TAM Receptor
TAM receptor inhibitors target the TAM family of receptor tyrosine kinases, which includes Tyro3, Axl, and Mer. These receptors are involved in the regulation of immune responses, cell survival, and clearance of apoptotic cells. Dysregulation of TAM receptors is implicated in cancer, autoimmune diseases, and chronic inflammation. At CymitQuimica, we offer TAM receptor inhibitors to aid your research in immunology, oncology, and inflammation.
Found 32 products of "TAM Receptor"
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TAM-IN-2
CAS:<p>TAM-IN-2 is an inhibitor of TAM.</p>Formula:C31H27F2N7O3Purity:98.09% - 99.74%Color and Shape:SolidMolecular weight:583.59Tilvestamab
CAS:<p>Tilvestamab (BGB149) is a humanized monoclonal antibody targeting AXL with anti-tumor and anti-fibrotic activities, inhibiting Gas6-induced AXL activation.</p>Purity:>95%Color and Shape:LiquidEnapotamab vedotin
CAS:<p>Enapotamab vedotin (anti-AXL ADC) targets AXL with MMAE payload, showing potential against AXL-expressing, EGFR-resistant NSCLC.</p>Purity:95%Color and Shape:LiquidMecbotamab vedotin
CAS:<p>Mecbotamab vedotin (BA301) is an inhibitory IgG1 antibody that targets human tyrosine kinase receptor AXL and the humanized murine monoclonal BA301 γ1 chain. It can be utilized in the preparation of immunoconjugates for research into cancers expressing the Axl type.</p>Color and Shape:LiquidUNC 569 hydrochloride
<p>UNC 569 hydrochloride: reversible ATP-competitive Mer inhibitor, IC50 2.9 nM, Ki 4.3 nM, also inhibits Axl/Tyro3; used in leukemia, teratoid tumor studies.</p>Formula:C22H30ClFN6Purity:99.93%Color and Shape:SolidMolecular weight:432.96UNC2541
CAS:<p>UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor.</p>Formula:C24H34FN7O2Purity:98.33%Color and Shape:SolidMolecular weight:471.572-D08
CAS:<p>2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.</p>Formula:C15H10O5Purity:98.58% - 98.95%Color and Shape:SolidMolecular weight:270.24Bemcentinib
CAS:<p>Bemcentinib (R428) is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated for the treatment of NSCLC.</p>Formula:C30H34N8Purity:97% - 99.8%Color and Shape:SolidMolecular weight:506.64RU-301
CAS:<p>RU-301 is a novel pan-tam inhibitor</p>Formula:C21H19F3N4O4SPurity:98.87%Color and Shape:SolidMolecular weight:480.46UNC569
CAS:<p>UNC569 selectively inhibits kidney URAT1, regulating uric acid excretion and aiding gout patient's uric balance.</p>Formula:C22H29FN6Purity:98.91% - 99.67%Color and Shape:SolidMolecular weight:396.5BMS 777607
CAS:<p>BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met/Axl/Ron/Tyro3. BMS-777607 has been investigated for the basic science of Malignant Solid Tumour.</p>Formula:C25H19ClF2N4O4Purity:98.30% - >99.99%Color and Shape:SolidMolecular weight:512.89CEP-40783
CAS:<p>CEP-40783 (RXDX-106) is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM).</p>Formula:C31H26F2N4O6Purity:99.76% - 99.84%Color and Shape:SolidMolecular weight:588.56Ningetinib Tosylate
CAS:<p>Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.</p>Formula:C38H37FN4O8SPurity:99.93%Color and Shape:SolidMolecular weight:728.79NPS-1034
CAS:<p>NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.</p>Formula:C31H23F2N5O3Purity:98.48%Color and Shape:SolidMolecular weight:551.54Gilteritinib
CAS:<p>Gilteritinib (ASP2215) is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM,</p>Formula:C29H44N8O3Purity:97.75% - 99.90%Color and Shape:SolidMolecular weight:552.71UNC2881
