Protease-activated Receptor
Protease-activated Receptor (PAR) inhibitors are compounds that target and inhibit the activity of PARs, a family of G-protein-coupled receptors that are activated by proteolytic cleavage. These receptors play a role in various physiological processes, including coagulation, inflammation, and tissue repair. PAR inhibitors are valuable tools for studying the mechanisms of these processes and their involvement in diseases such as cancer, cardiovascular disorders, and chronic inflammation. At CymitQuimica, we provide PAR inhibitors to aid your research in signal transduction, immune response, and therapeutic discovery.
Found 54 products of "Protease-activated Receptor"
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TRAP-6 amide
CAS:TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide.Formula:C34H57N11O8Color and Shape:SolidMolecular weight:747.899PAR-4 Agonist Peptide, amide
CAS:PAR-4 Agonist Peptide, amide (AY-NH2) is an agonist of proteinase-activated receptor-4 (PAR-4).Formula:C34H48N8O7Purity:98%Color and Shape:SolidMolecular weight:680.79Thrombin Receptor Activator for Peptide 5 (TRAP-5)
CAS:Thrombin Receptor Activator for Peptide 5 (TRAP-5) is also called Coagulation Factor II Receptor (1-5), used in the research of coronary heart disease (CHD).Formula:C30H50N8O7Purity:98%Color and Shape:SolidMolecular weight:634.77PAR650097
PAR650097 is a humanized monoclonal antibody targeting PAR2, used in migraine research.Purity:96.67% (SEC-HPLC) - 98.83% (SEC-HPLC)Color and Shape:LiquidMolecular weight:144.1 kDaPZ-128
CAS:PZ-128, a PAR1 antagonist, is used potentially for the treatment of thrombosis.Formula:C55H99N13O9Purity:98%Color and Shape:SolidMolecular weight:1086.46PAR-4 Agonist Peptide, amide acetate
PAR-4 Agonist Peptide, amide acetate is an agonist of proteinase-activated receptor-4 (PAR-4).Formula:C36H52N8O9Purity:98%Color and Shape:SolidMolecular weight:740.86Parstatin(mouse)
CAS:Peptide inhibits endothelial migration/proliferation (IC50 ~20μM), induces cell cycle arrest, triggers apoptosis, and has cardioprotective effects.Formula:C189H326N58O57S3Purity:98%Color and Shape:SolidMolecular weight:4419.19AC-264613
CAS:AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5.Formula:C19H18BrN3O2Purity:98%Color and Shape:SolidMolecular weight:400.28Parstatin(human)
CAS:Cell-permeable PAR1-derived peptide; inhibits endothelial migration, proliferation (IC50 ~3μM), induces apoptosis, and has cardioprotective effects.Formula:C191H330N64O53S3Purity:98%Color and Shape:SolidMolecular weight:4467.292-Furoyl-LIGRLO-amide
CAS:2-Furoyl-LIGRLO-amide TFA is a peptide that acts as a proteinase-activated receptor-2 (PAR2) agonist, and contains a furoyl group addition at its N-terminal.Formula:C36H63N11O8Purity:98%Color and Shape:SolidMolecular weight:777.95Parstatin(human) TFA
Parstatin(human) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, effectively inhibits angiogenesis, as indicated by studies [1] [2].Formula:C193H331F3N64O55S3Color and Shape:SolidMolecular weight:4581.28RAG8 peptide
RAG8 peptide is an antagonist of protease-activated receptor 4 (PAR 4), which inhibits late-stage platelet activation and reduces thrombosis without altering hemostasis or increasing bleeding risk. It is applicable in atherosclerosis research.Formula:C56H98N16O11Molecular weight:1170.7601tcY-NH2
CAS:Selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.Formula:C40H49N7O7Purity:98%Color and Shape:SolidMolecular weight:739.87FSLLRY-NH2
CAS:PAR2 antagonist; counters taxol effects, PKC in mice; inhibits ERK, collagen in fibroblasts; lessens dermatophyte itch in mice.Formula:C39H60N10O8Purity:98%Color and Shape:SolidMolecular weight:796.97Protease-Activated Receptor-1, PAR-1 Agonist TFA
PAR-1 Agonist TFA: Selective peptide, mimics thrombin, activates PAR-1 receptor.Color and Shape:LiquidAY 254
CAS:AY 254: Potent PAR2 agonist, ERK1/2 activation (EC50=2 nM), limits caspase 3/8, aids HT29 cell healing, boosts IL-8.
