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IDO

IDO

Indoleamine 2,3-dioxygenase (IDO) is an enzyme involved in the catabolism of tryptophan, leading to the production of kynurenine and other metabolites. IDO plays a role in immune tolerance and is often upregulated in cancer and chronic inflammatory conditions. Inhibitors of IDO are being explored as potential immunotherapeutic agents in cancer and autoimmune diseases. At CymitQuimica, we provide IDO inhibitors to support your research in immunology, oncology, and metabolic regulation.

Found 82 products of "IDO"

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  • IDO-IN-12
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    IDO-IN-12

    CAS:
    <p>IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).</p>
    Formula:C13H11BrFN5O3S
    Purity:99.727%
    Color and Shape:Solid
    Molecular weight:416.23

    Ref: TM-T11615

  • IACS-8968 S-enantiomer
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    IACS-8968 S-enantiomer

    CAS:
    <p>IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and &lt;5 for TDO).</p>
    Formula:C17H18F3N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:381.35

    Ref: TM-T11628

  • IACS-8968
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    IACS-8968

    CAS:
    <p>IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and &lt;5 for TDO).</p>
    Formula:C17H18F3N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:381.35

    Ref: TM-T11626

  • IDO-IN-8
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    IDO-IN-8

    CAS:
    <p>IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).</p>
    Formula:C18H21FN2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:316.37

    Ref: TM-T11621

  • IDO1-IN-2
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    IDO1-IN-2

    CAS:
    <p>IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.</p>
    Formula:C15H17FN6O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:364.33

    Ref: TM-T11624

  • IDO-IN-3
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    IDO-IN-3

    CAS:
    <p>IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).</p>
    Formula:C11H12BrFN6O2
    Color and Shape:Solid
    Molecular weight:359.15

    Ref: TM-T11617

  • TDO-IN-1
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    TDO-IN-1

    CAS:
    <p>TDO-IN-1 is a tryptophan 2,3-dioxygenase (TDO) inhibitor with antitumor activity that acts by reversing local immune tolerance in tumor tissues.</p>
    Formula:C16H13F3N4O2
    Purity:99.86%
    Color and Shape:Solid
    Molecular weight:350.3

    Ref: TM-T61202

  • (R)-IDO/TDO-IN-1
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    (R)-IDO/TDO-IN-1

    CAS:
    <p>(R)-IDO/TDO-IN-1 (compound 25), an indoleamine-2,3-dioxygenase (IDO) inhibitor, demonstrates good pharmacokinetic properties and exerts anti-tumor effects in the MC38 xenograft model. This compound exhibits synergy when combined with the anti-PD-1 monoclonal antibody (SHR-1210) [1].</p>
    Formula:C25H24FN5
    Color and Shape:Solid
    Molecular weight:413.49

    Ref: TM-T84728

  • IDO-IN-9
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    IDO-IN-9

    CAS:
    <p>IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).</p>
    Formula:C13H13BrFN7O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:446.25

    Ref: TM-T11622

  • NUCC-0223619
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    NUCC-0223619

    CAS:
    <p>NUCC-0223619 is an IDO1 inhibitor that induces the degradation of IDO protein and can be involved in the synthesis of PROTAC.</p>
    Formula:C24H24ClFN2O2
    Color and Shape:Solid
    Molecular weight:426.91

    Ref: TM-T62326

  • IDO1/TDO-IN-6
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    IDO1/TDO-IN-6

    CAS:
    <p>IDO1/TDO-IN-6 (compound 11) is a dual inhibitor targeting IDO1 and TDO, exhibiting IC50 values of 2.25 μM for IDO1 and 2.89 μM for TDO.</p>
    Formula:C20H17NO5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:351.35

    Ref: TM-T78795

  • IDO1/2-IN-1
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    IDO1/2-IN-1

    CAS:
    <p>First potent oral dual IDO1/IDO2 inhibitor with antitumor properties; IC50: 28 nM (IDO1), 144 nM (IDO2).</p>
    Formula:C16H18BrFN8O4
    Color and Shape:Solid
    Molecular weight:485.27

    Ref: TM-T63222

  • 1-Isopropyltryptophan
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    1-Isopropyltryptophan

    CAS:
    <p>1-Isopropyltryptophan (1-IsoPT), an IDO1 inhibitor, suppresses the expression of IDO-1 and IDO-2 mRNA induced by IFN-γ stimulation [1].</p>
    Formula:C14H18N2O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:246.3

    Ref: TM-T79189

  • IDO1/2-IN-1 hydrochloride
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    IDO1/2-IN-1 hydrochloride

    CAS:
    <p>IDO1/2-IN-1 hydrochloride: Dual IDO1/2 inhibitor, IC50 of 28/144 nM, oral, with antitumor properties.</p>
    Formula:C16H19BrClFN8O4
    Color and Shape:Solid
    Molecular weight:521.73

    Ref: TM-T63651

  • IDO antagonist-1
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    IDO antagonist-1

    CAS:
    <p>IDO antagonist-1 (compound 163), an IDO antagonist, effectively inhibits the growth of pancreatic adenocarcinoma cells in C57BL/6 mice [1].</p>
    Formula:C39H53N7O5
    Color and Shape:Solid
    Molecular weight:699.88

    Ref: TM-T86703

  • VS-15
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    VS-15

    CAS:
    <p>VS-15 is a selective inhibitor of IDO1, specifically binding to its apo-heme form. Additionally, VS-15 serves as an inhibitor of iNOS.</p>
    Formula:C29H27N5O3
    Color and Shape:Solid
    Molecular weight:493.56

    Ref: TM-T200480

  • CymitQuimica logo
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    IDO1-IN-14

    <p>IDO1-IN-14 is an IDO1 enzyme inhibitor with an IC50 of 396.9 nM and suppresses HeLa cell activity with an EC50 of 3393 nM.</p>
    Formula:C18H12Cl2FN3O2
    Color and Shape:Solid
    Molecular weight:392.21

    Ref: TM-T61789

  • IDO1-IN-25
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    IDO1-IN-25

    CAS:
    <p>IDO1-IN-25, a dual inhibitor of IDO1/TDO2, showcases IC50 values of 0.17 μM for IDO1 and 3.2 μM for TDO2. It effectively suppresses NO production in RAW264.7 cells following stimulation with lipopolysaccharide (LPS). Additionally, IDO1-IN-25 demonstrates anti-inflammatory properties in a mouse ear edema model of acute inflammation induced by croton oil.</p>
    Formula:C14H8Cl3NO2S
    Color and Shape:Solid
    Molecular weight:360.64

    Ref: TM-T200055

  • CymitQuimica logo
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    IDO1-IN-13

    <p>IDO1-IN-13 is a potent IDO1 inhibitor (IC50: 61.6 nM, EC50: 30 nM in HeLa) that reduces kyn/trp ratio by 51% in SK-OV-3 tumors.</p>
    Formula:C20H16BrN5O2S
    Color and Shape:Solid
    Molecular weight:470.34

    Ref: TM-T63034

  • IDO1 ligand-1
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    IDO1 ligand-1

    CAS:
    <p>IDO1ligand-1 is the target protein ligand for PROTAC NU227326, which is utilized for degrading IDO1.</p>
    Formula:C29H34FN3O2
    Color and Shape:Solid
    Molecular weight:475.598

    Ref: TM-T206464