CymitQuimica logo
Tyrosine Kinase/Adaptors

Tyrosine Kinase/Adaptors

Tyrosine kinase and adaptor inhibitors are compounds that target tyrosine kinases and their associated adaptor proteins, which play pivotal roles in cell signaling, growth, and differentiation. These inhibitors are essential tools in cancer research, as many tyrosine kinases are involved in the signaling pathways that drive tumor growth and metastasis. By inhibiting tyrosine kinases, these compounds can block critical signaling cascades, offering potential therapeutic strategies for various cancers and other diseases involving abnormal cell signaling. At CymitQuimica, we provide a comprehensive range of high-quality tyrosine kinase and adaptor inhibitors to support your research in oncology, molecular biology, and targeted therapy development.

Subcategories of "Tyrosine Kinase/Adaptors"

Show 13 more subcategories

Found 1372 products of "Tyrosine Kinase/Adaptors"

Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
products per page.
  • EML4-ALK kinase inhibitor 1
    Targetmol
    + Info

    EML4-ALK kinase inhibitor 1

    CAS:
    <p>Potent oral EML4-ALK inhibitor with a 1 nM IC50.</p>
    Formula:C31H48N8O3
    Purity:99.62%
    Color and Shape:Solid
    Molecular weight:580.76

    Ref: TM-T11184

  • Epertinib
    Targetmol
    + Info

    Epertinib

    CAS:
    <p>Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).</p>
    Formula:C30H27ClFN5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:560.02

    Ref: TM-T11213L

  • Bezuclastinib
    Targetmol
    + Info

    Bezuclastinib

    CAS:
    <p>Bezuclastinib (CGT9486) is a novel, potent and highly selective tyrosine kinase and c-kit D816V inhibitor for the study of advanced mastocytosis.</p>
    Formula:C19H17N5O
    Purity:99.55%
    Color and Shape:Solid
    Molecular weight:331.37

    Ref: TM-T60976

  • DBPR112
    Targetmol
    + Info

    DBPR112

    CAS:
    <p>DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.</p>
    Formula:C32H31N5O3
    Purity:99.25%
    Color and Shape:Solid
    Molecular weight:533.62

    Ref: TM-T10965

  • AC710 Mesylate
    Targetmol
    + Info

    AC710 Mesylate

    CAS:
    <p>AC710 Mesylate is a potent PDGFR inhibitor (Kds: 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ).</p>
    Formula:C32H46N6O7S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:658.81

    Ref: TM-T10228

  • EGFR-IN-28
    Targetmol
    + Info

    EGFR-IN-28

    CAS:
    <p>EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity .</p>
    Formula:C31H39BrN10O3S
    Color and Shape:Solid
    Molecular weight:711.68

    Ref: TM-T73105

  • AC710
    Targetmol
    + Info

    AC710

    CAS:
    <p>AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).</p>
    Formula:C31H42N6O4
    Purity:99.67%
    Color and Shape:Solid
    Molecular weight:562.7

    Ref: TM-TQ0235

  • EGFR-IN-73
    Targetmol
    + Info

    EGFR-IN-73

    CAS:
    <p>EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].</p>
    Formula:C19H17ClFN3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:405.81

    Ref: TM-T73165

  • Limertinib
    Targetmol
    + Info

    Limertinib

    CAS:
    <p>Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.</p>
    Formula:C29H32ClN7O2
    Purity:97.44%
    Color and Shape:Solid
    Molecular weight:546.06

    Ref: TM-T35897

  • ALK-IN-5
    Targetmol
    + Info

    ALK-IN-5

    CAS:
    <p>ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).</p>
    Formula:C24H25FN6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:464.49

    Ref: TM-T10283

  • (E/Z)-CP-724714
    Targetmol
    + Info

    (E/Z)-CP-724714

    CAS:
    <p>(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].</p>
    Formula:C27H27N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:469.54

    Ref: TM-T6046

  • SSR128129E free acid
    Targetmol
    + Info

    SSR128129E free acid

    CAS:
    <p>SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).</p>
    Formula:C18H16N2O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:324.33

