TRP/TRPV Channel
TRP (Transient Receptor Potential) channels, including the TRPV subfamily, are a group of ion channels involved in various sensory processes, such as temperature sensation, pain perception, and osmoregulation. TRP channels are widely expressed in different tissues and play a role in physiological responses to environmental stimuli. The TRPV channels, in particular, are involved in detecting temperature changes and are implicated in conditions such as chronic pain, inflammation, and cancer. At CymitQuimica, we offer a comprehensive range of TRP/TRPV channel modulators to support your research in sensory biology, pain management, and signal transduction.
Found 92 products of "TRP/TRPV Channel"
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(Z)-Capsaicin
CAS:<p>(Z)-Capsaicin (Zucapsaicin) is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.(Z)-Capsaicin is a synthetic cis isomer of</p>Formula:C18H27NO3Purity:97.33% - 98.91%Color and Shape:SolidMolecular weight:305.41Vocacapsaicin hydrochloride
CAS:<p>Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and is used for pain relief.</p>Formula:C26H42ClN3O4Purity:99.66% - 99.80%Color and Shape:SolidMolecular weight:496.08TRPV4 agonist-1 free base
CAS:<p>TRPV4 agonist-1 free base (OUN67600) is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).</p>Formula:C25H22F2N4O2Purity:99.79%Color and Shape:SolidMolecular weight:448.46BI-749327
CAS:<p>BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).</p>Formula:C23H21F3N4O2Purity:99.68%Color and Shape:SolidMolecular weight:442.43IA-Alkyne
CAS:<p>IA-Alkyne: TRPC agonist, cysteine-reactivity probe, potential in respiratory infection study.</p>Formula:C8H12INOPurity:99.76%Color and Shape:SolidMolecular weight:265.09GFB-8438
CAS:<p>GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).</p>Formula:C16H14ClF3N4O2Purity:99.58%Color and Shape:SolidMolecular weight:386.76PF-04745637
CAS:<p>PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].</p>Formula:C27H32ClF3N2O2Purity:98.88% - 99.3%Color and Shape:SolidMolecular weight:509Oleoyl Serotonin
CAS:<p>Oleoyl Serotonin is an antagonist of hTRPV1 with an IC50 of 2.57 μM.</p>Formula:C28H44N2O2Purity:99.88%Color and Shape:SolidMolecular weight:440.66L-R4W2
CAS:<p>Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.</p>Formula:C46H71N21O6Purity:98%Color and Shape:SolidMolecular weight:1014.2TRPA1-IN-2
CAS:<p>TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 µM.TRPA1-IN-2 has anti-inflammatory activity.</p>Formula:C24H25F3N4OPurity:98.05%Color and Shape:SoildMolecular weight:442.48RN-1665
CAS:<p>RN-1665 is a potent and selective TRPV4 receptor antagonist.</p>Formula:C20H24F5N3O3S2Purity:>99.99%Color and Shape:SoildMolecular weight:513.54CBP-1008
<p>CBP-1008 is a dual-ligand peptide-drug conjugate (PDC) with MMAE, targeting folate receptor (FRα) and TRPV6. It exhibits high binding affinity to FRα and low affinity to TRPV6. CBP-1008 shows antitumor activity and can be utilized for research in advanced solid tumors such as colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma, and follicular dendritic cell sarcoma.</p>Color and Shape:Odour SolidAP 18
CAS:<p>AP-18 is a potent and selective TRPA1 inhibitor.</p>Formula:C11H12ClNOPurity:99.85% - 99.96%Color and Shape:SolidMolecular weight:209.67TRPM8 antagonist 3
CAS:<p>TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM).</p>Formula:C13H12N2O4SPurity:99.74%Color and Shape:SolidMolecular weight:292.31GSK2798745
CAS:<p>GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4).</p>Formula:C25H28N6O3Color and Shape:SolidMolecular weight:460.53Resolvin D2
CAS:<p>Resolvin D2 (RvD2) is a TRPV1 inhibitor and pro-ablative mediator with anti-inflammatory, anti-infective and pro-ablative effects.</p>Formula:C22H32O5Purity:98%Color and Shape:SolidMolecular weight:376.49NGD-8243
CAS:<p>NGD-8243 (N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine) is a TRPV1 inhibitor and can be used in studies for prevention</p>Formula:C21H12F6N4Purity:95.26%Color and Shape:SolidMolecular weight:434.34(S)-ABT 102
CAS:<p>N-[(1S)-1H-inden-1-yl]-N'-indazol-4-ylurea is a strong TRPV1 blocker with a 123 nM IC50 against capsaicin.</p>Formula:C21H24N4OPurity:99.65% - 99.77%Color and Shape:SoildMolecular weight:348.44BTD
CAS:<p>BTD is a TRPC5 activator that activates heteromeric channel complexes composed of TRPC5 and its closest relatives TRPC1 or TRPC4.</p>Formula:C24H33N3O4SColor and Shape:SolidMolecular weight:459.6Phenazopyridine
CAS:<p>Phenazopyridine is an orally administered azo dye with local analgesic effects on urinary tract infections,. against SARM1 and TRPM8.</p>Formula:C11H11N5Purity:99.98%Color and Shape:SolidMolecular weight:213.24ASP7663
CAS:<p>ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.</p>Formula:C14H14FNO3Purity:98.61%Color and Shape:SolidMolecular weight:263.26PF-4840154
CAS:<p>PF-4840154: potent TrpA1 agonist; EC50 of 97 nM (rat) & 23 nM (human); triggers nociception in mice.</p>Formula:C26H38N6O2Purity:>99.99%Color and Shape:SolidMolecular weight:466.62GSK2193874
