Fibroblast Growth Factor Receptor (FGFR)
FGFR inhibitors are targeted therapies that block the activity of fibroblast growth factor receptors (FGFRs), which are involved in cell proliferation, differentiation, and angiogenesis. FGFR signaling contributes to the formation of new blood vessels in tumors, promoting their growth and survival. Inhibiting FGFR can therefore reduce angiogenesis and tumor progression. At CymitQuimica, we provide a range of high-quality FGFR inhibitors to support your research in cancer, developmental biology, and angiogenesis.
Found 180 products of "Fibroblast Growth Factor Receptor (FGFR)"
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SM27
CAS:SM27 is a fibroblast growth factor 2 (FGF2) inhibitor with anti-angiogenic activity and can be used to study tumours.Formula:C21H16N2O9S2Purity:98.83%Color and Shape:SolidMolecular weight:504.49PD 173074
CAS:Formula:C28H41N7O3Purity:>95.0%(HPLC)Color and Shape:White to Yellow to Orange powder to crystalMolecular weight:523.68PD-161570
CAS:Formula:C26H35Cl2N7OPurity:>98.0%(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:532.51FGFR4-IN-1
CAS:FGFR4-IN-1 is a potent FGFR4 inhibitor (IC50: 0.7 nM).Formula:C24H27N7O5Purity:98.96%Color and Shape:SolidMolecular weight:493.52Derazantinib
CAS:Derazantinib (ARQ-087) is a potent, ATP-competitive, orally active tyrosine kinase inhibitor.Cost-effective and quality-assured.Formula:C29H29FN4OPurity:99.71%Color and Shape:SolidMolecular weight:468.57Ref: TM-TQ0228
1mg50.00€5mg110.00€10mg160.00€25mg258.00€50mg380.00€100mg567.00€200mg805.00€1mL*10mM (DMSO)118.00€Dovitinib lactate
CAS:Dovitinib lactate (TKI-258 lactate)(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).Formula:C24H27FN6O4Purity:99.54% - 99.77%Color and Shape:SolidMolecular weight:482.51Ref: TM-T7104
5mg49.00€10mg74.00€25mg122.00€50mg202.00€100mg339.00€200mg507.00€500mg800.00€1mL*10mM (DMSO)54.00€Gandotinib
CAS:LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM).Formula:C23H25ClFN7OPurity:99.33% - 99.86%Color and Shape:SolidMolecular weight:469.94Zoligratinib
CAS:Zoligratinib (CH5183284) is a selective and orally available FGFR inhibitor, which is for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.Formula:C20H16N6OPurity:95.28% - 99.51%Color and Shape:SolidMolecular weight:356.38PF 477736
CAS:PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Formula:C22H25N7O2Purity:97.58% - 99.94%Color and Shape:SolidMolecular weight:419.48Masitinib
CAS:Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.Formula:C28H30N6OSPurity:97.56% - >99.99%Color and Shape:SolidMolecular weight:498.64SUN11602
CAS:SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.Formula:C26H37N5O2Purity:99.36%Color and Shape:SolidMolecular weight:451.6Orantinib
CAS:Orantinib (NSC 702827) , a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation.Formula:C18H18N2O3Purity:98.92% - 99.52%Color and Shape:SolidMolecular weight:310.35Roblitinib
CAS:Roblitinib (FGF-401), an FGFR4 inhibitor, potentially blocks tumor growth by halting cell proliferation and survival.Formula:C25H30N8O4Purity:97.27% - 99%Color and Shape:SolidMolecular weight:506.56SU4984
CAS:SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).Formula:C20H19N3O2Purity:97.20%Color and Shape:SolidMolecular weight:333.38BLU9931
CAS:BLU9931 is the first selective small molecule inhibitor of FGFR4.