    Ref: TM-T13003

  • BAY 2476568
    Targetmol
    + Info

    BAY 2476568

    CAS:
    <p>BAY 2476568 is a selective and potent EGFR inhibitor that acts on both wild-type EGFR (IC50 &lt;0.2 nM) and mutant EGFR (IC50 &lt;0.2 nM).</p>
    Formula:C24H27FN4O4
    Color and Shape:Solid
    Molecular weight:454.49

    Ref: TM-T62795

  • ALK2-IN-2
    Targetmol
    + Info

    ALK2-IN-2

    CAS:
    <p>ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.</p>
    Formula:C28H27N5O2S
    Purity:99.55%
    Color and Shape:Solid
    Molecular weight:497.61

    Ref: TM-T10287

  • Mutated EGFR-IN-2
    Targetmol
    + Info

    Mutated EGFR-IN-2

    CAS:
    <p>Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.</p>
    Formula:C29H35FN8O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:562.64

    Ref: TM-T12130

  • c-Kit-IN-2
    Targetmol
    + Info

    c-Kit-IN-2

    CAS:
    <p>c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (</p>
    Formula:C25H29N9O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:519.62

    Ref: TM-T10650

  • LDC0496
    Targetmol
    + Info

    LDC0496

    CAS:
    <p>LDC0496: Potent EGFR/Her2 exon 20 inhibitor; selective for wild-type EGFR, kinase-specific.</p>
    Formula:C32H35N5O3
    Color and Shape:Solid
    Molecular weight:537.65

    Ref: TM-T63792

  • AG-183
    Targetmol
    + Info

    AG-183

    CAS:
    <p>(Z)-Tyrphostin A51, a Z-isomer of Lanoconazole A51, is a strong PTK inhibitor blocking [3 H]taurine release and tyrosyl phosphorylation.</p>
    Formula:C13H8N4O3
    Color and Shape:Brown Solid
    Molecular weight:268.23

    Ref: TM-T21783

  • GW 583340 dihydrochloride
    Targetmol
    + Info

    GW 583340 dihydrochloride

    CAS:
    <p>GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.</p>
    Formula:C28H27Cl3FN5O3S2
    Purity:98.80%
    Color and Shape:Solid
    Molecular weight:671.03

    Ref: TM-T22827

  • NSC81111
    Targetmol
    + Info

    NSC81111

    CAS:
    <p>NSC81111 shows anticaner effects which is a potent and orally active inhibitor of EGFR-TK (IC50 = 0.15 nM) [1].</p>
    Formula:C19H16O4
    Color and Shape:Solid
    Molecular weight:308.33

    Ref: TM-T60734

  • c-Fms-IN-8
    Targetmol
    + Info

    c-Fms-IN-8

    CAS:
    <p>c-Fms-IN-8 is a colony-stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor (IC50: 9.1 nM). It is compound 4a in the reference.</p>
    Formula:C27H30N2O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:462.54

    Ref: TM-T10647

  • EGFR-IN-67
    Targetmol
    + Info

    EGFR-IN-67

    CAS:
    <p>EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].</p>
    Formula:C18H17N3S
    Color and Shape:Solid
    Molecular weight:307.41

    Ref: TM-T60729

  • MS 154N
    Targetmol
    + Info

    MS 154N

    CAS:
    <p>MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.</p>
    Formula:C47H56ClFN8O8
    Color and Shape:Solid
    Molecular weight:915.45

    Ref: TM-T41157

  • EGFR/HER2-IN-9
    Targetmol
    + Info

    EGFR/HER2-IN-9

    CAS:
    <p>EGFR/HER2-IN-9, a compound inhibiting both EGFR and HER2, demonstrates potency with IC50 values of 3.2 nM for EGFR, 14 nM for HER2, and 8.3 nM against the EGFR</p>
    Formula:C25H25ClFN5O4
    Color and Shape:Solid
    Molecular weight:513.95

    Ref: TM-T72854

  • Tyrphostin 51
    Targetmol
    + Info

    Tyrphostin 51

    CAS:
    <p>Tyrphostin 51 is an effective inhibitor of EGFR kinase.</p>
    Formula:C13H8N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:268.23

