CFTR
CFTR is a chloride channel protein that regulates the transport of chloride and bicarbonate ions across epithelial cell membranes, playing a crucial role in maintaining fluid balance in tissues. Mutations in the CFTR gene lead to cystic fibrosis, a genetic disorder characterized by the production of thick mucus that can clog airways and lead to severe respiratory and digestive problems. At CymitQuimica, we provide a selection of CFTR modulators to support your research in cystic fibrosis, ion transport, and genetic disorders.
Found 66 products of "CFTR"
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Elexacaftor
CAS:Elexacaftor (VX-445) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector.Cost-effective and quality-assured.Formula:C26H34F3N7O4SPurity:98.87% - 99.87%Color and Shape:SolidMolecular weight:597.65Ref: TM-T14935
1mg93.00€2mg130.00€5mg230.00€1mL*10mM (DMSO)304.00€10mg371.00€25mg730.00€50mg1,018.00€100mg1,369.00€Glibenclamide
CAS:Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Formula:C23H28ClN3O5SPurity:99.05% - 99.75%Color and Shape:SolidMolecular weight:494.00WAY-326766
CAS:WAY-326766 increases ion transport through mutant CFTR and can be used to alter the lifespan of eukaryotes.WAY-326766 can be used to treat cystic fibrosis (CF).Formula:C21H23N3O5Purity:99.87%Color and Shape:SolidMolecular weight:397.42Cavosonstat
CAS:Cavosonstat (N91115) is an oral GSNOR inhibitor aiding CFTR in cystic fibrosis.Formula:C16H10ClNO3Purity:99.64%Color and Shape:SolidMolecular weight:299.71Crofelemer
CAS:Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.Color and Shape:SolidCP-628006
CAS:CP-628006 is a small molecule CFTR potentiator that effectively restores ATP-dependent channel gating to G551D-CFTR, the mutant form found in cystic fibrosis.Formula:C32H35F3N2O2Color and Shape:SolidMolecular weight:536.639kCAL01
CAS:kCAL01 is a CAL inhibitor with a Ki value of 2.3 μM and holds potential for research in cystic fibrosis (CF).Formula:C36H57N11O9Color and Shape:SolidMolecular weight:787.91H2-Gamendazole
CAS:H2-Gamendazole: inhibits spermatogenesis, cancer therapy, targets heat shock proteins & EF1α, regulates Hsp90.Formula:C18H13Cl2F3N2O2Purity:97.39%Color and Shape:SolidMolecular weight:417.21Ref: TM-T72076
1mg73.00€5mg180.00€1mL*10mM (DMSO)203.00€10mg269.00€25mg477.00€50mg642.00€100mg880.00€200mg1,161.00€Zatonacaftor
CAS:Zatonacaftor, a cystic fibrosis transmembrane regulator (CFTR) modulator, is utilized in the research of cystic fibrosis [1] [2].Formula:C24H27N3O4SColor and Shape:SolidMolecular weight:453.55(R)-Crinecerfont
CAS:4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine is an enantiomericFormula:C27H28ClFN2OSPurity:99.02%Color and Shape:SoildMolecular weight:483.04Ref: TM-T60126
500mgTo inquire1mg109.00€2mg163.00€5mg241.00€1mL*10mM (DMSO)289.00€10mg355.00€25mg532.00€50mg745.00€100mg1,018.00€(Rac)-Tezacaftor
CAS:(Rac)-Tezacaftor, a racemate, corrects F508del CFTR for cystic fibrosis research.Formula:C26H27F3N2O6Color and Shape:SolidMolecular weight:520.5CFTR activator 2
CAS:CFTR activator 2 (WAY-326769) is an activator of mutant CFTR (cystic fibrosis transmembrane conductance regulator), which increases ion transport activity and can be used for research into cystic fibrosis (CF).Formula:C27H27N3O3Purity:99.70%Color and Shape:SolidMolecular weight:441.52Astressin 2B
CAS:CRF2 antagonist with IC50 of 1.3 nM; >500 nM for CRF1. Aids gastric emptying.Formula:C183H307N49O53Purity:98%Color and Shape:SolidMolecular weight:4041.69Vanzacaftor
CAS:Vanzacaftor is a CFTR modulator improving protein processing and surface trafficking, restoring chloride transport and aiding cystic fibrosis therapy research.Formula:C32H39N7O4SPurity:99.14%Color and Shape:SolidMolecular weight:617.76Ref: TM-T74417
1mg191.00€5mg350.00€1mL*10mM (DMSO)477.00€10mg511.00€25mg754.00€50mg1,142.00€100mg1,700.00€Crinecerfont hydrochloride
