Wnt/beta-catenin
Wnt/beta-catenin inhibitors are compounds that target and inhibit the Wnt/beta-catenin signaling pathway, which is crucial for the regulation of embryonic development, cell proliferation, and stem cell maintenance. Dysregulation of this pathway is linked to various cancers and degenerative diseases. Inhibitors of Wnt/beta-catenin signaling are valuable in research focused on understanding the role of this pathway in disease and developing targeted therapies. At CymitQuimica, we offer Wnt/beta-catenin inhibitors to support your research in stem cell biology, developmental biology, and cancer research.
Found 80 products for "Wnt/beta-catenin".
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5T4_0108
5T4_0108 (MEDI0641 antibody) is a human monoclonal antibody (mAb) that targets TPBG. It is applicable for research in breast and prostate cancers.ZW4864 free base
CAS:ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor.Formula:C33H42N6O3Purity:99.81%Color and Shape:SolidMolecular weight:570.725Anti-Human LGR5/GPR49 Antibody (18G7H6A3)
Anti-LGR5/GPR49 Antibody (18G7H6A3) is a human-derived monoclonal antibody (mAb) that targets LGR5/GPR49. The recommended isotype control for this antibody is Human IgG1 kappa.Wnt pathway activator 2
CAS:Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.Formula:C17H15NO4Purity:99.41%Color and Shape:White SolidMolecular weight:297.3053GB1874
CAS:GB1874 is an inhibitor of the Wnt pathway targeting β-catenin-TCF4 protein-protein interaction (PPI), affecting proliferation in Wnt-dependent CRC cells.Formula:C24H27N3O2SColor and Shape:Yellow SolidMolecular weight:421.555PF-04840082
PF-04840082 is a humanized IgG2 monoclonal antibody inhibitor targeting Dkk-1. It binds to the physiological antagonist (Dkk-1) of the Wnt/LRP5 signaling pathway, which enhances bone mass and density by activating osteoblasts. PF-04840082 is applicable for osteoporosis research.TNKS-IN-1
CAS:TNKS-IN-1 is a tankyrase inhibitor used in Wnt/β-catenin signaling and colorectal cancer research models.Formula:C18H18N2OPurity:99.98%Color and Shape:SolidMolecular weight:278.3483FJ9
CAS:FJ9 is an FZD7 inhibitor that disrupts the protein interaction between Frz7 and the DVL PDZ domain and induces apoptosis in melanoma and non-small cell lung cancer cell lines.Formula:C23H27NO3Purity:99.41% - 99.60%Color and Shape:White SolidMolecular weight:365.47Wnt/β-catenin agonist 4
CAS:Wnt/β-catenin agonist 4 is an agonist of Wnt that activates Wnt/β-catenin signaling and directs signaling.Formula:C16H15FN4O2Purity:99.96%Color and Shape:SolidMolecular weight:314.3143FzM1
CAS:FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2)Formula:C21H16N2O2SPurity:99.37% - 99.89%Color and Shape:Yellow SolidMolecular weight:360.429FzM1.8
CAS:FzM1.8: allosteric FZD4 agonist, pEC50=6.4; boosts TCF/LEF, activates WNT/β-catenin with no WNT needed.Formula:C18H14N2O4Purity:99.89%Color and Shape:SolidMolecular weight:322.3148JW 67
CAS:JW 67 is an inhibitor of canonical Wnt pathway signaling.Formula:C21H18N2O6Purity:99.02%Color and Shape:SolidMolecular weight:394.38Pterostilbene-isothiocyanate
CAS:Pterostilbene-isothiocyanate is a Wnt/β-catenin inhibitor; disrupts β-catenin/TCF-4 binding; inhibits osteosarcoma cell proliferation.Formula:C18H19N3O3SPurity:99.81%Color and Shape:Yellow SolidMolecular weight:357.43NRX-2663
CAS:NRX-2663 is an enhancer of β-catenin/SCFβ-TrCP interaction (Kd = 54.8 nM, EC50 = 22.9 nM), promoting β-catenin ubiquitination and degradation.Formula:C20H13F3N2O5Color and Shape:SolidMolecular weight:418.32281(R),2(S)-epoxy Cannabidiol
CAS:1(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analog of phytocannabinoids, exhibiting significant inhibitory activity on the Wnt/β-catenin pathway. It holds potential for research as a neuroprotective agent.Formula:C21H30O3Color and Shape:SolidMolecular weight:330.46β-Catenin modulator-8
CAS:β-Catenin modulator-8 (Compound Ⅸa) is a specific β-catenin modulator for use in cancer research.Formula:C17H20N2O2SPurity:99.97%Color and Shape:SolidMolecular weight:316.42BMD4503-1
CAS:BMD4503-1 is a quinoxaline derivative that can inhibit the interaction between LRP5/6 and sclerostin, thereby modulating the Wnt signaling pathway.Formula:C22H19N5O3SMolecular weight:433.483E722-2648
CAS:E722-2648 is a potent inhibitor of the β-catenin/BCL9 complex, specifically preventing its formation and inhibiting Wnt activity. It disrupts cholesterol homeostasis through increased cholesterol esterification and accumulation of lipid droplets. Additionally, E722-2648 exhibits antitumor activity [1].Formula:C21H30N2OS2Molecular weight:390.61Basroparib
CAS:Basroparib is a TNKS1/2 inhibitor that stabilizes AXIN, blocks Wnt/β-catenin signaling, and shows antitumor activity in colorectal cancer xenografts.Formula:C18H21F2N7O3Purity:98.24%Color and Shape:SolidMolecular weight:421.40NRX-103095
CAS:NRX-103095 increases β-catenin binding to SCFβ-TrCP E3 ligase; EC50 is 163 nM for pSer33/Ser37 affinity boost.Formula:C22H16Cl2F3N3O3SPurity:99.85% - 99.95%Color and Shape:SolidMolecular weight:530.347