    Ref: TM-T24909

  • PDGFRα kinase inhibitor 1
    Targetmol
    + Info

    PDGFRα kinase inhibitor 1

    CAS:
    <p>PDGFRα kinase inhibitor 1 is a type II PDGFRα kinase inhibitor that inhibits both PDGFRα and PDGFRβ.</p>
    Formula:C34H34N8O2
    Purity:99.78%
    Color and Shape:Solid
    Molecular weight:586.69

    Ref: TM-T12396

  • TrkA-IN-1
    Targetmol
    + Info

    TrkA-IN-1

    CAS:
    <p>TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.</p>
    Formula:C25H20N4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:392.45

    Ref: TM-T13208

  • c-Fms-IN-2
    Targetmol
    + Info

    c-Fms-IN-2

    CAS:
    <p>c-Fms-IN-2 is an inhibitor of c-FMS kinase (IC50 = 24 nM).</p>
    Formula:C19H21N3O3
    Purity:99.56%
    Color and Shape:Solid
    Molecular weight:339.39

    Ref: TM-T10775

  • EGFR/C797S-IN-1
    Targetmol
    + Info

    EGFR/C797S-IN-1

    CAS:
    <p>EGFR/C797S-IN-1: Potent EGFR-C797S inhibitor, IC50 of 0.128 µM, dose-dependent p-EGFR suppression, anti-tumor properties.</p>
    Formula:C28H30N4O3
    Color and Shape:Solid
    Molecular weight:470.56

    Ref: TM-T72788

  • BKI-1369
    Targetmol
    + Info

    BKI-1369

    CAS:
    <p>BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).</p>
    Formula:C23H27N7O
    Color and Shape:Solid
    Molecular weight:417.51

    Ref: TM-T10556

  • EGFR-IN-63
    Targetmol
    + Info

    EGFR-IN-63

    CAS:
    <p>EGFR- IN-63 is an EGFR inhibitor with an IC50 value of 0.096 μM. EGFR- IN-63 exhibited anticancer effects on MCF-7 cells (IC50: 2.49 μM).</p>
    Formula:C20H12BrN5S
    Color and Shape:Solid
    Molecular weight:434.31

    Ref: TM-T62446

  • Tavilermide
    Targetmol
    + Info

    Tavilermide

    CAS:
    <p>Tavilermide (MIM-D3) is a selective TrkA agonist, a cyclic mimetic, which can be used to study dry keratoconjunctivitis and dry eye syndrome.</p>
    Formula:C24H32N6O11
    Purity:98.98%
    Color and Shape:Solid
    Molecular weight:580.54

    Ref: TM-T17000

  • DUN73423
    Targetmol
    + Info

    DUN73423

    CAS:
    <p>DUN73423 (RET-IN-21) is a potent tyrosine kinase (RET) inhibitor with antitumour activity for the study of cancer.</p>
    Formula:C19H16N6O
    Purity:98.09%
    Color and Shape:Solid
    Molecular weight:344.37

    Ref: TM-T69644

  • JNJ28871063 hydrochloride
    Targetmol
    + Info

    JNJ28871063 hydrochloride

    CAS:
    <p>ErbB receptor family inhibitor</p>
    Formula:C24H28Cl2N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:519.42

    Ref: TM-T22881

  • UNC-CA359
    Targetmol
    + Info

    UNC-CA359

    CAS:
    <p>UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.</p>
    Formula:C18H14ClN3O2
    Color and Shape:Solid
    Molecular weight:339.78

    Ref: TM-T61077

  • BIBX 1382 Dihydrochloride
    Targetmol
    + Info

    BIBX 1382 Dihydrochloride

    CAS:
    <p>BIBX 1382 Dihydrochloride blocks Lassa/Ebola entry, aids in studying virus-host interactions, and hints at kinase targets for therapy.</p>
    Formula:C18H21Cl3FN7
    Color and Shape:Solid
    Molecular weight:460.76

    Ref: TM-T30443

  • PDZ1i
    Targetmol
    + Info

    PDZ1i

    CAS:
    <p>PDZ1i: potent MDA-9/Syntenin inhibitor; crosses blood-brain barrier; targets GBM, FAK, EGFRvIII; lowers MMP secretion.</p>
    Formula:C28H26N8O4
    Color and Shape:Solid
    Molecular weight:538.56

