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Tyrosine Kinase/Adaptors

Tyrosine Kinase/Adaptors

Tyrosine kinase and adaptor inhibitors are compounds that target tyrosine kinases and their associated adaptor proteins, which play pivotal roles in cell signaling, growth, and differentiation. These inhibitors are essential tools in cancer research, as many tyrosine kinases are involved in the signaling pathways that drive tumor growth and metastasis. By inhibiting tyrosine kinases, these compounds can block critical signaling cascades, offering potential therapeutic strategies for various cancers and other diseases involving abnormal cell signaling. At CymitQuimica, we provide a comprehensive range of high-quality tyrosine kinase and adaptor inhibitors to support your research in oncology, molecular biology, and targeted therapy development.

Subcategories of "Tyrosine Kinase/Adaptors"

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Found 1357 products of "Tyrosine Kinase/Adaptors"

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  • PROTAC EGFR degrader 11
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    PROTAC EGFR degrader 11

    CAS:
    <p>PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader targeting the epidermal growth factor receptor (EGFR), with a DC50 of less than 100 nM. It binds to CRBN-DDB1 with a Ki of 36 nM. This compound effectively degrades EGFR, focal adhesion kinase (FAK), and RSK1, and inhibits the proliferation of BaF3 wild-type and EGFR mutant cells, exhibiting an IC50 of less than 100 nM.</p>
    Formula:C49H64ClFN10O7S
    Color and Shape:Solid
    Molecular weight:991.61

    Ref: TM-T88077

  • NBI-31772
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    NBI-31772

    CAS:
    <p>NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM).</p>
    Formula:C17H11NO7
    Purity:99.79%
    Color and Shape:Solid
    Molecular weight:341.27

    Ref: TM-T8906

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    Timigutuzumab

    CAS:
    <p>Timigutuzumab (GEXMab73) is a humanized monoclonal antibody designed to target ErbB2, showing potential application in cancer research [1].</p>
    Color and Shape:Liquid

    Ref: TM-T76977

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    EGFR-TK-IN-5

    <p>EGFR-TK-IN-5 (Compound NCE 2) is a thiazolyl pyrazoline derivative with significant inhibitory activity and stability against EGFR. It is applicable in tumor research.</p>
    Formula:C26H20ClFN4OS
    Color and Shape:Solid
    Molecular weight:490.98

    Ref: TM-T205705

  • Simotinib hydrochloride
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    Simotinib hydrochloride

    CAS:
    <p>Simotinib hydrochloride: selective oral EGFR inhibitor, IC50 19.9 nM, potent anticancer agent.</p>
    Formula:C25H27Cl2FN4O4
    Color and Shape:Solid
    Molecular weight:537.41

    Ref: TM-T39019

  • IGF-I (24-41)
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    IGF-I (24-41)

    CAS:
    <p>IGF-I (24-41) is a fragment of IGF-I, affecting GH activities with anabolic, antioxidant, anti-inflammatory, and cytoprotective properties.</p>
    Formula:C88H133N27O28
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2017.16

    Ref: TM-TP1124

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    DP-C-4

    <p>DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1].</p>
    Color and Shape:Liquid

    Ref: TM-T36251

  • Secretin, canine
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    Secretin, canine

    CAS:
    Secretin: endocrine hormone, increases bicarbonate-rich pancreatic fluid, regulates canine gastric functions via Src kinase pathway.
    Formula:C131H222N44O41
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3069.43

    Ref: TM-TP1610

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    EGFR/PI3Kα-IN-1

    <p>EGFR/PI3Kα-IN-1 (compound 30k), a dual EGFR/PI3Kα inhibitor, exhibits potent activity with IC 50 values of 3.6 nM (EGFRL858R/T790M) and 30 nM (PI3Kα). It effectively inhibits tumor cell proliferation and demonstrates significant anticancer activity.</p>
    Formula:C50H49N11O5S
    Color and Shape:Solid
    Molecular weight:916.06

    Ref: TM-T200282

  • EGFR-IN-140
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    EGFR-IN-140

