Gamma-secretase
Gamma-Secretase inhibitors are compounds that target the gamma-secretase enzyme complex, which is involved in the cleavage of amyloid precursor protein (APP) to produce beta-amyloid peptides. These peptides can aggregate to form amyloid plaques, a hallmark of Alzheimer's disease. By inhibiting gamma-secretase, these compounds aim to reduce the production of beta-amyloid and its accumulation in the brain, making them a key focus in Alzheimer's disease research. At CymitQuimica, we offer gamma-secretase inhibitors to support your research in amyloid biology, Alzheimer's therapy, and neurodegenerative diseases.
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CB-103
CAS:218457-67-1
CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.
Formula:
C15H18N2O
Purity:
99.44%
Color and Shape:
Solid
Molecular weight:
242.32
Ref: TM-T12246
| 100mg | 39.00 € | ||
| 200mg | 52.00 € | ||
| 1mL*10mM (DMSO) | 34.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Brontictuzumab
CAS:1447814-75-6
Brontictuzumab (OMP 52M5) is an anti-Notch1 monoclonal antibody with antitumor activity that inhibits tumor cell …
Color and Shape:
Liquid
Ref: TM-T76785
| 1mg | 278.00 € | ||
| 5mg | 724.00 € | ||
| 10mg | 1,148.00 € | ||
| 25mg | 1,708.00 € | ||
| 50mg | 2,315.00 € | ||
| 100mg | 3,108.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Demcizumab
CAS:1243262-17-0
Demcizumab (OMP 21M18), an anti-DLL4 antibody, inhibits the Notch pathway and fights various cancers solo …
Purity:
> 95%
Color and Shape:
Liquid
Molecular weight:
145.34 kDa
Ref: TM-T76788
| 1mg | 347.00 € | ||
| 5mg | 869.00 € | ||
| 10mg | 1,392.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
BMS-906024
CAS:1401066-79-2
BMS-906024 (Osugacestat) is a gamma secretase inhibitor, a Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity.
Formula:
C26H26F6N4O3
Purity:
100% - 99.87%
Color and Shape:
Solid
Molecular weight:
556.5
Ref: TM-T14680
| 1mg | 533.00 € | ||
| 2mg | 743.00 € | ||
| 5mg | 1,113.00 € | ||
| 10mg | 1,688.00 € | ||
| 25mg | 2,527.00 € | ||
| 50mg | 3,413.00 € | ||
| 100mg | 4,601.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
Rovalpituzumab
CAS:1613313-01-1
Rovalpituzumab: humanized antibody against DLL3, forms ADCs, treats small cell lung cancer.
Purity:
> 95%
Color and Shape:
Liquid
Molecular weight:
145.02 kDa
Ref: TM-T76698
| 1mg | 171.00 € | ||
| 5mg | 441.00 € | ||
| 10mg | 702.00 € | ||
| 25mg | 1,093.00 € | ||
| 50mg | 1,458.00 € | ||
| 100mg | 1,968.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
RBPJ Inhibitor-1
CAS:2682114-39-0
RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively …
Formula:
C17H14FN3O2
Purity:
99.58%
Color and Shape:
Soild
Molecular weight:
311.31
Ref: TM-T35566
| 1mg | 40.00 € | ||
| 2mg | 53.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 134.00 € | ||
| 25mg | 226.00 € | ||
| 50mg | 390.00 € | ||
| 100mg | 562.00 € | ||
| 1mL*10mM (DMSO) | 87.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
CIA-1 (Free base)
CAS:452087-38-6
CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor …
Formula:
C17H19N3O2S
Purity:
99%
Color and Shape:
Liquid
Molecular weight:
329.42
Ref: TM-T71534L
| 1mg | 56.00 € | ||
| 5mg | 119.00 € | ||
| 10mg | 183.00 € | ||
| 25mg | 368.00 € | ||
| 50mg | 575.00 € | ||
| 100mg | 884.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
5β-Cholanic acid
CAS:546-18-9
5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.