CAS:<p>UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.</p>Formula:C25H33N7O2Purity:98.97% - 99.85%Color and Shape:SolidMolecular weight:463.58SGI-7079
CAS:<p>SGI-7079: selective Axl inhibitor; hinders tumor growth dose-dependently; may target EGFR inhibitor resistance.</p>Formula:C26H26FN7Purity:95.51% - 99.26%Color and Shape:SolidMolecular weight:455.53LDC1267
CAS:<p>LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).</p>Formula:C30H26F2N4O5Purity:99.38% - 99.88%Color and Shape:SolidMolecular weight:560.55Ningetinib
CAS:<p>Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.</p>Formula:C31H29FN4O5Purity:99.95% - 99.98%Color and Shape:SolidMolecular weight:556.58ONO-7475
CAS:<p>ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase</p>Formula:C32H26N4O6Purity:98.74%Color and Shape:SolidMolecular weight:562.57XL092
CAS:<p>XL092 (JUN04542) is an Axl Mer cMet KDR inhibitor for the treatment of Axl and Mer receptor tyrosine kinase- dependent disorders.</p>Formula:C29H25FN4O5Purity:98.60%Color and Shape:SolidMolecular weight:528.53Cabozantinib
CAS:<p>Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM).</p>Formula:C28H24FN3O5Purity:99.68% - 99.88%Color and Shape:SolidMolecular weight:501.51Cabozantinib hydrochloride
CAS:<p>Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6</p>Formula:C28H25ClFN3O5Purity:99.97%Color and Shape:SolidMolecular weight:537.96UNC2250
CAS:<p>UNC2250 is an effective and specific Mer inhibitor (IC50=1.7 nM).</p>Formula:C24H36N6O2Purity:98.57% - 99.87%Color and Shape:SolidMolecular weight:440.58DS-1205
CAS:<p>DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.</p>Formula:C41H42FN5O7Purity:99.75%Color and Shape:SolidMolecular weight:735.8Dubermatinib
CAS:<p>Dubermatinib (TP0903) is a potent and selective Axl kinase inhibitor.</p>Formula:C24H30ClN7O2SPurity:98.65% - 99.58%Color and Shape:SolidMolecular weight:516.06RU-302
CAS:<p>RU-302 is a pan inhibitor of TAM Receptor blocking the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain.</p>Formula:C24H24F3N3O2SPurity:99.84%Color and Shape:SolidMolecular weight:475.53R916562
CAS:<p>R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis.</p>Formula:C26H30ClN9SPurity:98%Color and Shape:SolidMolecular weight:536.09AXL-IN-14
CAS:<p>AXL-IN-14: orally active, potent AXL inhibitor (IC50=0.8 nM); hinders Gas6/AXL migration, invasion; lowers p-AXL, p-AKT; anti-tumor.</p>Formula:C32H24F2N4O4Purity:98%Color and Shape:SolidMolecular weight:566.55AXL-IN-15
CAS:<p>AXL-IN-15 (cpd391) is a potent inhibitor of Axl, exhibiting both a dissociation constant (K i) and a half-maximal inhibitory concentration (IC50) of less than 1</p>Formula:C26H32F3N9O3Purity:98%Color and Shape:SolidMolecular weight:575.59MerTK-IN-1
CAS:<p>MerTK-IN-1 (compound 31) serves as an inhibitor of MerTK, with the capability to bind to the target in vivo.</p>Formula:C23H26N8O4Color and Shape:SolidMolecular weight:478.50MerTK/Axl-IN-1
CAS:<p>MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual inhibitor of MerTK/Axl, exhibiting IC50 values of 4.2 nM and 8.8 nM in Ba/F3 cells, and 0.2 nM and 0.9 nM in HTRF cells, respectively. It effectively inhibits pMerTK in vivo and possesses a long half-life and high oral bioavailability.</p>Formula:C40H47FN6O4Color and Shape:SolidMolecular weight:694.84
