Membrane Transporter/Ion Channel
Membrane transporter and ion channel inhibitors are compounds that block the function of proteins responsible for the transport of ions, nutrients, and other molecules across cell membranes. These inhibitors are crucial for studying the regulation of cellular homeostasis, signal transduction, and neurotransmission. Membrane transporter and ion channel inhibitors are also important in developing treatments for disorders such as epilepsy, cardiovascular diseases, and metabolic syndromes. At CymitQuimica, we provide a diverse selection of high-quality membrane transporter and ion channel inhibitors to support your research in physiology, neuroscience, and pharmacology.
Subcategories of "Membrane Transporter/Ion Channel"
- ABC(3 products)
- ATPase(99 products)
- Adiponectin receptor(5 products)
- CFTR(66 products)
- CGRP Receptor(53 products)
- Calcium Channel(549 products)
- Chloride channel(54 products)
- GABA Receptor(369 products)
- Monoamine Transporter(30 products)
- Monocarboxylate transporter(18 products)
- NKCC(2 products)
- NPC1L1(3 products)
- Na-K-Cl cotransporter(10 products)
- OAT(32 products)
- OCT(7 products)
- P-gp(55 products)
- Potassium Channel(289 products)
- Proton pump(41 products)
- SGLT(31 products)
- Sodium Channel(223 products)
- TRP/TRPV Channel(96 products)
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Found 2649 products of "Membrane Transporter/Ion Channel"
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WS-917
WS-917 is an efficacious and orally active regulator of ABCB1. It enhances the ABCB1 ATPase activity and significantly boosts the antitumor efficacy of combined paclitaxel and anti-PD-1 antibody therapy. WS-917 also promotes the activation of CD8+ T cells.Formula:C16H13N5OS2Color and Shape:SolidMolecular weight:355.44Ebio3
Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.Formula:C19H23F2N3O2Color and Shape:SolidMolecular weight:363.4Trans (2,3)-Dihydrotetrabenazine
CAS:Trans (2,3)-Dihydrotetrabenazine is a Tetrabenazine metabolite, shows inhibition activity on vesicular monoamine transporter (VMAT2).Formula:C19H29NO3Purity:98%Color and Shape:SolidMolecular weight:319.44GYKI-47261 dihydrochloride
CAS:GYKI-47261 dihydrochloride is an AMPA receptor antagonist and CYP2E1 inducer, demonstrating broad-spectrum anticonvulsant and neuroprotective activities.
Formula:C18H17Cl3N4Purity:98.32% - 99.14%Color and Shape:SolidMolecular weight:395.71ATP synthase inhibitor 2 TFA
ATP Synthase Inhibitor 2 (Compound 22) TFA is a potent inhibitor of Pseudomonas aeruginosa ATP synthase with an IC50 value of 10 μg/mL.Formula:C23H23F3N2O5SColor and Shape:SolidMolecular weight:496.5AQP3-IN-1
CAS:AQP3-IN-1 (compounds 3), an AQP3 inhibitor, exhibits an IC 50 of 8.91 μM and effectively inhibits melanoma cell proliferation [1].