Formula:C30H49N9O6Color and Shape:SolidMolecular weight:631.779Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2
CAS:Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biologically active peptide functioning as a selective agonist for Protease Activated Receptor 1 (PAR-1), a subtypeFormula:C42H63FN12O8Color and Shape:SolidMolecular weight:883.02PAR-2 (1-6) (human)
CAS:PAR-2 (1-6) (human) (SLIGKV), a peptide ligand, is a PAR-2 agonist [1] .Formula:C28H53N7O8Color and Shape:SolidMolecular weight:615.76SFNGGP-NH2
CAS:SFNGGP-NH2 is a biologically active peptide that interacts with Protease-Activated Receptor 3 (PAR-3), a high-affinity thrombin receptor.Formula:C25H36N8O8Color and Shape:SolidMolecular weight:576.6Protease-Activated Receptor-1, PAR-1 Agonist
CAS:Selective peptide agonist that mimics thrombin to activate PAR-1 receptor, enabling targeted receptor activation.Formula:C35H58N10O9Color and Shape:SolidMolecular weight:762.91FLLRN
CAS:FLLRN is a biologically active peptide serving as a PAR1-specific antagonist.Formula:C31H51N9O7Color and Shape:SolidMolecular weight:661.79YFLLRNP
CAS:YFLLRNP is a biologically active peptide functioning as a partial agonist of PAR-1, selectively activating the G12/13 signaling pathway.Formula:C45H67N11O10Color and Shape:SolidMolecular weight:922.08TRAP-5 amide
CAS:TRAP-5 amide is a peptide agonist for protease-activated receptor 1 (PAR 1) [1].Formula:C30H51N9O6Color and Shape:SolidMolecular weight:633.78PAR 4 (1-6) (TFA)
PAR 4 (1-6) TFA (GYPGQV TFA), a hexapeptide derived from protease-activated receptor 4 (PAR 4), serves as a specific agonist for PAR 4.Formula:C28H41N7O9·xC2HF3O2Color and Shape:SolidP4pal10 TFA
P4pal10 TFA, the TFA salt form of P4pal10, serves as an antagonist of the protease-activated receptor 4 (PAR4). This compound inhibits platelet aggregation and thrombin generation induced by tissue factor (TF), exhibiting anticoagulant and antithrombotic activities. Additionally, P4pal10 TFA alleviates carrageenan-induced edema and neutrophil infiltration, and ameliorates damage in rat myocardial ischemia/reperfusion (I/R) models.Color and Shape:Odour SolidTRAP-6 amide TFA
CAS:TRAP-6 amide TFA is a PAR-1 thrombin receptor agonist peptide.Formula:C36H58F3N11O10Color and Shape:SolidMolecular weight:861.922TFLLR-NH2(TFA)
CAS:TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM. EC50: 1.9 μM (PAR1)Formula:C33H54F3N9O8Purity:98%Color and Shape:SolidMolecular weight:761.83SLIGRL-NH2
CAS:SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is a PAR-2 agonist that induces non-histaminergic pruritus.Formula:C29H56N10O7Purity:98.29%Color and Shape:SolidMolecular weight:656.82AZ3451
CAS:AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).Formula:C30H27BrN4O3Purity:98.12%Color and Shape:SolidMolecular weight:571.46PAR-2-IN-1
CAS:PAR-2-IN-1 (IUN76750) is a PAR- 2 signaling pathway inhibitor with anti-inflammatory and anticancer effects.
