Stem Cells
Stem cell inhibitors are compounds that specifically target stem cells and their signaling pathways, affecting their ability to self-renew and differentiate. These inhibitors are crucial in research focused on controlling stem cell behavior, understanding developmental processes, and developing therapies for diseases like cancer, where stem cells are thought to play a key role. At CymitQuimica, we offer a variety of stem cell inhibitors to support your research in regenerative medicine, developmental biology, and oncology.
Found 234 products of "Stem Cells"
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Trevogrumab
CAS:Trevogrumab is a human monoclonal antibody that inhibits myostatin (GDF8) to promote muscle growth, and is under research for treating age-related muscle loss (sarcopenia).Purity:95% - 97.6% (SDS-PAGE); 95.9% (SEC-HPLC)Color and Shape:LiquidMolecular weight:144.02 kDaTEAD-IN-6
CAS:TEAD-IN-6 (Example 11-1) is a TEAD modulator that inhibits the YAP1/TAZ-TEAD interaction, and has applications in cancer research [1].Formula:C19H17F3N4O3SPurity:98%Color and Shape:SolidMolecular weight:438.42VT103
CAS:VT103, an oral TEAD1 palmitoylation inhibitor, shows promise against various cancers by disrupting YAP/TAZ-TEAD interactions.Formula:C18H17F3N4O2SPurity:99.58%Color and Shape:SolidMolecular weight:410.41Ref: TM-T62077
1mg112.00€5mg268.00€10mg424.00€25mg735.00€50mg1,071.00€100mg1,549.00€200mg2,097.00€1mL*10mM (DMSO)295.00€JAK3/BTK-IN-2
CAS:JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.
Formula:C25H32N8O2Purity:99.64% - 99.87%Color and Shape:SolidMolecular weight:476.57Aβ42-IN-2
CAS:Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].Formula:C24H26N6O2Purity:98.09% - 99.87%Color and Shape:SolidMolecular weight:430.5Ref: TM-T9641
1mg42.00€5mg94.00€10mg134.00€25mg215.00€50mg304.00€100mg420.00€200mg582.00€1mL*10mM (DMSO)93.00€TEAD-IN-2
CAS:TEAD-IN-2 is a potent and bifunctional TEAD inhibitor to induce TEAD protein degradation via the ubiquitination pathway, with anticancer potential.Formula:C16H18BrF3N2OColor and Shape:SolidMolecular weight:391.23CJJ300
CAS:CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, and halts cell migration.Formula:C30H33N3Purity:99.51%Color and Shape:SolidMolecular weight:435.6Ref: TM-T62483
2mg35.00€5mg51.00€10mg90.00€25mg164.00€50mg259.00€100mg393.00€200mg552.00€1mL*10mM (DMSO)57.00€CAY10746
CAS:CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.Formula:C26H23N3O5Purity:99.71%Color and Shape:SolidMolecular weight:457.48Ref: TM-T36196
2mg35.00€5mg57.00€10mg90.00€25mg182.00€50mg274.00€100mg434.00€200mg582.00€1mL*10mM (DMSO)57.00€BRD0209
CAS:BRD0209 is a highly selective and potent GSK3 inhibitor.
Formula:C22H25N3OPurity:99.92%Color and Shape:SolidMolecular weight:347.45AF-2112
AF-2112, a TEAD inhibitor derived from Flufenamic acid, significantly diminishes the expression of CTGF, Cyr61, Axl, and NF2.
Formula:C21H18FNO3Purity:98%Color and Shape:SolidMolecular weight:351.37Chromenone 1
CAS:Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).Formula:C18H10F3N3O2Purity:99.83% - 99.93%Color and Shape:SolidMolecular weight:357.29Ref: TM-T61301
1mg52.00€5mg111.00€10mg162.00€25mg235.00€50mg330.00€100mg452.00€200mg607.00€1mL*10mM (DMSO)113.00€JA310
CAS:JA310 is a highly selective inhibitor of the MST3 kinase, demonstrating significant cellular potency with an EC50 value of 106 nM [1].Formula:C17H19N7OColor and Shape:SolidMolecular weight:337.38(Rac)-SIS3 free base
CAS:SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.Formula:C28H27N3O3Purity:98%Color and Shape:SolidMolecular weight:453.53TGFβRI-IN-1
CAS:TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII,Formula:C20H14D3N5O2Purity:98%Color and Shape:SolidMolecular weight:362.4Wnt pathway activator 2
CAS:Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.Formula:C17H15NO4Purity:99.41%Color and Shape:SolidMolecular weight:297.31Ref: TM-T13345
1mg52.00€5mg100.00€10mg160.00€25mg329.00€50mg533.00€100mg770.00€200mg1,035.00€1mL*10mM (DMSO)111.00€GSK-3β inhibitor 12
CAS:GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3βFormula:C14H13N3OSPurity:98.58%Color and Shape:SolidMolecular weight:271.34MSC-4106
CAS:MSC-4106, an oral YAP/TAZ-TEAD inhibitor, blocks TEAD1/3 auto-palmitoylation and suppresses NCI-H226 tumors.
