7
    Color and Shape:Solid
    Molecular weight:467.6

    Ref: TM-TJS1874

  • PtdIns-(1,2-dioctanoyl) (sodium salt)
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    PtdIns-(1,2-dioctanoyl) (sodium salt)

    CAS:
    <p>PtdIns phosphates, a minor membrane lipid fraction, are vital for cell signaling. Synthetic PtdIns-(1,2-dioctanoyl) has C8:0 fatty acids and high solubility.</p>
    Formula:C25H47NaO13P
    Color and Shape:Solid
    Molecular weight:609.602

    Ref: TM-T36937

  • Tariquidar dimesylate
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    Tariquidar dimesylate

    CAS:
    <p>Tariquidar, a non-competitive P-glycoprotein inhibitor, may help combat cancer drug resistance.</p>
    Formula:C80H94N8O25S4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1695.9

    Ref: TM-T6287L

  • Resolvin D2
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    Resolvin D2

    CAS:
    <p>Resolvin D2 (RvD2) is a TRPV1 inhibitor and pro-ablative mediator with anti-inflammatory, anti-infective and pro-ablative effects.</p>
    Formula:C22H32O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:376.49

    Ref: TM-T12707

  • BMS 199264
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    BMS 199264

    CAS:
    <p>BMS 199264 hydrochlorid a inhibitor of mitochondrial F1F0 ATP hydrolase, thus preventing ATP reduction to ameliorate cardiac necrosis during ischemia.</p>
    Formula:C26H31ClN4O4S
    Purity:99.83%
    Color and Shape:Soild
    Molecular weight:531.07

    Ref: TM-T26843L

  • Venturicidin A
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    Venturicidin A

    CAS:
    <p>Venturicidin A is a macrolide antibiotic.</p>
    Formula:C41H67NO11
    Purity:98%
    Color and Shape:Solid
    Molecular weight:749.97

    Ref: TM-T23505

  • Foslevcromakalim
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    Foslevcromakalim

    CAS:
    <p>Foslevcromakalim (QLS-101), an ATP-sensitive potassium channel opener, serves as a proagent for ocular hypotensive effects [1] [2].</p>
    Formula:C16H19N2O6P
    Color and Shape:Solid
    Molecular weight:366.31

    Ref: TM-T75084

  • α-Casozepine
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    α-Casozepine

    CAS:
    <p>α-Casozepine,Bioactive peptide from milk α-S1 casein. Binds GABA receptors. Anti-anxiety effects.</p>
    Formula:C60H94N14O16
    Color and Shape:Solid
    Molecular weight:1267.47

    Ref: TM-T29892

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    P-gp inhibitor 13

    <p>P-gp Inhibitor 13, a P-glycoprotein antagonist, can counteract paclitaxel resistance in A2780/T cells, proving valuable for advanced acute myeloid leukemia</p>
    Formula:C32H34O8
    Color and Shape:Solid
    Molecular weight:546.61

    Ref: TM-T78974

  • NT 13
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    NT 13

    CAS:
    <p>NT 13 is a partial N-methyl-D-aspartate receptor (NMDAR) agonist used in the study of depression, anxiety, and other related diseases.</p>
    Formula:C18H30N4O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:414.45

    Ref: TM-TP1023

  • 3-Aminopropylphosphinic acid
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    3-Aminopropylphosphinic acid

    CAS:
    <p>3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of gamma-aminobutyric acid (GABA).</p>
    Formula:C3H10NO2P
    Color and Shape:Solid
    Molecular weight:123.092

    Ref: TM-T38438

  • Vedroprevir
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    Vedroprevir

    CAS:
    <p>Vedroprevir (GS9451), a selective HCV NS3 protease inhibitor, targets genotype 1 HCV.</p>
    Formula:C45H60ClN7O9S
    Color and Shape:Solid
    Molecular weight:910.53

    Ref: TM-T35043

  • A 80915A
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    A 80915A

    CAS:
    <p>A80915A: Semi-naphthoquinone antibiotic, blocks gastric (H(+)-K+)-ATPase; potency varies with enzyme conformation; K+ reduces binding rate.</p>
    Formula:C26H31Cl3O5
    Color and Shape:Solid
    Molecular weight:529.88

    Ref: TM-T26450

  • (±)5(6)-DiHETE
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    (±)5(6)-DiHETE

    CAS:
    <p>Eicosapentaenoic acid is an ω-3 polyunsaturated fatty acid that is abundant in marine organisms and fish oils.</p>
    Formula:C20H32O4
    Color and Shape:Solid
    Molecular weight:336.472

    Ref: TM-T37242

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    6-FAM-AEEAC-SHK TFA

    <p>6-FAM-AEEAC-SHK TFA, a peptide neurotoxin derived from Stichodactyla helianthus and conjugated with a fluorescent marker, selectively blocks voltage-gated potassium channels (kv1.1 and kv1.2). By prolonging action potentials, it interferes with neural signal conduction, making it valuable in neuroscience research.</p>
    Formula:C196H295N55O57S7·xCHF3O2
    Color and Shape:Solid
    Molecular weight:4558.23 (free acid)

    Ref: TM-TP2872

  • ω-Conotoxin MVIIC
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    ω-Conotoxin MVIIC

    CAS:
    <p>Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.</p>
    Formula:C106H178N40O32S7
    Purity:98%
    Color and Shape:White Lyophilised Solid
    Molecular weight:2749

    Ref: TM-TP2064