IDO
Indoleamine 2,3-dioxygenase (IDO) is an enzyme involved in the catabolism of tryptophan, leading to the production of kynurenine and other metabolites. IDO plays a role in immune tolerance and is often upregulated in cancer and chronic inflammatory conditions. Inhibitors of IDO are being explored as potential immunotherapeutic agents in cancer and autoimmune diseases. At CymitQuimica, we provide IDO inhibitors to support your research in immunology, oncology, and metabolic regulation.
Found 84 products of "IDO"
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IDO1-IN-15
CAS:IDO1-IN-15 is an effective IDO1 inhibitor with IC50 of 127 nM. The potency of IDO1-IN-15 against IDO1 enzyme is comparable with Epacadostat in vitro.Formula:C13H14BrFN6O3Color and Shape:SolidMolecular weight:401.19IDO-IN-16
CAS:IDO-IN-16 (compound 5) is an IDO inhibitor (IC50: 36 nM).Formula:C22H21F3N4OColor and Shape:SolidMolecular weight:414.42IDO1-IN-17
CAS:IDO1-IN-17 (I-4) is an IDO1 inhibitor, with an IC 50 of 0.44 μM in hela cells .Formula:C28H32BrClFN5O2Color and Shape:SolidMolecular weight:604.94IDO-IN-14
CAS:IDO-IN-14 is an IDO inhibitor (IC50: 0.6928 nM).Formula:C23H23ClN4O2Color and Shape:SolidMolecular weight:422.91MMG-0358
CAS:MMG-0358 is a novel potent IDO1 inhibitor, showing low cytotoxicity and higher selectivity for IDO1 over TDO enzyme.Formula:C8H6ClN3OColor and Shape:SolidMolecular weight:195.61IDO1-IN-21
CAS:IDO1-IN-21 (compound 10m), with an IC50 of 0.64 μM, acts as an IDO1 inhibitor and has demonstrated efficacy in suppressing tumor growth in murine models [1].Formula:C21H19F2N3O6SPurity:98%Color and Shape:SolidMolecular weight:479.45IDO-IN-5
CAS:IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).Formula:C18H21FN2O2Purity:98%Color and Shape:SolidMolecular weight:316.37Roxyl-9
CAS:Roxyl-9 is an inhibitor of IDO1 (Indoleamine 2,3-dioxygenase 1) [1].Formula:C18H13N3O2Color and Shape:SolidMolecular weight:303.31TDO-IN-1
CAS:TDO-IN-1 is a tryptophan 2,3-dioxygenase (TDO) inhibitor with antitumor activity that acts by reversing local immune tolerance in tumor tissues.Formula:C16H13F3N4O2Purity:99.86%Color and Shape:SolidMolecular weight:350.3IDO1/2-IN-1
CAS:First potent oral dual IDO1/IDO2 inhibitor with antitumor properties; IC50: 28 nM (IDO1), 144 nM (IDO2).Formula:C16H18BrFN8O4Color and Shape:SolidMolecular weight:485.27(R)-IDO/TDO-IN-1
CAS:(R)-IDO/TDO-IN-1 (compound 25), an indoleamine-2,3-dioxygenase (IDO) inhibitor, demonstrates good pharmacokinetic properties and exerts anti-tumor effects in the MC38 xenograft model. This compound exhibits synergy when combined with the anti-PD-1 monoclonal antibody (SHR-1210) [1].Formula:C25H24FN5Color and Shape:SolidMolecular weight:413.49NUCC-0223619
CAS:NUCC-0223619 is an IDO1 inhibitor that induces the degradation of IDO protein and can be involved in the synthesis of PROTAC.Formula:C24H24ClFN2O2Color and Shape:SolidMolecular weight:426.91IDO1/2-IN-1 hydrochloride
CAS:IDO1/2-IN-1 hydrochloride: Dual IDO1/2 inhibitor, IC50 of 28/144 nM, oral, with antitumor properties.Formula:C16H19BrClFN8O4Color and Shape:SolidMolecular weight:521.73IDO1/TDO-IN-6
CAS:IDO1/TDO-IN-6 (compound 11) is a dual inhibitor targeting IDO1 and TDO, exhibiting IC50 values of 2.25 μM for IDO1 and 2.89 μM for TDO.Formula:C20H17NO5Purity:98%Color and Shape:SolidMolecular weight:351.35IDO-IN-9
CAS:IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).Formula:C13H13BrFN7O3SPurity:98%Color and Shape:SolidMolecular weight:446.251-Isopropyltryptophan
CAS:1-Isopropyltryptophan (1-IsoPT), an IDO1 inhibitor, suppresses the expression of IDO-1 and IDO-2 mRNA induced by IFN-γ stimulation [1].Formula:C14H18N2O2Purity:98%Color and Shape:SolidMolecular weight:246.3IDO1 ligand-1
CAS:IDO1ligand-1 is the target protein ligand for PROTAC NU227326, which is utilized for degrading IDO1.Formula:C29H34FN3O2Color and Shape:SolidMolecular weight:475.598IDO2-IN-1
CAS:IDO2-IN-1: potent oral IDO2 inhibitor, IC50 = 112 nM, for inflammatory autoimmunity research.Formula:C21H21BrN10O3Color and Shape:SolidMolecular weight:541.36VS-15
CAS:VS-15 is a selective inhibitor of IDO1, specifically binding to its apo-heme form. Additionally, VS-15 serves as an inhibitor of iNOS.Formula:C29H27N5O3Color and Shape:SolidMolecular weight:493.56IDO1-IN-13
IDO1-IN-13 is a potent IDO1 inhibitor (IC50: 61.6 nM, EC50: 30 nM in HeLa) that reduces kyn/trp ratio by 51% in SK-OV-3 tumors.Formula:C20H16BrN5O2SColor and Shape:SolidMolecular weight:470.34