Formula:C18H12F3N3O2Purity:99.89%Color and Shape:SoildMolecular weight:359.3XL413 xHCl
CAS:BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215
Formula:C14H12ClN3O2·xHClPurity:99.37% - 99.67%Color and Shape:SolidMolecular weight:326.18IHMT-MST1-58
CAS:IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity.
Formula:C21H22N6O3SPurity:98.31% - 99.92%Color and Shape:SolidMolecular weight:438.5BIP-135
CAS:BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.
Formula:C21H13BrN2O3Purity:99.93%Color and Shape:SolidMolecular weight:421.24GSK-3β inhibitor 2
CAS:GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50
Formula:C14H14N4O3SPurity:99.08%Color and Shape:SolidMolecular weight:318.35ABC1183
CAS:ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.
Formula:C18H14N4OSPurity:98.92%Color and Shape:SolidMolecular weight:334.39LEQ506
CAS:LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.Formula:C25H32N6OPurity:99.76%Color and Shape:SolidMolecular weight:432.56Ref: TM-T11838
1mg64.00€5mg145.00€10mg210.00€25mg338.00€50mg455.00€100mg610.00€200mg823.00€1mL*10mM (DMSO)160.00€CID-5056270
CAS:CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma
Formula:C17H13N3O3SPurity:99.6%Color and Shape:SolidMolecular weight:339.37GSK-3 Inhibitor XIII
CAS:GSK-3 InhibitorXIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.Formula:C18H15N5Purity:99.85% - 99.86%Color and Shape:SolidMolecular weight:301.35Ref: TM-T78578
1mg106.00€5mg243.00€10mg437.00€25mg934.00€50mg1,283.00€100mg1,730.00€200mg2,337.00€1mL*10mM (DMSO)251.00€GSK-3β inhibitor 11
CAS:GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM.
Formula:C20H15N3O4SPurity:97.33%Color and Shape:SolidMolecular weight:393.42SJ000063181
CAS:SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.
Formula:C14H14ClFN2O2Purity:99.94%Color and Shape:SolidMolecular weight:296.72FzM1
CAS:FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2)Formula:C21H16N2O2SPurity:99.37% - 99.89%Color and Shape:SolidMolecular weight:360.43Ref: TM-T24076
1mg42.00€5mg64.00€10mg99.00€25mg188.00€50mg328.00€100mg528.00€500mg1,130.00€1mL*10mM (DMSO)62.00€TT-10
CAS:TT-10 (TAZ-K) activates YAP-TEAD; useful in heart disease with cardiomyocyte loss research.
Formula:C11H10FN3OS2Purity:99.29%Color and Shape:SolidMolecular weight:283.35JAK1-IN-8
CAS:JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).
