CFTR
CFTR is a chloride channel protein that regulates the transport of chloride and bicarbonate ions across epithelial cell membranes, playing a crucial role in maintaining fluid balance in tissues. Mutations in the CFTR gene lead to cystic fibrosis, a genetic disorder characterized by the production of thick mucus that can clog airways and lead to severe respiratory and digestive problems. At CymitQuimica, we provide a selection of CFTR modulators to support your research in cystic fibrosis, ion transport, and genetic disorders.
Found 64 products of "CFTR"
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Elexacaftor
CAS:<p>Elexacaftor (VX-445) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector.Cost-effective and quality-assured.</p>Formula:C26H34F3N7O4SPurity:98.87% - 99.87%Color and Shape:SolidMolecular weight:597.65Glibenclamide
CAS:<p>Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.</p>Formula:C23H28ClN3O5SPurity:99.05% - 99.75%Color and Shape:SolidMolecular weight:494.00Vanzacaftor
CAS:<p>Vanzacaftor is a CFTR modulator improving protein processing and surface trafficking, restoring chloride transport and aiding cystic fibrosis therapy research.</p>Formula:C32H39N7O4SPurity:99.14%Color and Shape:SolidMolecular weight:617.76Astressin 2B
CAS:<p>CRF2 antagonist with IC50 of 1.3 nM; >500 nM for CRF1. Aids gastric emptying.</p>Formula:C183H307N49O53Purity:98%Color and Shape:SolidMolecular weight:4041.69CFTR activator 2
CAS:<p>CFTR activator 2 (WAY-326769) is an activator of mutant CFTR (cystic fibrosis transmembrane conductance regulator), which increases ion transport activity and can be used for research into cystic fibrosis (CF).</p>Formula:C27H27N3O3Purity:99.70%Color and Shape:SolidMolecular weight:441.52(Rac)-Tezacaftor
CAS:<p>(Rac)-Tezacaftor, a racemate, corrects F508del CFTR for cystic fibrosis research.</p>Formula:C26H27F3N2O6Color and Shape:SolidMolecular weight:520.5Crofelemer
CAS:<p>Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.</p>Color and Shape:SolidCP-628006
CAS:<p>CP-628006 is a small molecule CFTR potentiator that effectively restores ATP-dependent channel gating to G551D-CFTR, the mutant form found in cystic fibrosis.</p>Formula:C32H35F3N2O2Color and Shape:SolidMolecular weight:536.639H2-Gamendazole
CAS:<p>H2-Gamendazole: inhibits spermatogenesis, cancer therapy, targets heat shock proteins & EF1α, regulates Hsp90.</p>Formula:C18H13Cl2F3N2O2Purity:97.36%Color and Shape:SolidMolecular weight:417.21Zatonacaftor
CAS:<p>Zatonacaftor, a cystic fibrosis transmembrane regulator (CFTR) modulator, is utilized in the research of cystic fibrosis [1] [2].</p>Formula:C24H27N3O4SColor and Shape:SolidMolecular weight:453.554-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine
CAS:<p>4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine is an enantiomeric</p>Formula:C27H28ClFN2OSPurity:99.02%Color and Shape:SoildMolecular weight:483.04WAY-326766
CAS:<p>WAY-326766 increases ion transport through mutant CFTR and can be used to alter the lifespan of eukaryotes.WAY-326766 can be used to treat cystic fibrosis (CF).</p>Formula:C21H23N3O5Purity:98.76%Color and Shape:SolidMolecular weight:397.42Crinecerfont hydrochloride
CAS:<p>SSR-125543, a potent CRF1 receptor non-peptide antagonist, effective in CAH research, taken orally.</p>Formula:C27H29Cl2FN2OSColor and Shape:SolidMolecular weight:519.5(R)-BPO-27
CAS:<p>(R)-BPO-27 is an orally active and potent ATP-competitive CFTR inhibitor (IC50: 4 nM) for the study of diarrhoea and polycystic kidney.</p>Formula:C26H18BrN3O6Purity:99.1%Color and Shape:SolidMolecular weight:548.34Ataluren
CAS:<p>Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations.</p>Formula:C15H9FN2O3Purity:99.16% - 99.84%Color and Shape:SolidMolecular weight:284.24PPQ-102
CAS:<p>PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).</p>Formula:C26H22N4O3Purity:99.7% - ≥95%Color and Shape:SolidMolecular weight:438.48GlyH-101
CAS:<p>GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.</p>Formula:C19H15Br2N3O3Purity:98.71% - 98.78%Color and Shape:SolidMolecular weight:493.15Ivacaftor
CAS:<p>Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells,</p>Formula:C24H28N2O3Purity:99% - 99.98%Color and Shape:SolidMolecular weight:392.49GLPG1837
CAS:<p>GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.</p>Formula:C16H20N4O3SPurity:99.64% - 99.91%Color and Shape:SolidMolecular weight:348.42Lumacaftor
CAS:<p>Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.</p>Formula:C24H18F2N2O5Purity:99.48% - 99.68%Color and Shape:SolidMolecular weight:452.41Glibenclamide potassium
CAS:<p>Glibenclamide potassium, a more soluble form of Glibenclamide, exists as anhydrous and hydrate salts.</p>Formula:C23H27ClKN3O5SColor and Shape:SolidMolecular weight:532.09CFTR corrector 2
CAS:<p>CFTR corrector 2 (FDL169) is a novel and potent CFTR corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.</p>Formula:C27H23FN4O4Purity:99.66%Color and Shape:SolidMolecular weight:486.49Lubiprostone
