IDO
Indoleamine 2,3-dioxygenase (IDO) is an enzyme involved in the catabolism of tryptophan, leading to the production of kynurenine and other metabolites. IDO plays a role in immune tolerance and is often upregulated in cancer and chronic inflammatory conditions. Inhibitors of IDO are being explored as potential immunotherapeutic agents in cancer and autoimmune diseases. At CymitQuimica, we provide IDO inhibitors to support your research in immunology, oncology, and metabolic regulation.
Found 82 products of "IDO"
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GNF-PF-3777
CAS:<p>GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).</p>Formula:C15H7N3O4Purity:97.88%Color and Shape:SolidMolecular weight:293.23IDO-IN-13
CAS:<p>IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).</p>Formula:C26H17F3N4OPurity:99.29%Color and Shape:SolidMolecular weight:458.43LY3381916
CAS:<p>IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.</p>Formula:C23H25FN2O3Purity:99.3%Color and Shape:SolidMolecular weight:396.45CAY10581
CAS:<p>CAY10581, a derivative of pyranonaphthoquinone, serves as a highly specific and reversible uncompetitive inhibitor of IDO, demonstrating potency with an IC50</p>Formula:C22H21NO4Color and Shape:SolidMolecular weight:363.41human TDO2-IN-1
<p>Human TDO2-IN-1 (Cpd-2) is a potent inhibitor of human TDO2, with an IC50 of 14.8 nM. It plays a significant role in studies related to metabolism, inflammation, and tumor immune surveillance.</p>Formula:C30H36N4O5Color and Shape:SolidMolecular weight:532.631XW-032
<p>XW-032 is an apo-IDO1 inhibitor with an IC50 of 21 nM. In the CT26 syngeneic mouse model, XW-032 demonstrates significant in vivo antitumor efficacy with a TGI of 63%, showing potential for cancer research applications.</p>Color and Shape:Odour SolidIDO1-IN-24
<p>IDO1-IN-24 (compound 2c) inhibits the production of IDO1 during cell assays, with an IC50 value of 17 μM.</p>Formula:C18H22N2O4Molecular weight:330.15796NLG802
CAS:<p>NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.</p>Formula:C20H30ClN3O3Purity:99.61%Color and Shape:SolidMolecular weight:395.92TDO-IN-2
<p>TDO-IN-2 is an orally active TDO inhibitor with an IC50 of 1.25 μM. It exhibits antitumor activity in a Hepa1-6 liver cancer allograft mouse model. Additionally, TDO-IN-2 works synergistically with PD-1/PD-L1 inhibitor BMS-202, making it useful for studying tumor immune tolerance.</p>Formula:C20H15N3O3Color and Shape:SolidMolecular weight:345.11134BMT-297376
CAS:<p>BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor.</p>Formula:C23H29F2N3O3Color and Shape:SolidMolecular weight:433.5NU227326
CAS:<p>NU227326 is a PROTAC degrader of indoleamine 2,3-dioxygenase 1 (IDO1) with a DC50 value of 4.5 nM. It effectively degrades IDO1 in U87 and GBM43 cells, with DC50 values of 7.1 nM and 11.8 nM, respectively. NU227326 exhibits favorable pharmacokinetic properties, with a plasma half-life of 5.7 hours and a brain tissue half-life of 11.8 hours. (Pink: ligand for target protein IDO1 ligand-1; Black: linker; Blue: ligand for E3 ligase Cereblon).</p>Formula:C53H61FN8O7Color and Shape:SolidMolecular weight:941.099IDO1-IN-7
CAS:<p>IDO1-IN-7 is a potent IDO1 inhibitor with a 6.1 nM IC50 and immunomodulatory effects for cancer research.</p>Formula:C22H19ClFN3O3Color and Shape:SolidMolecular weight:427.86PROTAC IDO1 Degrader-1
CAS:<p>First potent PROTAC IDO1 degrader; links IDO1 to CRBN E3 ligase for UPS-induced degradation (DC50=2.84 μM), boosts H ER2 CAR-T cell efficacy.</p>Formula:C40H53BrFN9O13Color and Shape:SolidMolecular weight:966.816IDO1-IN-23
<p>IDO1-IN-23 (compound 41) is a potent inhibitor of human indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 of 13 μM [1].</p>Purity:98%Color and Shape:Odour SolidIDO-IN-15
CAS:<p>IDO-IN-15 is an IDO1 inhibitor ( IC 50 < 0.51 nM).</p>Formula:C29H39N5O4Color and Shape:SolidMolecular weight:521.662IDO1/TDO-IN-8
<p>IDO1/TDO-IN-8 (Compound CZ-17) is a dual IDO1 and TDO inhibitor capable of crossing the blood-brain barrier, with EC50 values of 0.33 μM and 1.78 μM, respectively. It modulates the kynurenine pathway of tryptophan metabolism, reducing the kynurenine/tryptophan ratio. IDO1/TDO-IN-8 has neuroprotective effects, alleviating motor dysfunction and improving depressive behavior, making it relevant for research into Parkinson's disease with comorbid depression.</p>Formula:C17H14N2SColor and Shape:SolidMolecular weight:278.37IDO1-IN-11
CAS:<p>IDO1-IN-11 is an IDO1 inhibitor with an IC 50 value of 0.6 nM.</p>Formula:C22H17ClFN3O3Color and Shape:SolidMolecular weight:425.84NU223612
CAS:<p>"NU223612 is a potent IDO1-degrading PROTAC with Kd 640 nM, binds CRBN at 290 nM, and crosses the BBB."</p>Formula:C49H55FN6O9Color and Shape:SolidMolecular weight:890.99IDO1-IN-12
CAS:<p>IDO1-IN-12 is a potent and orally available IDO1 inhibitor.</p>Formula:C21H19F3N2O2Color and Shape:SolidMolecular weight:388.39IDO1/TDO-IN-7
<p>IDO1/TDO-IN-7 (Compound 43b), an isochinoline derivative, functions as a potent dual inhibitor of IDO1/TDO with IC50 values of 0.31 μM and 0.08 μM, respectively. Demonstrating favorable pharmacokinetics and strong antitumor efficacy in the B16-F10 tumor model, this compound also exhibits low toxicity.</p>Color and Shape:Odour Solid
