Gamma-secretase
Gamma-Secretase inhibitors are compounds that target the gamma-secretase enzyme complex, which is involved in the cleavage of amyloid precursor protein (APP) to produce beta-amyloid peptides. These peptides can aggregate to form amyloid plaques, a hallmark of Alzheimer's disease. By inhibiting gamma-secretase, these compounds aim to reduce the production of beta-amyloid and its accumulation in the brain, making them a key focus in Alzheimer's disease research. At CymitQuimica, we offer gamma-secretase inhibitors to support your research in amyloid biology, Alzheimer's therapy, and neurodegenerative diseases.
Read more
CB-103
CAS:218457-67-1
CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.
Formula:
C15H18N2O
Purity:
99.44%
Color and Shape:
Solid
Molecular weight:
242.32
Ref: TM-T12246
| 100mg | 39.00 € | ||
| 200mg | 52.00 € | ||
| 1mL*10mM (DMSO) | 34.00 € |
Estimated delivery in United States, on Wednesday 30 Apr 2025
CIA-1 (Free base)
CAS:452087-38-6
CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor …
Formula:
C17H19N3O2S
Purity:
99%
Color and Shape:
Liquid
Molecular weight:
329.42
Ref: TM-T71534L
| 1mg | 57.00 € | ||
| 5mg | 120.00 € | ||
| 10mg | 187.00 € | ||
| 25mg | 376.00 € | ||
| 50mg | 588.00 € | ||
| 100mg | 905.00 € |
Estimated delivery in United States, on Friday 2 May 2025
Rovalpituzumab
CAS:1613313-01-1
Rovalpituzumab: humanized antibody against DLL3, forms ADCs, treats small cell lung cancer.
Purity:
> 95%
Color and Shape:
Liquid
Molecular weight:
145.02 kDa
Ref: TM-T76698
| 1mg | 170.00 € | ||
| 5mg | 449.00 € | ||
| 10mg | 717.00 € | ||
| 25mg | 1,111.00 € | ||
| 50mg | 1,491.00 € | ||
| 100mg | 2,015.00 € |
Estimated delivery in United States, on Friday 2 May 2025
Demcizumab
CAS:1243262-17-0
Demcizumab (OMP 21M18), an anti-DLL4 antibody, inhibits the Notch pathway and fights various cancers solo …
Purity:
> 95%
Color and Shape:
Liquid
Molecular weight:
145.34 kDa
Ref: TM-T76788
| 1mg | 354.00 € | ||
| 5mg | 887.00 € | ||
| 10mg | 1,415.00 € |
Estimated delivery in United States, on Friday 2 May 2025
BMS-906024
CAS:1401066-79-2
BMS-906024 (Osugacestat) is a gamma secretase inhibitor, a Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity.
Formula:
C26H26F6N4O3
Purity:
100% - 99.87%
Color and Shape:
Solid
Molecular weight:
556.5
Ref: TM-T14680
| 1mg | 537.00 € | ||
| 2mg | 748.00 € | ||
| 5mg | 1,121.00 € | ||
| 10mg | 1,700.00 € | ||
| 25mg | 2,547.00 € | ||
| 50mg | 3,440.00 € | ||
| 100mg | 4,636.00 € |
Estimated delivery in United States, on Friday 2 May 2025
5β-Cholanic acid
CAS:546-18-9
5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.
Formula:
C24H40O2
Purity:
99.89%
Color and Shape:
Soild
Molecular weight:
360.57
Ref: TM-T88859
| 5mg | 48.00 € | ||
| 10mg | 69.00 € | ||
| 25mg | 88.00 € | ||
| 1mL*10mM (DMSO) | 75.00 € |
Estimated delivery in United States, on Friday 2 May 2025
RBPJ Inhibitor-1
CAS:2682114-39-0
RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively …
Formula:
C17H14FN3O2
Purity:
99.58%
Color and Shape:
Soild
Molecular weight:
311.31
Ref: TM-T35566
| 1mg | 40.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 88.00 € | ||
| 10mg | 137.00 € | ||
| 25mg | 227.00 € | ||
| 50mg | 393.00 € | ||
| 100mg | 567.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Friday 2 May 2025
Brontictuzumab
CAS:1447814-75-6
Brontictuzumab (OMP 52M5) is an anti-Notch1 monoclonal antibody with antitumor activity that inhibits tumor cell …
Color and Shape:
Liquid
Ref: TM-T76785
| 1mg | 283.00 € | ||
| 5mg | 737.00 € | ||
| 10mg | 1,169.00 € | ||
| 25mg | 1,738.00 € | ||
| 50mg | 2,357.00 € | ||
| 100mg | 3,163.00 € |
Estimated delivery in United States, on Friday 2 May 2025
γ-Secretase modulator 13
CAS:1353570-40-7
γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that can be used to study Alzheimer's …
Formula:
C22H23FN6S
Purity:
99.68%
Color and Shape:
Liquid
Molecular weight:
422.52
Ref: TM-T62263
| 1mg | 279.00 € | ||
| 5mg | 685.00 € | ||
| 10mg | 938.00 € | ||
| 25mg | 1,444.00 € | ||
| 50mg | 1,882.00 € | ||
| 100mg | 2,375.00 € |
Estimated delivery in United States, on Monday 5 May 2025
RO7185876
CAS:2226038-71-5
RO7185876 is a selective gamma secretase modulator, which can be used in the study of …
Formula:
C25H28F3N7
Purity:
98.63%
Color and Shape:
Liquid
Molecular weight:
483.532
Ref: TM-T39702
| 1mg | 279.00 € | ||
| 5mg | 685.00 € | ||
| 10mg | 938.00 € | ||
| 25mg | 1,444.00 € | ||
| 50mg | 1,882.00 € |
Estimated delivery in United States, on Monday 5 May 2025
Enoticumab
CAS:1192578-27-0
Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits cancer …
Color and Shape:
Liquid
Ref: TM-T80615
| 1mg | 250.00 € | ||
| 5mg | 755.00 € | ||
| 10mg | 1,198.00 € | ||
| 25mg | 1,776.00 € | ||
| 50mg | 2,395.00 € |
Estimated delivery in United States, on Monday 5 May 2025
Legumain inhibitor 1
CAS:2361157-34-6
Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity …
Formula:
C23H25N5O4S
Purity:
98.14%
Color and Shape:
Liquid
Molecular weight:
467.54
Ref: TM-T39905
| 1mg | 284.00 € |
Estimated delivery in United States, on Monday 5 May 2025
γ-secretase modulator 3
CAS:1431697-84-5
Gamma-secretase modulator 3 (γ-secretase modulator 3) is a γ-secretase modulator that reduces Aβ production.
