CaMK
Calcium/Calmodulin-Dependent Protein Kinase (CaMK) inhibitors are compounds that block the activity of CaMK, a kinase involved in regulating various cellular processes, including synaptic plasticity, memory formation, and gene expression in the nervous system. CaMK plays a critical role in translating calcium signals into cellular responses, and its dysregulation is associated with neurological disorders. Inhibitors of CaMK are valuable tools for studying synaptic signaling, learning, and memory. At CymitQuimica, we offer CaMK inhibitors to support your research in synaptic plasticity, cognitive function, and neuropharmacology.
Found 68 products of "CaMK"
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Nifedipine
CAS:<p>Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent.</p>Formula:C17H18N2O6Purity:99.39% - 99.49%Color and Shape:Yellow Crystals Physical Description Odorless Yellow Crystals Or Powder Tasteless (Ntp 1992)Molecular weight:346.33Dibucaine
CAS:<p>Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia.</p>Formula:C20H29N3O2Purity:99.698% - 99.88%Color and Shape:Colorless Or Almost Colorless Powder SolidMolecular weight:343.46A-3 hydrochloride
CAS:<p>A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.</p>Formula:C12H14Cl2N2O2SPurity:99.32%Color and Shape:SolidMolecular weight:321.22Y-33075 dihydrochloride
CAS:<p>Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).</p>Formula:C16H18Cl2N4OPurity:98.88% - 99.89%Color and Shape:SolidMolecular weight:353.25Trifluoperazine dihydrochloride
CAS:<p>Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.</p>Formula:C21H26Cl2F3N3SPurity:99.57% - 99.96%Color and Shape:Cream Fine PowderMolecular weight:480.43Elziverine
CAS:<p>Elziverine: oral calmodulin antagonist, inhibits Ca-induced acanthocyte formation, potential for neurological and cognitive disorder treatment.</p>Formula:C32H37N3O5Purity:99.79%Color and Shape:SolidMolecular weight:543.65Cloxacepride
CAS:<p>cloxacepride is a CaM antagonist that is used to treat asthma disease.</p>Formula:C22H27Cl2N3O4Purity:99.62%Color and Shape:SolidMolecular weight:468.37TAT-CN21 (scrambled)
<p>TAT-CN21(scrambled) is a control peptide lacking specific targeting activity and serves as a negative control for TatCN21. TatCN21 is an effective and selective inhibitory peptide for calcium/calmodulin-dependent protein kinase II (CaMKII).</p>Color and Shape:Odour SolidTAT-CN21
<p>TatCN21, with an IC 50 of 77 nM, serves as a potent and selective inhibitor peptide of the calcium/calmodulin-dependent protein kinase II (CaMKII), a ubiquitously-expressed multifunctional serine/threonine protein kinase. It is particularly useful in research pertaining to ischemia and neurodegenerative diseases.</p>Formula:C169H303N69O43Color and Shape:SolidMolecular weight:3989.65Beauverolide Ja
CAS:<p>Beauverolide Ja: cyclotetradepsipeptide, CaM inhibitor; Kd 0.078 μM, Ki 0.39 μM; from Isaria fumosorosea.</p>Formula:C35H46N4O5Color and Shape:SolidMolecular weight:602.76CALP2
CAS:<p>CALP2 is a CaM antagonist blocking EF-hand/Ca2+ site; inhibits CaM phosphodiesterase, raises Ca2+, and activates alveolar macrophages.</p>Formula:C68H104N14O13SPurity:98%Color and Shape:SolidMolecular weight:1357.72Calmodulin-Dependent Protein Kinase II (281-309)
CAS:<p>Calmodulin-Dependent Protein Kinase II (281-309) is a synthetic peptide that can be phosphorylated at Thr286 by PKC and inhibits CaM kinase II (IC50 = 80 nM).</p>Formula:C146H254N46O39S3Purity:98%Color and Shape:SolidMolecular weight:3374.06Acremonidin A
CAS:<p>Acremonidin A, from Purpureocillium lilacinum, is a strong CaM inhibitor binding to hCaM M124C-mBBr with a Kd of 19.40 nM.</p>Formula:C33H26O12Color and Shape:SolidMolecular weight:614.55Fasciculic acid C