Formula:C12H14ClN3O2Purity:99.75%Color and Shape:SolidMolecular weight:267.71Vorapaxar
CAS:Vorapaxar (MK-5348) (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: 8.1 nM).Formula:C29H33FN2O4Purity:98.77% - 99.93%Color and Shape:SolidMolecular weight:492.58Ref: TM-T7013
1mg71.00€5mg138.00€10mg192.00€25mg326.00€50mg447.00€100mg642.00€200mg888.00€1mL*10mM (DMSO)152.00€Vorapaxar sulfate
CAS:Vorapaxar sulfate (Zontivity) is a potent and orally active thrombin receptor (PAR-1) antagonist.Formula:C29H35FN2O8SPurity:99.9% - >99.99%Color and Shape:SolidMolecular weight:590.66Ref: TM-T3098
1mg38.00€2mg49.00€5mg79.00€10mg119.00€25mg210.00€50mg354.00€100mg528.00€500mg1,159.00€1mL*10mM (DMSO)99.00€TFLLR-NH2 2TFA(197794-83-5(free base))
TFLLR-NH2 2TFA(197794-83-5(free base)) is an agonist of PAR1 (EC50 :1.9 μM).Formula:C35H55F6N9O10Purity:99.56%Color and Shape:SolidMolecular weight:875.87I-191
CAS:I-191 is a potent antagonist of protease-activated receptor 2 (PAR2), inhibits multiple signaling functions in human cancer cells.Formula:C23H26FN5O2Purity:99.8%Color and Shape:SolidMolecular weight:423.48TRAP-6
CAS:TRAP-6 (Thrombin Receptor Activator Peptide 6)(2TFA) is an agonist of protease-activated receptor 1 (PAR1).Formula:C34H56N10O9Purity:>99.99%Color and Shape:SolidMolecular weight:748.87Ref: TM-T7625
1mg40.00€2mg52.00€5mg88.00€10mg126.00€25mg274.00€50mg411.00€100mg550.00€200mg785.00€1mL*10mM (DMSO)126.00€PAR-4 Agonist Peptide, amide TFA
CAS:PAR-4 agonist peptide doesn't affect PAR-1/PAR-2; blocked by PAR-4 antagonist.Formula:C36H49F3N8O9Purity:99.72%Color and Shape:SolidMolecular weight:794.82Ref: TM-TP1065
1mg34.00€5mg92.00€10mg138.00€25mg225.00€50mg323.00€100mg467.00€200mg643.00€1mL*10mM (DMSO)131.00€Protease-Activated Receptor-1, PAR-1 Agonist acetate
PAR-1 Agonist acetate is a selective PAR-1 agonist that mimics thrombin action.Formula:C37H62N10O11Purity:98.1800%Color and Shape:SolidMolecular weight:822.95PAR-2 Activating Peptide acetate
PAR-2 Activating Peptide acetate (SLIGRL-NH2 acetate) is an agonist of Protease-Activated Receptor-2 (PAR-2).Formula:C31H60N10O9Purity:98.5% - 99.92%Color and Shape:SolidMolecular weight:716.88AC-55541
CAS:AC-55541 (AOB2796), a PAR2 agonist, activates PAR2 in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays.