Formula:C26H22Cl2N4O3Purity:96.958% - 99.85%Color and Shape:SolidMolecular weight:509.38Heparan Sulfate
CAS:Heparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG). Cost effective and quality assured.Formula:C12H19NO20S3(monomer)Purity:98%Color and Shape:SolidMolecular weight:593.47(monomer)EOC317
CAS:EOC317 (ACTB-1003) is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).Formula:C27H26F5N7O3Purity:98.00% - 99.26%Color and Shape:SolidMolecular weight:591.53GW786034B
CAS:Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.Formula:C21H23N7O2S·HClPurity:99.87%Color and Shape:SolidMolecular weight:473.98PRN1371
CAS:PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).Formula:C26H30Cl2N6O4Purity:98.65%Color and Shape:SolidMolecular weight:561.46Ref: TM-TQ0015
1mg77.00€2mg100.00€5mg166.00€10mg289.00€25mg492.00€50mg710.00€100mg973.00€1mL*10mM (DMSO)200.00€FIIN-3
CAS:FIIN-3 is an irreversible inhibitor of FGFR.Formula:C34H36Cl2N8O4Purity:97.63% - 98.92%Color and Shape:SolidMolecular weight:691.61Ponatinib
CAS:Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectivelyFormula:C29H27F3N6OPurity:98% - 99.60%Color and Shape:SolidMolecular weight:532.56S49076
CAS:S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.Formula:C22H22N4O4SPurity:95.35% - 97.4%Color and Shape:SolidMolecular weight:438.5Ref: TM-T3274
1mg34.00€2mg44.00€5mg58.00€10mg93.00€25mg167.00€50mg260.00€100mg432.00€200mg618.00€1mL*10mM (DMSO)64.00€FGFR2-IN-3 hydrochloride
CAS:FGFR2-IN-3 hydrochloride is a selective, orally active FGFR2 inhibitor.Formula:C28H25ClFN7O2Color and Shape:SolidMolecular weight:546.0Regorafenib
CAS:Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFormula:C21H15ClF4N4O3Purity:98% - 99.95%Color and Shape:SolidMolecular weight:482.82Ref: TM-T1792
5mg34.00€10mg49.00€25mg75.00€50mg90.00€100mg137.00€200mg175.00€500mg294.00€1mL*10mM (DMSO)54.00€PD168393
CAS:PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.Formula:C17H13BrN4OPurity:99.13% - 99.83%Color and Shape:SolidMolecular weight:369.22Ref: TM-T6932
1mg37.00€2mg50.00€5mg63.00€10mg94.00€25mg146.00€50mg210.00€100mg294.00€1mL*10mM (DMSO)52.00€Lenvatinib mesylate
CAS:Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.Formula:C22H23ClN4O7SPurity:99.03% - 99.79%Color and Shape:SolidMolecular weight:522.96SSR128129E
CAS:SSR128129E (SSR) is an allosteric and orally-active FGFR1 inhibitor (IC50: 1.9 μM), but not affecting other related RTKs.Formula:C18H15N2O4·NaPurity:98.79% - ≥95%Color and Shape:SolidMolecular weight:346.31H3B-6527
CAS:H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma, with antineoplastic activity.Formula:C29H34Cl2N8O4Purity:97.45%Color and Shape:SolidMolecular weight:629.54Ref: TM-T7738
1mg66.00€5mg160.00€10mg260.00€25mg502.00€50mg710.00€100mg1,009.00€1mL*10mM (DMSO)268.00€Futibatinib
CAS:Futibatinib (TAS-120) is an orally active, potent,and irreversible FGFR inhibitor of FGFR1, FGFR2, FGFR3, and FGFR4.Cost-effective and quality-assured.Formula:C22H22N6O3Purity:97.66% - 99.44%Color and Shape:SolidMolecular weight:418.45Ref: TM-T5044
1mg50.00€5mg114.00€10mg167.00€25mg313.00€50mg485.00€100mg627.00€200mg890.00€1mL*10mM (DMSO)127.00€Dovitinib lactate hydrate
CAS:Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit).Formula:C24H27FN6O4Purity:99.82%Color and Shape:SolidMolecular weight:482.51Fisogatinib
CAS:Fisogatinib (BLU-554) is a highly potent, selective, and orally active FGFR4 inhibitor.Cost-effective and quality-assured.Formula:C24H24Cl2N4O4Purity:99.27% - ≥95%Color and Shape:SolidMolecular weight:503.38Ref: TM-T3456
1mg50.00€5mg114.00€10mg167.00€25mg294.00€50mg444.00€100mg670.00€500mg1,341.00€1mL*10mM (DMSO)127.00€Masitinib mesylate
CAS:Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;Formula:C29H34N6O4S2Purity:97.67% - 98.44%Color and Shape:SolidMolecular weight:594.75KHS 101
CAS:KHS101 is a novel inhibitor of transforming acidic coiled-coil protein 3 (TACC3). It is a selective inducer of neuronal differentiation.
