Microbiology/Virology

Artemisone (BAY 44-9585) is a potent and semi-synthetic antimalarial, inhibits P.

Benfotiamine (S-Benzoylthiamine O-monophosphate) is a synthetic S-acyl derivative of thiamine (vitamin B1), used as an antioxidant dietary supplement.

HCV-IN-29 is a hepatitis C virus (HCV) inhibitor.

Quinoxyfen has antimicrobial activity and can be used to study powdery mildew.

Dinitolmide (Zoalene), a poultry feed additive, is a coccidiostat for poultry.

Milbemycin oxime is a broad spectrum antiparasitic, used as a veterinary drug.

Loxoribine (RWJ 21757), a guanosine analog, is an oral TLR7 agonist with antiviral and antitumor properties.

Ampicillin (Aminobenzylpenicillin) is a semi-synthetic penicillin belonging to the β-lactam group of antibiotics.

GT-1 (LCB10-0200), a siderophore cephalosporin, fights P. aeruginosa, K. oxytoca, Proteus, S. marcescens, E. aerogenes.

PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT.

ASP-1 is a potent antistaphylococcal peptide, exhibiting minimum inhibitory concentrations (MICs) ranging from 2 μg/mL to 64 μg/mL against both S.

AR ligand-30 serves as the target protein ligand for PROTAC Bavdegalutamide, utilized in prostate cancer research.

Modoflaner is an antiparasitic (veterinary use).

PROTACHBeAg degrader-1 is a PROTAC-based targeted degrader of HBeAg. It effectively recruits the VHL E3 ligase, yet its ability to degrade the hepatitis B virus protein (HBeAg) does not depend on VHL recruitment. This compound decreases levels of both secreted and intracellular HBeAg and is suitable for research involving the hepatitis B virus (HBV).

Amdoxovir is a reverse transcriptase inhibitor.

SCH 725674, a macrolide, halts fungi like S. cerevisiae and C. albicans growth; MICs are 8 and 32 μg/ml.

CK 492B is a bio-active chemical.

The compound exhibits excellent antifungal and antiviral activities, including against HIV.

Isoegomaketone (IK), an essential oil component in P. frutescens, displays anti-inflammatory and antitumor properties. It has been demonstrated to alleviate inflammatory response and oxidative stress in sepsis-induced ALI, positioning it as a potential therapeutic agent for managing sepsis-associated ALI.

Nanangenine F, a drimane sesquiterpene from A. nanangensis, inhibits B. subtilis (IC50=78μg/ml) and is cytotoxic to various cells (IC50=49-95μg/ml).

Polynucleotide Kinase is a DNA repair enzyme. It exhibits 5'-kinase activity by catalyzing the transfer of phosphate from ATP to the 5'-hydroxyl (OH) end, and also shows 3'-phosphatase activity by converting the 3'-phosphate end into a 3'-OH end.

Boc-GRR-AMC (TFA) is a tripeptide substrate utilized in fluorescence assays to analyze substrate specificity of West Nile virus (WNV) NS2B-NS3 protease or to determine the optimal pH for LdMC activity.

OM-7D3-B3 is a monoclonal antibody that targets human tight junction protein 1 (CLDN1) with a dissociation constant (Kd) of 4 nM. This antibody inhibits the role of CLDN1 in the cellular entry of the hepatitis C virus (HCV) and holds potential for research into HCV infection.

Woodorien is a potent inhibitor of HSV-1. It is also a glucoside that can be isolated from Woodwardia orientalis.

KC12 acts as an inhibitor of the FOXM1 transcription factor. In cancer cells of the MDA-MB-231 line, KC12 exhibits cytotoxicity with an IC50 of 6.13 µM.

Actinobolin ((+)-Actinobolin) is an antibiotic that inhibits protein synthesis by targeting ribosomes in both bacteria and eukaryotes. It suppresses the activity of Mycobacterium smegmatis, Escherichia coli, and rabbit reticulocyte lysate (RRL), with IC50 values of 19.2 μmol/L, 27.9 μmol/L, and 288 μmol/L, respectively.