CAS:SSR-125543, a potent CRF1 receptor non-peptide antagonist, effective in CAH research, taken orally.Formula:C27H29Cl2FN2OSColor and Shape:SolidMolecular weight:519.5Lubiprostone
CAS:Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.Formula:C20H32F2O5Purity:97.31% - 98.54%Color and Shape:White Odorless Crystals Or Crystalline PowderMolecular weight:390.46Lumacaftor
CAS:Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.Formula:C24H18F2N2O5Purity:99.48% - 99.68%Color and Shape:SolidMolecular weight:452.41PPQ-102
CAS:PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).Formula:C26H22N4O3Purity:98.80% - ≥95%Color and Shape:SolidMolecular weight:438.48Nesolicaftor
CAS:Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.Formula:C18H18N4O4Purity:99.79%Color and Shape:SolidMolecular weight:354.36Ref: TM-T16681
1mg90.00€5mg203.00€1mL*10mM (DMSO)225.00€10mg358.00€25mg617.00€50mg878.00€100mg1,189.00€CFTR(inh)-172
CAS:CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.Formula:C18H10F3NO3S2Purity:98% - 99.72%Color and Shape:SolidMolecular weight:409.4Ref: TM-T2355
1mg34.00€2mg43.00€5mg63.00€1mL*10mM (DMSO)65.00€10mg92.00€25mg178.00€50mg340.00€100mg502.00€CFTR corrector 2
CAS:CFTR corrector 2 (FDL169) is a novel and potent CFTR corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.Formula:C27H23FN4O4Purity:99.66%Color and Shape:SolidMolecular weight:486.49Ref: TM-T5312
2mg37.00€5mg55.00€1mL*10mM (DMSO)59.00€10mg80.00€25mg147.00€50mg215.00€100mg318.00€200mg444.00€GlyH-101
CAS:GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.Formula:C19H15Br2N3O3Purity:98.71% - 98.78%Color and Shape:SolidMolecular weight:493.15Ref: TM-T2451
1mg34.00€5mg71.00€1mL*10mM (DMSO)80.00€10mg103.00€25mg210.00€50mg354.00€100mg530.00€200mg755.00€Ivacaftor
CAS:Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells,Formula:C24H28N2O3Purity:99% - 99.98%Color and Shape:SolidMolecular weight:392.49Ref: TM-T2588
1mg35.00€2mg50.00€5mg77.00€1mL*10mM (DMSO)84.00€10mg120.00€25mg195.00€50mg288.00€100mg416.00€200mg600.00€Tezacaftor
CAS:Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.Formula:C26H27F3N2O6Purity:98.84% - >99.99%Color and Shape:SolidMolecular weight:520.5Ref: TM-T2263
1mg38.00€2mg50.00€5mg78.00€1mL*10mM (DMSO)94.00€10mg116.00€25mg200.00€50mg324.00€100mg477.00€GLPG1837
CAS:GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.Formula:C16H20N4O3SPurity:99.64% - 99.91%Color and Shape:SolidMolecular weight:348.42Glibenclamide potassium
CAS:Glibenclamide potassium, a more soluble form of Glibenclamide, exists as anhydrous and hydrate salts.Formula:C23H27ClKN3O5SColor and Shape:SolidMolecular weight:532.09IOWH-032
CAS:IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.Formula:C22H15Br2N3O4Purity:98.92% - ≥95%Color and Shape:SolidMolecular weight:545.18KM11060
CAS:KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasmaFormula:C19H17Cl2N3O2SPurity:98.86%Color and Shape:SolidMolecular weight:422.33Icenticaftor
CAS:Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.Formula:C12H13F6N3O3Purity:99.76%Color and Shape:SolidMolecular weight:361.24Ref: TM-T9499
1mg152.00€1mL*10mM (DMSO)248.00€5mg313.00€10mg469.00€25mg750.00€50mg1,054.00€100mg1,494.00€200mg2,025.00€Ataluren
CAS:Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations.Formula:C15H9FN2O3Purity:99.16% - 99.84%Color and Shape:SolidMolecular weight:284.24Ref: TM-T1805
5mg35.00€1mL*10mM (DMSO)46.00€10mg54.00€25mg88.00€50mg117.00€100mg178.00€200mg213.00€500mg359.00€SRI-41315
CAS:SRI-41315 is an eRF1 degrader that acts as a molecular glue at the ribosomal decoding center.SRI-41315 induces extended pauses at the termination codon.Formula:C22H19N3O2Purity:99.87%Color and Shape:SolidMolecular weight:357.41Ref: TM-T2S1837
1mg49.00€1mL*10mM (DMSO)73.00€5mg89.00€10mg154.00€25mg250.00€50mg371.00€100mg552.00€200mg785.00€(R)-Olacaftor