Formula:C25H20BrN5O3Purity:98% - 99.33%Color and Shape:SolidMolecular weight:518.36LRGILS-NH2 acetate
LRGILS-NH2 acetate is a PAR-2-inactive reversed peptide.Formula:C29H56N10O7Purity:96.65%Color and Shape:SolidMolecular weight:656.82FSLLRY-NH2 TFA(245329-02-6 free base)
FSLLRY-NH2 TFA inhibits PAR2, reverses taxol-induced pain, and reduces itch in mice; blocks ERK and collagen in fibroblasts.Formula:C41H61F3N10O10Purity:99.32%Color and Shape:SolidMolecular weight:910.99tcY-NH2 TFA(327177-34-4 free base)
tcY-NH2 TFA is a selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.Formula:C42H50F3N7O9Purity:>99.99%Color and Shape:SolidMolecular weight:853.9Thrombin Receptor Activator for Peptide
Thrombin Receptor Activator (TRAP) or Coagulation Factor II (1-5), used in CHD research.Formula:C32H51F3N8O9Purity:99.88%Color and Shape:SolidMolecular weight:748.79Parmodulin 2
CAS:ML161 (Parmodulin 2) inhibits PAR1, blocking platelet activation and thrombin-induced activity (IC50: 0.26μM).Formula:C17H17BrN2O2Purity:97.35% - 99.95%Color and Shape:SolidMolecular weight:361.23Protease-Activated Receptor-4 diTFA
Protease-Activated Receptor-4 diTFA,2454 is the proteinase-activated receptor-4 (PAR4)agonistFormula:C37H48F6N8O11Purity:98.54%Color and Shape:SolidMolecular weight:894.81Ref: TM-T7740
1mg46.00€2mg57.00€5mg81.00€10mg131.00€25mg259.00€50mg389.00€100mg575.00€1mL*10mM (DMSO)161.00€Protease-Activated Receptor-2, amide
CAS:Protease-Activated Receptor-2, amide (SLIGKV-NH2) is an agonist of PAR2 (IC50 : 10.4 M)Formula:C28H54N8O7Purity:>99.99%Color and Shape:SolidMolecular weight:614.782-Furoyl-LIGRLO-amide TFA(729589-58-6 free base)
2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base) is a potent and selective protease-activated receptor 2 (PAR2) agonist.Formula:C38H64F3N11O10Purity:>99.99%Color and Shape:SolidMolecular weight:891.98VKGILS-NH2 Acetate
VKGILS-NH2 Acetate is a reversed amino acid sequence control peptide for SLIGKV-NH2, a protease-activated receptor 2 (PAR2) agonist.Formula:C30H58N8O9Purity:98.83%Color and Shape:SolidMolecular weight:674.83Ref: TM-T21699L
1mg33.00€2mg49.00€5mg62.00€10mg92.00€25mg155.00€50mg224.00€100mg331.00€200mg470.00€1mL*10mM (DMSO)92.00€ML-354
CAS:ML354 is a selective antagonist of PAR4 with an IC 50 of 140 nM [1].Formula:C16H14N2O3Purity:99.44%Color and Shape:SolidMolecular weight:282.29iso-TRAP-6
CAS:iso-TRAP-6 (iso-SFLLRN), a hexapeptide made from isoserine instead of serine, is a PAR1 agonist that activates platelets via PAR-1.Formula:C34H56N10O9Purity:98.55%Color and Shape:SolidMolecular weight:748.87PAR4 antagonist 3
CAS:PAR4 antagonist3 (Compound 36) is a selective antagonist of protease-activated receptor 4 (PAR4). It exhibits antiplatelet activity with an IC50 of 26.1 nM and enhances metabolic stability in human liver microsomes, with a half-life (T1/2) of 97.6 minutes.Formula:C22H16FN3O5SMolecular weight:453.44PAR-2-IN-2
CAS:PAR-2-IN-2 (compound P-596) is an inhibitor of protease-activated receptor 2 (PAR-2), with an IC50 of 10.79 μM for SLIGKV and an IC50 greater than 200 μM for trypsin.Formula:C25H20F3N5O2Color and Shape:SolidMolecular weight:479.454BMS-986141
CAS:BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614Formula:C27H23N5O5S2Purity:98.43% - 99.26%Color and Shape:SolidMolecular weight:561.63Protease-Activated Receptor-4
CAS:Protease-Activated Receptor-4 (PAR4) is a proteinase-activated receptor-4 agonist used in antiplatelet therapy.Formula:C33H46N8O7Purity:98%Color and Shape:SolidMolecular weight:666.77
