LRRK2
LRRK2 inhibitors are compounds that target and inhibit the activity of Leucine-Rich Repeat Kinase 2 (LRRK2), an enzyme involved in several cellular processes, including autophagy, vesicle trafficking, and inflammation. Mutations in the LRRK2 gene are associated with an increased risk of developing Parkinson's disease, making LRRK2 a significant target for neurodegenerative disease research. Inhibitors of LRRK2 are crucial for exploring its role in Parkinson's disease and for developing potential therapeutic strategies. At CymitQuimica, we offer a selection of LRRK2 inhibitors to support your research in neurodegeneration, kinase signaling, and therapeutic development.
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BIX 02565
CAS:1311367-27-7
BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).
Formula:
C26H30N6O2
Purity:
97.44%
Color and Shape:
Solid
Molecular weight:
458.56
Ref: TM-T5428
| 1mg | 171.00 € | ||
| 5mg | 410.00 € | ||
| 10mg | To inquire | ||
| 25mg | To inquire | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 496.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
MLi-2
CAS:1627091-47-7
MLi-2: Novel, potent CNS-active LRRK2 inhibitor; IC50s: 0.76nM in vitro, 1.4nM cellular, 3.4nM binding.
Formula:
C21H25N5O2
Purity:
98.96%
Color and Shape:
Solid
Molecular weight:
379.46
Ref: TM-T16115
| 1mg | 65.00 € | ||
| 2mg | 95.00 € | ||
| 5mg | 130.00 € | ||
| 10mg | 193.00 € | ||
| 25mg | 425.00 € | ||
| 50mg | 644.00 € | ||
| 100mg | 916.00 € | ||
| 1mL*10mM (DMSO) | 142.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Nictide
CAS:1159973-22-4
Nictide, a peptide substrate for LRRK2 (leucine-rich repeat protein kinase-2), undergoes phosphorylation by the activated …
Formula:
C123H193N45O28
Color and Shape:
Liquid
Molecular weight:
2750.13
Ref: TM-TP2837
| 10mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Thursday 5 Dec 2024
LRRK2 inhibitor 1
CAS:1802525-61-6
LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 …
Formula:
C20H23N5O4
Purity:
99.73%
Color and Shape:
Solid
Molecular weight:
397.43
Ref: TM-T11878
| 1mg | 74.00 € | ||
| 2mg | 96.00 € | ||
| 5mg | 159.00 € | ||
| 10mg | 263.00 € | ||
| 25mg | 554.00 € | ||
| 50mg | 937.00 € | ||
| 100mg | 1,481.00 € | ||
| 1mL*10mM (DMSO) | 169.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
CZC-54252 hydrochloride
CAS:1784253-05-9
CZC-54252 hydrochloride: selective LRRK2 inhibitor; IC50 = 1.85/1.28 nM (wild-type/G2019S); neuroprotective; EC50 = 1 nM …
Formula:
C22H26Cl2N6O4S
Purity:
98.21%
Color and Shape:
Solid
Molecular weight:
541.45
Ref: TM-T39202
| 5mg | 51.00 € | ||
| 10mg | 73.00 € | ||
| 25mg | 130.00 € | ||
| 50mg | 208.00 € | ||
| 100mg | 307.00 € | ||
| 200mg | 434.00 € | ||
| 1mL*10mM (DMSO) | 62.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
EB-42486
CAS:2390475-81-5
EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.
Formula:
C22H22N8O
Purity:
98.06%
Color and Shape:
Solid
Molecular weight:
414.46
Ref: TM-T39972
| 1mg | 68.00 € | ||
| 2mg | 90.00 € | ||
| 5mg | 150.00 € | ||
| 10mg | 218.00 € | ||
| 25mg | 394.00 € | ||
| 50mg | 588.00 € | ||
| 100mg | 836.00 € | ||
| 200mg | 1,118.00 € | ||
| 1mL*10mM (DMSO) | 164.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
PF-06447475
CAS:1527473-33-1
PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM …
Formula:
C17H15N5O
Purity:
98.61% - 99.62%
Color and Shape:
Solid
Molecular weight:
305.33
Ref: TM-T2050
| 5mg | 55.00 € | ||
| 10mg | 71.00 € | ||
| 25mg | 101.00 € | ||
| 50mg | 133.00 € | ||
| 100mg | 214.00 € | ||
| 200mg | 374.00 € | ||
| 1mL*10mM (DMSO) | 53.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
PF-06454589
CAS:1527473-30-8
PF-06454589 is a potent inhibitor of LRRK2.
Formula:
C14H16N6O
Purity:
96.29%
Color and Shape:
Solid
Molecular weight:
284.32
Ref: TM-T7729
| 2mg | 35.00 € | ||
| 5mg | 50.00 € | ||
| 10mg | 78.00 € | ||
| 25mg | 131.00 € | ||
| 50mg | 193.00 € | ||
| 100mg | 299.00 € | ||
| 200mg | 431.00 € | ||
| 1mL*10mM (DMSO) | 54.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
HG-10-102-01
CAS:1351758-81-0
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
Formula:
C17H20ClN5O3
Purity:
99.59%
Color and Shape:
Solid
Molecular weight:
377.83
Ref: TM-T7196
| 2mg | 37.00 € | ||
| 5mg | 56.00 € | ||
| 10mg | 91.00 € | ||
| 25mg | 164.00 € | ||
| 50mg | 255.00 € | ||
| 100mg | 367.00 € | ||
| 200mg | 521.00 € | ||
| 1mL*10mM (DMSO) | 63.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
JH-II-127
CAS:1700693-08-8
JH-II-127 is an oral LRRK2 inhibitor with IC50s: 6.6 nM (WT), 2.2 nM (G2019S), 47.7 …
Formula:
C19H21ClN6O3
Purity:
≥98%
Color and Shape:
Solid
Molecular weight:
416.86
Ref: TM-T7155
| 1mg | 49.00 € | ||
| 5mg | 103.00 € | ||
| 10mg | 167.00 € | ||
| 25mg | 279.00 € | ||
| 50mg | 450.00 € | ||
| 100mg | 637.00 € | ||
| 1mL*10mM (DMSO) | 114.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
IKK 16
CAS:873225-46-8
IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK …
Formula:
C28H29N5OS
Purity:
99.61%
Color and Shape:
Solid
Molecular weight:
483.63
Ref: TM-T6176
| 1mg | 40.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 86.00 € | ||
| 10mg | 137.00 € | ||
| 25mg | 240.00 € | ||
| 50mg | 398.00 € | ||
| 100mg | 593.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
CZC-25146
CAS:1191911-26-8
CZC-25146, a stable LRRK2 inhibitor, IC50: 4.76 nM (wild-type), 6.87 nM (G2019S).