Formula:
C24H40O2
Color and Shape:
Soild
Molecular weight:
360.57
Ref: TM-T88859
| 5mg | 47.00 € | ||
| 10mg | 68.00 € | ||
| 25mg | 87.00 € | ||
| 1mL*10mM (DMSO) | 75.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
RO7185876
CAS:2226038-71-5
RO7185876 is a selective gamma secretase modulator, which can be used in the study of …
Formula:
C25H28F3N7
Purity:
98.63%
Color and Shape:
Liquid
Molecular weight:
483.532
Ref: TM-T39702
| 1mg | 276.00 € | ||
| 5mg | 679.00 € | ||
| 10mg | 928.00 € | ||
| 25mg | 1,430.00 € | ||
| 50mg | 1,862.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Legumain inhibitor 1
CAS:2361157-34-6
Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity …
Formula:
C23H25N5O4S
Purity:
98.14%
Color and Shape:
Solid
Molecular weight:
467.54
Ref: TM-T39905
| 1mg | 278.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
γ-Secretase modulator 13
CAS:1353570-40-7
γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that can be used to study Alzheimer's …
Formula:
C22H23FN6S
Purity:
99.68%
Color and Shape:
Liquid
Molecular weight:
422.52
Ref: TM-T62263
| 1mg | 274.00 € | ||
| 5mg | 675.00 € | ||
| 10mg | 923.00 € | ||
| 25mg | 1,421.00 € | ||
| 50mg | 1,850.00 € | ||
| 100mg | 2,336.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
Enoticumab
CAS:1192578-27-0
Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits cancer …
Color and Shape:
Liquid
Ref: TM-T80615
| 1mg | 246.00 € | ||
| 5mg | 742.00 € | ||
| 10mg | 1,176.00 € | ||
| 25mg | 1,745.00 € | ||
| 50mg | 2,352.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
IMR-1
CAS:310456-65-6
IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of …
Formula:
C15H15NO5S2
Purity:
98.08% - 98.38%
Color and Shape:
Solid
Molecular weight:
353.41
Ref: TM-T6861
| 5mg | 35.00 € | ||
| 10mg | 51.00 € | ||
| 25mg | 98.00 € | ||
| 50mg | 172.00 € | ||
| 100mg | 282.00 € | ||
| 200mg | 408.00 € | ||
| 1mL*10mM (DMSO) | 56.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
IMR-1A
CAS:331862-41-0
IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting …
Formula:
C13H11NO5S2
Purity:
97.1% - 99.06%
Color and Shape:
Solid
Molecular weight:
325.36
Ref: TM-T3540
| 1mg | 73.00 € | ||
| 5mg | 157.00 € | ||
| 10mg | 244.00 € | ||
| 25mg | 365.00 € | ||
| 50mg | 491.00 € | ||
| 100mg | 738.00 € | ||
| 1mL*10mM (DMSO) | 161.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
LY900009
CAS:209984-68-9
LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase …
Formula:
C23H27N3O4
Purity:
97.07%
Color and Shape:
Solid
Molecular weight:
409.48
Ref: TM-T9015
| 1mg | 37.00 € | ||
| 5mg | 82.00 € | ||
| 10mg | 115.00 € | ||
| 25mg | 200.00 € | ||
| 50mg | 296.00 € | ||
| 100mg | 428.00 € | ||
| 200mg | 600.00 € | ||
| 1mL*10mM (DMSO) | 90.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
JLK6
CAS:62252-26-0
JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling
Formula:
C10H8ClNO3
Purity:
96.50%
Color and Shape:
Solid
Molecular weight:
225.63
Ref: TM-T21890
| 1mg | 130.00 € | ||
| 5mg | 256.00 € | ||
| 10mg | 367.00 € | ||
| 25mg | 615.00 € | ||
| 50mg | 874.00 € | ||
| 100mg | 1,191.00 € | ||
| 500mg | 2,362.00 € | ||
| 1mL*10mM (DMSO) | 269.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
FLI-06
CAS:313967-18-9
FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).
Formula:
C25H30N2O5
Purity:
100% - ≥98%
Color and Shape:
Solid
Molecular weight:
438.52
Ref: TM-T3075
| 1mg | 35.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 73.00 € | ||
| 10mg | 97.00 € | ||
| 25mg | 169.00 € | ||
| 50mg | 307.00 € | ||
| 100mg | 532.00 € | ||
| 500mg | 1,161.00 € | ||
| 1mL*10mM (DMSO) | 82.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Aβ-IN-1
CAS:2766509-32-2
Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM).
Formula:
C35H49N
Purity:
99.14%
Color and Shape:
Soild
Molecular weight:
483.77
Ref: TM-T63208
| 1mg | 326.00 € | ||
| 5mg | 772.00 € | ||
| 10mg | 1,056.00 € | ||
| 25mg | 1,483.00 € | ||
| 50mg | 1,846.00 € | ||
| 100mg | 2,322.00 € | ||
| 500mg | 4,551.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
γ-secretase modulator 1
CAS:1172637-87-4
gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies …
Formula:
C24H24N4OS
Purity:
99.48% - 99.75%
Color and Shape:
Solid
Molecular weight:
416.54
Ref: TM-T11358
| 1mg | 40.00 € | ||
| 5mg | 81.00 € | ||
| 10mg | 130.00 € | ||
| 25mg | 246.00 € | ||
| 50mg | 365.00 € | ||
| 100mg | To inquire | ||
| 500mg | To inquire |
Estimated delivery in United States, on Wednesday 22 Jan 2025
ELN318463 racemate
CAS:851599-82-1
ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor …
Formula:
C19H20BrClN2O3S
Purity:
99.73%
Color and Shape:
Solid
Molecular weight:
471.8
Ref: TM-T11178L
| 1mg | 159.00 € | ||
| 5mg | 384.00 € | ||
| 10mg | 603.00 € | ||
| 25mg | 888.00 € | ||
| 50mg | 1,210.00 € | ||
| 100mg | 1,629.00 € | ||
| 1mL*10mM (DMSO) | 445.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