CAS:<p>GSK2193874 was identified as a selective, orally active TRPV4 blocker.</p>Formula:C37H38BrF3N4OPurity:98.79% - ≥95%Color and Shape:SolidMolecular weight:691.62JNJ-17203212
CAS:<p>JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).</p>Formula:C17H15F6N5OPurity:99.18%Color and Shape:SolidMolecular weight:419.32M8-B Hydrochloride
CAS:<p>M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.</p>Formula:C22H25ClN2O3SPurity:99.33%Color and Shape:SolidMolecular weight:432.96SB-366791
CAS:<p>SB-366791 is a new and selective cinnamide TRPV1 antagonist.</p>Formula:C16H14ClNO2Purity:99.51%Color and Shape:SolidMolecular weight:287.74Ononetin
CAS:<p>Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM).</p>Formula:C15H14O4Purity:98.06%Color and Shape:SolidMolecular weight:258.27Evifacotrep
CAS:<p>Evifacotrep: TRPC5 antagonist for neurological disease research (WO2020061162, compound 100).</p>Formula:C18H12ClF4N5O2Purity:98.6%Color and Shape:SolidMolecular weight:441.77HC067047 Hydrochloride(883031-03-6 free base)
CAS:<p>HC-067047 hydrochloride, a TRPV4 antagonist, selectively inhibits human, rat, and mouse currents with IC50s: 486 nM, 133 nM, and 17 nM.</p>Formula:C26H29ClF3N3O2Purity:99.95%Color and Shape:SolidMolecular weight:507.98HC-030031
CAS:<p>HC-030031 (TOSLAB 829227) is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2 and 5.3 μM, respectively.</p>Formula:C18H21N5O3Purity:99.69% - ≥95%Color and Shape:SolidMolecular weight:355.39ML204
CAS:<p>ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.</p>Formula:C15H18N2Purity:98.1% - 99.72%Color and Shape:SolidMolecular weight:226.32RN-1734
CAS:<p>RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM,5.9 μM,3.2 μM for hTRPV4, mTRPV4 and rTRPV4,respectively)</p>Formula:C14H22Cl2N2O2SPurity:99.1% - 99.3%Color and Shape:SolidMolecular weight:353.31AMG 333
CAS:<p>AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.</p>Formula:C20H12F5N3O4Purity:99.95%Color and Shape:SolidMolecular weight:453.32Chembridge-5861528
CAS:<p>Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM.</p>Formula:C19H23N5O3Purity:99.97%Color and Shape:SolidMolecular weight:369.42RQ-00203078
CAS:<p>RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.</p>Formula:C21H13ClF6N2O5SPurity:98% - 99.6%Color and Shape:SolidMolecular weight:554.85A-967079
CAS:<p>A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively</p>Formula:C12H14FNOPurity:98.34% - 99.75%Color and Shape:SolidMolecular weight:207.24ICILIN
CAS:<p>ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.</p>Formula:C16H13N3O4Purity:98.45% - ≥95%Color and Shape:Light Yellow SolidMolecular weight:311.29HC-067047
CAS:<p>HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .</p>Formula:C26H28F3N3O2Purity:99.45% - 99.97%Color and Shape:SolidMolecular weight:471.51AM-0902
CAS:<p>AM-0902 is a potent and specific TRPA1 antagonist (IC50s: 71/131 nM for rTRPA1 and hTRPA1).</p>Formula:C17H15ClN6O2Purity:>99.99%Color and Shape:SolidMolecular weight:370.79SB 452533
CAS:<p>SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8).</p>Formula:C18H22BrN3OPurity:99.87%Color and Shape:SolidMolecular weight:376.29Pico145
CAS:<p>Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels.</p>Formula:C23H20ClF3N4O5Purity:99.06%Color and Shape:SolidMolecular weight:524.88TRPM4-IN-1
CAS:<p>TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.</p>Formula:C15H11Cl2NO4Purity:97.22%Color and Shape:SolidMolecular weight:340.16MK6-83
CAS:<p>MK6-83 is the transient receptor potential channel ML3 agonist.</p>Formula:C16H20N2O2S2Purity:99.5%Color and Shape:SolidMolecular weight:336.479-Phenanthrol
CAS:<p>9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.</p>Formula:C14H10OPurity:98.48%Color and Shape:SolidMolecular weight:194.23TC-I2000
CAS:<p>TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM.</p>Formula:C23H18F4N2OPurity:99.778%Color and Shape:SolidMolecular weight:414.4ML204 hydrochloride
CAS:<p>ML204 hydrochloride (ML204 HCl) is a TRPC4/TRPC5 channel antagonist.</p>Formula:C15H19ClN2Color and Shape:SolidMolecular weight:262.78WS-12
CAS:<p>WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)</p>Formula:C18H27NO2Purity:99.99%Color and Shape:Whitish To White Solid CrystallineMolecular weight:289.41Pyr10
CAS:<p>Pyr10, a pyrazole derivative, selectively inhibits TRPC3, not STIM1/Orai1, with IC50 of 0.72 μM in TRPC3-HEK293, and 13.08 μM in BRL-2H3 cells.</p>Formula:C18H13F6N3O2SPurity:99.69% - 99.7%Color and Shape:SolidMolecular weight:449.37SB-705498
CAS:<p>SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.</p>Formula:C17H16BrF3N4OPurity:99.57% - ≥95%Color and Shape:SolidMolecular weight:429.23Vanilloid receptor antagonist 1
CAS:<p>Vanilloid receptor antagonist 1 (4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile) is a potent vanilloid receptor TRPV1 antagonist.</p>Formula:C18H15N3O2Purity:98.14%Color and Shape:SolidMolecular weight:305.33