Formula:C22H23FN4O3SPurity:98.4%Color and Shape:SolidMolecular weight:442.51LM-41
CAS:LM-41 is a TEAD binding agent with potential anticancer activity for the study of breast cancer.Formula:C19H14FNO2Purity:99.73%Color and Shape:SolidMolecular weight:307.32SWTX-143
CAS:SWTX-143, a novel covalent inhibitor, specifically and irreversibly binds to the palmitoylation pocket of all four TEAD isoforms, inhibiting the transcriptionalFormula:C19H18F3N3OPurity:98%Color and Shape:SolidMolecular weight:361.36ABBV-712
CAS:ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseases
Formula:C24H28N4O5Purity:98%Color and Shape:SolidMolecular weight:452.5ML115
CAS:ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.Formula:C15H15ClN2O4Purity:99.97%Color and Shape:SolidMolecular weight:322.74Ref: TM-T35544
1mg95.00€5mg227.00€10mg359.00€25mg630.00€50mg882.00€100mg1,188.00€200mg1,596.00€500mg2,357.00€1mL*10mM (DMSO)251.00€TGFβ-IN-5
CAS:TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.Formula:C20H16N4Purity:99.29% - 99.62%Color and Shape:SolidMolecular weight:312.37ROCK2-IN-6 hydrochloride
CAS:ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。Formula:C26H22ClF2N7OPurity:98%Color and Shape:SolidMolecular weight:521.95DT-6
CAS:DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing
Formula:C89H130N20O29S2Purity:98%Color and Shape:SolidMolecular weight:2008.23TM2 TEAD inhibitor
CAS:TM2 TEAD inhibitor, a robust and reversible inhibitor of the TEA domain transcription factor, presents dual inhibitory concentrations (IC50) of 38 nM for TEAD4Formula:C26H33N3O3Purity:99.91%Color and Shape:SolidMolecular weight:435.57Stafib-2
CAS:Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,
Formula:C28H26N2O12P2Purity:98.48%Color and Shape:SolidMolecular weight:644.463,7-DMF
CAS:3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation.Formula:C17H14O4Purity:98%Color and Shape:SolidMolecular weight:282.29BRD5648
CAS:BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.Formula:C20H23N3OPurity:99.89%Color and Shape:SolidMolecular weight:321.42Myristoyl tetrapeptide-12
CAS:Myristoyl Tetrapeptide-12 activates SMAD2 and facilitates the association of SMAD3 with DNA, promoting eyelash hair growth [1] [2].Formula:C32H63N7O5Purity:98%Color and Shape:SolidMolecular weight:625.89TP0427736
CAS:TP0427736: ALK5 inhibitor, IC50=2.72 nM, 300x > ALK3 selectivity; counters TGF-β in human cells, extends anagen in mice.Formula:C14H10N4S2Purity:97.26%Color and Shape:SolidMolecular weight:298.39YAP-TEAD-IN-2
CAS:YAP-TEAD-IN-2 (compound 6) serves as a potent inhibitor of the YAP-TEAD protein-protein interaction (PPI), demonstrating an inhibitory concentration 50 (IC50)Formula:C25H24ClFN2O4Purity:98%Color and Shape:SolidMolecular weight:470.92ROCK-IN-1
CAS:ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurologicalFormula:C20H18FN3OPurity:>99.99%Color and Shape:SolidMolecular weight:335.37GNE-7883
CAS:GNE-7883 is an inhibitor targeting TEAD transcription factor, inhibits cell proliferation and suppresses YAP/TAZ activation, and can be used to study YAP/TAZ-dependent tumors.Formula:C28H29FN6O2Purity:97.61%Color and Shape:SolidMolecular weight:500.57Ref: TM-T78558
1mg116.00€5mg283.00€10mg455.00€25mg747.00€50mg1,026.00€100mg1,444.00€200mg1,882.00€1mL*10mM (DMSO)310.00€YAP/TAZ inhibitor-3
CAS:YAP/TAZ inhibitor-3 (Compound 24) is a YAP/TAZ inhibitor applicable for relevant research within the life sciences field.Formula:C21H18F3NO3Purity:99.63%Color and Shape:SolidMolecular weight:389.37Ref: TM-T87651
1mg90.00€5mg215.00€10mg344.00€25mg695.00€50mg1,108.00€100mg1,791.00€200mg2,412.00€1mL*10mM (DMSO)236.00€Casein kinase 1δ-IN-13
CAS:Casein kinase1δ-IN-13 (compound 401) is an inhibitor of Casein kinase1δ. It is utilized in the research of neurodegenerative diseases.Formula:C15H13N3O2SColor and Shape:SolidMolecular weight:299.35WZ-2-033
CAS:WZ-2-033 is a potent STAT3 inhibitor. It inhibits proliferation, colony survival, migration, and invasion of MDA-MB-231, HCC70, and MDA-MB231-4175 cells, with IC50 values of 0.7, 1.3, and 1.3 μM respectively.Formula:C25H18F3N3O4SColor and Shape:SolidMolecular weight:513.49Kartogenin sodium
CAS:Kartogenin (KGN) sodium acts as an inducer of chondrogenic tissue formation (EC 50: 100 nM). It promotes chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and modulating the CBFβ-RUNX1 transcriptional program. Additionally, Kartogenin sodium aids tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. It is extensively utilized in cell-free therapies for cartilage regeneration and protection, tendon-bone healing, wound healing, and limb development. The compound is also vital for cartilage repair, coordinating limb development, and osteoarthritis (OA) research [1] [2] [3] [4].Formula:C20H14NNaO3Color and Shape:SolidMolecular weight:339.32