CAS:<p>Fasciculic acid C is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.</p>Formula:C38H63NO11Purity:98%Color and Shape:SolidMolecular weight:709.91Fasciculic acid A
CAS:<p>Fasciculic acid A is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.</p>Formula:C36H60O8Color and Shape:SolidMolecular weight:620.868RA306
<p>RA306 is an orally active CAMK2 inhibitor that effectively disrupts the PEAK1/CAMK2 signaling pathway. It demonstrates anti-tumor activity by inhibiting proliferation, migration, and invasion of breast cancer cells. Additionally, RA306 shows potential in cardiac disease research, as it improves dilated cardiomyopathy in mice.</p>Color and Shape:Odour SolidCalmodulin Binding Peptide 1
CAS:<p>Calmodulin Binding Peptide 1, a high-affinity MLCK-derived inhibitor, blocks IP3-induced Ca2+ release.</p>Formula:C231H373N69O70S2Purity:98%Color and Shape:SolidMolecular weight:5301.1Fasciculic acid B
CAS:<p>Fasciculic acid B: ester of fasciculol B, 3-hydroxy-methylglutaric acid; a calmodulin antagonist from Naematoloma fasciculare.</p>Formula:C36H60O9Purity:98%Color and Shape:SolidMolecular weight:636.86Fluphenazine-N-2-chloroethane (hydrochloride)
CAS:<p>Fluphenazine: antipsychotic, binds dopamine D2 (Ki=0.55nM), inhibits calmodulin. Its derivative adds irreversible D2 antagonism and anticancer potential.</p>Formula:C22H27Cl3F3N3SColor and Shape:SolidMolecular weight:528.89Encecalinol
CAS:<p>Encecalinol, a compound isolated from the aerial parts of Ageratina grandifolia, acts as a potent inhibitor of calmodulin [1].</p>Formula:C14H18O3Color and Shape:SolidMolecular weight:234.29Calmodulin-Dependent Protein Kinase II 290-309 acetate
<p>Calmodulin-Dependent Protein Kinase II 290-309 acetate is an effective antagonist of Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM).</p>Formula:C105H189N31O26SPurity:96.7%Color and Shape:SolidMolecular weight:2333.88CALP2 TFA
<p>CALP2 TFA, a CaM antagonist with 7.9 µM Kd, blocks CaM-dependent enzymes, boosts Ca2+ levels, and activates macrophages.</p>Formula:C70H105F3N14O15SColor and Shape:SolidMolecular weight:1471.72Syntide 2 TFA
<p>Syntide 2 (TFA) is a CaMKII substrate that selectively hinders GA response without affecting other plant processes.</p>Formula:C70H123N20F3O20Color and Shape:SolidMolecular weight:1621.84AC3-I, myristoylated
<p>Myristoylated AC3-I is a biologically active peptide and a myristoylated variant of the Autocamtide-3-Derived Inhibitory Peptide (AC3-I).</p>Formula:C78H137N21O20Purity:98%Color and Shape:SolidMolecular weight:1689.05Calmodulin Kinase IINtide, Myristoylated
<p>Myristoylated Calmodulin Kinase IINtide (Myr-CaMKIINtide) serves as a selective and noncompetitive inhibitor of CaMKII [1].</p>Formula:C156H275N47O43Purity:98%Color and Shape:SolidMolecular weight:3497.14CaMKIIα-PHOTAC
<p>CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) that specifically targets Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα).</p>Formula:C54H58Cl2N10O11Purity:98%Color and Shape:SolidMolecular weight:1094CAMKIV Protein, Human, Recombinant (GST)
<p>CAMKIV Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag.</p>Color and Shape:Lyophilized PowderMolecular weight:79 kDa (predicted); 100 kDa (reducing conditions)KN-93
CAS:<p>KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.</p>Formula:C26H29ClN2O4SPurity:99.56% - 99.86%Color and Shape:White SolidMolecular weight:501.04Trifluoperazine
CAS:<p>Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.</p>Formula:C21H24F3N3SPurity:98.3% - 99.46%Color and Shape:White To Yellowish Crystalline PowderMolecular weight:407.5NH125
CAS:<p>NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.</p>Formula:C27H45IN2Purity:98.60%Color and Shape:SolidMolecular weight:524.56CALP1 acetate
