Protease-activated Receptor
Protease-activated Receptor (PAR) inhibitors are compounds that target and inhibit the activity of PARs, a family of G-protein-coupled receptors that are activated by proteolytic cleavage. These receptors play a role in various physiological processes, including coagulation, inflammation, and tissue repair. PAR inhibitors are valuable tools for studying the mechanisms of these processes and their involvement in diseases such as cancer, cardiovascular disorders, and chronic inflammation. At CymitQuimica, we provide PAR inhibitors to aid your research in signal transduction, immune response, and therapeutic discovery.
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AC-264613
CAS:1051487-82-1
AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory …
Formula:
C19H18BrN3O2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
400.28
Ref: TM-T4186
| 1mg | 92.00 € | ||
| 5mg | 275.00 € | ||
| 10mg | 506.00 € | ||
| 25mg | 1,148.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
PAR-2-IN-1
CAS:1690176-75-0
PAR-2-IN-1 (IUN76750) is a PAR- 2 signaling pathway inhibitor with anti-inflammatory and anticancer effects.
Formula:
C12H14ClN3O2
Purity:
99.75%
Color and Shape:
Solid
Molecular weight:
267.71
Ref: TM-T8917
| 1mg | 40.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 135.00 € | ||
| 25mg | 271.00 € | ||
| 50mg | 421.00 € | ||
| 100mg | 618.00 € | ||
| 500mg | 1,281.00 € | ||
| 1mL*10mM (DMSO) | 92.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Vorapaxar
CAS:618385-01-6
Vorapaxar (MK-5348) (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: …
Formula:
C29H33FN2O4
Purity:
99.27% - 99.93%
Color and Shape:
Solid
Molecular weight:
492.58
Ref: TM-T7013
| 1mg | 74.00 € | ||
| 5mg | 143.00 € | ||
| 10mg | 213.00 € | ||
| 25mg | 384.00 € | ||
| 50mg | 574.00 € | ||
| 100mg | 820.00 € | ||
| 500mg | 1,624.00 € | ||
| 1mL*10mM (DMSO) | 160.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Vorapaxar sulfate
CAS:705260-08-8
Vorapaxar sulfate (Zontivity) is a potent and orally active thrombin receptor (PAR-1) antagonist.
Formula:
C29H35FN2O8S
Purity:
99.46% - 99.9%
Color and Shape:
Solid
Molecular weight:
590.66
Ref: TM-T3098
| 1mg | 38.00 € | ||
| 2mg | 49.00 € | ||
| 5mg | 78.00 € | ||
| 10mg | 118.00 € | ||
| 25mg | 207.00 € | ||
| 50mg | 346.00 € | ||
| 100mg | 516.00 € | ||
| 500mg | 1,133.00 € | ||
| 1mL*10mM (DMSO) | 98.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
TFLLR-NH2 2TFA(197794-83-5(free base))
TFLLR-NH2 2TFA(197794-83-5(free base)) is an agonist of PAR1 (EC50 :1.9 μM).
Formula:
C35H55F6N9O10
Purity:
99.56%
Color and Shape:
Solid
Molecular weight:
875.87
Ref: TM-T7573L
| 1mL*10mM (DMSO) | 659.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Thrombin Receptor Activator for Peptide
Thrombin Receptor Activator (TRAP) or Coagulation Factor II (1-5), used in CHD research.
Formula:
C32H51F3N8O9
Purity:
99.88%
Color and Shape:
Solid
Molecular weight:
748.79
Ref: TM-T7674
| 1mg | 45.00 € | ||
| 5mg | 88.00 € | ||
| 10mg | 141.00 € | ||
| 25mg | 249.00 € | ||
| 50mg | 359.00 € | ||
| 100mg | 516.00 € | ||
| 200mg | 703.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Parmodulin 2
CAS:423735-93-7
ML161 (Parmodulin 2) inhibits PAR1, blocking platelet activation and thrombin-induced activity (IC50: 0.26μM).
