Beta Amyloid
Beta Amyloid inhibitors are compounds that target and prevent the formation or aggregation of beta-amyloid peptides, which are implicated in the pathogenesis of Alzheimer's disease. The accumulation of beta-amyloid plaques in the brain is a hallmark of the disease, leading to neuronal dysfunction and cognitive decline. Inhibitors of beta-amyloid aggregation are being explored as potential therapeutic agents to slow or prevent the progression of Alzheimer's disease. At CymitQuimica, we provide a range of beta-amyloid inhibitors to support your research in neurodegeneration, protein aggregation, and Alzheimer's therapy.
Found 231 products of "Beta Amyloid"
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Anti-amyloid agent-1
CAS:Anti-amyloid agent-1 is a potent compound that inhibits amyloid aggregation, offering a promising approach for research into the treatment of amyloidosis [1].Formula:C21H17F3N2O3Color and Shape:SolidMolecular weight:402.37RAGE/SERT-IN-1
CAS:RAGE/SERT-IN-1 is a potent, orally active inhibitor of advanced glycation end products (RAGE) and serotonin transporter (SERT), with IC50 values of 8.26 μM andFormula:C38H41ClN4OSColor and Shape:SolidMolecular weight:637.28BMS 433796
CAS:BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease.Formula:C21H20F2N4O4Purity:99.17%Color and Shape:SolidMolecular weight:430.4Aβ/tau aggregation-IN-3
CAS:Aβ/tau aggregation-IN-3 is a potent inhibitor of amyloid protein aggregation, exhibiting an IC50 value of 0.85 µM in an Aβ-Thioflavin T (Aβ-ThT) functionalFormula:C23H22N4O3Color and Shape:SolidMolecular weight:402.45NNC 26-9100
CAS:Somatostatin sst4 receptor agonistFormula:C22H25BrCl2N6SPurity:98%Color and Shape:SolidMolecular weight:556.35γ-Secretase-IN-1
CAS:γ-Secretase-IN-1 is a γ-secretase inhibitor that displays partial antiproliferative activity against T-47D cells.Formula:C27H24F2N4O3Purity:99.56%Color and Shape:SolidMolecular weight:490.5Ref: TM-T3521
1mg120.00€5mg385.00€1mL*10mM (DMSO)416.00€10mg618.00€25mg1,224.00€50mg1,648.00€100mg2,232.00€MDR-1339
CAS:MDR-1339 is a blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.Formula:C20H22O4Purity:98.57%Color and Shape:SolidMolecular weight:326.39Anti-Aβ agent 1A
Anti-Aβ agent 1A is a potent anti-amyloid-β agent.Formula:C35H49NO4Color and Shape:SolidMolecular weight:547.77Amilo-5MER
CAS:Amilo-5MER (5-MP) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically suppresses the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER reduces chronic inflammation and alleviates symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research in autoimmune and chronic inflammatory diseases.Formula:C23H40N6O9SColor and Shape:SolidMolecular weight:576.664γ-secretase modulator 5
Compound 22d is a GSM that crosses the blood-brain barrier, inhibits Aβ42 production (IC50: 60 nM), and may help study Alzheimer's.Color and Shape:SolidMAO-B-IN-10
MAO-B-IN-10: Potent, selective MAO-B inhibitor; crosses blood-brain barrier; IC50 5.3 μM; reduces Aβ aggregation 58.2%, disaggregates 43.3%.Formula:C23H26N2O4Color and Shape:SolidMolecular weight:394.462002-G12
CAS:2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.Formula:C20H16N6Color and Shape:SolidMolecular weight:340.381MAO-B-IN-45
CAS:MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. It selectively inhibits MAO-B with an IC50 of 87.47 nM, demonstrating a selectivity over MAO-A by more than 229 times. In vitro, MAO-B-IN-45 exhibits significant anti-ferroptosis activity by modulating iron metabolism pathways and the GSH-GPX4 axis. Additionally, it improves cognitive and behavioral deficits in 3×Tg (APP/Tau/Ps1) Alzheimer's disease mice and significantly reduces levels of ferritin heavy chain 1 (FTH1), β-amyloid protein (APP), and Tau protein phosphorylation (p-Tau) in their brains.Formula:C17H14ClNO3Color and Shape:SolidMolecular weight:315.75Glutaminyl Cyclase Inhibitor 3