Formula:C18H21N5SPurity:99.63%Color and Shape:SolidMolecular weight:339.46Ferulic acid sodium
CAS:Ferulic acid sodium (Sodium ferulic) is an agent used in the treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis.Formula:C10H9NaO4Purity:99.58%Color and Shape:White Crystalline PowderMolecular weight:216.16R1530
CAS:R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.Formula:C18H14ClFN4OPurity:98.422%Color and Shape:SolidMolecular weight:356.78Ref: TM-TQ0317
1mg39.00€2mg52.00€5mg84.00€10mg130.00€25mg264.00€50mg423.00€100mg640.00€1mL*10mM (DMSO)93.00€Alofanib
CAS:Alofanib (RPT835) selectively inhibits FGFR2 in KATO III cells with IC50 <10 nM; doesn’t affect FGFR1/3 or FGF2-FGFR2 binding.Formula:C19H15N3O6SPurity:99.53% - 99.81%Color and Shape:SolidMolecular weight:413.4KW-2449
CAS:KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Formula:C20H20N4OPurity:98.43% - 99.69%Color and Shape:SolidMolecular weight:332.4Nintedanib esylate
CAS:Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/βFormula:C31H33N5O4·C2H6O3SPurity:99.43% - 99.98%Color and Shape:SolidMolecular weight:649.76FIIN-2
CAS:FIIN-2, an irreversible, pan-FGFR inhibitor, inhibits FGFR1/2/3/4 with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM, respectively.Formula:C35H38N8O4Purity:97.82% - 99.65%Color and Shape:Crystalline SolidMolecular weight:634.73LY2874455
CAS:LY2874455 has been used in trials studying the treatment of Advanced Cancer.Formula:C21H19Cl2N5O2Purity:97.22% - 99.46%Color and Shape:SolidMolecular weight:444.31Ref: TM-T2361
1mg47.00€5mg92.00€10mg145.00€25mg281.00€50mg447.00€100mg670.00€200mg888.00€1mL*10mM (DMSO)101.00€Erdafitinib
CAS:Erdafitinib (JNJ-42756493) is a quinoxaline derivative compound, acts on FGFR1/2/3/4.Formula:C25H30N6O2Purity:97.00% - 99.36%Color and Shape:SolidMolecular weight:446.54ASP5878
CAS:ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, 3, and 4 with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L.Formula:C18H19F2N5O4Purity:99.8% - 99.89%Color and Shape:SolidMolecular weight:407.37AZD4547
CAS:AZD4547 is an FGFR family inhibitor, and is able to act on FGFR1, FGFR2, FGFR3 and FGFR4. IC50:165 nM).Cost-effective and quality-assured.Formula:C26H33N5O3Purity:99.37% - 99.88%Color and Shape:SolidMolecular weight:463.57Ref: TM-T1948
2mg37.00€5mg50.00€10mg59.00€25mg84.00€50mg107.00€100mg147.00€200mg207.00€500mg348.00€1mL*10mM (DMSO)52.00€CHIR-98014
CAS:CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.Formula:C20H17Cl2N9O2Purity:97.25% - 99.59%Color and Shape:SolidMolecular weight:486.31Ref: TM-T2608
5mg71.00€10mg102.00€25mg205.00€50mg334.00€100mg537.00€500mg1,134.00€1mL*10mM (DMSO)To inquirePD173074
CAS:PD173074 inhibits FGFR1 (IC50: 25 nM) and VEGFR2 (100-200 nM); ~1000x more selective for FGFR1 over PDGFR/c-Src.Formula:C28H41N7O3Purity:98.15% - 98.21%Color and Shape:Yellow SolidMolecular weight:523.67Ref: TM-T2642
5mg40.00€10mg54.00€25mg94.00€50mg133.00€100mg210.00€200mg371.00€500mg620.00€1mL*10mM (DMSO)56.00€SU 5402
CAS:SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.Formula:C17H16N2O3Purity:98.91% - 99.64%Color and Shape:Yellow-Green SolidMolecular weight:296.32PD-161570
CAS:PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.Formula:C26H35Cl2N7OPurity:99.92%Color and Shape:SolidMolecular weight:532.51Ref: TM-T23127
1mg34.00€5mg96.00€10mg141.00€25mg289.00€50mg465.00€100mg662.00€200mg888.00€1mL*10mM (DMSO)118.00€XL 999
CAS:Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）Formula:C26H28FN5OPurity:98.24% - 99.55%Color and Shape:SolidMolecular weight:445.53PD-166866
CAS:PD-166866 is a selective FGFR tyrosine kinase inhibitor.Formula:C20H24N6O3Purity:98.29%Color and Shape:SolidMolecular weight:396.44BO-264
CAS:BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM).Formula:C18H19N5O3Purity:98.03% - 99.81%Color and Shape:SolidMolecular weight:353.38