CAS:<p>Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.</p>Formula:C20H32F2O5Purity:97.31% - 98.54%Color and Shape:White Odorless Crystals Or Crystalline PowderMolecular weight:390.46IOWH-032
CAS:<p>IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.</p>Formula:C22H15Br2N3O4Purity:98.92% - ≥95%Color and Shape:SolidMolecular weight:545.18KM11060
CAS:<p>KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma</p>Formula:C19H17Cl2N3O2SPurity:98.86%Color and Shape:SolidMolecular weight:422.33Icenticaftor
CAS:<p>Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.</p>Formula:C12H13F6N3O3Purity:99.76%Color and Shape:SolidMolecular weight:361.24CFTR(inh)-172
CAS:<p>CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.</p>Formula:C18H10F3NO3S2Purity:98% - 99.72%Color and Shape:SolidMolecular weight:409.4Nesolicaftor
CAS:<p>Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.</p>Formula:C18H18N4O4Purity:99.79%Color and Shape:SolidMolecular weight:354.36Tezacaftor
CAS:<p>Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.</p>Formula:C26H27F3N2O6Purity:98.84% - >99.99%Color and Shape:SolidMolecular weight:520.5SRI-41315
CAS:<p>SRI-41315 is an eRF1 degrader that acts as a molecular glue at the ribosomal decoding center.SRI-41315 induces extended pauses at the termination codon.</p>Formula:C22H19N3O2Purity:99.87%Color and Shape:SolidMolecular weight:357.41GLPG-3221
CAS:<p>GLPG-3221, a potent oral CFTR corrector for cystic fibrosis treatment, has an EC50 of 105 nM.</p>Formula:C30H37F3N2O6Purity:98%Color and Shape:SolidMolecular weight:578.62CFTR corrector 9
CAS:<p>CFTR corrector 9 is a CF modulator used to research cystic fibrosis and related disorders.</p>Formula:C16H14N2O4Purity:98.24%Color and Shape:SolidMolecular weight:298.29Posenacaftor
CAS:<p>Posenacaftor (PTI-801) regulates CFTR protein for cystic fibrosis research.</p>Formula:C27H27NO5Color and Shape:SolidMolecular weight:445.51Posenacaftor sodium
CAS:<p>Posenacaftor (PTI-801) sodium, a CFTR modulator for CF research, corrects CFTR protein folding and trafficking.</p>Formula:C27H27NNaO5Color and Shape:SolidMolecular weight:468.505Corrector C4
CAS:<p>Corrector C4, a corrector commonly used to study cystic fibrosis mutants, works by alleviating the interaction between CFTR transmembrane domain mutants and</p>Formula:C21H17ClN4O2S2Purity:98.36%Color and Shape:SolidMolecular weight:456.97Galicaftor
CAS:<p>ABBV-2222 is a CFTR corrector which is studied for the treatment of cystic fibrosis (CF).</p>Formula:C28H21F4NO7Purity:98%Color and Shape:SolidMolecular weight:559.46(R)-Posenacaftor sodium
CAS:<p>(R)-Posenacaftor sodium is a modulator for correcting cystic fibrosis protein folding.</p>Formula:C27H27NNaO5Color and Shape:SolidMolecular weight:468.505(R)-Olacaftor
CAS:<p>(R)-Olacaftor (VX-440) is a CFTR modulator with promise for researching cystic fibrosis.</p>Formula:C29H34FN3O4SColor and Shape:SolidMolecular weight:539.66Ivacaftor-D9
CAS:<p>CTP-656, a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis.</p>Formula:C24H19D9N2O3Color and Shape:SolidMolecular weight:401.55AF-2785
CAS:<p>In epididymal epithelial cells, AF-2785 inhibits cystic fibrosis transmembrane conductance regulator Cl(-) channels.</p>Formula:C17H12Cl2N2O2Purity:98%Color and Shape:SolidMolecular weight:347.2SRI-37240
CAS:<p>SRI-37240 suppresses CFTR nonsense mutations, aids in fixing premature termination codons, works with G418.</p>Formula:C24H23N3O2Purity:98.73%Color and Shape:SolidMolecular weight:385.46VRT-532
CAS:<p>VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects.</p>Formula:C16H14N2OPurity:99.88% - 99.93%Color and Shape:SolidMolecular weight:250.3Bamocaftor
CAS:<p>Bamocaftor corrects CFTR in CF, restoring F508del-CFTR function, used with tezacaftor and VX-561 for F508del/MF patients.</p>Formula:C28H32F3N5O4SPurity:99.71%Color and Shape:SolidMolecular weight:591.65Crinecerfont
CAS:<p>Crinecerfont (SSR-125543) is a CRF1 antagonist, useful in congenital adrenal hyperplasia research.</p>Formula:C27H28ClFN2OSPurity:98.01% - 98.55%Color and Shape:SolidMolecular weight:483.04UCCF-853
CAS:<p>UCCF-853 是一种小分子 CFTR 调节剂，可用于研究囊性纤维化。</p>Formula:C14H8ClF3N2OPurity:99.82%Color and Shape:SolidMolecular weight:312.67PG01
CAS:<p>PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.</p>Formula:C28H29N3O2Purity:99.87%Color and Shape:SolidMolecular weight:439.55CFTR corrector 8
CAS:<p>CFTR corrector 8: potent for cystic fibrosis research, modulates CFTR protein.</p>Formula:C29H27F2NO7Purity:99.57%Color and Shape:SolidMolecular weight:539.52CFTR corrector 12
CAS:<p>CFTR corrector 12 is a CFTR corrector that rescues all mutant proteins except M760R ABCA3 and can be used to study cystic fibrosis.</p>Formula:C19H21ClN4O2S2Purity:99.47%Color and Shape:SolidMolecular weight:436.98CP 154526
CAS:<p>CRF1 receptor antagonist</p>Formula:C23H33ClN4Purity:98%Color and Shape:SolidMolecular weight:400.99
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