PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
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PF-04822163
CAS:1798334-07-2
PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.
Formula:
C19H17ClN2O2
Purity:
100%
Color and Shape:
Solid
Molecular weight:
340.8
Ref: TM-T28367
| 1mg | 326.00 € | ||
| 5mg | 769.00 € | ||
| 50mg | 1,838.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
Naproxen etemesil
CAS:385800-16-8
Naproxen, a COX-1/2 inhibitor, has IC50s of 8.72/5.15 μM. Its prodrug, naproxen etemesil, is lipophilic …
Formula:
C17H20O5S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
336.4
Ref: TM-T16272
| 25mg | 792.00 € | ||
| 50mg | 1,039.00 € | ||
| 100mg | 1,507.00 € | ||
| 1mL*10mM (DMSO) | 245.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
Lirimilast
CAS:329306-27-6
Lirimilast: oral PDE4 inhibitor (IC50: 49 nM), anti-inflammatory, treats asthma/COPD.
Formula:
C17H12Cl2N2O6S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
443.26
Ref: TM-T15766
| 25mg | 1,410.00 € | ||
| 50mg | 1,845.00 € | ||
| 100mg | 2,329.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
BAY 73-6691
CAS:794568-92-6
BAY 73-6691 is an inhibitor of brain penetrant PDE9A.
Formula:
C15H12ClF3N4O
Color and Shape:
Solid
Molecular weight:
356.73
Ref: TM-T10481L
| 25mg | 640.00 € | ||
| 50mg | 840.00 € | ||
| 100mg | 1,395.00 € | ||
| 1mL*10mM (DMSO) | 185.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
Autotaxin-IN-1
CAS:1619971-30-0
Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.
Formula:
C21H23N7O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
405.45
Ref: TM-T14352
| 25mg | 1,549.00 € | ||
| 50mg | 2,038.00 € | ||
| 100mg | 2,617.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
Deltasonamide 2 (TFA)
CAS:2235358-74-2
Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.
Formula:
C32H40ClF3N6O6S2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
761.28
Ref: TM-T10994L2
| 25mg | 916.00 € | ||
| 50mg | 1,263.00 € | ||
| 100mg | 2,033.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
Tanimilast
CAS:1239278-59-1
Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for …
Formula:
C30H30Cl2F2N2O8S
Purity:
98.3%
Color and Shape:
Liquid
Molecular weight:
687.54
Ref: TM-T38625
| 1mg | 214.00 € | ||
| 5mg | 530.00 € | ||
| 10mg | 795.00 € | ||
| 25mg | 1,361.00 € | ||
| 50mg | 1,841.00 € | ||
| 100mg | 2,461.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
uk-50001
CAS:857900-47-1
UK-50001 is a PDE4 inhibitor for treating inflammation, allergies, respiratory issues, and wounds.
Formula:
C26H24F3N3O4
Purity:
99.83%
Color and Shape:
Liquid
Molecular weight:
499.48
Ref: TM-T67815
| 1mg | 156.00 € | ||
| 5mg | 372.00 € | ||
| 10mg | 558.00 € | ||
| 25mg | 890.00 € | ||
| 50mg | 1,194.00 € | ||
| 100mg | 1,624.00 € | ||
| 500mg | 3,240.00 € | ||
| 1mL*10mM (DMSO) | 465.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
WAY127093B racemate
CAS:145743-63-1
WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral …
Formula:
C23H28N4O4
Purity:
98.63%
Color and Shape:
Solid
Molecular weight:
424.49
Ref: TM-T13331
| 1mg | 78.00 € | ||
| 5mg | 160.00 € | ||
| 10mg | 228.00 € | ||
| 25mg | 341.00 € | ||
| 50mg | 480.00 € | ||
| 100mg | 645.00 € | ||
| 200mg | 854.00 € | ||
| 1mL*10mM (DMSO) | 172.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
PDE7-IN-2
CAS:107522-19-0
PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used …
Formula:
C14H11ClN2O3S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
322.77
Ref: TM-T22491
| 1mg | 92.00 € | ||
| 5mg | 374.00 € | ||
| 10mg | 657.00 € | ||
| 25mg | 1,460.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
Imazodan hydrochloride
CAS:89198-09-4
Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in …
Formula:
C13H13ClN4O
Purity:
99.84%
Color and Shape:
Solid
Molecular weight:
276.72
Ref: TM-T27596
| 1mg | 279.00 € | ||
| 5mg | 686.00 € | ||
| 10mg | 938.00 € | ||
| 25mg | 1,410.00 € | ||
| 50mg | 1,851.00 € | ||
| 100mg | 2,337.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
Carbazeran
CAS:70724-25-3
Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies …
Formula:
C18H24N4O4
Purity:
97.28%
Color and Shape:
Solid
Molecular weight:
360.41
Ref: TM-T21457
| 2mg | 44.00 € | ||
| 5mg | 65.00 € | ||
| 10mg | 91.00 € | ||
| 25mg | 178.00 € | ||
| 50mg | 270.00 € | ||
| 100mg | 405.00 € | ||
| 200mg | 625.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
PAT-048
CAS:1359983-15-5
PAT-048 is an effective and selective autotaxin inhibitor.
