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CFTR

CFTR

CFTR is a chloride channel protein that regulates the transport of chloride and bicarbonate ions across epithelial cell membranes, playing a crucial role in maintaining fluid balance in tissues. Mutations in the CFTR gene lead to cystic fibrosis, a genetic disorder characterized by the production of thick mucus that can clog airways and lead to severe respiratory and digestive problems. At CymitQuimica, we provide a selection of CFTR modulators to support your research in cystic fibrosis, ion transport, and genetic disorders.

Found 64 products of "CFTR"

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  • Elexacaftor
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    Elexacaftor

    CAS:
    <p>Elexacaftor (VX-445) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector.Cost-effective and quality-assured.</p>
    Formula:C26H34F3N7O4S
    Purity:98.87% - 99.87%
    Color and Shape:Solid
    Molecular weight:597.65

    Ref: TM-T14935

  • Glibenclamide
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    Glibenclamide

    CAS:
    <p>Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.</p>
    Formula:C23H28ClN3O5S
    Purity:99.05% - 99.75%
    Color and Shape:Solid
    Molecular weight:494.00

    Ref: TM-T1634

  • CP-628006
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    CP-628006

    CAS:
    <p>CP-628006 is a small molecule CFTR potentiator that effectively restores ATP-dependent channel gating to G551D-CFTR, the mutant form found in cystic fibrosis.</p>
    Formula:C32H35F3N2O2
    Color and Shape:Solid
    Molecular weight:536.639

    Ref: TM-T40386

  • 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-me…
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    4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine

    CAS:
    <p>4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine is an enantiomeric</p>
    Formula:C27H28ClFN2OS
    Purity:99.02%
    Color and Shape:Soild
    Molecular weight:483.04

    Ref: TM-T60126

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    Crofelemer

    CAS:
    <p>Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.</p>
    Color and Shape:Solid

    Ref: TM-T205474

  • (Rac)-Tezacaftor
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    (Rac)-Tezacaftor

    CAS:
    <p>(Rac)-Tezacaftor, a racemate, corrects F508del CFTR for cystic fibrosis research.</p>
    Formula:C26H27F3N2O6
    Color and Shape:Solid
    Molecular weight:520.5

    Ref: TM-T75230

  • Vanzacaftor
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    Vanzacaftor

    CAS:
    <p>Vanzacaftor is a CFTR modulator improving protein processing and surface trafficking, restoring chloride transport and aiding cystic fibrosis therapy research.</p>
    Formula:C32H39N7O4S
    Purity:99.14%
    Color and Shape:Solid
    Molecular weight:617.76

    Ref: TM-T74417

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    Astressin 2B

    CAS:
    <p>CRF2 antagonist with IC50 of 1.3 nM; &gt;500 nM for CRF1. Aids gastric emptying.</p>
    Formula:C183H307N49O53
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4041.69

    Ref: TM-TP2095

  • CFTR activator 2
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    CFTR activator 2

    CAS:
    <p>CFTR activator 2 (WAY-326769) is an activator of mutant CFTR (cystic fibrosis transmembrane conductance regulator), which increases ion transport activity and can be used for research into cystic fibrosis (CF).</p>
    Formula:C27H27N3O3
    Purity:99.70%
    Color and Shape:Solid
    Molecular weight:441.52

    Ref: TM-T203322

  • H2-Gamendazole
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    H2-Gamendazole

    CAS:
    <p>H2-Gamendazole: inhibits spermatogenesis, cancer therapy, targets heat shock proteins &amp; EF1α, regulates Hsp90.</p>
    Formula:C18H13Cl2F3N2O2
    Purity:97.36%
    Color and Shape:Solid
    Molecular weight:417.21

    Ref: TM-T72076

  • WAY-326766
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    WAY-326766

    CAS:
    <p>WAY-326766 increases ion transport through mutant CFTR and can be used to alter the lifespan of eukaryotes.WAY-326766 can be used to treat cystic fibrosis (CF).</p>
    Formula:C21H23N3O5
    Purity:98.76%
    Color and Shape:Solid
    Molecular weight:397.42

    Ref: TM-T77604

  • Zatonacaftor
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    Zatonacaftor

    CAS:
    <p>Zatonacaftor, a cystic fibrosis transmembrane regulator (CFTR) modulator, is utilized in the research of cystic fibrosis [1] [2].</p>
    Formula:C24H27N3O4S
    Color and Shape:Solid
    Molecular weight:453.55

    Ref: TM-T74748

  • (R)-BPO-27
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    (R)-BPO-27

    CAS:
    <p>(R)-BPO-27 is an orally active and potent ATP-competitive CFTR inhibitor (IC50: 4 nM) for the study of diarrhoea and polycystic kidney.</p>
    Formula:C26H18BrN3O6
    Purity:99.1%
    Color and Shape:Solid
    Molecular weight:548.34

    Ref: TM-T10591L

  • Crinecerfont hydrochloride
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    Crinecerfont hydrochloride

    CAS:
    <p>SSR-125543, a potent CRF1 receptor non-peptide antagonist, effective in CAH research, taken orally.</p>
    Formula:C27H29Cl2FN2OS
    Color and Shape:Solid
    Molecular weight:519.5

    Ref: TM-T40398

  • KM11060
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    KM11060

    CAS:
    <p>KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma</p>
    Formula:C19H17Cl2N3O2S
    Purity:98.86%
    Color and Shape:Solid
    Molecular weight:422.33

    Ref: TM-T3135

  • Icenticaftor
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    Icenticaftor

    CAS:
    <p>Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.</p>
    Formula:C12H13F6N3O3
    Purity:99.76%
    Color and Shape:Solid
    Molecular weight:361.24

    Ref: TM-T9499

  • Tezacaftor
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    Tezacaftor

    CAS:
    <p>Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.</p>
    Formula:C26H27F3N2O6
    Purity:98.84% - >99.99%
    Color and Shape:Solid
    Molecular weight:520.5

    Ref: TM-T2263

  • IOWH-032
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    IOWH-032

    CAS:
    <p>IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.</p>
    Formula:C22H15Br2N3O4
    Purity:98.92% - ≥95%
    Color and Shape:Solid
    Molecular weight:545.18

    Ref: TM-T2486

  • Ataluren
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    Ataluren

    CAS:
    <p>Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations.</p>
    Formula:C15H9FN2O3
    Purity:99.16% - 99.84%
    Color and Shape:Solid
    Molecular weight:284.24

    Ref: TM-T1805

  • PPQ-102
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    PPQ-102

    CAS:
    <p>PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).</p>
    Formula:C26H22N4O3
    Purity:99.7% - ≥95%
    Color and Shape:Solid
    Molecular weight:438.48

    Ref: TM-T1874