Formula:
C17H17BrN2O2
Purity:
96.72% - 99.95%
Color and Shape:
Solid
Molecular weight:
361.23
Ref: TM-T1893
| 1mg | 35.00 € | ||
| 5mg | 71.00 € | ||
| 10mg | 97.00 € | ||
| 25mg | 157.00 € | ||
| 50mg | 239.00 € | ||
| 100mg | 371.00 € | ||
| 1mL*10mM (DMSO) | 65.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
AZ3451
CAS:2100284-59-9
AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).
Formula:
C30H27BrN4O3
Purity:
98.12%
Color and Shape:
Solid
Molecular weight:
571.46
Ref: TM-TQ0012
| 2mg | 45.00 € | ||
| 5mg | 66.00 € | ||
| 10mg | 96.00 € | ||
| 25mg | 228.00 € | ||
| 50mg | 402.00 € | ||
| 100mg | 596.00 € | ||
| 1mL*10mM (DMSO) | 85.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Protease-Activated Receptor-4 diTFA
Protease-Activated Receptor-4 diTFA,2454 is the proteinase-activated receptor-4 (PAR4)agonist
Formula:
C37H48F6N8O11
Purity:
98.54%
Color and Shape:
Solid
Molecular weight:
894.81
Ref: TM-T7740
| 1mg | 47.00 € | ||
| 2mg | 60.00 € | ||
| 5mg | 85.00 € | ||
| 10mg | 137.00 € | ||
| 25mg | 271.00 € | ||
| 50mg | 407.00 € | ||
| 100mg | 599.00 € | ||
| 1mL*10mM (DMSO) | 168.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
I-191
CAS:1690172-25-8
I-191 is a potent antagonist of protease-activated receptor 2 (PAR2), inhibits multiple signaling functions in …
Formula:
C23H26FN5O2
Purity:
99.80%
Color and Shape:
Solid
Molecular weight:
423.48
Ref: TM-T7137
| 1mg | 88.00 € | ||
| 2mg | 114.00 € | ||
| 5mg | 185.00 € | ||
| 10mg | 277.00 € | ||
| 25mg | 463.00 € | ||
| 50mg | 673.00 € | ||
| 100mg | 920.00 € | ||
| 1mL*10mM (DMSO) | 209.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Atopaxar Hydrobromide
CAS:474550-69-1
Atopaxar, a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling.
Formula:
C29H39BrFN3O5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
608.54
Ref: TM-T1986L
| 1mg | 239.00 € | ||
| 2mg | 351.00 € | ||
| 5mg | 594.00 € | ||
| 10mg | 827.00 € | ||
| 25mg | 1,271.00 € | ||
| 50mg | 1,654.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
ENMD-1068 HCl
CAS:789488-77-3
ENMD-1068 HCl (ENMD 1068) is a PAR-2 antagonist. ENMD-1068 HCl inhibits the development of endometriosis …
Formula:
C15H29N3O2
Purity:
95.79%
Color and Shape:
Solid
Molecular weight:
283.41
Ref: TM-T27267
| 10mg | 54.00 € | ||
| 25mg | 94.00 € | ||
| 50mg | 132.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
Atopaxar
CAS:751475-53-3
Atopaxar (E5555), a reversible PAR-1 thrombin receptor antagonist, interferes with platelet signaling.
Formula:
C29H38FN3O5
Purity:
98.25% - 98.5%
Color and Shape:
Solid
Molecular weight:
527.63
Ref: TM-T1986
| 1mg | 73.00 € | ||
| 5mg | 135.00 € | ||
| 10mg | 240.00 € | ||
| 25mg | 435.00 € | ||
| 50mg | 640.00 € | ||
| 100mg | 909.00 € | ||
| 1mL*10mM (DMSO) | 155.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
BMS-986141
CAS:1478711-48-6
BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an …
Formula:
C27H23N5O5S2
Purity:
98.36% - 99.11%
Color and Shape:
Liquid
Molecular weight:
561.63
Ref: TM-T63966
| 1mg | 736.00 € | ||
| 5mg | 1,476.00 € | ||
| 10mg | 1,840.00 € | ||
| 25mg | 2,634.00 € | ||
| 50mg | 3,531.00 € | ||
| 100mg | 4,792.00 € |
Estimated delivery in United States, on Wednesday 5 Mar 2025
