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FLT

FLT

FLT (Fms-like tyrosine kinase) inhibitors are compounds that target FLT receptors, which are involved in the regulation of angiogenesis through the VEGF (vascular endothelial growth factor) pathway. FLT receptors play a crucial role in the development of new blood vessels in tumors. Inhibiting FLT receptors can effectively reduce angiogenesis and tumor growth, making these inhibitors important in cancer therapy. At CymitQuimica, we offer a selection of high-quality FLT inhibitors to support your research in oncology, vascular biology, and angiogenesis.

Found 86 products for "FLT".

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  • Multi-kinase inhibitor 4
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    Multi-kinase inhibitor 4

    CAS:
    Multi-kinase inhibitor 4 (compound 14) serves as an orally effective inhibitor targeting FLT1, KDR, FLT3, FLT4, PDGFRα, and PDGFRβ, exhibiting IC50 values of 1.97 nM, 1.04 nM, 0.33 nM, 1.44 nM, 0.18 nM, and 0.89 nM respectively. This compound plays a crucial role in cancer research.
    Formula:C25H24N6O2
    Color and Shape:Solid
    Molecular weight:440.50

    Ref: TM-T201144

  • Multi-kinase inhibitor 3
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    Multi-kinase inhibitor 3

    CAS:
    Multi-kinase inhibitor 3 (compound 12) is an orally active and effective multikinase (multikinase) inhibitor, demonstrating potent IC50 values against FLT1/VEGFR1, KDR/VEGFR2, FLT4/VEGFR3, FLT3, PDGFRα, and PDGFRβ, at 1.59, 1.23, 1.19, 0.59, 0.22, and 1.15 nM respectively. This compound exhibits anti-proliferative and anticancer activities.
    Formula:C26H26N6O2
    Color and Shape:Solid
    Molecular weight:454.52

    Ref: TM-T200518

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    FLT3-IN-40

    CAS:
    FLT3-IN-40 (compound 1) is a type I ATP-competitive FLT3 inhibitor with an IC50 of 16.26 nM. It reduces the autophosphorylation levels of FLT3 and the phosphorylation levels of downstream ERK. FLT3-IN-40 exhibits antiproliferative activity, cell cycle regulation, and apoptosis induction. It is applicable in research related to acute myeloid leukemia.
    Formula:C24H22N6O2
    Molecular weight:426.47

    Ref: TM-T218483

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    LT-850-166

    LT-850-166 is a potent inhibitor of FLT3 and has shown efficacy in overcoming a wide range of FLT3 mutations.
    Formula:C30H29Cl2N7O
    Color and Shape:Solid
    Molecular weight:574.5

    Ref: TM-T64062

  • JNJ-47117096
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    JNJ-47117096

    CAS:
    JNJ-47117096 is a potent and selective MELK inhibitor with an IC50 of 23 nM, and it also exhibits strong activity against Flt3 with an IC50 of 18 nM.
    Formula:C21H22N4O2
    Color and Shape:Solid
    Molecular weight:362.425

    Ref: TM-T204607

  • Lomonitinib
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    Lomonitinib

    CAS:
    Lomonitinib is a potent and selective pan-FLT3/IRAK4 inhibitor with antitumor properties. It shows promise for research in myeloid leukemia.
    Formula:C27H24N4O2
    Color and Shape:Solid
    Molecular weight:436.505

    Ref: TM-T205470