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Membrane Transporter/Ion Channel

Membrane Transporter/Ion Channel

Membrane transporter and ion channel inhibitors are compounds that block the function of proteins responsible for the transport of ions, nutrients, and other molecules across cell membranes. These inhibitors are crucial for studying the regulation of cellular homeostasis, signal transduction, and neurotransmission. Membrane transporter and ion channel inhibitors are also important in developing treatments for disorders such as epilepsy, cardiovascular diseases, and metabolic syndromes. At CymitQuimica, we provide a diverse selection of high-quality membrane transporter and ion channel inhibitors to support your research in physiology, neuroscience, and pharmacology.

Subcategories of "Membrane Transporter/Ion Channel"

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Found 2290 products of "Membrane Transporter/Ion Channel"

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  • CymitQuimica logo
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    6-FAM-AEEAC-SHK TFA

    <p>6-FAM-AEEAC-SHK TFA, a peptide neurotoxin derived from Stichodactyla helianthus and conjugated with a fluorescent marker, selectively blocks voltage-gated potassium channels (kv1.1 and kv1.2). By prolonging action potentials, it interferes with neural signal conduction, making it valuable in neuroscience research.</p>
    Formula:C196H295N55O57S7·xCHF3O2
    Color and Shape:Solid
    Molecular weight:4558.23 (free acid)

    Ref: TM-TP2872

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    Anticonvulsant agent 8

    <p>Anticonvulsant agent 8 (compound D4) is a chemical used in treating epilepsy by inhibiting GABAA currents. In mouse models, its ED50 values are 2.23 mg/kg for the maximal electroshock (MES) test and 24.60 mg/kg for the pentylenetetrazol (PTZ) test.</p>
    Formula:C15H11N5O
    Color and Shape:Solid
    Molecular weight:277.28

    Ref: TM-T205302

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    Urease-IN-19

    <p>Urease-IN-19 (Compound 3c) is a potent inhibitor of urease, demonstrating an IC50 value of 2.7 µM. It shows potential for use in research related to kidney stones and gastric ulcers.</p>
    Formula:C17H16FN3S
    Color and Shape:Solid
    Molecular weight:313.39

    Ref: TM-T205469

  • Chlorocresol
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    Chlorocresol

    CAS:
    <p>Chlorocresol (4-Chloro-3-methylphenol) is an antiseptic medication.</p>
    Formula:C7H7ClO
    Color and Shape:Solid
    Molecular weight:142.58

    Ref: TM-T75311

  • NF864
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    NF864

    CAS:
    NF864, a suramin analog, is a P2X1 receptor inhibitor.
    Formula:C57H28N6Na12O41S12
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2113.5

    Ref: TM-T25863

  • FD 12-9
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    FD 12-9

    CAS:
    FD 12-9, Anti-glioblastoma activity. is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively.
    Formula:C51H47N3O11
    Purity:98%
    Color and Shape:Solid
    Molecular weight:877.93

    Ref: TM-T11268

  • Lei-Dab7
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    Lei-Dab7

    CAS:
    Selective KCa2.2 channel blocker with Kd 3.8 nM, >200-fold specificity, enhances LTP, convulsive in vivo.
    Formula:C141H236N46O39S6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3392.06

    Ref: TM-TP2007

  • (S)-PF-03716556
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    (S)-PF-03716556

    CAS:
    <p>(S)-PF-03716556 can be used as an acid pump inhibitor for the treatment of disease conditions mediated by acid pump inhibitory activity.</p>
    Formula:C22H26N4O3
    Purity:99.8% - 99.91%
    Color and Shape:Soild
    Molecular weight:394.47

    Ref: TM-T2093L

  • AP14145 hydrochloride
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    AP14145 hydrochloride

    CAS:
    <p>AP14145 hydrochloride inhibits KCa2.2 and KCa2.3 channels with 1.1 μM IC50, affecting AERP and antiarrhythmic in AF models.</p>
    Formula:C18H18ClF3N4O
    Color and Shape:Solid
    Molecular weight:398.81

    Ref: TM-T39963

  • Elgodipine
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    Elgodipine

    CAS:
    <p>Elgodipine decreases angina severity, inhibits muscle growth, and is voltage-sensitive, showing promise for angina treatment.</p>
    Formula:C29H33FN2O6
    Purity:98.95% - 99.50%
    Color and Shape:Solid
    Molecular weight:524.58

    Ref: TM-T68060

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    ATP synthase inhibitor 2 TFA

