PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
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GSK256066 Trifluoroacetate
CAS:1415560-64-3
GSK 256066 Trifluoroacetate: selective PDE4 inhibitor, IC50: 3.2 pM for PDE4B, treats COPD.
Formula:
C29H27F3N4O7S
Color and Shape:
Solid
Molecular weight:
632.61
Ref: TM-T11483
| 2mg | 86.00 € | ||
| 50mg | 682.00 € | ||
| 100mg | 945.00 € |
Estimated delivery in United States, on Monday 28 Apr 2025
Deltarasin
CAS:1440898-61-2
Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for …
Formula:
C40H37N5O
Purity:
99.06%
Color and Shape:
Solid
Molecular weight:
603.75
Ref: TM-T6462
| 2mg | 46.00 € | ||
| 5mg | 82.00 € | ||
| 10mg | 133.00 € | ||
| 25mg | 215.00 € | ||
| 50mg | 391.00 € | ||
| 100mg | 620.00 € | ||
| 1mL*10mM (DMSO) | 97.00 € |
Estimated delivery in United States, on Tuesday 27 May 2025
ent-Tadalafil
CAS:629652-72-8
ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS).
Formula:
C22H19N3O4
Purity:
98%
Color and Shape:
Solid
Molecular weight:
389.4
Ref: TM-T11206
| 25mg | 1,444.00 € | ||
| 50mg | 1,882.00 € | ||
| 100mg | 2,375.00 € |
Estimated delivery in United States, on Tuesday 27 May 2025
PDE7-IN-2
CAS:107522-19-0
PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used …
Formula:
C14H11ClN2O3S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
322.77
Ref: TM-T22491
| 1mg | 92.00 € | ||
| 5mg | 374.00 € | ||
| 10mg | 658.00 € | ||
| 25mg | 1,464.00 € |
Estimated delivery in United States, on Tuesday 10 Jun 2025
PDE IV-IN-1
CAS:225100-12-9
PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment …
Formula:
C20H23ClN4O2
Purity:
98.57%
Color and Shape:
Solid
Molecular weight:
386.88
Ref: TM-T10201
| 1mg | 341.00 € | ||
| 5mg | 723.00 € | ||
| 10mg | 969.00 € | ||
| 25mg | 1,454.00 € | ||
| 50mg | 1,948.00 € | ||
| 100mg | 2,632.00 € | ||
| 1mL*10mM (DMSO) | 815.00 € |
Estimated delivery in United States, on Tuesday 10 Jun 2025
Isomazole
CAS:86315-52-8
Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 …
Formula:
C14H13N3O2S
Purity:
99.12%
Color and Shape:
Solid
Molecular weight:
287.34
Ref: TM-T27632
| 1mg | 143.00 € | ||
| 5mg | 333.00 € | ||
| 10mg | 504.00 € | ||
| 25mg | 817.00 € | ||
| 50mg | 1,121.00 € | ||
| 100mg | 1,510.00 € | ||
| 500mg | 3,030.00 € |
Estimated delivery in United States, on Tuesday 10 Jun 2025
Deltasonamide 2
CAS:2088485-34-9
Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.
Formula:
C30H39ClN6O4S2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
647.25
Ref: TM-T10994
| 25mg | 1,444.00 € | ||
| 50mg | 1,882.00 € | ||
| 100mg | 2,375.00 € |
Estimated delivery in United States, on Tuesday 10 Jun 2025
PDE4B-IN-2
CAS:915082-52-9
PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: …
Formula:
C19H18ClN3O2S
Purity:
99.37%
Color and Shape:
Liquid
Molecular weight:
387.88
Ref: TM-T36832
| 1mg | 37.00 € | ||
| 5mg | 79.00 € | ||
| 10mg | 111.00 € | ||
| 25mg | 216.00 € | ||
| 50mg | 354.00 € | ||
| 100mg | 567.00 € | ||
| 500mg | 1,198.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Tuesday 10 Jun 2025
Dovramilast
CAS:340019-69-4
Dovramilast (CC-11050) is a PDE4 inhibitor that reduces the production of pro-inflammatory mediators in lupus …
Formula:
C24H28N2O6S
Purity:
98.75% - 99.74%
Color and Shape:
Liquid
Molecular weight:
472.55
Ref: TM-T63056
| 1mg | 124.00 € | ||
| 2mg | 177.00 € | ||
| 5mg | 298.00 € | ||
| 10mg | 472.00 € | ||
| 25mg | 905.00 € | ||
| 50mg | 1,415.00 € |
Estimated delivery in United States, on Tuesday 10 Jun 2025
ATX inhibitor 5
CAS:2402772-45-4
ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.