CAS:(R)-Olacaftor (VX-440) is a CFTR modulator with promise for researching cystic fibrosis.Formula:C29H34FN3O4SColor and Shape:SolidMolecular weight:539.66SRI-37240
CAS:SRI-37240 suppresses CFTR nonsense mutations, aids in fixing premature termination codons, works with G418.Formula:C24H23N3O2Purity:98.73%Color and Shape:SolidMolecular weight:385.46Ivacaftor-D9
CAS:CTP-656, a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis.Formula:C24H19D9N2O3Color and Shape:SolidMolecular weight:401.55AF-2785
CAS:In epididymal epithelial cells, AF-2785 inhibits cystic fibrosis transmembrane conductance regulator Cl(-) channels.Formula:C17H12Cl2N2O2Purity:98%Color and Shape:SolidMolecular weight:347.2CFTR corrector 9
CAS:CFTR corrector 9 is a CF modulator used to research cystic fibrosis and related disorders.Formula:C16H14N2O4Purity:99.75%Color and Shape:SolidMolecular weight:298.29Ref: TM-T60653
2mg39.00€1mL*10mM (DMSO)58.00€5mg60.00€10mg96.00€25mg170.00€50mg253.00€100mg363.00€200mg510.00€Corrector C4
CAS:Corrector C4, a corrector commonly used to study cystic fibrosis mutants, works by alleviating the interaction between CFTR transmembrane domain mutants andFormula:C21H17ClN4O2S2Purity:99.98%Color and Shape:SolidMolecular weight:456.97Galicaftor
CAS:ABBV-2222 is a CFTR corrector which is studied for the treatment of cystic fibrosis (CF).Formula:C28H21F4NO7Purity:98.84%Color and Shape:SolidMolecular weight:559.46Ref: TM-T22252
1mgTo inquire10mgTo inquire5mg192.00€1mL*10mM (DMSO)236.00€25mg625.00€50mg982.00€100mg1,639.00€Posenacaftor sodium
CAS:Posenacaftor (PTI-801) sodium, a CFTR modulator for CF research, corrects CFTR protein folding and trafficking.Formula:C27H27NNaO5Color and Shape:SolidMolecular weight:468.505GLPG2451
CAS:GLPG2451 is an effective CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) enhancer, potentiates cold-rescued F508del CFTR (EC50=11.1 nM).Formula:C16H16F3N3O5SPurity:99.13%Color and Shape:SolidMolecular weight:419.38Ref: TM-T13705
1mg106.00€5mg253.00€1mL*10mM (DMSO)279.00€10mg387.00€25mg785.00€50mg1,170.00€100mg1,564.00€(R)-Posenacaftor sodium
CAS:(R)-Posenacaftor sodium is a modulator for correcting cystic fibrosis protein folding.Formula:C27H27NNaO5Color and Shape:SolidMolecular weight:468.505Posenacaftor
CAS:Posenacaftor (PTI-801) regulates CFTR protein for cystic fibrosis research.Formula:C27H27NO5Color and Shape:SolidMolecular weight:445.51GLPG-3221
CAS:GLPG-3221, a potent oral CFTR corrector for cystic fibrosis treatment, has an EC50 of 105 nM.Formula:C30H37F3N2O6Purity:98%Color and Shape:SolidMolecular weight:578.62Bamocaftor
CAS:Bamocaftor corrects CFTR in CF, restoring F508del-CFTR function, used with tezacaftor and VX-561 for F508del/MF patients.Formula:C28H32F3N5O4SPurity:99.71%Color and Shape:SolidMolecular weight:591.65Ref: TM-T30293
1mg354.00€5mg847.00€10mg1,159.00€1mL*10mM (DMSO)1,225.00€25mg1,700.00€50mg2,308.00€100mg3,117.00€PG01
CAS:PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.Formula:C28H29N3O2Purity:99.79%Color and Shape:SolidMolecular weight:439.55Ref: TM-T16516
1mg55.00€1mL*10mM (DMSO)144.00€5mg148.00€10mg215.00€25mg344.00€50mg465.00€100mg630.00€200mg850.00€Crinecerfont
CAS:Crinecerfont (SSR-125543) is a CRF1 antagonist, useful in congenital adrenal hyperplasia research.Formula:C27H28ClFN2OSPurity:97.79% - 98.55%Color and Shape:SolidMolecular weight:483.04VRT-325
CAS:VRT-325 aids in dimerizing NBDs and folding TMDs, speeding up CF cell monolayer repair.Formula:C27H34N4O4SPurity:99.15% - 99.58%Color and Shape:SolidMolecular weight:510.65UCCF-853
CAS:UCCF-853 是一种小分子 CFTR 调节剂，可用于研究囊性纤维化。Formula:C14H8ClF3N2OPurity:99.82%Color and Shape:SolidMolecular weight:312.67VRT-532
CAS:VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects.
Formula:C16H14N2OPurity:99.88% - 99.93%Color and Shape:SolidMolecular weight:250.3