    <p>ATP Synthase Inhibitor 2 (Compound 22) TFA is a potent inhibitor of Pseudomonas aeruginosa ATP synthase with an IC50 value of 10 μg/mL.</p>
    Formula:C23H23F3N2O5S
    Color and Shape:Solid
    Molecular weight:496.5

    Ref: TM-T79004

  • D-GsMTx4
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    D-GsMTx4

    <p>TRPC1/6 &amp; Piezo2 inhibitor; mimics GsMTx4; blocks ~70% mechanosensitive currents; aids in mouse heart attack models; protease-resistant.</p>
    Color and Shape:Soild

    Ref: TM-T37697

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    Dendrotoxin K

    CAS:
    <p>Dendrotoxin K blocks Kv1.1 channels, modulating glutamate release in CA3 neurons by controlling presynaptic spike timing.</p>
    Formula:C294H462N84O75S6
    Color and Shape:Solid
    Molecular weight:6559.66

    Ref: TM-T76187

  • Sulcardine 2HCl
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    Sulcardine 2HCl

    CAS:
    <p>Sulcardine 2HCl is a multi-ion channel blocker that blocks the properties of hERG and hNav1.5 channels and can be used to study atrial fibrillation.</p>
    Formula:C24H35Cl2N3O4S
    Purity:99.33% - 99.76%
    Color and Shape:Soild
    Molecular weight:532.523

    Ref: TM-T83979

  • Cevadine
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    Cevadine

    <p>Cevadine is a natural product that can be used as a reference standard.</p>
    Formula:C32H49NO9
    Color and Shape:Solid
    Molecular weight:591.742

    Ref: TM-T124525

  • Tacrine hydrochloride
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    Tacrine hydrochloride

    CAS:
    <p>Tacrine: a cholinergic agonist, anticholinesterase; inhibits AChE/BChE with IC50s of 31/25.6 nM.</p>
    Formula:C13H15ClN2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:234.73

    Ref: TM-T22435

  • P2X4 antagonist-4
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    P2X4 antagonist-4

    <p>P2X4 antagonist-4 (compound 64) is a potent P2X4R antagonist with an IC50 value of 8 µM. It can inhibit ATP-induced activation of the NLRP3 inflammasome and the subsequent release of IL-1β.</p>
    Formula:C27H22FN3O4S
    Color and Shape:Solid
    Molecular weight:503.545

    Ref: TM-T204441

  • Halazone
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    Halazone

    CAS:
    <p>Halazone (Pantocid) is fine white powder with an odor of chlorine. It has been widely used to disinfect drinking water.</p>
    Formula:C7H5Cl2NO4S
    Purity:98.64%
    Color and Shape:Physical Description Fine White Powder With An Odor Of Chlorine (Ntp 1992)
    Molecular weight:270.09

    Ref: TM-T0037

  • sFTX-3.3
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    sFTX-3.3

    CAS:
    <p>sFTX-3.3 is a calcium ion channel antagonist, exhibiting IC50 values of approximately 0.24 mM and 0.70 mM against P-type and N-type channels respectively.</p>
    Formula:C12H29N7O
    Color and Shape:Solid
    Molecular weight:287.412

    Ref: TM-T38854

  • Lesogaberan napadisylate
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    Lesogaberan napadisylate

    CAS:
    <p>Lesogaberan (AZD-3355) is a selective GABAB agonist with EC50 of 8.6 nM, Ki of 5.1 nM in rats, and acts peripherally on the esophageal sphincter.</p>
    Formula:C13H17FNO5PS
    Color and Shape:Solid
    Molecular weight:349.31

    Ref: TM-T40572

  • Ziconotide
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    Ziconotide

    CAS:
    <p>Ziconotide: analgesic from cone snail for severe, chronic pain; synthetic ω-conotoxin.</p>
    Formula:C102H172N36O32S7
    Purity:98%
    Color and Shape:White Powder
    Molecular weight:2639.13

    Ref: TM-TP1559

  • S-Sulfo-L-cysteine sodium salt
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    S-Sulfo-L-cysteine sodium salt

    CAS:
    <p>S-Sulfo-L-cysteine sodium salt shows a weak affinity for mGluR1α and mGluR5a at high concentrations and has potential antioxidant activity.</p>
    Formula:C3H6NNaO5S2
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:223.2

    Ref: TM-T23303

  • NF279
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    NF279

    CAS:
    <p>P2X1 antagonist</p>
    Formula:C49H36N6Na6O23S6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1407.17

    Ref: TM-TP2274

  • Margatoxin
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    Margatoxin

    CAS:
    <p>KV1.3 channel blocker, IC50 36 pM, no effect on calcium-activated channels, hinders VEGF-induced Ca++ influx &amp; NO in endothelial cells.</p>
    Formula:C178H286N52O50S7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4178.96

