Phospholipase
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic substances, playing a critical role in membrane biology and the generation of signaling molecules. Inhibitors of phospholipases are used to study their role in inflammatory diseases, cardiovascular disorders, and neurodegeneration. These inhibitors are also valuable in exploring lipid signaling pathways and their implications in disease mechanisms. At CymitQuimica, we provide a variety of phospholipase inhibitors to support your research in inflammation, lipid metabolism, and cell signaling.
Found 85 products of "Phospholipase"
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Difluprednate
CAS:Difluprednate (Myser)(Durezol) is a corticosteroid, approved for the treatment of post-operative ocular inflammation and pain.
Formula:C27H34F2O7Purity:99.23% - 99.86%Color and Shape:SolidMolecular weight:508.55Cambinol
CAS:Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.Formula:C21H16N2O2SPurity:98.02% - 99.83%Color and Shape:SolidMolecular weight:360.43Ref: TM-T4019
1mg38.00€2mg50.00€5mg80.00€10mg117.00€25mg207.00€50mg333.00€100mg495.00€500mg1,071.00€1mL*10mM (DMSO)63.00€CAY10594
CAS:CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.Formula:C26H28N4O2Purity:98%Color and Shape:SolidMolecular weight:428.53trans-Benzylideneacetone
CAS:trans-Benzylideneacetone (Acetocinnamone) is used in various synthetic preparations.Formula:C10H10OPurity:97.48%Color and Shape:Light Yellow Low Melting Crystalline MassMolecular weight:146.19Aristolochic acid C
CAS:Aristolochic acid C is a derivative of Aristolochic acid which is a phospholipase A2 inhibitor.Formula:C16H9NO7Purity:99.8%Color and Shape:White PowderMolecular weight:327.25CAY10650
CAS:CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).Formula:C28H25NO6Purity:97.33%Color and Shape:SolidMolecular weight:471.5Ref: TM-TQ0105
1mg49.00€5mg114.00€10mg172.00€25mg334.00€50mg467.00€100mg620.00€1mL*10mM (DMSO)118.00€U-73122
CAS:U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.Formula:C29H40N2O3Purity:97.50%Color and Shape:Solid Off-WhiteMolecular weight:464.64m-3M3FBS
CAS:m-3M3FBS is a phospholipase C (PLC) activator.Formula:C16H16F3NO2SPurity:99.66%Color and Shape:SolidMolecular weight:343.36Melittin
CAS:Melittin: principal bee venom toxin, 26 amino acids, activates low-weight PLA2, not high-weight PLA2.Formula:C131H229N39O31Purity:98.37% - 99.92%Color and Shape:SolidMolecular weight:2846.46Neomycin sulfate
CAS:Neomycin sulfate (Framycin sulfate) is a broad-spectrum aminoglycoside antibiotic that blocks the synthesis of bacterial proteins in order to exertFormula:C23H46N6O13·3H2SO4Purity:99.4% - 99.88%Color and Shape:Tan PowderMolecular weight:908.87VU0155056
CAS:VU0155056 is a dual PLD1/2 inhibitor with IC50 < 1 µM in cellular assays, inhibits breast cancer cell invasion.Formula:C25H26N4O2Purity:98.6% - 99.15%Color and Shape:SolidMolecular weight:414.5LCL521
CAS:LCL521 inhibits lysosomal acid sphingomyelinase (ASMase).LCL521 is an acid ceramidase (ACDase) inhibitor.Formula:C31H52N4O7Purity:98%Color and Shape:SolidMolecular weight:592.77Omeprazole Sodium
CAS:Omeprazole Sodium is a proton pump inhibitor(PPI) and suppresses gastric acid secretion.Formula:C17H18N3NaO3SPurity:99.84%Color and Shape:Clear In WaterMolecular weight:367.42-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
CAS:2-Decenoylaminoethyl cyclohexylethyl sulfide prevents stress ulcers, stabilizes phospholipase A2 and prostaglandin E2.Formula:C20H37NOSPurity:98%Color and Shape:SolidMolecular weight:339.58ML299
CAS:ML299 (VU0463568) is a dual PLD1/2 inhibitor (PLD1 and PLD2, IC50 of 6 nM, 20 nM, respectively).Formula:C23H26BrFN4O2Purity:98%Color and Shape:SolidMolecular weight:489.38ASM-IN-1
CAS:ASM-IN-1: Oral acid sphingomyelinase inhibitor, IC50 = 1.5 µM; reduces lipid plaques, plasma ceramide, Ox-LDL.Formula:C16H12BrN3O4Purity:98%Color and Shape:SolidMolecular weight:390.19Lp-PLA2-IN-3
CAS:Lp-PLA2-IN-3: Potent oral inhibitor of human Lp-PLA2 with a 14 nM IC50.Formula:C20H13ClF3N3O3SPurity:99.84%Color and Shape:SolidMolecular weight:467.85Ref: TM-T11874
1mg90.00€2mg132.00€5mg215.00€10mg340.00€25mg565.00€50mg797.00€100mg1,063.00€500mg2,142.00€1mL*10mM (DMSO)220.00€GK187
CAS:GK187 is a selective and potent Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor, used in the study of neurological disorders.Formula:C14H15F5O2Color and Shape:SolidMolecular weight:310.26Ref: TM-T37221
1mg79.00€5mg172.00€10mg268.00€25mg510.00€50mg802.00€100mg1,305.00€1mL*10mM (DMSO)178.00€Giripladib
CAS:Giripladib (PLA695/PLX-695) blocks radiation-boosted phosphorylation of ERK and Akt in endothelial cells.