Siamycin I, a tricyclic peptide from Streptomyces, has anti-HIV (ED50: 0.05-5.7 μM) and antibacterial effects, also inhibits E. faecalis quorum sensing.

RSV-IN-11 (compound 10b) exhibits antiviral activity against RSV, with an IC50 value of 4 μM. It is applicable for research on respiratory infections.

LEAP-2 (Human liver expressed antimicrobial peptide-2) is an antimicrobial peptide, a growth hormone-releasing peptide antagonist, and a GHS-R1a inverse agonist

Abacavir carboxylate, an inactive abacavir metabolite, forms via aldehyde intermediates bonding to valine in proteins.

Amycolatopsin C, from Amycolatopsis, targets M. bovis/tuberculosis and fights colorectal/lung cancer. Not effective on common bacteria.

SNM1A-IN-1 (compound 11a) serves as an inhibitor of the DNA damage repair enzyme SNM1A, exhibiting cytotoxic properties [1].

Neospiramycin I, a spiramycin I derivative, is an antibiotic effective against several bacteria, with varying MIC values, and protects mice from S. pneumoniae.

BING is an antimicrobial peptide isolated from Japanese medaka fish. It exhibits broad-spectrum toxicity against pathogenic bacteria, including resistant strains. BING disrupts the periplasmic peptidyl-prolyl isomerase in Gram-negative bacteria and reduces RNA levels of cpxR, which plays a crucial role in the development of antibiotic resistance.

Cyclopeptide 1 (Compound 1) is an antimicrobial peptide exhibiting moderate efficacy in inhibiting B.

SEB Domain (152-161) TFA represents amino acid positions 152-161 within the structural domain of staphylococcal enterotoxin B, produced by Staphylococcus aureus. This segment is highly conserved and inhibits the transcytosis of multiple staphylococcal enterotoxins, including SEA, SEE, and TSST-1.

Kocurin: a thiazolyl peptide with antibiotic properties, effective against MRSA, B. subtilis, and various enterococci, including vancomycin-resistant strains.

FITC-labeled TAT (47-57) peptide enhances protein yields & solubility; TAT is a CPP.

Felvizumab (SB 209763), a humanized IgG1κ monoclonal antibody, targets specific neutralizing epitopes on the F glycoprotein of Respiratory Syncytial Virus (RSV

Bostrycin, an anthraquinone derived from B. alpestre, exhibits a broad spectrum of biological activities including antibacterial, antiproliferative, and phytotoxic effects. This compound demonstrates efficacy against Gram-positive bacteria like methicillin-resistant S. aureus (MRSA), M. tuberculosis, and C. botulinum. Additionally, Bostrycin shows antiproliferative action against A549 lung adenocarcinoma cells, particularly by arresting the cell cycle at the G0/G1 phase and triggering apoptosis within a concentration range of 10 to 30 µM. As a phytotoxin, it causes necrosis in water hyacinth leaves at approximately 7 µg/ml. Furthermore, Bostrycin serves as a protein immobilization cross-linking agent, managing to preserve its bacteriostatic properties when affixed to nonwoven polypropylene fabric.

Ac-DEMEEC-OH is a competitive inhibitor of the HCV NS3 protease with a Ki of 0.6 µM.

Nornidulin, a depsidone from A. nidulans, fights various bacteria, fungi, MRSA (MIC=2 μg/ml), and has larvicidal (LC50=1.7 μg/ml) and cytotoxic properties.

TAT-NSF700scr, a control peptide, contains a TAT domain, glycine linker, and scrambled NSF amino acids, not inhibiting SNARE exocytosis.

Gallinamide A TFA is a peptide that exhibits linear deposition and serves as a potent inhibitor of cathepsin L (CatL) with an IC50 of 17.6 pM. It inhibits SARS-CoV-2 infection by targeting CatL (EC50: 28 nM) and also inhibits Plasmodium falciparum with an IC50 of 50 nM [1] [2].