Formula:
C24H23FN4OS
Purity:
98%
Color and Shape:
Solid
Molecular weight:
434.53
Ref: TM-T11360
| 2mg | 329.00 € | ||
| 5mg | To inquire | ||
| 10mg | To inquire |
Estimated delivery in United States, on Monday 5 May 2025
IMR-1A
CAS:331862-41-0
IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting …
Formula:
C13H11NO5S2
Purity:
97.1% - 99.06%
Color and Shape:
Solid
Molecular weight:
325.36
Ref: TM-T3540
| 1mg | 74.00 € | ||
| 5mg | 160.00 € | ||
| 10mg | 250.00 € | ||
| 25mg | 374.00 € | ||
| 50mg | 502.00 € | ||
| 100mg | 755.00 € | ||
| 1mL*10mM (DMSO) | 164.00 € |
Estimated delivery in United States, on Wednesday 7 May 2025
IMR-1
CAS:310456-65-6
IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of …
Formula:
C15H15NO5S2
Purity:
97.96% - 98.38%
Color and Shape:
Solid
Molecular weight:
353.41
Ref: TM-T6861
| 5mg | 35.00 € | ||
| 10mg | 52.00 € | ||
| 25mg | 101.00 € | ||
| 50mg | 177.00 € | ||
| 100mg | 293.00 € | ||
| 200mg | 423.00 € | ||
| 1mL*10mM (DMSO) | 58.00 € |
Estimated delivery in United States, on Wednesday 7 May 2025
LY900009
CAS:209984-68-9
LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase …
Formula:
C23H27N3O4
Purity:
97.07%
Color and Shape:
Solid
Molecular weight:
409.48
Ref: TM-T9015
| 1mg | 38.00 € | ||
| 5mg | 85.00 € | ||
| 10mg | 118.00 € | ||
| 25mg | 207.00 € | ||
| 50mg | 306.00 € | ||
| 100mg | 444.00 € | ||
| 200mg | 622.00 € | ||
| 1mL*10mM (DMSO) | 93.00 € |
Estimated delivery in United States, on Wednesday 7 May 2025
JLK6
CAS:62252-26-0
JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling
Formula:
C10H8ClNO3
Purity:
96.50%
Color and Shape:
Solid
Molecular weight:
225.63
Ref: TM-T21890
| 1mg | 131.00 € | ||
| 5mg | 259.00 € | ||
| 10mg | 371.00 € | ||
| 25mg | 622.00 € | ||
| 50mg | 885.00 € | ||
| 100mg | 1,206.00 € | ||
| 500mg | 2,403.00 € | ||
| 1mL*10mM (DMSO) | 271.00 € |
Estimated delivery in United States, on Wednesday 7 May 2025
FLI-06
CAS:313967-18-9
FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).
Formula:
C25H30N2O5
Purity:
100% - ≥98%
Color and Shape:
Solid
Molecular weight:
438.52
Ref: TM-T3075
| 1mg | 35.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 74.00 € | ||
| 10mg | 99.00 € | ||
| 25mg | 172.00 € | ||
| 50mg | 311.00 € | ||
| 100mg | 542.00 € | ||
| 500mg | 1,188.00 € | ||
| 1mL*10mM (DMSO) | 82.00 € |
Estimated delivery in United States, on Wednesday 7 May 2025
ELN318463 racemate
CAS:851599-82-1
ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor …
Formula:
C19H20BrClN2O3S
Purity:
99.73%
Color and Shape:
Solid
Molecular weight:
471.8
Ref: TM-T11178L
| 1mg | 162.00 € | ||
| 5mg | 391.00 € | ||
| 10mg | 615.00 € | ||
| 25mg | 907.00 € | ||
| 50mg | 1,235.00 € | ||
| 100mg | 1,663.00 € | ||
| 1mL*10mM (DMSO) | 447.00 € |
Estimated delivery in United States, on Wednesday 18 Jun 2025
Aβ42-IN-2
CAS:1914989-80-2
Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ …
Formula:
C24H26N6O2
Purity:
100% - 99.49%
Color and Shape:
Liquid
Molecular weight:
430.5
Ref: TM-T9641
| 1mg | 42.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 134.00 € | ||
| 25mg | 215.00 € | ||
| 50mg | 304.00 € | ||
| 100mg | 420.00 € | ||
| 200mg | 582.00 € | ||
| 1mL*10mM (DMSO) | 93.00 € |
Estimated delivery in United States, on Wednesday 18 Jun 2025