Formula:
C22H18ClF2N3O2S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
461.91
Ref: TM-T16434
| 25mg | 1,549.00 € | ||
| 50mg | 2,039.00 € | ||
| 100mg | 2,619.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
K134
CAS:189362-06-9
K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, …
Formula:
C22H29N3O4
Purity:
98%
Color and Shape:
Solid
Molecular weight:
399.48
Ref: TM-T15640
| 25mg | 1,549.00 € | ||
| 50mg | 2,031.00 € | ||
| 100mg | 2,609.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
Imazodan
CAS:84243-58-3
Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor …
Formula:
C13H12N4O
Purity:
98.56% - 99.36%
Color and Shape:
Liquid
Molecular weight:
240.26
Ref: TM-T71744
| 1mg | 37.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 94.00 € | ||
| 25mg | 121.00 € | ||
| 50mg | 171.00 € | ||
| 100mg | 254.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
PF-04447943
CAS:1082744-20-4
PF-04447943, a selective PDE9A inhibitor (IC50=12nM), may aid sickle cell anemia research with its anti-inflammatory …
Formula:
C20H25N7O2
Purity:
99.11% - 99.11%
Color and Shape:
Solid
Molecular weight:
395.46
Ref: TM-T16478
| 1mg | 36.00 € | ||
| 5mg | 79.00 € | ||
| 10mg | 107.00 € | ||
| 25mg | 182.00 € | ||
| 50mg | 272.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
Nanterinone
CAS:102791-47-9
Nanterinone: oral phosphodiesterase inhibitor, improves acute heart failure hemodynamics.
Formula:
C15H15N3O
Purity:
99.11%
Color and Shape:
Solid
Molecular weight:
253.3
Ref: TM-T33589
| 1mg | 139.00 € | ||
| 5mg | 335.00 € | ||
| 10mg | 493.00 € | ||
| 25mg | 801.00 € | ||
| 50mg | 1,096.00 € | ||
| 100mg | 1,483.00 € | ||
| 500mg | 2,962.00 € |
Estimated delivery in United States, on Tuesday 18 Feb 2025
AMG 579
CAS:1227067-61-9
AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).
Formula:
C25H23N5O3
Purity:
99.35%
Color and Shape:
Solid
Molecular weight:
441.48
Ref: TM-T14217
| 1mg | 35.00 € | ||
| 2mg | 46.00 € | ||
| 5mg | 72.00 € | ||
| 10mg | 103.00 € | ||
| 25mg | To inquire | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 82.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
Sulmazole
CAS:73384-60-8
Sulmazole (AR-L 115-BS) is a small molecule Sulmazole is a small molecule cGMP-PDE inhibitor.Sulmazole is …
Formula:
C14H13N3O2S
Purity:
99.64%
Color and Shape:
Solid
Molecular weight:
287.34
Ref: TM-T28881
| 1mg | 38.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 102.00 € | ||
| 25mg | 171.00 € | ||
| 50mg | 247.00 € | ||
| 100mg | 369.00 € | ||
| 500mg | 883.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
Gisadenafil
CAS:334826-98-1
Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 …
Formula:
C23H33N7O5S
Purity:
98.25% - 99.06%
Color and Shape:
Solid
Molecular weight:
519.62
Ref: TM-T15381
| 1mg | 182.00 € | ||
| 5mg | 406.00 € | ||
| 10mg | 600.00 € | ||
| 25mg | 917.00 € | ||
| 50mg | 1,281.00 € | ||
| 100mg | 1,727.00 € | ||
| 1mL*10mM (DMSO) | 517.00 € |
Estimated delivery in United States, on Tuesday 4 Mar 2025
