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Protease-activated Receptor

Protease-activated Receptor

Protease-activated Receptor (PAR) inhibitors are compounds that target and inhibit the activity of PARs, a family of G-protein-coupled receptors that are activated by proteolytic cleavage. These receptors play a role in various physiological processes, including coagulation, inflammation, and tissue repair. PAR inhibitors are valuable tools for studying the mechanisms of these processes and their involvement in diseases such as cancer, cardiovascular disorders, and chronic inflammation. At CymitQuimica, we provide PAR inhibitors to aid your research in signal transduction, immune response, and therapeutic discovery.

Found 54 products of "Protease-activated Receptor"

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  • TRAP-6 amide TFA
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    TRAP-6 amide TFA

    CAS:
    <p>TRAP-6 amide TFA is a PAR-1 thrombin receptor agonist peptide.</p>
    Formula:C36H58F3N11O10
    Color and Shape:Solid
    Molecular weight:861.922

    Ref: TM-T38887

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    P4pal10 TFA

    <p>P4pal10 TFA, the TFA salt form of P4pal10, serves as an antagonist of the protease-activated receptor 4 (PAR4). This compound inhibits platelet aggregation and thrombin generation induced by tissue factor (TF), exhibiting anticoagulant and antithrombotic activities. Additionally, P4pal10 TFA alleviates carrageenan-induced edema and neutrophil infiltration, and ameliorates damage in rat myocardial ischemia/reperfusion (I/R) models.</p>
    Color and Shape:Odour Solid

    Ref: TM-TP2784

  • TRAP-5 amide
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    TRAP-5 amide

    CAS:
    <p>TRAP-5 amide is a peptide agonist for protease-activated receptor 1 (PAR 1) [1].</p>
    Formula:C30H51N9O6
    Color and Shape:Solid
    Molecular weight:633.78

    Ref: TM-T80111

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    PAR 4 (1-6) (TFA)

    <p>PAR 4 (1-6) TFA (GYPGQV TFA), a hexapeptide derived from protease-activated receptor 4 (PAR 4), serves as a specific agonist for PAR 4.</p>
    Formula:C28H41N7O9·xC2HF3O2
    Color and Shape:Solid

    Ref: TM-T75904

  • FLLRN
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    FLLRN

    CAS:
    <p>FLLRN is a biologically active peptide serving as a PAR1-specific antagonist.</p>
    Formula:C31H51N9O7
    Color and Shape:Solid
    Molecular weight:661.79

    Ref: TM-T78545

  • Parstatin(mouse)
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    Parstatin(mouse)

    CAS:
    <p>Peptide inhibits endothelial migration/proliferation (IC50 ~20μM), induces cell cycle arrest, triggers apoptosis, and has cardioprotective effects.</p>
    Formula:C189H326N58O57S3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4419.19

    Ref: TM-TP1966

  • YFLLRNP
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    YFLLRNP

    CAS:
    <p>YFLLRNP is a biologically active peptide functioning as a partial agonist of PAR-1, selectively activating the G12/13 signaling pathway.</p>
    Formula:C45H67N11O10
    Color and Shape:Solid
    Molecular weight:922.08

    Ref: TM-T80235

  • Parstatin(human)
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    Parstatin(human)

    CAS:
    <p>Cell-permeable PAR1-derived peptide; inhibits endothelial migration, proliferation (IC50 ~3μM), induces apoptosis, and has cardioprotective effects.</p>
    Formula:C191H330N64O53S3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4467.29

    Ref: TM-TP1965

  • 2-Furoyl-LIGRLO-amide
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    2-Furoyl-LIGRLO-amide

    CAS:
    <p>2-Furoyl-LIGRLO-amide TFA is a peptide that acts as a proteinase-activated receptor-2 (PAR2) agonist, and contains a furoyl group addition at its N-terminal.</p>
    Formula:C36H63N11O8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:777.95

    Ref: TM-TP1478

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    PAR650097

    <p>PAR650097 is a humanized monoclonal antibody targeting PAR2, used in migraine research.</p>
    Purity:96.67% (SEC-HPLC) - 98.83% (SEC-HPLC)
    Color and Shape:Liquid
    Molecular weight:145.5kDa

    Ref: TM-T77402

  • tcY-NH2
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    tcY-NH2

    CAS:
    <p>Selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.</p>
    Formula:C40H49N7O7
    Purity:98%
    Color and Shape:Solid
    Molecular weight:739.87

    Ref: TM-TP1925

  • PZ-128
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    PZ-128

    CAS:
    <p>PZ-128, a PAR1 antagonist, is used potentially for the treatment of thrombosis.</p>
    Formula:C55H99N13O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1086.46

    Ref: TM-T28477

  • FSLLRY-NH2
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    FSLLRY-NH2

    CAS:
    <p>PAR2 antagonist; counters taxol effects, PKC in mice; inhibits ERK, collagen in fibroblasts; lessens dermatophyte itch in mice.</p>
    Formula:C39H60N10O8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:796.97

    Ref: TM-TP1904

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    Protease-Activated Receptor-1, PAR-1 Agonist TFA

    <p>PAR-1 Agonist TFA: Selective peptide, mimics thrombin, activates PAR-1 receptor.</p>
    Color and Shape:Liquid

    Ref: TM-T36288

  • AY 254
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    AY 254

    CAS:
    <p>AY 254: Potent PAR2 agonist, ERK1/2 activation (EC50=2 nM), limits caspase 3/8, aids HT29 cell healing, boosts IL-8.</p>
    Formula:C30H49N9O6
    Color and Shape:Solid
    Molecular weight:631.779

    Ref: TM-T41189

  • Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2
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    Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2

    CAS:
    <p>Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biologically active peptide functioning as a selective agonist for Protease Activated Receptor 1 (PAR-1), a subtype</p>
    Formula:C42H63FN12O8
    Color and Shape:Solid
    Molecular weight:883.02

    Ref: TM-T80240

  • PAR-2 (1-6) (human)
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    PAR-2 (1-6) (human)

    CAS:
    <p>PAR-2 (1-6) (human) (SLIGKV), a peptide ligand, is a PAR-2 agonist [1] .</p>
    Formula:C28H53N7O8
    Color and Shape:Solid
    Molecular weight:615.76

    Ref: TM-T76650

  • SFNGGP-NH2
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    SFNGGP-NH2

    CAS:
    <p>SFNGGP-NH2 is a biologically active peptide that interacts with Protease-Activated Receptor 3 (PAR-3), a high-affinity thrombin receptor.</p>
    Formula:C25H36N8O8
    Color and Shape:Solid
    Molecular weight:576.6

    Ref: TM-T80234

  • Protease-Activated Receptor-1, PAR-1 Agonist
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    Protease-Activated Receptor-1, PAR-1 Agonist

    CAS:
    <p>Selective peptide agonist that mimics thrombin to activate PAR-1 receptor, enabling targeted receptor activation.</p>
    Formula:C35H58N10O9
    Color and Shape:Solid
    Molecular weight:762.91

    Ref: TM-T38836

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    Parstatin(human) TFA

    <p>Parstatin(human) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, effectively inhibits angiogenesis, as indicated by studies [1] [2].</p>
    Formula:C193H331F3N64O55S3
    Color and Shape:Solid
    Molecular weight:4581.28

    Ref: TM-T75873