Formula:C41H36ClF3N2O4SPurity:99.64%Color and Shape:SolidMolecular weight:745.25VU0155069
CAS:VU0155069, a selective PLD1 inhibitor (IC50: 46 nM), halts cancer cell migration in transwell assays.Formula:C26H27ClN4O2Purity:99.5%Color and Shape:SolidMolecular weight:462.97Halopemide
CAS:Halopemide is a potent inhibitor of PLD (IC50 = 220 and 310 nM for human PLD1 and PLD2).Formula:C21H22ClFN4O2Purity:96.57%Color and Shape:SolidMolecular weight:416.88VU0364739
CAS:VU0364739, a selective phospholipase D2 (PLD2) inhibitor with an IC50 of 22 nM, effectively reduces cancer cell proliferation [1].Formula:C26H27FN4O2Purity:98%Color and Shape:SolidMolecular weight:446.52Lp-PLA2-IN-13
CAS:Lp-PLA2-IN-13 (compound 15), a potent Lp-PLA2 inhibitor, holds potential for research in neurodegenerative-related diseases [1].Formula:C22H17F5N4O4Purity:98%Color and Shape:SolidMolecular weight:496.39Lp-PLA2-IN-2
CAS:Lp-PLA2-IN-2 is a selective and potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.Formula:C19H23FN2O4SPurity:98%Color and Shape:SolidMolecular weight:394.46Lp-PLA2-IN-14
CAS:Lp-PLA2-IN-14 (Compound 19), an inhibitor of rhLp-PLA2, exhibits a potent inhibitory effect with a pIC50 value of 8.4.Formula:C16H14F3N3O3Purity:98%Color and Shape:SolidMolecular weight:353.37,7-Dimethyl-(5Z,8Z)-eicosadienoic acid
CAS:7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid (DEDA, 5 μM) significantly impacts the response to βA(25-35) stimulation. It reduces the formation of ROS.Formula:C22H40O2Color and Shape:SolidMolecular weight:336.55Varespladib methyl
CAS:Varespladib methyl (LY333013), a bioavailable prodrug of Varespladib, is a selective group II secretory phospholipase A2 inhibitor.Formula:C22H22N2O5Purity:99.42% - 99.97%Color and Shape:SolidMolecular weight:394.42Ref: TM-T17218
1mg93.00€2mg123.00€5mg200.00€10mg319.00€25mg528.00€50mg730.00€100mg999.00€200mg1,333.00€1mL*10mM (DMSO)220.00€Ecopladib
CAS:Ecopladib inhibits cPLA2α with IC50 of 0.15 μM (micelles) & 0.11 μM (rat blood).
Formula:C39H33Cl3N2O5SPurity:95.15%Color and Shape:SolidMolecular weight:748.11Rilapladib
CAS:Rilapladib (SB 659032) is a selective inhibitor of Lipoprotein-Associated Phospholipase A2(Lp-PLA2, IC50 = 230 pM) and an antagonist of the platelet activatingFormula:C40H38F5N3O3SPurity:99.92%Color and Shape:SolidMolecular weight:735.8Ref: TM-T16751
1mg87.00€5mg215.00€10mg349.00€25mg537.00€50mg745.00€100mg1,108.00€200mg1,504.00€1mL*10mM (DMSO)349.00€MAFP
CAS:MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective irreversible inhibitor of anandamide amidase.Formula:C21H36FO2PColor and Shape:SolidMolecular weight:370.48GK420
CAS:GK420 (AVX420) is a potent inhibitor of cytoplasmic phospholipase A2α (cPLA2α), with an XI(50) value of 0.0016. It effectively inhibits the release of arachidonic acid, with an EC50 of 0.09 μM. GK420 plays a significant role in cancer research.Formula:C20H25NO5SColor and Shape:SolidMolecular weight:391.481Ro 23-9358
CAS:Ro 23-9358 is a potent inhibitor of secretory phospholipase A2, exhibiting anti-inflammatory properties.Formula:C30H51NO6Color and Shape:SolidMolecular weight:521.729Lp-PLA2-IN-16
CAS:Lp-PLA2-IN-16 (Example 1) is an inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) with potential applications in Alzheimer's disease research [1].
Formula:C22H17F5N4O3Purity:98%Color and Shape:SolidMolecular weight:480.39Lp-PLA2-IN-12
CAS:Lp-PLA2-IN-12 (compound 19), an Lp-PLA2 inhibitor, is utilized in researching neurodegenerative diseases including Alzheimer's disease (AD), glaucoma, age-
Formula:C24H23F2N5O3Purity:98%Color and Shape:SolidMolecular weight:467.47Lp-PLA2-IN-15
CAS:Lp-PLA2-IN-15 (example 2) is an inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) with potential application in Alzheimer's disease research [1].
Formula:C22H17F5N4O3Purity:98%Color and Shape:SolidMolecular weight:480.39
