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Ubiquitination

Ubiquitination

Ubiquitination inhibitors are compounds that interfere with the process of ubiquitination, where proteins are tagged with ubiquitin molecules for degradation by the proteasome. These inhibitors are critical for studying protein turnover, signal transduction, and the regulation of various cellular processes. Ubiquitination plays a key role in many diseases, including cancer, neurodegenerative disorders, and immune system dysfunction. By modulating ubiquitination, these inhibitors can provide insights into the mechanisms of disease and open up new avenues for therapeutic intervention. At CymitQuimica, we offer a wide selection of high-quality ubiquitination inhibitors to support your research in cell biology, proteomics, and drug discovery.

Subcategories of "Ubiquitination"

Found 107 products of "Ubiquitination"

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  • USP30 inhibitor 18
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    USP30 inhibitor 18

    CAS:
    <p>USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.</p>
    Formula:C26H28FN3O4S
    Purity:99.85%
    Color and Shape:Solid
    Molecular weight:497.58

    Ref: TM-T36682

  • Cbl-b-IN-13
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    Cbl-b-IN-13

    CAS:
    <p>Cbl-b-IN-13 (Example 520) is a potent Cbl-b inhibitor exhibiting an IC50 of less than 100 nM and is capable of activating T-cells [1].</p>
    Formula:C29H30F3N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:537.58

    Ref: TM-T79900

  • Cbl-b-IN-6
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    Cbl-b-IN-6

    CAS:
    <p>Cbl-b-IN-6 (Compound 246) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (</p>
    Formula:C30H32F5N5O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:573.6

    Ref: TM-T79893

  • Cbl-b-IN-10
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    Cbl-b-IN-10

    CAS:
    <p>Cbl-b-IN-10 (Compound 463) is a potent inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (</p>
    Formula:C31H37F3N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:566.66

    Ref: TM-T79897

  • Cbl-b-IN-9
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    Cbl-b-IN-9

    CAS:
    <p>Cbl-b-IN-9 (Compound 300) is an inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting potent inhibitory activity with half-maximal</p>
    Formula:C30H33F3N6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:566.62

    Ref: TM-T79896

  • Cbl-b-IN-12
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    Cbl-b-IN-12

    CAS:
    <p>Cbl-b-IN-12 (Example 10) is an inhibitor of casitas B-lineage lymphoma-b (CBL-B), demonstrating a half-maximal inhibitory concentration (IC50) of less than 100</p>
    Formula:C28H29F3N6O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:538.56

    Ref: TM-T79899

  • Cbl-b-IN-7
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    Cbl-b-IN-7

    CAS:
    <p>Cbl-b-IN-7 (Compound 248) is an inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (IC50s</p>
    Formula:C29H31F4N5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:557.58

    Ref: TM-T79894

  • Skp2 inhibitor 2
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    Skp2 inhibitor 2

    CAS:
    <p>Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1.</p>
    Formula:C27H32N4O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:428.57

    Ref: TM-T78194

  • Cbl-b-IN-8
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    Cbl-b-IN-8

    CAS:
    <p>Cbl-b-IN-8 (Compound 293) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half maximal inhibitory concentrations (IC50s) of 5</p>
    Formula:C35H44F3N7O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:667.76

    Ref: TM-T79895

  • Cbl-b-IN-11
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    Cbl-b-IN-11

    CAS:
    <p>Cbl-b-IN-11 (Compound 466) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s) of</p>
    Formula:C31H35F5N6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:602.64

    Ref: TM-T79898

  • USP7-IN-1
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    USP7-IN-1

    CAS:
    <p>USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).</p>
    Formula:C23H24ClN3O3
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:425.91

    Ref: TM-T13268

  • LDN-91946
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    LDN-91946

    CAS:
    <p>LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).</p>
    Formula:C15H10N2O4S
    Purity:97.12%
    Color and Shape:Solid
    Molecular weight:314.32

    Ref: TM-T15729

  • UPCDC30766
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    UPCDC30766

    CAS:
    <p>UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].</p>
    Formula:C30H32F2N6O3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:594.68

    Ref: TM-T79255

  • FT671
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    FT671

    CAS:
    <p>FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).</p>
    Formula:C24H23F4N7O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:533.48

    Ref: TM-T12621L

  • PYZD-4409
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    PYZD-4409

    CAS:
    <p>PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM.</p>
    Formula:C14H7ClFN3O5
    Purity:99.71%
    Color and Shape:Solid
    Molecular weight:351.67

    Ref: TM-T16699

  • CC0651
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    CC0651

    CAS:
    <p>CC0651 is a highly selective allosteric inhibitor of human Cdc34 ubiquitin-conjugating enzyme (UCE), inhibiting p27 Kip1 ubiquitination (IC50=1.72 μM).</p>
    Formula:C20H21Cl2NO6
    Purity:99.03%
    Color and Shape:Solid
    Molecular weight:442.29

    Ref: TM-T14896

  • UC-764864
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    UC-764864

    CAS:
    <p>UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling in</p>
    Formula:C19H18N2OS
    Purity:99.3%
    Color and Shape:Solid
    Molecular weight:322.42

    Ref: TM-T79133

  • IMP-1710
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    IMP-1710

    CAS:
    <p>IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.</p>
    Formula:C23H19N5O
    Purity:99.3%
    Color and Shape:Solid
    Molecular weight:381.43

    Ref: TM-T37591

  • BC-1293
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    BC-1293

    CAS:
    <p>BC-1293 inhibits FBXO24, stabilizes DARS2, and elevates cytokines in mice, showing immunostimulatory potential for immune modulation research.</p>
    Formula:C26H28N4O4S
    Purity:98.40%
    Color and Shape:Solid
    Molecular weight:492.59

    Ref: TM-T89425

  • PRC1-IN-1
    Targetmol
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    PRC1-IN-1

    CAS:
    <p>PRC1-IN-1 (compound RB-4) is an inhibitor of the polycomb repressive complex 1 (PRC1) with an IC50 of 2.3 μM. It targets RING1B-BMI1, RING1A-BMI1, and RING1B-PCGF1, exhibiting IC50 values of 2.8 μM, 2.6 μM, and 1.8 μM, respectively.</p>
    Formula:C24H19ClFN3O2
    Color and Shape:Solid
    Molecular weight:435.878

    Ref: TM-T205306