    <p>EGFR-IN-140 (Compound 31) is an inhibitor of EGFR, effectively targeting both wild-type EGFR and the EGFRL858R/T790M/C797S mutant, with Ki values of 0.95 nM and 2.1 nM, respectively. Additionally, it inhibits EGFRdel19/T790M/C797S in Ba/F3 cells with an IC50 of 56.9 nM and demonstrates antitumor activity in mouse models.</p>
    Formula:C27H37FN8O2
    Color and Shape:Solid
    Molecular weight:524.633

    Ref: TM-T204256

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    YH32367

    <p>YH32367 (ABL105) is a bispecific antibody targeting HER2 and 4-1BB. It induces the secretion of IFN-γ, resulting in the death of tumor cells when co-cultured with hPBMC and HER2-expressing tumor cells. YH32367 demonstrates notable antitumor activity.</p>
    Color and Shape:Odour Liquid

    Ref: TM-T9901A-800

  • cis-NVP-ADW742
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    cis-NVP-ADW742

    CAS:
    <p>NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, &gt;16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.</p>
    Formula:C28H31N5O
    Color and Shape:Solid
    Molecular weight:453.59

    Ref: TM-T2107

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    EGFR/VEGFR2-IN-5

    <p>EGFR/VEGFR2-IN-5 (Compound 14) is an orally active dual inhibitor of EGFR and VEGFR2, exhibiting an IC50 value of 1.15 µM for VEGFR2 and 0.28 µM for EGFRT790M. This compound demonstrates significant anticancer activity.</p>
    Formula:C17H15N7O5S
    Color and Shape:Solid
    Molecular weight:429.41

    Ref: TM-T205483

  • KN1022
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    KN1022

    CAS:
    <p>KN1022 is an inhibitor of phosphorylation of platelet-derived growth factor (PDGF) receptor with IC50 of 0.26 μM.</p>
    Formula:C21H22N6O5
    Purity:99.68%
    Color and Shape:Soild
    Molecular weight:438.44

    Ref: TM-T60110

  • Sotuletinib hydrochloride
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    Sotuletinib hydrochloride

    CAS:
    <p>Sotuletinib hydrochloride (BLZ945 HCl) is a selective, brain-penetrant CSF-1R (c-Fms) inhibitor (IC50=1 nM),for ALS and TNBC.</p>
    Formula:C20H23ClN4O3S
    Purity:98.812%
    Color and Shape:Solid
    Molecular weight:434.94

    Ref: TM-T72211

  • Kemptide
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    Kemptide

    CAS:
    <p>Kemptide is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK).</p>
    Formula:C32H61N13O9
    Purity:98%
    Color and Shape:Solid
    Molecular weight:771.91

    Ref: TM-TP1351

  • Herceptide
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    Herceptide

    CAS:
    <p>Herceptide (HER2-targeting peptide), a peptide that targets HER2, can be conjugated with the near-infrared fluorescent dye indocyanine green (ICG), facilitating the development of theranostic agents.</p>
    Formula:C76H110N22O23
    Color and Shape:Solid
    Molecular weight:1699.82

    Ref: TM-TP2876

  • CLK1-IN-3
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    CLK1-IN-3

    CAS:
    <p>Clk1-in-3 is a + selective and highly potent sexual Clk1 inhibitor with an IC50 of 5 nM and 300 pairs higher affinity than Dyrk1A.</p>
    Formula:C24H23FN6O
    Purity:98.46% - 99.76%
    Color and Shape:Soild
    Molecular weight:430.48

    Ref: TM-T72039

  • BI-4732
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    BI-4732

    CAS:
    <p>DL-Homocystine is a mutagen secreted by F. nucleatum.</p>
    Formula:C32H36N10O2
    Purity:98.88%
    Color and Shape:Solid
    Molecular weight:592.69

    Ref: TM-T85354

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    AMX-818

    <p>AMX-818 is a conditionally activated, masked T cell engager (TCE) that targets HER2. It demonstrates potent T cell cytotoxicity against HER2-positive tumor cell lines and can induce tumor regression in vivo. AMX-818 holds promise for research into HER2-positive solid tumors.</p>
    Color and Shape:Odour Liquid

    Ref: TM-T9901A-962