Propionylmaridomycin is a macrolide antibiotic.

Apramycin: a veterinary aminoglycoside antibiotic, blocks translocation, binds to eukaryotic/bacterial RNA despite differing key residues.

HIV-1integrase inhibitor 12 (Compound 17) is an inhibitor of HIV-1 integrase with an IC50 of 1.4 nM. It effectively inhibits both HIV-1WT and HIV-1T125A with IC50 values of 7.4 nM and 120 nM, respectively. This compound exhibits metabolic stability and Caco-2 permeability in rats, with favorable pharmacokinetic properties, including good bioavailability (64%) and low clearance rate (0.16 L/hr/kg).

TAC is a TERT (telomerase reverse transcriptase) activator, promotes telomere synthesis, reduces cellular senescence and inflammatory cytokines

Fusionglycoprotein92-106 is a peptide derived from the respiratory syncytial virus (RSV) fusion protein. It functions as an MHC class I-restricted cytotoxic T lymphocyte (CTL) epitope, with all 15 amino acids effectively recognized by CTLs.

HIV-1inhibitor-66 is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) that exhibits inhibitory activity against wild-type HIV-1 reverse transcriptase (HIV-1 reverse transcriptase) with an IC50 of 40 nM.

Cefotiam hydrochloride is a third-gen cephalosporin that disrupts bacterial cell wall synthesis by inhibiting PBPs.

FPR2 antagonist; blocks NADPH oxidase, no FPR1 effect; hinders cell movement; antiviral against influenza.

L 693989 is a pneumocandin.

CMVpp65 (415-429) is a CEF control peptide derived from cytomegalovirus (CMV).

SARS-CoV-2 Mpro-IN-37 (compound 8r) is an inhibitor of the SARS-CoV-2 main protease (Mpro), with an IC50 value of 0.0199 μM. It exhibits IC50 values of 0.00945 μM against SARS-CoV-1 Mpro and 0.111 μM against MERS-CoV Mpro. SARS-CoV-2 Mpro-IN-37 demonstrates potent antiviral activity in the nanomolar range without showing cytotoxicity.

Compound 480-68-2, with CAS No. 480-68-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 480-68-2 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Adustin is an antifungal antibiotic characterized as a polypeptide that inhibits translation. It effectively suppresses translation in a cell-free rabbit reticulocyte lysate system, exhibiting an IC50 of 0.34 μM.

Compound YJ196 (Compound 59) serves as an inhibitor of New Delhi Metallo-β-lactamase-1 (NDM-1) [1].

His-Cys-Lys-Phe-Trp-Trp functions as an inhibitor of the human immunodeficiency virus (HIV) integrase, exhibiting an IC50 value of 2 μM.

Tazobactam sodium,β-Lactamase inhibitor.

DprE1-IN-13 (Compound 42) is an inhibitor of decaprenyl-phosphoryl-β-d-ribose oxidase (DprE1) with an IC50 value of 12.72 μM. It effectively inhibits Mycobacterium tuberculosis H37Ra, with a MIC50 of 1.071 μM.

Thermospermine is a structural isomer of spermine that plays a role in inhibiting xylem differentiation.Cost-effective and quality-assured.

2, 3-Dichloro-1, 4-naphthoquinone is an inhibitor of Itch, a HECT domain-E3 ligase. It is also used in pesticide formulations.

Streptochlorin from Streptomyces sp. SF2583 has antiangiogenic, antiproliferative, anti-allergic effects, and hinders cancer cell growth.

2-Bromoaldisine, a pyrrole alkaloid isolated from Stylissa carter, is known to inhibit HIV-1 infection and suppress the Raf/MEK/MAPK pathway.

Mpro ligand 1 is the target protein ligand for PROTACSARS-CoV-2 Mpro degrader-3. It is the active form of Mpro ligand 2.