    Ref: TM-TP2004

  • CP-628006
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    CP-628006

    CAS:
    <p>CP-628006 is a small molecule CFTR potentiator that effectively restores ATP-dependent channel gating to G551D-CFTR, the mutant form found in cystic fibrosis.</p>
    Formula:C32H35F3N2O2
    Color and Shape:Solid
    Molecular weight:536.639

    Ref: TM-T40386

  • rac-trans-4-hydroxy Glyburide
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    rac-trans-4-hydroxy Glyburide

    CAS:
    <p>rac-trans-4-hydroxy Glyburide, a metabolite of glyburide, inhibits binding at SUR1/Kir6.2 sites with IC50 values of 0.95 and 100 nM.</p>
    Formula:C23H28ClN3O6S
    Color and Shape:Solid
    Molecular weight:510.0

    Ref: TM-T35635

  • Oleoyl-D-lysine
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    Oleoyl-D-lysine

    CAS:
    <p>Oleoyl-D-lysine: lipid-based GlyT2 inhibitor, eases neuropathic pain in mice, safe, non-sedative, no respiratory depression.</p>
    Formula:C24H46N2O3
    Color and Shape:Solid
    Molecular weight:410.63

    Ref: TM-T74739

  • BKCa activator-1
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    BKCa activator-1

    <p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>
    Formula:C22H23F7N2O3
    Color and Shape:Solid
    Molecular weight:496.418

    Ref: TM-T205564

  • ω-Agatoxin IVA
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    ω-Agatoxin IVA

    CAS:
    Selective blocker of P-type calcium channels (IC50 < 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations.
    Formula:C217H360N68O60S10
    Purity:98%
    Color and Shape:Solid
    Molecular weight:5202.25

    Ref: TM-TP2087

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    ABCB1-IN-1

    <p>ABCB1-IN-1 (compound 3) is a potent inhibitor of ABCB1 that promotes cell apoptosis.</p>
    Formula:C36H33F3FeN2O4PS
    Color and Shape:Solid
    Molecular weight:733.54

    Ref: TM-T78763

  • ProTx II
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    ProTx II

    CAS:
    <p>Selective NaV1.7 inhibitor, alters activation, reduces current, 100x more selective for 1.7 over other Na+ channels.</p>
    Formula:C168H250N46O41S8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3826.59

    Ref: TM-TP1680

  • (±)5(6)-DiHETE
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    (±)5(6)-DiHETE

    CAS:
    <p>Eicosapentaenoic acid is an ω-3 polyunsaturated fatty acid that is abundant in marine organisms and fish oils.</p>
    Formula:C20H32O4
    Color and Shape:Solid
    Molecular weight:336.472

    Ref: TM-T37242

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    PptT-IN-4

    <p>PptT-IN-4 (Compound 3a) is a PptT inhibitor exhibiting an IC50 of 0.71 μM.</p>
    Formula:C17H23N3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:269.38

    Ref: TM-T78714

  • α5-GABAA receptor modulator 1
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    α5-GABAA receptor modulator 1

    <p>α5-GABAA receptor modulator 1 (Compound A-4) is a selective silent allosteric modulator (SAM) targeting the α5 subunit of GABAA receptors, useful for research into central nervous system (CNS) disorders.</p>
    Formula:C21H20FN3O4
    Color and Shape:Solid
    Molecular weight:397.4

    Ref: TM-T205217

  • SNX-482
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    SNX-482

    CAS:
    Potent CaV2.3 calcium channel blocker, selective, voltage-dependent, with 30 nM IC50. Offers antinociceptive effects on C and Aδ fibres.
    Formula:C192H274N52O60S7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4495.01

    Ref: TM-TP2118

  • Dalazatide HCl
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    Dalazatide HCl

    <p>Dalazatide HCl is a peptide and specific Kv1.3 inhibitor that suppresses the activation and proliferation of memory effector T cells,</p>
    Color and Shape:Solid
    Molecular weight:4317.53 (Free base)

    Ref: TM-T76280L1

  • Zatonacaftor
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    Zatonacaftor

    CAS:
    <p>Zatonacaftor, a cystic fibrosis transmembrane regulator (CFTR) modulator, is utilized in the research of cystic fibrosis [1] [2].</p>
    Formula:C24H27N3O4S
    Color and Shape:Solid
    Molecular weight:453.55

    Ref: TM-T74748

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    BuChE-IN-9

    <p>BuChE-IN-9 (compound 22a), an eqBuChE (equine serum-derived butyrylcholinesterase) inhibitor, exhibits potent activity with an IC50 of 173 nM.</p>
    Formula:C28H34N4O2
    Color and Shape:Solid
    Molecular weight:458.6

