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Membrane Transporter/Ion Channel

Membrane Transporter/Ion Channel

Membrane transporter and ion channel inhibitors are compounds that block the function of proteins responsible for the transport of ions, nutrients, and other molecules across cell membranes. These inhibitors are crucial for studying the regulation of cellular homeostasis, signal transduction, and neurotransmission. Membrane transporter and ion channel inhibitors are also important in developing treatments for disorders such as epilepsy, cardiovascular diseases, and metabolic syndromes. At CymitQuimica, we provide a diverse selection of high-quality membrane transporter and ion channel inhibitors to support your research in physiology, neuroscience, and pharmacology.

Subcategories of "Membrane Transporter/Ion Channel"

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Found 2280 products of "Membrane Transporter/Ion Channel"

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  • D-GsMTx4
    Targetmol
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    D-GsMTx4

    <p>TRPC1/6 &amp; Piezo2 inhibitor; mimics GsMTx4; blocks ~70% mechanosensitive currents; aids in mouse heart attack models; protease-resistant.</p>
    Color and Shape:Soild

    Ref: TM-T37697

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    LY393615

    <p>LY393615 (NCC1048) is a novel blocker of both neuronal Ca²⁺ (calcium) and Na⁺ (sodium) channels, exhibiting half-maximal inhibitory concentrations (IC₅₀) of 1.9</p>
    Purity:98%
    Color and Shape:Odour Solid

    Ref: TM-T78626

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    Crofelemer

    CAS:
    <p>Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.</p>
    Color and Shape:Solid

    Ref: TM-T205474

  • TRPA1-IN-1
    Targetmol
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    TRPA1-IN-1

    CAS:
    <p>TRPA1-IN-1 is a potent, selective antagonist of the TRPA1 channel, demonstrating significant oral bioavailability as a small molecule.</p>
    Formula:C19H17ClN6O3
    Color and Shape:Solid
    Molecular weight:412.83

    Ref: TM-T39935

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    P2X3 antagonist 39

    <p>P2X3 antagonist 39 (compound 26a) is a selective P2X3 receptor antagonist with an IC50 of 54.9 nM. It is utilized in the study of neuropathic pain models.</p>
    Color and Shape:Odour Solid

    Ref: TM-T89459

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    Dendrotoxin K

    CAS:
    <p>Dendrotoxin K blocks Kv1.1 channels, modulating glutamate release in CA3 neurons by controlling presynaptic spike timing.</p>
    Formula:C294H462N84O75S6
    Color and Shape:Solid
    Molecular weight:6559.66

    Ref: TM-T76187

  • GsMTx4
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    GsMTx4

    CAS:
    <p>GsMTx-4, mechanosensitive and stretch-activated ion channel inhibitor (CAS 1209500-46-8).</p>
    Formula:C185H273N49O45S6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4095.84

    Ref: TM-TP1670

  • Conantokin-R
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    Conantokin-R

    CAS:
    <p>Conantokin-R is an NMDA receptor peptide antagonist (IC50=93 nM); Conantokin-R exhibits anticonvulsant activity; Conantokin-R binds Zn2+ and Mg2+ (Kds 0.15 μM</p>
    Formula:C127H201N35O49S3
    Color and Shape:Solid
    Molecular weight:3098.38

    Ref: TM-T38388

  • RN-1665
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    RN-1665

    CAS:
    <p>RN-1665 is a potent and selective TRPV4 receptor antagonist.</p>
    Formula:C20H24F5N3O3S2
    Purity:>99.99%
    Color and Shape:Soild
    Molecular weight:513.54

    Ref: TM-T77723

  • NMDA receptor antagonist 2
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    NMDA receptor antagonist 2

    CAS:
    <p>Potent, oral NR2B-selective NMDA receptor antagonist; IC50 of 1.0 nM, Ki of 0.88 nM; used for neuropathic pain and Parkinson's research.</p>
    Formula:C20H21N7O
    Color and Shape:Solid
    Molecular weight:375.436

    Ref: TM-T40999

  • Isotachysterol 3
    Targetmol
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    Isotachysterol 3

    CAS:
    <p>Isotachysterol 3 boosts calcium transport in gut and bone mobilization in kidneyless rats.</p>
    Formula:C27H44O
    Color and Shape:Solid
    Molecular weight:384.64