Formula:C11H9AuCl2N2Color and Shape:SolidMolecular weight:437.08KGP-25
KGP-25 is an inhibitor of the voltage-gated sodium channel 1.8 (Nav1.8), utilized for analgesia by targeting the peripheral nervous system (PNS). Additionally, it targets the γ-aminobutyric acid subtype A receptor (GABAA) in the central nervous system (CNS) for use as a general anesthetic.Color and Shape:Odour SolidChlorotoxin TFA
Chlorotoxin TFA, a scorpion venom peptide, blocks chloride channels and has anti-cancer properties.Formula:C160H250F3N53O49S11Color and Shape:SolidMolecular weight:4109.74Ampullosporin A
CAS:Ampullosporin A is a peptaibol-type polypeptide isolated from the fungus Sepedonium ampullosporum (HKI-0053), exhibiting neuromodulatory activity. It inhibits hyperactivity induced by the NMDA receptor antagonist MK-801 and ameliorates social behavior abnormalities caused by subchronic ketamine treatment. Ampullosporin A modulates glutamate receptor activity without affecting dopamine D1 and D2 receptors.Formula:C77H127N19O19Color and Shape:SolidMolecular weight:1622.95Levamlodipine besylate Hemipentahydrate
CAS:Levamlodipine besylate hemipentahydrate is the besylate hemipentahydrate salt form of Levamlodipine. It is an orally effective calcium channel blocker with antioxidative and vasodilatory properties. This compound can reduce serum malondialdehyde (MDA) levels, enhance the activity of superoxide dismutase (SOD), and alleviate oxidative stress. Levamlodipine besylate hemipentahydrate is relevant for research in vascular dementia, hypertension, and cerebrovascular diseases.Formula:C20H25ClN2O5·C6H6O3SH2OColor and Shape:SolidMolecular weight:1224.185-Tridecanol
CAS:5-Tridecanol blocks ion flux in sodium channels.Formula:C13H28OPurity:97.87%Color and Shape:SolidMolecular weight:200.3617(S)-HETE
CAS:Arachidonic acid and its CYP450 metabolite, 17(S)-HETE, regulate kidney electrolytes; 17(S)-HETE reduces proximal tubule ATPase activity by 70% at 2 μM.
Formula:C20H32O3Color and Shape:SolidMolecular weight:320.473Anticonvulsant agent 9
Anticonvulsant agent 9 (compound 4f) is an activator of the α1β2γ2GABA_A receptor, with an EC50 value of 1.24 μM. It inhibits the inactivation of Nav1.2 channels and exhibits significant anticonvulsant activity.Formula:C22H24N4O2Color and Shape:SolidMolecular weight:376.45VMAT2-IN-3
VMAT2-IN-3 (compound 10) is a potent inhibitor of vesicular monoamine transporter 2 (VMAT2), with a Ki value of 0.71 nM, showing promise for research in neurological or psychiatric disorders.Formula:C22H35NO4Molecular weight:377.25661AQP4 (201-220) TFA
AQP4 (201-220) TFA is an encephalitogenic epitope of AQP-4. This compound can induce experimental autoimmune encephalomyelitis (EAE), characterized by midline brain lesions, retinal abnormalities, and lesions at the grey/white matter boundary of the spinal cord. AQP-4 is the target antigen in neuromyelitis optica.Color and Shape:Odour SolidHomocarnosine
CAS:Homocarnosine is an endogenous dipeptide in cerebral regions and cerebrospinal fluid.Formula:C10H16N4O3Color and Shape:SolidMolecular weight:240.26Ouabagenin
CAS:Ouabagenin, a naturally occurring LXR ligand with selective agonist activity, functions as an EC 3.6.3.9 (Na(+)/K(+)-transport ATPase) inhibitor [1] [2].Formula:C23H34O8Color and Shape:SolidMolecular weight:438.51Phe-Met-Arg-Phe amide trifluoroacetate
CAS:Phe-met-arg-phe amide trifluoroacetate is an activator of K+ current with an ED50 of 23nm on the fundus nerve.Formula:C33H44F6N8O8SPurity:98%Color and Shape:SolidMolecular weight:826.81AQP4 (205-215) TFA
AQP4 (205-215) TFA is a fragment of the water channel protein-4 (AQP4). AQP4 acts as an autoimmune antigen in neuromyelitis optica, upregulating and presenting in B cells upon binding with CD40. AQP4 is associated with neuromyelitis optica (NMO), an autoimmune inflammatory disease of the central nervous system (CNS).Color and Shape:Odour Solid3'-Deoxy-3'-amino-ATP
CAS:3'-Deoxy-3'-amino-ATP is a competitive ATP inhibitor with a 2.3 μM Ki, used to synthesize tRNA.Formula:C10H17N6O12P3Color and Shape:SolidMolecular weight:506.197
