GluR
Glutamate Receptor inhibitors are compounds that block the activity of glutamate receptors, which are the main excitatory neurotransmitter receptors in the brain. These receptors play a pivotal role in synaptic transmission, plasticity, learning, and memory. Dysregulation of glutamate signaling is associated with various neurological disorders, including epilepsy, stroke, and neurodegenerative diseases. GluR inhibitors are essential for investigating the mechanisms of excitotoxicity and developing neuroprotective strategies. At CymitQuimica, we offer a range of glutamate receptor inhibitors to support your research in synaptic function, neuroprotection, and cognitive disorders.
Found 255 products of "GluR"
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DHPG
CAS:<p>DHPG is a potent Group I mGluR agonist; doesn't affect Group II/III; linked to phospholipase D.</p>Formula:C8H9NO4Purity:99.55%Color and Shape:SolidMolecular weight:183.16LY339434 HCl
<p>LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA)</p>Formula:C18H20ClNO4Purity:97.96% - 99.68%Color and Shape:SoildMolecular weight:349.81VU0650786
CAS:<p>VU0650786: selective mGlu3 NAM, CNS-penetrant, IC50 392 nM, shows antidepressant/anxiolytic effects in rodents.</p>Formula:C18H15ClFN5O2Purity:99.09%Color and Shape:SolidMolecular weight:387.8Piracetam
CAS:<p>Piracetam (UCB-6215), a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders.</p>Formula:C6H10N2O2Purity:97.16%Color and Shape:Crystals From Isopropanol SolidMolecular weight:142.16NBQX disodium
CAS:<p>NBQX Disodium (FG9202 disodium) is a highly selective, competitive AMPA receptor antagonist with neuroprotective and anticonvulsant activity.</p>Formula:C12H6N4Na2O6SPurity:97.6% - 98.22%Color and Shape:SolidMolecular weight:380.2415Org-26576
CAS:<p>Org-26576 is a positive allosteric modulator of the AMPA receptor.</p>Formula:C11H12N2O2Purity:99.67%Color and Shape:SolidMolecular weight:204.23(R)-ADX-47273
CAS:<p>(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ).</p>Formula:C20H17F2N3O2Purity:99.87%Color and Shape:SolidMolecular weight:369.36γ-DGG acetate(6729-55-1 free base)
CAS:<p>gamma-DGG acetate(6729-55-1 free base) (γ-D-Glutamylglycine) is a competitive blocker of AMPA receptor.</p>Formula:C9H16N2O7Purity:99.81%Color and Shape:SolidMolecular weight:264.23KM02894
CAS:<p>KM02894 inhibits glutamate release, potentially reducing cancer-induced bone pain in tumor studies.</p>Formula:C7H9N3OS2Purity:99.98%Color and Shape:SolidMolecular weight:215.3AZD-8529 mesylate
CAS:<p>AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM).</p>Formula:C25H28F3N5O6SPurity:99.19%Color and Shape:SolidMolecular weight:583.58Basimglurant
CAS:<p>Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).</p>Formula:C18H13ClFN3Purity:98.35%Color and Shape:SolidMolecular weight:325.77(R)-3,4-DCPG HCl
<p>(R)-3,4-DCPG HCl is a potent and selective mGlu8a receptor agonist that activates metabotropic glutamate receptors on primary afferent terminals in the neonatal</p>Formula:C10H10ClNO6Purity:98.80% - 99.89%Color and Shape:SoildMolecular weight:275.64Decoglurant
CAS:<p>Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3 and it also is developed as an antidepressant.</p>Formula:C21H11F6N5Purity:99.77%Color and Shape:SolidMolecular weight:447.34JF-NP-26
<p>Releases pain-blocking raseglurant under 405 nm light. Inhibits Quisqualate. Analgesic in vivo. Quantum yield: 0.18.</p>Color and Shape:SolidMMPIP hydrochloride
CAS:<p>MMPIP hydrochloride is a selective antagonist of allosteric mGluR7.</p>Formula:C19H16ClN3O3Purity:99.88%Color and Shape:SolidMolecular weight:369.8GYKI-47261 dihydrochloride