    Ref: TM-T37312

  • FGIN-1-43
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    FGIN-1-43

    CAS:
    <p>FGIN-1-43 is a potent and specific ligand for the mitochondrial DBI receptor.</p>
    Formula:C28H36Cl2N2O
    Purity:99.57%
    Color and Shape:Solid
    Molecular weight:487.5

    Ref: TM-T22783

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    EVT-401

    <p>EVT-401 (P2X7 receptor antagonist-1), a purinergic P2X7 receptor antagonist, demonstrates efficacy in combating neuroinflammation [1].</p>
    Formula:C22H20F4N2O3
    Color and Shape:Solid
    Molecular weight:436.4

    Ref: TM-T74409

  • Conantokin G
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    Conantokin G

    CAS:
    <p>GluN2B-specific NMDA receptor blocker; IC50=480 nM in neurons, ~300 nM in oocytes; neuroprotective.</p>
    Formula:C88H138N26O44
    Purity:98%
    Color and Shape:White Lyophilised Solid
    Molecular weight:2264.21

    Ref: TM-TP2060

  • Eltanexor
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    Eltanexor

    CAS:
    <p>Eltanexor, an oral XPO1 inhibitor, induces apoptosis in leukemia cells; EC50=60.9 nM.</p>
    Formula:C17H10F6N6O
    Purity:99.6% - ≥98%
    Color and Shape:Solid
    Molecular weight:428.29

    Ref: TM-T11766L

  • Chrodrimanin B
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    Chrodrimanin B

    CAS:
    <p>Chrodrimanin B is a useful organic compound for research related to life sciences. The catalog number is T126052 and the CAS number is 132196-54-4.</p>
    Formula:C27H32O8
    Color and Shape:Solid
    Molecular weight:484.545

    Ref: TM-T126052

  • Bendroflumethiazide
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    Bendroflumethiazide

    CAS:
    <p>Bendroflumethiazide (Naturetin) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)</p>
    Formula:C15H14F3N3O4S2
    Purity:98% - >99.99%
    Color and Shape:Crystals From Dioxane Solid
    Molecular weight:421.41

    Ref: TM-T1204

  • Flufiprole
    Targetmol
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    Flufiprole

    CAS:
    <p>Flufiprole is used as a phenylpyrazole pesticide. It has enantioselective metabolism in human and rat liver microsomes.</p>
    Formula:C16H10Cl2F6N4OS
    Color and Shape:Solid
    Molecular weight:491.24

    Ref: TM-T25428

  • Elgodipine
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    Elgodipine

    CAS:
    <p>Elgodipine decreases angina severity, inhibits muscle growth, and is voltage-sensitive, showing promise for angina treatment.</p>
    Formula:C29H33FN2O6
    Purity:98.95% - 99.50%
    Color and Shape:Solid
    Molecular weight:524.58

    Ref: TM-T68060

  • LU-32-176B
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    LU-32-176B

    CAS:
    <p>LU32-176B is a bioactive chemical.</p>
    Formula:C23H24F2N2O2
    Color and Shape:Solid
    Molecular weight:398.45

    Ref: TM-T32911

  • (R)-IDHP
    Targetmol
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    (R)-IDHP

    CAS:
    <p>(R)-IDHP, a salvia derivative, relaxes blood vessels by blocking calcium channels, aiding cardiovascular research.</p>
    Formula:C12H16O5
    Color and Shape:Solid
    Molecular weight:240.25

    Ref: TM-T74193

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    Chlorotoxin(linear)

    <p>Chlorotoxin(linear): 36-amino-acid peptide from Egyptian scorpion venom, used in research as chloride channel blocker.</p>
    Formula:C158H256N52O48S11
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4004.76

    Ref: TM-TP1285

  • 4'-hydroxy Trazodone
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    4'-hydroxy Trazodone

    CAS:
    <p>4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone.1It is an inhibitor of organic anion transporter 3 (OAT3; Ki= 16.9 μM) and is</p>
    Formula:C19H22ClN5O2
    Color and Shape:Solid
    Molecular weight:387.87

    Ref: TM-T35721

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    AQP4 (205-215) TFA

    <p>AQP4 (205-215) TFA is a fragment of the water channel protein-4 (AQP4). AQP4 acts as an autoimmune antigen in neuromyelitis optica, upregulating and presenting in B cells upon binding with CD40. AQP4 is associated with neuromyelitis optica (NMO), an autoimmune inflammatory disease of the central nervous system (CNS).</p>
    Color and Shape:Odour Solid