    Ref: TM-T63797

  • PF-4618433
    Targetmol
    + Info

    PF-4618433

    CAS:
    <p>PF-4618433 is a selective PYK2 inhibitor with osteogenic activity.</p>
    Formula:C24H27N7O2
    Purity:99.95%
    Color and Shape:Solid
    Molecular weight:445.52

    Ref: TM-T22397

  • EGFR-IN-64
    Targetmol
    + Info

    EGFR-IN-64

    CAS:
    <p>EGFR-IN-64 inhibits EGFR with 0.33 μM IC50, showing promising anticancer properties.</p>
    Formula:C20H21N3O3
    Color and Shape:Solid
    Molecular weight:351.4

    Ref: TM-T61225

  • Rp-cAMPS triethylammonium salt
    Targetmol
    + Info

    Rp-cAMPS triethylammonium salt

    CAS:
    <p>Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinase I and II.</p>
    Formula:C16H27N6O5PS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:446.46

    Ref: TM-T12764

  • MMPP
    Targetmol
    + Info

    MMPP

    CAS:
    <p>MMPP is a VEGFR2 inhibitor with anti-inflammatory activity, inhibits STAT3 , inhibits angiogenesis, and can be used to alleviate myocardial injury.</p>
    Formula:C17H18O3
    Purity:99.31% - 99.83%
    Color and Shape:Solid
    Molecular weight:270.32

    Ref: TM-T28077

  • Syk-IN-3
    Targetmol
    + Info

    Syk-IN-3

    CAS:
    <p>Syk-IN-3 is a Syk inhibitor with potential anti-inflammatory and anticancer activity and can be used to study immune dysregulation.</p>
    Formula:C24H28N4O3S
    Purity:97.29% - >99.99%
    Color and Shape:Solid
    Molecular weight:452.57

    Ref: TM-T13045

  • EGFR-IN-21
    Targetmol
    + Info

    EGFR-IN-21

    CAS:
    <p>EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.</p>
    Formula:C36H44BrN10O2P
    Color and Shape:Solid
    Molecular weight:759.68

    Ref: TM-T73103

  • GSK-2250665A
    Targetmol
    + Info

    GSK-2250665A

    CAS:
    <p>GSK-2250665A is an (Itk) inhibitor (pKi 9.2) with selectivity over Aurora B and Btk, inhibiting IFNγ in PBMCs for T-cell signaling studies.</p>
    Formula:C26H29N5OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:459.61

    Ref: TM-T27458

  • c-Fms-IN-1
    Targetmol
    + Info

    c-Fms-IN-1

    CAS:
    <p>c-Fms-IN-1 is an inhibitor of c-FMS kinase (IC50 = 0.8 nM).</p>
    Formula:C22H27N5O2
    Purity:99.94%
    Color and Shape:Solid
    Molecular weight:393.48

    Ref: TM-T10643

  • Antiproliferative agent-34
    Targetmol
    + Info

    Antiproliferative agent-34

    CAS:
    <p>Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.</p>
    Formula:C27H27N7O5
    Purity:98%
    Color and Shape:Solid
    Molecular weight:529.55

    Ref: TM-T79368

  • Mutated EGFR-IN-3
    Targetmol
    + Info

    Mutated EGFR-IN-3

    CAS:
    <p>Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.</p>
    Formula:C31H29FN4O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:508.59

    Ref: TM-T12131

  • Tyrphostin AG 112
    Targetmol
    + Info

    Tyrphostin AG 112

    CAS:
    <p>Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.</p>
    Formula:C13H8N4O
    Purity:97.01%
    Color and Shape:Solid
    Molecular weight:236.23

    Ref: TM-T8534

  • Glesatinib hydrochloride
    Targetmol
    + Info

    Glesatinib hydrochloride

    CAS:
    <p>Glesatinib hydrochloride is an orally active and potent dual inhibitor of MET/SMO.</p>
    Formula:C31H28ClF2N5O3S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:656.16

    Ref: TM-T15383

  • Infigratinib phosphate
    Targetmol
    + Info

    Infigratinib phosphate

    CAS:
    <p>Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and</p>
    Formula:C26H34Cl2N7O7P
    Purity:99.24% - 99.6%
    Color and Shape:Solid
    Molecular weight:658.47

    Ref: TM-T16364