<p>CALP1 acetate is a calmodulin (CaM) agonist (Kd of 88 µM) that binds to the CaM EF-hand/Ca2+-binding site.</p>Formula:C42H79N9O12Purity:99.63%Color and Shape:SolidMolecular weight:902.13Autocamtide-2-related inhibitory peptide
CAS:<p>Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.</p>Formula:C64H116N22O19Purity:>99.99%Color and Shape:SolidMolecular weight:1497.74Autocamtide 2 TFA(129198-88-5 free base)
<p>Autocamtide 2 TFA, selective CaMKII peptide substrate, used in its activity assay.</p>Formula:C67H119F3N22O22Purity:98%Color and Shape:SolidMolecular weight:1641.79lavendustin C
CAS:<p>lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.</p>Formula:C14H13NO5Purity:98.06%Color and Shape:Yellow To Tan PowderMolecular weight:275.26CaMKII-IN-1
CAS:<p>CaMKII-IN-1 is a potent and highly selective inhibitor of CaMKII (IC50 = 63 nM).</p>Formula:C29H30ClN5O2SPurity:99.69%Color and Shape:SolidMolecular weight:548.1Syntide 2 acetate(108334-68-5 free base)
<p>Syntide-2 acetate is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 μM).</p>Formula:C70H126N20O20Purity:99.74%Color and Shape:SolidMolecular weight:1567.85KN-92 hydrochloride
CAS:<p>KN-92 hydrochloride is an inactive derivative of KN-93.</p>Formula:C24H26Cl2N2O3SPurity:99.68%Color and Shape:SolidMolecular weight:493.45A-484954
CAS:<p>A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.</p>Formula:C13H15N5O3Purity:97.47% - 99.86%Color and Shape:SolidMolecular weight:289.29CaM kinase II inhibitor TFA salt
<p>CaM kinase II inhibitor TFA salt (Autocamtide-2-related inhibitory peptide (TFA)) is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.</p>Formula:C66H117F3N22O21Purity:>99.99%Color and Shape:SolidMolecular weight:1611.77STO-609
CAS:<p>STO-609 inhibits CaM-KKα/KKβ (Ki: 80/15 ng/mL), is specific, cell-permeable, and targets Ca2+/calmodulin-dependent protein kinase kinase.</p>Formula:C19H10N2O3Purity:97.14% - 98.8%Color and Shape:SolidMolecular weight:314.29KN-62
CAS:<p>KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.</p>Formula:C38H35N5O6S2Purity:99.80% - >99.99%Color and Shape:White SolidMolecular weight:721.84CaMKP Inhibitor
CAS:<p>CaMKP Inhibitor can inhibit CaMKP.</p>Formula:C10H8NNaO7S2Purity:96.55% - 99.98%Color and Shape:SolidMolecular weight:341.28IGS-1.76
CAS:<p>IGS-1.76 binds strongly to hNCS-1, modulates its Ric8a interaction, and inhibits the hNCS-1/Ric8a complex.</p>Formula:C22H18N2OSPurity:98.18% - 98.56%Color and Shape:SolidMolecular weight:358.46GSK3i XIII
CAS:<p>GSK3i XIII (GSK3 inhibitor XIII) is a GSK-3 ATP-binding site inhibitor.</p>Formula:C18H19N5Purity:98.87%Color and Shape:SolidMolecular weight:305.38CALP2 acetate(261969-04-4 free base)
<p>CALP2 acetate is an antagonist of calmodulin showing high affinity for binding to the CaM EF-hand/Ca2+-binding site with a Kd of 7.9 µM.</p>Formula:C68H104N14O13SPurity:97.43%Color and Shape:SolidMolecular weight:1357.7L-6355
CAS:<p>L-6355 is an agent of bioactive chemicals.</p>Formula:C25H30INO3Color and Shape:SolidMolecular weight:519.42CK59
CAS:<p>CK59 inhibits CaMKII and several voltage-gated calcium channels, with an IC50 of ~50 μM.</p>Formula:C21H37N7O3Purity:98%Color and Shape:SolidMolecular weight:435.56W-5 hydrochloride
CAS:<p>W-5 hydrochloride (N-(6-Aminohexyl)-1-naphthalenesulfonamide HCl) is a potent calmodulin antagonist.</p>Formula:C16H23ClN2O2SPurity:99.35%Color and Shape:Off-White Crystalline SolidMolecular weight:342.88Bisindolylmaleimide VII
CAS:<p>Bisindolylmaleimide VII is a selective inhibitor of protein kinase C.</p>Formula:C27H27N5O2Color and Shape:SolidMolecular weight:453.54TIM-063
CAS:<p>TIM-063: ATP-competitive CaMKKα/β inhibitor, cell-permeable, Ki: 0.35/0.2 μM, IC50: 0.63/0.96 μM.</p>Formula:C18H9N3O4Color and Shape:SolidMolecular weight:331.28CBP501