    Ref: TM-TP3237

  • TRPA1 Antagonist 3
    Targetmol
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    TRPA1 Antagonist 3

    CAS:
    <p>TRPA1 Antagonist 3 is a compound with photoswitchable properties that acts as an agonist on the TRPA1 channel, providing the ability for optical control.</p>
    Formula:C11H8ClN3
    Color and Shape:Solid
    Molecular weight:217.66

    Ref: TM-T40822

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    Huwentoxin I

    CAS:
    <p>Huwentoxin I (HWTX-I) is a peptide toxin that targets and inhibits both voltage-gated sodium channels and N-type calcium channels.</p>
    Formula:C161H246N48O44S6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3750.36

    Ref: TM-T80185

  • CymitQuimica logo
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    MS7710

    <p>MS7710 is a brain-penetrant inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. It reduces Ih current by inhibiting HCN channels, thereby decreasing the activity of dopamine neurons in the ventral tegmental area (VTA). MS7710 effectively improves social interaction deficits and reward-related cognitive flexibility in mouse models of chronic social defeat stress (CSDS) and shows promise for depression research.</p>
    Color and Shape:Odour Solid

    Ref: TM-T207039

  • Myomodulin
    Targetmol
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    Myomodulin

    CAS:
    <p>Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.Myomodulin is present in two identified aplysia neurons that contain myomodulin A the</p>
    Formula:C36H67N11O8S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:846.12

    Ref: TM-TP1852

  • ω-Conotoxin GVIA
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    ω-Conotoxin GVIA

    CAS:
    <p>Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo.</p>
    Formula:C120H182N38O43S6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3037

    Ref: TM-TP2062

  • Oleoyl-D-lysine
    Targetmol
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    Oleoyl-D-lysine

    CAS:
    <p>Oleoyl-D-lysine: lipid-based GlyT2 inhibitor, eases neuropathic pain in mice, safe, non-sedative, no respiratory depression.</p>
    Formula:C24H46N2O3
    Color and Shape:Solid
    Molecular weight:410.63

    Ref: TM-T74739

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    P-gp/BCRP-IN-2

    <p>P-gp/BCRP-IN-2 (compound 15), an oxadiazole derivative, functions as a dual inhibitor targeting both the ABC transporter P-glycoprotein (IC50: 1.6 nM) and BCRP</p>
    Formula:C32H35N3O6
    Color and Shape:Solid
    Molecular weight:557.64

    Ref: TM-T79353

  • GYKI-47261 dihydrochloride
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    GYKI-47261 dihydrochloride

    CAS:
    <p>GYKI-47261 dihydrochloride is an AMPA receptor antagonist and CYP2E1 inducer, demonstrating broad-spectrum anticonvulsant and neuroprotective activities.</p>
    Formula:C18H17Cl3N4
    Purity:98.32% - 99.14%
    Color and Shape:Solid
    Molecular weight:395.71

    Ref: TM-T38601

  • Chlorocresol
    Targetmol
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    Chlorocresol

    CAS:
    <p>Chlorocresol (4-Chloro-3-methylphenol) is an antiseptic medication.</p>
    Formula:C7H7ClO
    Color and Shape:Solid
    Molecular weight:142.58

    Ref: TM-T75311

  • L-R4W2
    Targetmol
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    L-R4W2

    CAS:
    <p>Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.</p>
    Formula:C46H71N21O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1014.2

    Ref: TM-TP1934

  • ML353
    Targetmol
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    ML353

    <p>ML353 activates TREK-1/2, binds mGlu5 SAM (Ki=18.2 nM), surpasses 5mpep, may address SAM activity/blocking.</p>
    Formula:C19H15FN2O
    Purity:99.98% - 99.98%
    Color and Shape:Soild
    Molecular weight:306.33

    Ref: TM-T67917

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    AmmTX3

    <p>KV4 channel blocker that inhibits A-type K+ current in mouse neurons; requires DPP6 and DPP10 for effect.</p>
    Formula:C158H262N50O48S6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3822.47

    Ref: TM-TP2090

  • (±)17-HETE
    Targetmol
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    (±)17-HETE

    CAS:
    <p>Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.</p>
    Formula:C20H32O3
    Color and Shape:Solid
    Molecular weight:320.473

