Protease-activated Receptor
Protease-activated Receptor (PAR) inhibitors are compounds that target and inhibit the activity of PARs, a family of G-protein-coupled receptors that are activated by proteolytic cleavage. These receptors play a role in various physiological processes, including coagulation, inflammation, and tissue repair. PAR inhibitors are valuable tools for studying the mechanisms of these processes and their involvement in diseases such as cancer, cardiovascular disorders, and chronic inflammation. At CymitQuimica, we provide PAR inhibitors to aid your research in signal transduction, immune response, and therapeutic discovery.
Found 54 products of "Protease-activated Receptor"
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TRAP-6 amide TFA
CAS:TRAP-6 amide TFA is a PAR-1 thrombin receptor agonist peptide.Formula:C36H58F3N11O10Color and Shape:SolidMolecular weight:861.922P4pal10 TFA
P4pal10 TFA, the TFA salt form of P4pal10, serves as an antagonist of the protease-activated receptor 4 (PAR4). This compound inhibits platelet aggregation and thrombin generation induced by tissue factor (TF), exhibiting anticoagulant and antithrombotic activities. Additionally, P4pal10 TFA alleviates carrageenan-induced edema and neutrophil infiltration, and ameliorates damage in rat myocardial ischemia/reperfusion (I/R) models.Color and Shape:Odour SolidTRAP-5 amide
CAS:TRAP-5 amide is a peptide agonist for protease-activated receptor 1 (PAR 1) [1].Formula:C30H51N9O6Color and Shape:SolidMolecular weight:633.78PAR 4 (1-6) (TFA)
PAR 4 (1-6) TFA (GYPGQV TFA), a hexapeptide derived from protease-activated receptor 4 (PAR 4), serves as a specific agonist for PAR 4.Formula:C28H41N7O9·xC2HF3O2Color and Shape:SolidFLLRN
CAS:FLLRN is a biologically active peptide serving as a PAR1-specific antagonist.Formula:C31H51N9O7Color and Shape:SolidMolecular weight:661.79Parstatin(mouse)
CAS:Peptide inhibits endothelial migration/proliferation (IC50 ~20μM), induces cell cycle arrest, triggers apoptosis, and has cardioprotective effects.Formula:C189H326N58O57S3Purity:98%Color and Shape:SolidMolecular weight:4419.19YFLLRNP
CAS:YFLLRNP is a biologically active peptide functioning as a partial agonist of PAR-1, selectively activating the G12/13 signaling pathway.Formula:C45H67N11O10Color and Shape:SolidMolecular weight:922.08Parstatin(human)
CAS:Cell-permeable PAR1-derived peptide; inhibits endothelial migration, proliferation (IC50 ~3μM), induces apoptosis, and has cardioprotective effects.Formula:C191H330N64O53S3Purity:98%Color and Shape:SolidMolecular weight:4467.292-Furoyl-LIGRLO-amide
CAS:2-Furoyl-LIGRLO-amide TFA is a peptide that acts as a proteinase-activated receptor-2 (PAR2) agonist, and contains a furoyl group addition at its N-terminal.Formula:C36H63N11O8Purity:98%Color and Shape:SolidMolecular weight:777.95PAR650097
PAR650097 is a humanized monoclonal antibody targeting PAR2, used in migraine research.Purity:96.67% (SEC-HPLC) - 98.83% (SEC-HPLC)Color and Shape:LiquidMolecular weight:144.1 kDatcY-NH2
CAS:Selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.Formula:C40H49N7O7Purity:98%Color and Shape:SolidMolecular weight:739.87PZ-128
CAS:PZ-128, a PAR1 antagonist, is used potentially for the treatment of thrombosis.Formula:C55H99N13O9Purity:98%Color and Shape:SolidMolecular weight:1086.46FSLLRY-NH2
CAS:PAR2 antagonist; counters taxol effects, PKC in mice; inhibits ERK, collagen in fibroblasts; lessens dermatophyte itch in mice.Formula:C39H60N10O8Purity:98%Color and Shape:SolidMolecular weight:796.97Protease-Activated Receptor-1, PAR-1 Agonist TFA
PAR-1 Agonist TFA: Selective peptide, mimics thrombin, activates PAR-1 receptor.Color and Shape:LiquidAY 254
CAS:AY 254: Potent PAR2 agonist, ERK1/2 activation (EC50=2 nM), limits caspase 3/8, aids HT29 cell healing, boosts IL-8.
Formula:C30H49N9O6Color and Shape:SolidMolecular weight:631.779Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2
CAS:Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biologically active peptide functioning as a selective agonist for Protease Activated Receptor 1 (PAR-1), a subtypeFormula:C42H63FN12O8Color and Shape:SolidMolecular weight:883.02PAR-2 (1-6) (human)
CAS:PAR-2 (1-6) (human) (SLIGKV), a peptide ligand, is a PAR-2 agonist [1] .Formula:C28H53N7O8Color and Shape:SolidMolecular weight:615.76SFNGGP-NH2
CAS:SFNGGP-NH2 is a biologically active peptide that interacts with Protease-Activated Receptor 3 (PAR-3), a high-affinity thrombin receptor.Formula:C25H36N8O8Color and Shape:SolidMolecular weight:576.6Protease-Activated Receptor-1, PAR-1 Agonist
CAS:Selective peptide agonist that mimics thrombin to activate PAR-1 receptor, enabling targeted receptor activation.Formula:C35H58N10O9Color and Shape:SolidMolecular weight:762.91Parstatin(human) TFA
Parstatin(human) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, effectively inhibits angiogenesis, as indicated by studies [1] [2].Formula:C193H331F3N64O55S3Color and Shape:SolidMolecular weight:4581.28