Formula:
C22H25FN6O4S
Purity:
97.68%
Color and Shape:
Solid
Molecular weight:
488.54
Ref: TM-T3053
| 5mg | 45.00 € | ||
| 10mg | 72.00 € | ||
| 25mg | 145.00 € | ||
| 50mg | 253.00 € | ||
| 100mg | 362.00 € | ||
| 200mg | 526.00 € | ||
| 1mL*10mM (DMSO) | 52.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
GNE-9605
CAS:1536200-31-3
GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).
Formula:
C17H20ClF4N7O
Purity:
98.55% - 98.75%
Color and Shape:
Solid
Molecular weight:
449.83
Ref: TM-T1770
| 1mg | 38.00 € | ||
| 5mg | 79.00 € | ||
| 10mg | 119.00 € | ||
| 25mg | 200.00 € | ||
| 50mg | 305.00 € | ||
| 100mg | 446.00 € | ||
| 1mL*10mM (DMSO) | 88.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
GNE-7915
CAS:1351761-44-8
GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.
Formula:
C19H21F4N5O3
Purity:
98% - ≥95%
Color and Shape:
Solid
Molecular weight:
443.4
Ref: TM-T1945
| 5mg | 46.00 € | ||
| 10mg | 62.00 € | ||
| 25mg | 115.00 € | ||
| 50mg | 187.00 € | ||
| 100mg | 317.00 € | ||
| 200mg | 411.00 € | ||
| 500mg | 669.00 € | ||
| 1mL*10mM (DMSO) | 52.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
CZC-54252
CAS:1191911-27-9
CZC-54252 is a potent inhibitor of LRRK2.
Formula:
C22H25ClN6O4S
Purity:
99.39%
Color and Shape:
Solid
Molecular weight:
504.99
Ref: TM-T2022
| 1mg | 38.00 € | ||
| 2mg | 49.00 € | ||
| 5mg | 80.00 € | ||
| 10mg | 116.00 € | ||
| 25mg | 215.00 € | ||
| 50mg | 323.00 € | ||
| 1mL*10mM (DMSO) | 89.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
CZC-25146 hydrochloride
CAS:1330003-04-7
CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type …
Formula:
C22H26ClFN6O4S
Purity:
99.06%
Color and Shape:
Solid
Molecular weight:
525
Ref: TM-T5139
| 1mg | 35.00 € | ||
| 5mg | 71.00 € | ||
| 10mg | 113.00 € | ||
| 25mg | 181.00 € | ||
| 50mg | 270.00 € | ||
| 100mg | 394.00 € | ||
| 200mg | 547.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
GNE0877
CAS:1374828-69-9
GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor …
Formula:
C14H16F3N7
Purity:
98.01% - 99.96%
Color and Shape:
Solid
Molecular weight:
339.32
Ref: TM-T6031
| 1mg | 46.00 € | ||
| 2mg | 59.00 € | ||
| 5mg | 123.00 € | ||
| 10mg | 183.00 € | ||
| 25mg | 368.00 € | ||
| 50mg | 550.00 € | ||
| 100mg | 785.00 € | ||
| 500mg | 1,616.00 € | ||
| 1mL*10mM (DMSO) | 95.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
LRRK2-IN-1
CAS:1234480-84-2
LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.
Formula:
C31H38N8O3
Purity:
98% - 98.44%
Color and Shape:
Solid
Molecular weight:
570.69
Ref: TM-T2246
| 5mg | 65.00 € | ||
| 10mg | 93.00 € | ||
| 25mg | 171.00 € | ||
| 50mg | 298.00 € | ||
| 100mg | 526.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
PFE-360
CAS:1527475-61-1
PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in …
Formula:
C16H16N6O
Purity:
98.14% - 99.73%
Color and Shape:
Solid
Molecular weight:
308.34
Ref: TM-T16512
| 1mg | 73.00 € | ||
| 2mg | 95.00 € | ||
| 5mg | 167.00 € | ||
| 10mg | 222.00 € | ||
| 25mg | 456.00 € | ||
| 50mg | 665.00 € | ||
| 100mg | 920.00 € | ||
| 500mg | 1,840.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
GSK2578215A
CAS:1285515-21-0
GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
Formula:
C24H18FN3O2
Purity:
97.93% - 99.94%
Color and Shape:
Solid
Molecular weight:
399.42
Ref: TM-T2240
| 5mg | 34.00 € | ||
| 10mg | 50.00 € | ||
| 25mg | 89.00 € | ||
| 50mg | 153.00 € | ||
| 100mg | 218.00 € | ||
| 200mg | 328.00 € | ||
| 1mL*10mM (DMSO) | 34.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