    Ref: TM-T35523

  • Carbonic anhydrase inhibitor 32
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    Carbonic anhydrase inhibitor 32

    <p>Carbonic anhydrase inhibitor32 (compound 5B) is an orally active, selective inhibitor of hCA (carbonic anhydrase) II/VII, with Ki values of 6.3 nM for hCA II, 10.1 nM for hCA VII, and 681 nM for hCA I. It shows potential for neuroprotection and anticonvulsant effects by reducing mTOR activation and increasing hippocampal KCC2 levels.</p>
    Formula:C17H16N6O3S
    Color and Shape:Solid
    Molecular weight:384.41

    Ref: TM-T207684

  • Cavα2δ-IN-1
    Targetmol
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    Cavα2δ-IN-1

    CAS:
    <p>Cavα2δ-IN-1 demonstrates exceptional specificity for voltage-gated calcium channels Cavα2δ-1 (with a Ki value of 6 nM), in comparison to Cavα2δ-2 (with a Ki</p>
    Formula:C18H27N5O
    Color and Shape:Solid
    Molecular weight:329.448

    Ref: TM-T40071

  • Ruzinurad
    Targetmol
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    Ruzinurad

    CAS:
    <p>Ruzinurad (WO2020088641, compound I) is a potent URAT1 inhibitor, exhibiting high selectivity.</p>
    Formula:C14H12BrNO2S
    Color and Shape:Solid
    Molecular weight:338.22

    Ref: TM-T39116

  • ω-Conotoxin MVIIC
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    ω-Conotoxin MVIIC

    CAS:
    <p>Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.</p>
    Formula:C106H178N40O32S7
    Purity:98%
    Color and Shape:White Lyophilised Solid
    Molecular weight:2749

    Ref: TM-TP2064

  • NF110
    Targetmol
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    NF110

    CAS:
    <p>P2X3 antagonist</p>
    Formula:C41H32N6NaO17S4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1031.97

    Ref: TM-TP2273

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    AZ1422

    <p>AZ1422 is a selective MCT4 inhibitor, applicable for cancer research.</p>
    Formula:C31H40N2O6
    Molecular weight:536.28864

    Ref: TM-T208257

  • Venturicidin A
    Targetmol
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    Venturicidin A

    CAS:
    <p>Venturicidin A is a macrolide antibiotic.</p>
    Formula:C41H67NO11
    Purity:98%
    Color and Shape:Solid
    Molecular weight:749.97

    Ref: TM-T23505

  • BKCa activator-1
    Targetmol
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    BKCa activator-1

    <p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>
    Formula:C22H23F7N2O3
    Color and Shape:Solid
    Molecular weight:496.418

    Ref: TM-T205564

  • Phe-Met-Arg-Phe amide trifluoroacetate
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    Phe-Met-Arg-Phe amide trifluoroacetate

    CAS:
    <p>Phe-met-arg-phe amide trifluoroacetate is an activator of K+ current with an ED50 of 23nm on the fundus nerve.</p>
    Formula:C33H44F6N8O8S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:826.81

    Ref: TM-TP1440

  • (±)16-HETE
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    (±)16-HETE

    CAS:
    <p>Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.</p>
    Formula:C20H32O3
    Color and Shape:Solid
    Molecular weight:320.473

    Ref: TM-T35465

  • Ins(1,4,5)-P3 hexapotassium salt
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    Ins(1,4,5)-P3 hexapotassium salt

    CAS:
    <p>D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt is promotes endoplasmic The second messenger of net calcium ions.</p>
    Formula:C6H9K6O15P3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:648.64

    Ref: TM-T19266

  • PCO 400
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    PCO 400

    CAS:
    <p>PCO 400 is an analog of comakalim that acts as a selective and potent ATP-sensitive K+ channel opener.</p>
    Formula:C17H17NO4
    Purity:97.29% - 97.8%
    Color and Shape:Solid
    Molecular weight:299.32

    Ref: TM-T90604

  • Ryanodine
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    Ryanodine

    CAS:
    <p>Ryanodine: a diterpenoid modulating Ca2+ release via ryanodine receptors; concentration-dependent effects; found in Ryania speciosa; toxic.</p>
    Formula:C25H35NO9
    Purity:98%
    Color and Shape:White Solid
    Molecular weight:493.553

    Ref: TM-T12787