Abbeymycin is an antibiotic

NK 1971 is a bioactive chemical.

Bactobolin A, a microbial metabolite initially derived from Pseudomonas, exhibits both antibiotic and anticancer properties.

VIRIP (human α1-AT(353-372)) serves as an inhibitor of HIV-1. It impedes HIV-1 entry by binding to the gp41 fusion peptide, making it useful in virus research.

Cacaoidin, a glycosylated lantibiotic extracted from Streptomyces cacaoi, exhibits strong antibacterial effects against Gram-positive pathogens, notably

Antituberculosis agent-15 (Compound 18c) is a selective antimycobacterial agent with a minimum inhibitory concentration (MIC) of 0.45 μM against Mycobacterium tuberculosis H37Rv (ATCC 27294) and 0.28 μM against its wild-type strain H37Rv-LP (ATCC 25618). It exhibits potent intracellular inhibitory activity in macrophage infection models, with an IC50 of 0.16 μM. Antituberculosis agent-15 is applicable for tuberculosis research.

SARS-CoV-2-IN-70 (compound 6) is an effective inhibitor of SARS-CoV-2, with an IC50 value of 3.2 μM.

Drimentine A: Antibiotic from Actinomycete, fights Gram-positive/negative bacteria, fungi, yeast, and has anthelmintic traits.

Antitubercular agent-52 (Compound 7k) is a chemical compound that acts as an antitubercular agent targeting Mycobacterium tuberculosis (Mtb). It specifically inhibits the bacterium's cytochrome bcc (cyt-bcc) electron transport chain and also affects cytochrome bd (cyt-bd). By disrupting a crucial energy metabolism pathway in Mtb, Antitubercular agent-52 impedes electron transport and ATP production, showing potential for use in tuberculosis research.

S-MGB-234: Novel Minor Groove Binder, potential treatment for animal African trypanosomiasis, effective in mice.

FR-901235, from Paecilomyces carneus, normalizes suppressed lymphocyte growth.

Hybendazole hydrochloride is a bio-active chemical.

Saquayamycin C is a glycoside of aquayamycin.

Chalcomycin is a macrolide antibiotic effective against Gram-positive Staphylococcus aureus and Streptococcus pyogenes. It protects mice from infections caused by various Staphylococcus and Streptococcus strains and exhibits no significant toxicity (LD50>2500 mg/kg).

Ophiobolin B is a sesterterpene Helminthosporium oryzae metabolite, inhibits proton extrusion from maize coleoptiles.

SARS-CoV-2 Mpro-IN-17 (compound S5-28) is an orally active, non-covalent inhibitor of SARS-CoV-2 Mpro, with an EC50 value of 1.35 μM. It is applicable for research related to COVID-19.

Rivabazumab is a recombinant antibody against Pseudomonas aeruginosa pcrV [1] .

c-Met-IN-15 exhibits antibacterial activity.

Daunorubicinol is the main metabolite of daunomycin.

Bovine tracheal antimicrobial peptide, derived from the tracheal mucosa, exhibits antimicrobial efficacy against E.

Romlusevimab (BRII-198) is a recombinant antibody targeting the spike protein of SARS-CoV-2, with antiviral activity.

Cefazolin-13C2,15N, a standard for GC/LC-MS cefazolin quantification, is effective against many bacteria with MICs of 0.1-25 μg/ml.

Furylfuramide (also known as AF-2), a synthetic nitrofuran derivative, can be widely used as a food preservative in Japan.

Compound Fr13803, with CAS No. 14774-37-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13803 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Sibeprenlimab (VIS649) is a humanized IgG 2 monoclonal antibody that suppresses APRIL.

K11, an antimicrobial peptide, demonstrates activity against MDR/XDR K.

Compound Fr13414, with CAS No. 13114-72-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13414 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Pseudobactin A is a nonfluorescent extracellular siderophore produced by plant growth-promoting bacterium Pseudomonas B10.

Orazamide may be useful to treat chronic hepatitis and various skin diseases.