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Ubiquitination

Ubiquitination

Ubiquitination inhibitors are compounds that interfere with the process of ubiquitination, where proteins are tagged with ubiquitin molecules for degradation by the proteasome. These inhibitors are critical for studying protein turnover, signal transduction, and the regulation of various cellular processes. Ubiquitination plays a key role in many diseases, including cancer, neurodegenerative disorders, and immune system dysfunction. By modulating ubiquitination, these inhibitors can provide insights into the mechanisms of disease and open up new avenues for therapeutic intervention. At CymitQuimica, we offer a wide selection of high-quality ubiquitination inhibitors to support your research in cell biology, proteomics, and drug discovery.

Subcategories of "Ubiquitination"

Found 107 products of "Ubiquitination"

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  • C527
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    C527

    CAS:
    <p>C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).</p>
    Formula:C17H8FNO3
    Purity:97.22%
    Color and Shape:Solid
    Molecular weight:293.25

    Ref: TM-T14852

  • MF-094
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    MF-094

    CAS:
    <p>MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.</p>
    Formula:C30H37N3O4S
    Purity:99.93%
    Color and Shape:Solid
    Molecular weight:535.7

    Ref: TM-T12024

  • TAS4464 hydrochloride
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    TAS4464 hydrochloride

    CAS:
    <p>TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).</p>
    Formula:C21H24ClFN6O6S
    Purity:98.61% - 98.96%
    Color and Shape:Solid
    Molecular weight:542.97

    Ref: TM-T13090

  • NSC232003
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    NSC232003

    CAS:
    <p>NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.</p>
    Formula:C6H7N3O3
    Purity:97.72%
    Color and Shape:Solid
    Molecular weight:169.14

    Ref: TM-T12261

  • ML-792
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    ML-792

    CAS:
    <p>ML-792 is a specific small ubiquitin-like modifier activating enzyme (SUMO) inhibitor.Cost-effective and quality-assured.</p>
    Formula:C21H23BrN6O5S
    Purity:99.32% - 99.82%
    Color and Shape:Solid
    Molecular weight:551.41

    Ref: TM-T16102

  • WS-383
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    WS-383

    CAS:
    <p>WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).</p>
    Formula:C18H21Cl2N9S2
    Purity:98.46%
    Color and Shape:Solid
    Molecular weight:498.46

    Ref: TM-T13349

  • HBX 19818
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    HBX 19818

    CAS:
    <p>HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).</p>
    Formula:C25H28ClN3O
    Purity:97.71%
    Color and Shape:Solid
    Molecular weight:421.96

    Ref: TM-T15464

  • IU1-47
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    IU1-47

    CAS:
    <p>IU1-47 是一种特异性 USP14抑制剂，IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5， IC50为 20 μM。</p>
    Formula:C19H23ClN2O
    Purity:98.94%
    Color and Shape:Solid
    Molecular weight:330.85

    Ref: TM-T15604

  • USP8-IN-3
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    USP8-IN-3

    CAS:
    <p>USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.</p>
    Formula:C18H18F3N5O2S
    Purity:99.79%
    Color and Shape:Solid
    Molecular weight:425.43

    Ref: TM-T67873

  • E3 ligase Ligand 36
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    E3 ligase Ligand 36

    CAS:
    <p>E3 ligase Ligand 36 is an E3 ligase ligand that can be utilized for synthesizing PROTACs, such as PROTAC BRM/BRG1 degrader-1.</p>
    Formula:C25H30N4O5S
    Color and Shape:Solid
    Molecular weight:498.6

    Ref: TM-T201850

  • USP8-IN-2
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    USP8-IN-2

    CAS:
    <p>USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.</p>
    Formula:C19H20ClF3N4OS
    Purity:99.92%
    Color and Shape:Solid
    Molecular weight:444.9

    Ref: TM-T67876

  • E3 ligase Ligand 41
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    E3 ligase Ligand 41

    CAS:
    <p>E3 Ligase Ligand 41 (Compound SI-13) serves as a ligand for the E3 ubiquitin ligase DCAF16. It is designed to connect with SLF through a linker, enabling the formation of KB03-SLF.</p>
    Formula:C13H12ClF3N2O4
    Color and Shape:Solid
    Molecular weight:352.69

    Ref: TM-T201480

  • dCeMM3 
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    dCeMM3 

    CAS:
    <p>dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.</p>
    Formula:C14H11ClN4OS
    Purity:98.48% - 99.41%
    Color and Shape:Solid
    Molecular weight:318.78

    Ref: TM-T9758

  • CymitQuimica logo
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    NSC819701

    <p>NSC819701 is a triazole-based inhibitor of p97ATPase. It inhibits the activity of p97ATPase by binding to specific sites on p97.</p>
    Formula:C30H32F2N8O3S
    Color and Shape:Solid
    Molecular weight:622.69

    Ref: TM-T89915

  • Post-Translational Modification Compound Library
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    Post-Translational Modification Compound Library

    <p>Contains xnum active small molecules for research related to post-translational modifications (PTMs);</p>
    Color and Shape:Odour Solid

    Ref: TM-L1620

  • CymitQuimica logo
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    Skp2 inhibitor 3

    <p>Skp2 inhibitor 3 (E35), a potent antitumor agent, acts as a robust inhibitor of S-phase kinase-associated protein 2 (SKP2) with an IC50 of 4.86 μM for Skp2-Cks1 binding. It significantly suppresses colony formation and migration, while inducing cell cycle arrest in the S-phase.</p>
    Color and Shape:Odour Solid

    Ref: TM-T200788

  • CymitQuimica logo
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    BIO-2007817

    <p>BIO-2007817 is a positive allosteric modulator (PAM) of Parkin, an E3 ubiquitin ligase. This compound enhances the activity of wild-type Parkin, stimulates Parkin's autoubiquitination, and induces the appearance of mono-ubiquitinated forms of Miro1 (a Parkin substrate) with an EC50 of 0.17 μM.</p>
    Formula:C32H36N6O3
    Color and Shape:Solid
    Molecular weight:552.67

    Ref: TM-T201503

  • Ubiquitination Compound Library
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    Ubiquitination Compound Library

    <p>A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；</p>
    Color and Shape:Odour Solid

    Ref: TM-L8600

  • OTUB1/USP8-IN-1 HCl
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    OTUB1/USP8-IN-1 HCl

    <p>OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemia</p>
    Formula:C22H17Cl2FN2O4
    Purity:99.92%
    Color and Shape:Solid
    Molecular weight:463.29

    Ref: TM-T72784L

  • OTUB2-IN-1
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    OTUB2-IN-1

    <p>OTUB2-IN-1 is an OTUB2 inhibitor with antitumor activity and can be used to study skin cancer and non-small cell lung cancer (NSCLC).</p>
    Formula:C19H18N2O6S2
    Purity:98.19%
    Color and Shape:Solid
    Molecular weight:434.49

    Ref: TM-T87947