CAS:<p>CBP501 peptide inhibits kinases like MAPKAP-K2/C-Tak1/CHK1, preventing Cdc25C function and blocking the entry into mitosis.</p>Formula:C86H122F5N29O17Color and Shape:SolidMolecular weight:1929.06Ph-HTBA
CAS:<p>Ph-HTBA: high-affinity CaMKIIα modulator, brain-penetrant, Kd 757 nM, used in ischemia/neurodegeneration research.</p>Formula:C19H18O3Color and Shape:SolidMolecular weight:294.34A-7 hydrochloride
CAS:<p>A-7 hydrochloride is a calmodulin antagonist and causes alterations in the subpopulation of CD44+CD24- in MDA-MB-231 cells.</p>Formula:C20H30Cl2N2O2SPurity:99.38%Color and Shape:SolidMolecular weight:433.44RU 45144
CAS:<p>RU 45144 is an estradiol derivative with antiestrogenic activity.</p>Formula:C28H37NO3Purity:98%Color and Shape:SolidMolecular weight:435.6HOCPCA
CAS:<p>HOCPCA: potent, selective GHB site ligand; 27x higher affinity than GHB; crosses blood-brain barrier.</p>Formula:C6H8O3Purity:98%Color and Shape:SolidMolecular weight:128.13W-13 hydrochloride
CAS:<p>W-13 hydrochloride (W-13 HCl) is a calmodulin antagonist.</p>Formula:C14H18Cl2N2O2SPurity:98.51%Color and Shape:White PowderMolecular weight:349.28Prenylamine lactate
CAS:<p>Prenylamine lactate, an ex-angina drug, depletes heart catecholamines and blocks calcium channels.</p>Formula:C27H33NO3Purity:98%Color and Shape:SolidMolecular weight:419.56Zaldaride maleate
CAS:<p>Zaldaride maleate blocks Ca2+, Na+, K+ currents, and nAChR; inhibits CaM cAMP PDE (IC50: 3.3 nM) and estrogen signaling.</p>Formula:C30H32N4O6Purity:98%Color and Shape:SolidMolecular weight:544.6TX-1123
CAS:<p>TX-1123: PTK/COX inhibitor, Src/eEF2-K/PKA/EGFR-K/PKC targeted, IC50 of 1.16μM(COX2), 15.7μM(COX1), low mitochondrial toxicity.</p>Formula:C20H24O3Color and Shape:SolidMolecular weight:312.4CV-159
CAS:<p>CV-159 is a unique dihydropyridine Ca2+ antagonist with antiinflammatory activities. It has an anti-calmodulin (CaM) action.</p>Formula:C31H34N4O7Purity:98%Color and Shape:SolidMolecular weight:574.62W-9 hydrochloride
CAS:<p>W-9 hydrochloride is a calmodulin antagonist.</p>Formula:C16H22Cl2N2O2SPurity:98.9%Color and Shape:SolidMolecular weight:377.33Calmidazolium chloride
CAS:<p>Calmidazolium chloride blocks calmodulin, hinders phosphodiesterase (IC50=0.15µM), Ca2+-ATPase (IC50=0.35µM), and can induce cancer cell apoptosis.</p>Formula:C31H23Cl7N2OPurity:98.53%Color and Shape:SolidMolecular weight:687.7FO-4-15
CAS:<p>FO-4-15 is an activator of mGluR1/CaMKIIα. It exhibits protective effects against H2O2 in human neuroblastoma (SH-SY5Y) cells. In mice with Alzheimer's disease, FO-4-15 enhances cognitive function by activating the mGluR1/CaMKIIα pathway, reducing Aβ accumulation, Tau hyperphosphorylation, and synaptic damage.</p>Formula:C18H20N4O4SColor and Shape:SolidMolecular weight:388.44BRD0418
CAS:<p>BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.</p>Formula:C29H32N2O5Purity:99.57%Color and Shape:SolidMolecular weight:488.57CaMKK2-IN-1
CAS:<p>CaMKK2-IN-1 is a selective and potent inhibitor of CaMKK2, exhibiting an IC50 of 7 nM.</p>Formula:C22H22N2O3Molecular weight:362.42PTCA
CAS:<p>PTCA is a potent ligand for Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα), with a pKi value of 7.2.</p>Formula:C10H5Cl2NO2SColor and Shape:SolidMolecular weight:274.123CaMKIIα-IN-1
<p>CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub.</p>Formula:C14H11ClO4Color and Shape:SolidMolecular weight:278.69Calmodulin antagonist-1
CAS:<p>Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist that effectively inhibits calmodulin-activated Ca 2+ -phosphodiesterase (PDE) with an IC 50 of 28 μM. This compound also competitively inhibits trypsin-treated Ca 2+ -PDE with respect to cyclic GMP, exhibiting an IC 50 of 375 μM and a K i value of 300 μM.</p>Formula:C14H18Cl2N2O2SColor and Shape:SolidMolecular weight:349.27