Formula:
C22H18ClF3N6O
Purity:
99.23%
Color and Shape:
Solid
Molecular weight:
474.87
Ref: TM-T10409
| 1mg | 64.00 € | ||
| 5mg | 140.00 € | ||
| 10mg | 219.00 € | ||
| 25mg | 373.00 € | ||
| 50mg | 510.00 € | ||
| 100mg | 695.00 € | ||
| 200mg | 937.00 € | ||
| 1mL*10mM (DMSO) | 145.00 € |
Estimated delivery in United States, on Tuesday 10 Jun 2025
K134
CAS:189362-06-9
K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, …
Formula:
C22H29N3O4
Purity:
98%
Color and Shape:
Solid
Molecular weight:
399.48
Ref: TM-T15640
| 25mg | 1,586.00 € | ||
| 50mg | 2,072.00 € | ||
| 100mg | 2,660.00 € |
Estimated delivery in United States, on Tuesday 10 Jun 2025
PF-04447943
CAS:1082744-20-4
PF-04447943, a selective PDE9A inhibitor (IC50=12nM), may aid sickle cell anemia research with its anti-inflammatory …
Formula:
C20H25N7O2
Purity:
99.11% - 99.11%
Color and Shape:
Solid
Molecular weight:
395.46
Ref: TM-T16478
| 1mg | 35.00 € | ||
| 5mg | 81.00 € | ||
| 10mg | 111.00 € | ||
| 25mg | 188.00 € | ||
| 50mg | 283.00 € | ||
| 1mL*10mM (DMSO) | 89.00 € |
Estimated delivery in United States, on Tuesday 10 Jun 2025
Imazodan hydrochloride
CAS:89198-09-4
Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in …
Formula:
C13H13ClN4O
Purity:
99.84%
Color and Shape:
Solid
Molecular weight:
276.72
Ref: TM-T27596
| 1mg | 279.00 € | ||
| 5mg | 685.00 € | ||
| 10mg | 938.00 € | ||
| 25mg | 1,444.00 € | ||
| 50mg | 1,882.00 € | ||
| 100mg | 2,375.00 € |
Estimated delivery in United States, on Tuesday 10 Jun 2025
Carbazeran
CAS:70724-25-3
Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies …
Formula:
C18H24N4O4
Purity:
97.28%
Color and Shape:
Solid
Molecular weight:
360.41
Ref: TM-T21457
| 2mg | 44.00 € | ||
| 5mg | 65.00 € | ||
| 10mg | 92.00 € | ||
| 25mg | 178.00 € | ||
| 50mg | 270.00 € | ||
| 100mg | 406.00 € | ||
| 200mg | 627.00 € |
Estimated delivery in United States, on Tuesday 10 Jun 2025
PAT-048
CAS:1359983-15-5
PAT-048 is an effective and selective autotaxin inhibitor.
Formula:
C22H18ClF2N3O2S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
461.91
Ref: TM-T16434
| 25mg | 1,586.00 € | ||
| 50mg | 2,072.00 € | ||
| 100mg | 2,660.00 € |
Estimated delivery in United States, on Tuesday 10 Jun 2025
Nanterinone
CAS:102791-47-9
Nanterinone: oral phosphodiesterase inhibitor, improves acute heart failure hemodynamics.
Formula:
C15H15N3O
Purity:
99.11%
Color and Shape:
Solid
Molecular weight:
253.3
Ref: TM-T33589
| 1mg | 140.00 € | ||
| 5mg | 343.00 € | ||
| 10mg | 504.00 € | ||
| 25mg | 817.00 € | ||
| 50mg | 1,121.00 € | ||
| 100mg | 1,510.00 € | ||
| 500mg | 3,030.00 € |
Estimated delivery in United States, on Tuesday 10 Jun 2025
Imazodan
CAS:84243-58-3
Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor …
Formula:
C13H12N4O
Purity:
98.56% - 99.36%
Color and Shape:
Liquid
Molecular weight:
240.26
Ref: TM-T71744
| 1mg | 38.00 € | ||
| 5mg | 80.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 125.00 € | ||
| 50mg | 177.00 € | ||
| 100mg | 264.00 € |
Estimated delivery in United States, on Tuesday 10 Jun 2025
Lirimilast
CAS:329306-27-6
Lirimilast: oral PDE4 inhibitor (IC50: 49 nM), anti-inflammatory, treats asthma/COPD.
Formula:
C17H12Cl2N2O6S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
443.26
Ref: TM-T15766
| 25mg | 1,444.00 € | ||
| 50mg | 1,882.00 € | ||
| 100mg | 2,375.00 € |
Estimated delivery in United States, on Tuesday 10 Jun 2025
WAY127093B racemate
CAS:145743-63-1
WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral …
Formula:
C23H28N4O4
Purity:
98.63%
Color and Shape:
Solid
Molecular weight:
424.49
Ref: TM-T13331
| 1mg | 77.00 € | ||
| 5mg | 158.00 € | ||
| 10mg | 225.00 € | ||
| 25mg | 338.00 € | ||
| 50mg | 475.00 € | ||
| 100mg | 638.00 € | ||
| 200mg | 845.00 € | ||
| 1mL*10mM (DMSO) | 170.00 € |
Estimated delivery in United States, on Tuesday 10 Jun 2025
Verofylline
CAS:66172-75-6
Verofylline (Verofyllinum) is an orally available, long-acting, multiacting, methylxanthine-substituted bronchodilator with inhibitory effects on PDE4 …
Formula:
C12H18N4O2
Purity:
97.97% - 99.55%
Color and Shape:
Solid
Molecular weight:
250.3
Ref: TM-T35048
| 1mg | 143.00 € | ||
| 5mg | 333.00 € | ||
| 10mg | 504.00 € | ||
| 25mg | 817.00 € | ||
| 50mg | 1,121.00 € | ||
| 100mg | 1,510.00 € | ||
| 500mg | 3,030.00 € |
Estimated delivery in United States, on Tuesday 10 Jun 2025
