DUB
DUB inhibitors target deubiquitinases, enzymes that remove ubiquitin molecules from proteins, thereby regulating the stability, localization, and activity of proteins within the cell. Deubiquitinases play essential roles in various cellular processes, including cell cycle regulation, DNA repair, and immune responses. Dysregulation of DUB activity is linked to cancer, neurodegenerative disorders, and viral infections. Inhibitors of DUBs can modulate these processes, offering potential therapeutic approaches for these conditions. At CymitQuimica, we provide DUB inhibitors to support your research in protein homeostasis, cancer, and neurobiology.
Found 104 products for "DUB".
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Capzimin
CAS:Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.Formula:C30H24N6O2S4Purity:98.31% - 99.32%Color and Shape:SolidMolecular weight:628.81XL-188
CAS:XL-188: Potent, selective USP7 inhibitor, IC50 = 193 nM (domain), 90 nM (full). Boosts p53, p21; degrades HDM2. Unique among DUB inhibitors.Formula:C32H42N6O4Color and Shape:SolidMolecular weight:574.71USP7-IN-4
CAS:USP7-IN-4 is a non-competitive, potent and selective inhibitor of USP7, up-regulates p53 and p21, down-regulates MDM2,anti-proliferativity RS4;11 (leukemia) .Formula:C29H34N6O3Purity:98.27% - 99.09%Color and Shape:SolidMolecular weight:514.62USP28-IN-2
CAS:USP28-IN-2 selectively inhibits USP28 (IC50=0.3 μM), degrades c-Myc, kills cancer cells, lowers ankyrin-1/2, and enhances Regorafenib effects.Formula:C23H20Cl2N2O3SColor and Shape:SolidMolecular weight:475.39HBX28258
CAS:HBX28258, a human USP7 inhibitor, binds covalently and selectively deactivates USP7 in colon cancer and kidney cells.Formula:C26H30ClN3OPurity:98%Color and Shape:SolidMolecular weight:435.99BAP1-IN-1
CAS:BAP1-IN-1 is an inhibitor of the catalytic activity of BRCA1-associated protein 1 (BAP1), which is related to cancer and can be used to study cancer.Formula:C18H16N2O2Purity:98.11%Color and Shape:SolidMolecular weight:292.33I-138
CAS:I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.Formula:C26H23F3N6OPurity:99.66%Color and Shape:SolidMolecular weight:492.5Ref: TM-T73560
1mg105.00€5mg210.00€1mL*10mM (DMSO)230.00€10mg295.00€25mg424.00€50mg587.00€100mg880.00€USP28-IN-4
CAS:USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Formula:C22H18Cl2N2O3SPurity:98.39%Color and Shape:Yellow SolidMolecular weight:461.36USP28-IN-3
CAS:USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Formula:C23H20Cl2N2O3SPurity:99.92%Color and Shape:White SolidMolecular weight:475.39GSK2643943A
CAS:GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.Formula:C17H12FN3Purity:97.09%Color and Shape:SolidMolecular weight:277.3Ref: TM-T11485
1mg39.00€2mg50.00€5mg82.00€1mL*10mM (DMSO)90.00€10mg120.00€25mg236.00€50mg356.00€100mg537.00€200mg762.00€USP22-IN-1
CAS:USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.Formula:C22H18N4Purity:99.37%Color and Shape:SolidMolecular weight:338.41SJB3-019A
CAS:SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 timesFormula:C16H8N2O3Purity:99.72%Color and Shape:Yellow SolidMolecular weight:276.25Ref: TM-T12926
1mg77.00€2mg101.00€5mg168.00€10mg253.00€25mg416.00€50mg580.00€100mg783.00€200mg1,054.00€P22074
CAS:P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Formula:C12H9NO3S2Purity:99.97%Color and Shape:SolidMolecular weight:279.33Ref: TM-T28284
1mg137.00€1mL*10mM (DMSO)239.00€5mg314.00€10mg427.00€25mg600.00€50mg798.00€100mg1,099.00€200mg1,468.00€USP30 inhibitor 11
CAS:USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Formula:C17H16N6O2SPurity:98.49% - 98.84%Color and Shape:SolidMolecular weight:368.416RK73
CAS:6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM).Formula:C13H17N5O2SPurity:99.91%Color and Shape:SolidMolecular weight:307.37Ref: TM-T10188
1mg137.00€5mg281.00€1mL*10mM (DMSO)310.00€10mg484.00€25mg782.00€50mg1,071.00€100mg1,431.00€500mg2,898.00€OTUB1/USP8-IN-1
CAS:OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.Formula:C22H16ClFN2O4Purity:98.59%Color and Shape:SolidMolecular weight:426.83LDN-91946
CAS:LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).Formula:C15H10N2O4SPurity:97.12%Color and Shape:SolidMolecular weight:314.32USP30 inhibitor 18
CAS:USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.Formula:C26H28FN3O4SPurity:99.85%Color and Shape:SolidMolecular weight:497.58Ref: TM-T36682
1mg137.00€5mg281.00€1mL*10mM (DMSO)309.00€10mg447.00€25mg713.00€50mg1,018.00€100mg1,369.00€500mg2,673.00€USP7-IN-13
CAS:USP7-IN-13 (Compound 101), a USP7 inhibitor, exhibits an IC50 range of 0.2-1 μM and is applicable in researching multiple myeloma [1].Formula:C24H28N4O3Color and Shape:SolidMolecular weight:420.5DUB-IN-7
CAS:DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].Formula:C17H19N5OColor and Shape:SolidMolecular weight:309.37