CAS:<p>GYKI-47261 dihydrochloride is an AMPA receptor antagonist and CYP2E1 inducer, demonstrating broad-spectrum anticonvulsant and neuroprotective activities.</p>Formula:C18H17Cl3N4Purity:98.32% - 99.14%Color and Shape:SolidMolecular weight:395.71mGluR5 modulator 1
CAS:<p>mGluR5 modulator 1 is a positive modulator for mGluR5, used in schizophrenia and cognitive research.</p>Formula:C18H19ClFN3O2Color and Shape:SolidMolecular weight:363.82ML353
<p>ML353 activates TREK-1/2, binds mGlu5 SAM (Ki=18.2 nM), surpasses 5mpep, may address SAM activity/blocking.</p>Formula:C19H15FN2OPurity:99.98% - 99.98%Color and Shape:SoildMolecular weight:306.33VU0483605
CAS:<p>VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.</p>Formula:C20H10Cl3N3O3Purity:99.61%Color and Shape:SolidMolecular weight:446.67STX-107
CAS:<p>STX-107 is a potent and selective mGluR5 agonist for the study of Fragile X Syndrome.</p>Formula:C18H10FN3SPurity:99.17%Color and Shape:SolidMolecular weight:319.36LY3027788 hydrochloride
CAS:<p>LY3027788 HCl, potent oral prodrug of LY3020371, targets mGlu2/3 with antidepressant effects.</p>Formula:C25H32ClF2NO11SColor and Shape:SolidMolecular weight:628.03Pomaglumetad methionil anhydrous
CAS:<p>LY2140023, potential schizophrenia treatment, is an oral prodrug of LY404039, a selective mGlu2/3 agonist.</p>Formula:C12H18N2O7S2Purity:98%Color and Shape:SolidMolecular weight:366.41(S)-3,4-DCPG HCl
<p>(S)-3,4-DCPG HCl is a selective mGluR8a agonist, impacting AV12-664 cells with an EC50 of 31 nM.</p>Formula:C10H10ClNO6Purity:99.53% - 99.9%Color and Shape:SoildMolecular weight:275.64(S,S)-BMS-984923
CAS:<p>(S,S)-BMS-984923 is a weak mGluR5 modulator with EC50 >1μM; less active than its potent counterpart.</p>Formula:C22H15ClN2O2Color and Shape:SolidMolecular weight:374.82LY2812223
CAS:<p>LY2812223: selective mGlu2 agonist; binds mGlu2/mGlu3 (Ki=144/156 nM).</p>Formula:C10H12N4O4SPurity:98%Color and Shape:SolidMolecular weight:284.29LY3027788
CAS:<p>LY3027788, potent oral prodrug of LY3020371, is a strong mGlu2/3 antagonist with notable antidepressant effects.</p>Formula:C25H31F2NO11SColor and Shape:SolidMolecular weight:591.58(S)-AMPA HCl
<p>(S)-AMPA HCl (L-AMPA HCl) is a selective AMPA receptor agonist with potential antidepressant activity. It can be used in research on Parkinson's disease.</p>Formula:C7H11ClN2O4Purity:99.18%Color and Shape:SolidMolecular weight:222.63KRP-199 sodium
<p>KRP-199 sodium sodium is highly potent and selective for AMPA-R in vitro and exhibits good neuroprotection in vivo.</p>Formula:C22H12F3N5Na2O7Purity:97.27%Color and Shape:SoildMolecular weight:561.33MPPG
CAS:<p>MPPG is a selective L-AP4-sensitive receptor antagonist (kD=9.2 μM).</p>Formula:C9H12NO5PColor and Shape:SolidMolecular weight:245.171mGluR3 modulator-1
CAS:<p>1-ethyl-3-morpholin-4-yl tetrahydroisoquinoline: mGluR3 modulator, potential for Parkinson's.</p>Formula:C16H21N3OPurity:98.99%Color and Shape:SolidMolecular weight:271.361H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)-
CAS:<p>1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)- is a low activity isomer of S 18986.</p>Formula:C10H12N2O2SPurity:99.96%Color and Shape:SoildMolecular weight:224.28MGS0274
CAS:<p>MGS0274, a lipophilic prodrug of mGlu2/3 agonist MGS0008, enhances oral bioavailability, potentially aiding schizophrenia research.</p>Formula:C21H32FNO7Color and Shape:SolidMolecular weight:429.485(S)-3,4-DCPG
CAS:<p>(S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a selective agonist of human metabotropic glutamate receptor 8a (mGluR8a).</p>Formula:C10H9NO6Purity:98%Color and Shape:SolidMolecular weight:239.18L-AP3