CAS:Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.Formula:C24H32N6O2SPurity:98%Color and Shape:SolidMolecular weight:468.61BF-168
CAS:BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).Formula:C18H17FN2O2Color and Shape:SolidMolecular weight:312.34Amyloid-β-IN-2
CAS:Amyloid-β-IN-2 (Compound EX.112) is a selective inhibitor of γ-secretase. In H4 cells, it demonstrates inhibitory activity on Aβ42 secretion, with an EC50 value of 226 nM. Amyloid-β-IN-2 holds potential for research in Alzheimer's disease (AD) and diseases associated with Aβ deposition.Formula:C22H21F2N3O2Color and Shape:SolidMolecular weight:397.42Antioxidant agent-8
Antioxidant agent-8, an oral Aβ 1-42 inhibitor, reduces fibril aggregation & promotes disaggregation; it's neuroprotective & BBB permeable.Formula:C13H12O5Color and Shape:SolidMolecular weight:248.23Amyloid-β-IN-3
CAS:Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.Formula:C22H21F2N3O2Color and Shape:SolidMolecular weight:397.42IXA62
CAS:IXA62 is an orally active, selective IRE1/XBP1s agonist (EC50= 0.31 μM) that can reduce Aβ secretion.Formula:C24H23N3O3Color and Shape:SolidMolecular weight:401.458Thiazolo[5,4-c]pyridin-4(5H)-one
CAS:Thiazolo[5,4-c]pyridin-4(5H)-one is a compound used for diagnostic imaging of TDP-43, in PET imaging of neurodegenerative diseases ALS、AD、FTD、LATE.Formula:C22H22FN5O2SPurity:98.75%Color and Shape:SolidMolecular weight:439.51Aβ aggregation-IN-1
CAS:Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.Formula:C9H8BF3O2Color and Shape:SolidMolecular weight:215.965γ-secretase modulator 6
CAS:Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.Formula:C25H26N6O2Color and Shape:SolidMolecular weight:442.513Buntanetap L-Tartrate
CAS:Buntanetap (L-Tartrate) functions as an oral small molecule inhibitor targeting multiple neurotoxic proteins. It decreases the production of amyloid precursor protein (APP) by inhibiting the translation of its mRNA [1].Formula:C24H29N3O8Color and Shape:SolidMolecular weight:487.50Aβ-IN-2
Aβ-IN-2 is a peptide inhibitor of Aβ1-42.Formula:C37H51NOColor and Shape:SolidMolecular weight:525.81(9R)-RO7185876
CAS:(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.Formula:C25H28F3N7Color and Shape:SolidMolecular weight:483.532cSPM
cSPM (Cyclic spermine) is an Aβ42 inhibitor. cSPM inhibits the aggregation of three different peptides, Aβ42, tryptophan and insulin, and reduces cytotoxicity.Formula:C27H57N7Color and Shape:SolidMolecular weight:479.79QP5020
CAS:QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.Formula:C20H19FN6Molecular weight:362.40Aβ42 agonist-1
CAS:Aβ42 agonist-1 is a small molecule compound with anti-cancer activity and NF-κB inhibitory properties, inducing Aβ42 aggregation.Formula:C15H11NO2Purity:99.77%Color and Shape:SolidMolecular weight:237.25BMS 299897
CAS:BMS 299897, a sulfonamide γ-secretase inhibitor, inhibits Aβ production with an IC50 of 7 nM in HEK293 cells overexpressing APP.Formula:C24H21ClF3NO4SPurity:99.82%Color and Shape:SolidMolecular weight:511.94BF 227
CAS:BF 227 is a candidate for an amyloid imaging probe for PET [Ki: 4.3 nM for Aβ1-42 fibrils].Formula:C16H16FN3O2SColor and Shape:SolidMolecular weight:333.38Xanthocillin X permethyl ether
CAS:Xanthocillin X permethyl ether, a natural product extracted from fungal sources, exhibits Aβ-42 lowering activity.Formula:C20H16N2O2Purity:98%Color and Shape:SolidMolecular weight:316.35
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