    Ref: TM-T79423

  • α-Casozepine
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    α-Casozepine

    CAS:
    <p>α-Casozepine,Bioactive peptide from milk α-S1 casein. Binds GABA receptors. Anti-anxiety effects.</p>
    Formula:C60H94N14O16
    Color and Shape:Solid
    Molecular weight:1267.47

    Ref: TM-T29892

  • Dofetilide N-oxide
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    Dofetilide N-oxide

    CAS:
    Dofetilide N-oxide (UK-116856) is a metabolite of dofetilide. Dofetilide can block potassium channels and is a tertiary antiarrhythmic drug.
    Formula:C19H27N3O6S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:457.56

    Ref: TM-T11073

  • Vedroprevir
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    Vedroprevir

    CAS:
    <p>Vedroprevir (GS9451), a selective HCV NS3 protease inhibitor, targets genotype 1 HCV.</p>
    Formula:C45H60ClN7O9S
    Color and Shape:Solid
    Molecular weight:910.53

    Ref: TM-T35043

  • A-317567
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    A-317567

    CAS:
    A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM, and it has antidepressant and antinociception effects[1][2].
    Formula:C27H31N3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:397.56

    Ref: TM-T14070

  • BMS 199264
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    BMS 199264

    CAS:
    <p>BMS 199264 hydrochlorid a inhibitor of mitochondrial F1F0 ATP hydrolase, thus preventing ATP reduction to ameliorate cardiac necrosis during ischemia.</p>
    Formula:C26H31ClN4O4S
    Purity:99.83%
    Color and Shape:Soild
    Molecular weight:531.07

    Ref: TM-T26843L

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    Prilocaine acetate

    <p>Prilocaine acetate, an amino amide compound, functions as a Na/K-ATPase inhibitor, exhibiting neurotoxic effects [1] [2].</p>
    Formula:C15H24N2O3
    Color and Shape:Solid
    Molecular weight:280.36

    Ref: TM-T75280

  • Quinine hemisulfate hydrate
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    Quinine hemisulfate hydrate

    CAS:
    <p>Quinine hemisulfate hydrate: anti-malaria, derived from cinchona bark, inhibits mouse Slo3 channels with IC50 169 μM.</p>
    Formula:C20H26N2O3H2O4S·H2O
    Color and Shape:Solid
    Molecular weight:391.47

    Ref: TM-T75333

  • 3-Aminopropylphosphinic acid
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    3-Aminopropylphosphinic acid

    CAS:
    <p>3-Aminopropylphosphinic acid (3-APPA) is a phosphonic analog of gamma-aminobutyric acid (GABA).</p>
    Formula:C3H10NO2P
    Color and Shape:Solid
    Molecular weight:123.092

    Ref: TM-T38438

  • Sinapine hydroxide
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    Sinapine hydroxide

    CAS:
    <p>Sinapine hydroxide from crucifer seeds has anti-inflammatory, anti-oxidant, anti-tumor properties, and inhibits AChE, aiding neurodegenerative research.</p>
    Formula:C16H25NO6
    Color and Shape:Solid
    Molecular weight:327.377

    Ref: TM-T38606

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    L-Palmitoylcarnitine TFA

    <p>L-Palmitoylcarnitine TFA: long-chain fat metabolite that disrupts membranes in ischaemia &amp; inhibits KATP channels via Kir6.2 interaction.</p>
    Formula:C25H46F3NO6
    Color and Shape:Solid
    Molecular weight:513.63

    Ref: TM-T73764

  • (-)-(S)-Cibenzoline
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    (-)-(S)-Cibenzoline

    CAS:
    <p>Cibenzoline, also known as Escibenzoline, is the S(+)-enantiomer of Cibenzoline and functions as an antiarrhythmic agent.</p>
    Formula:C18H18N2
    Color and Shape:Solid
    Molecular weight:262.35

    Ref: TM-T38434

  • AQP4 (201-220)
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    AQP4 (201-220)

    CAS:
    <p>AQP4 (201-220) is the encephalitogenic epitope of AQP-4. AQP4 (201-220) can induce experimental autoimmune encephalomyelitis (EAE), characterized by midline brain lesions, retinal lesions, and lesions at the gray matter/white matter boundary of the spinal cord. AQP-4 is the target antigen in neuromyelitis optica.</p>
    Formula:C97H143N27O27S
    Color and Shape:Solid
    Molecular weight:2151.4

    Ref: TM-TP3213