CAS:<p>L-AP3 blocks mGluR, inhibits D/L-phosphoserine (IC50: 368/2087 μM).</p>Formula:C3H8NO5PColor and Shape:White Hygroscopic SolidMolecular weight:169.073(±)-LY367385
CAS:<p>(±)-LY367385 is the racemic form of LY367385, and LY367385 is a highly potent and selective mGluR1a antagonist.</p>Formula:C10H11NO4Color and Shape:SolidMolecular weight:209.201LY3020371
CAS:<p>LY3020371: potent, selective mGlu 2/3 receptor antagonist with Ki of 5.26 nM (hmGluR2) and 2.50 nM (hmGluR3); key in depression studies.</p>Formula:C15H15F2NO5SColor and Shape:SolidMolecular weight:359.34MGS0028
CAS:<p>MGS0028 is a selective agonist of metabotropic glutamate 2/3 receptor, it could reverse abnormal behaviors in mice induced by isolation rearing.</p>Formula:C8H8FNO5Color and Shape:SolidMolecular weight:217.15γ-DGG
CAS:<p>gamma-DGG is a competitive blocker of AMPA receptor.</p>Formula:C7H12N2O5Purity:98%Color and Shape:SolidMolecular weight:204.18LY341495
CAS:<p>LY341495 is a potent metabotropic glutamate receptor antagonist and can be used to study neurological disorders.</p>Formula:C20H19NO5Purity:98.53% - 99.37%Color and Shape:SolidMolecular weight:353.37NS-102
CAS:<p>NS-102 is a glutamate receptor and NMDA receptor antagonist that inhibits erythrocyanine (GluK2) and inhibits specific binding to the glur6 receptor.</p>Formula:C12H11N3O4Purity:98.48% - 98.95%Color and Shape:SolidMolecular weight:261.23GYKI 52466 dihydrochloride
CAS:<p>GYKI 52466 dihydrochloride is an AMPA/Kainate receptor antagonist with anticonvulsant activity and can be used to study neurological diseases.</p>Formula:C17H17Cl2N3O2Purity:99.38%Color and Shape:SolidMolecular weight:366.24AMN082
CAS:<p>AMN082 is an mGluR7 agonist with antidepressant effects. Neuroprotective effect of AMN082 on neuronal apoptosis in rats with traumatic brain injury.</p>Formula:C28H30Cl2N2Purity:97.13% - 98.63%Color and Shape:SolidMolecular weight:465.46GYKI 53655 hydrochloride
CAS:<p>GYKI 53655 hydrochloride (LY300168 hydrochloride) is an antagonist of AMPA and is used in the study of neurological disorders.</p>Formula:C19H21ClN4O3Purity:98.02%Color and Shape:SolidMolecular weight:388.85VU0422288
CAS:<p>VU0422288 (ML396) is a type III mGlu receptor (mGlus) orthosteric modulator with inhibitory effects on mGluR4.VU0422288 can be used to study Rett syndrome.</p>Formula:C17H11Cl2N3O2Purity:95.48%Color and Shape:SolidMolecular weight:360.19JNJ-46778212
CAS:<p>JNJ-46778212 (VU 0409551) is a selective and potent mGlu5 allosteric modulator (EC50: 260 nM) for the study of neurodissection.</p>Formula:C20H17FN2O3Purity:99.24%Color and Shape:SolidMolecular weight:352.36EGLU
CAS:<p>EGLU, an antidepressant and potent mGluR-2 antagonist, binds with a 66 μM Kd to (lS,3S)-ACPD sites.</p>Formula:C7H13NO4Purity:99.98%Color and Shape:SolidMolecular weight:175.18Ro 01-6128
CAS:<p>Positive allosteric modulator of mGlu1 receptors</p>Formula:C17H17NO3Purity:98%Color and Shape:SolidMolecular weight:283.32VU0364770 hydrochloride
CAS:<p>VU0364770 hydrochloride: potent, selective mGlu4 PAM; EC50=290 nM (rat), 1.1 μM (human).</p>Formula:C12H10Cl2N2OPurity:98%Color and Shape:SolidMolecular weight:269.13LY487379
CAS:<p>LY487379: human mGluR2 PAM, boosts glutamate binding, aids cognitive flexibility, may treat schizophrenia. EC50: 1.7 μM (mGlu2), >10 μM (mGlu3).</p>Formula:C21H19F3N2O4SColor and Shape:SolidMolecular weight:452.45CFMTI
CAS:<p>CFMTI: potent mGluR1 allosteric antagonist, 2000x selectivity over mGluR5, IC50: 2.6 nM.</p>Formula:C19H16FN5OPurity:97.23%Color and Shape:SolidMolecular weight:349.36
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