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DUB

DUB

DUB inhibitors target deubiquitinases, enzymes that remove ubiquitin molecules from proteins, thereby regulating the stability, localization, and activity of proteins within the cell. Deubiquitinases play essential roles in various cellular processes, including cell cycle regulation, DNA repair, and immune responses. Dysregulation of DUB activity is linked to cancer, neurodegenerative disorders, and viral infections. Inhibitors of DUBs can modulate these processes, offering potential therapeutic approaches for these conditions. At CymitQuimica, we provide DUB inhibitors to support your research in protein homeostasis, cancer, and neurobiology.

Found 110 products for "DUB".

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  • 8RK64
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    8RK64

    CAS:
    8RK64 is a covalent UCHL1 inhibitor ( IC 50 : 0.32 μM) .
    Formula:C14H16N8O2S
    Color and Shape:Solid
    Molecular weight:360.4

    Ref: TM-T69539

  • FT709
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    FT709

    CAS:
    FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.
    Formula:C23H22N4O7S
    Purity:98.13%
    Color and Shape:White Solid
    Molecular weight:498.51

    Ref: TM-T63375

  • USP1-IN-4
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    USP1-IN-4

    CAS:
    USP1-IN-4 (compound 10) serves as a potent inhibitor of USP1, exhibiting an IC 50 of 2.44 nM. It demonstrates anticancer properties and operates synergistically with various anticancer drugs [1].
    Formula:C26H23F3N6
    Color and Shape:Solid
    Molecular weight:476.50

    Ref: TM-T87600

  • USP7-IN-10
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    USP7-IN-10

    CAS:
    USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.
    Formula:C26H29ClN4O3S
    Color and Shape:Solid
    Molecular weight:513.05

    Ref: TM-T73136

  • USP1-IN-7
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    USP1-IN-7

    CAS:
    USP1-IN-7 (Compound 3), a potent inhibitor of ubiquitin specific peptidase 1 (USP1) and its cofactor UAF1, exhibits an inhibition concentration (IC 50) of ≤50 nM. It also effectively inhibits the proliferation of MDA-MB-436 cells at similar concentrations [1].
    Formula:C27H23F4N7O2
    Color and Shape:Solid
    Molecular weight:553.51

    Ref: TM-T87601

  • USP7-IN-6
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    USP7-IN-6

    CAS:
    USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).
    Formula:C41H43N7O4S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:729.89

    Ref: TM-T13271

  • USP7-797
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    USP7-797

    CAS:
    USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.
    Formula:C27H28ClN3O3S
    Purity:95.90% - 95.90%
    Color and Shape:Solid
    Molecular weight:510.05

    Ref: TM-T73234

  • USP5-IN-1
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    USP5-IN-1

    USP5-IN-1, a powerful USP5 deubiquitinase inhibitor, selectively binds with 2.8 μM affinity, blocking USP5's di-ubiquitin cleavage.
    Formula:C19H20ClN3O5S
    Purity:99.76%
    Color and Shape:Soild
    Molecular weight:437.9

    Ref: TM-T60130

  • VCPIP1-IN-1
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    VCPIP1-IN-1

    CAS:
    VCPIP1-IN-1 is a VCPIP1 inhibitor used in cancer research.
    Formula:C13H15ClN2O2
    Purity:99.77%
    Color and Shape:White Solid
    Molecular weight:266.72

    Ref: TM-T88664

  • USP15-IN-1
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    USP15-IN-1

    CAS:
    USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).
    Formula:C22H23N3O3
    Purity:99.50% - 99.81%
    Color and Shape:Solid
    Molecular weight:377.4363

    Ref: TM-T61575