IDO
Indoleamine 2,3-dioxygenase (IDO) is an enzyme involved in the catabolism of tryptophan, leading to the production of kynurenine and other metabolites. IDO plays a role in immune tolerance and is often upregulated in cancer and chronic inflammatory conditions. Inhibitors of IDO are being explored as potential immunotherapeutic agents in cancer and autoimmune diseases. At CymitQuimica, we provide IDO inhibitors to support your research in immunology, oncology, and metabolic regulation.
Found 84 products of "IDO"
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IDO1-IN-25
CAS:IDO1-IN-25, a dual inhibitor of IDO1/TDO2, showcases IC50 values of 0.17 μM for IDO1 and 3.2 μM for TDO2. It effectively suppresses NO production in RAW264.7 cells following stimulation with lipopolysaccharide (LPS). Additionally, IDO1-IN-25 demonstrates anti-inflammatory properties in a mouse ear edema model of acute inflammation induced by croton oil.Formula:C14H8Cl3NO2SColor and Shape:SolidMolecular weight:360.64IDO1-IN-14
IDO1-IN-14 is an IDO1 enzyme inhibitor with an IC50 of 396.9 nM and suppresses HeLa cell activity with an EC50 of 3393 nM.Formula:C18H12Cl2FN3O2Color and Shape:SolidMolecular weight:392.21IDO antagonist-1
CAS:IDO antagonist-1 (compound 163), an IDO antagonist, effectively inhibits the growth of pancreatic adenocarcinoma cells in C57BL/6 mice [1].Formula:C39H53N7O5Color and Shape:SolidMolecular weight:699.884-Phenyl-1H-1,2,3-triazole
CAS:4-Phenyl-1H-1,2,3-triazole, an inhibitor of the enzyme IDO1 (IC50: 60 µM), is utilized in cancer research [1].Formula:C8H7N3Purity:98%Color and Shape:SolidMolecular weight:145.16
