Aurora Kinase
Aurora kinase inhibitors target the Aurora kinases, a family of serine/threonine kinases that play a critical role in the regulation of mitosis. These kinases are essential for proper chromosome alignment, segregation, and cytokinesis during cell division. Abnormal Aurora kinase activity can lead to uncontrolled cell proliferation and cancer. By inhibiting Aurora kinases, these compounds can induce cell cycle arrest and apoptosis in cancer cells, making them valuable tools in cancer research and therapy. At CymitQuimica, we offer a wide range of high-quality Aurora kinase inhibitors to support your research in cell cycle regulation, mitosis, and oncology.
Found 109 products of "Aurora Kinase"
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TAK-901
CAS:<p>TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others</p>Formula:C28H32N4O3SPurity:99.02% - 99.59%Color and Shape:SolidMolecular weight:504.64dAURK-4 hydrochloride
dAURK-4 hydrochloride, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].Formula:C52H53Cl2FN8O12Purity:99.44%Color and Shape:SolidMolecular weight:1071.93Centrinone
CAS:Centrinone (LCR-263) (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).Formula:C26H25F2N7O6S2Purity:98.76%Color and Shape:SolidMolecular weight:633.65NU6140
CAS:<p>NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).</p>Formula:C23H30N6O2Purity:98.33%Color and Shape:SolidMolecular weight:422.52Tinengotinib
CAS:Tinengotinib is a multikinase inhibitor that targets a series of kinases , including Aurora kinases A/B, JAK1/2, FGFR1/2/3, VEGFRs, and many other kinases.Formula:C20H19ClN6OPurity:99.05%Color and Shape:SolidMolecular weight:394.86SK2187
CAS:SK2187 is a selective degrader of AURKAPROTAC with a DC50 of approximately 10 nM. It exhibits growth-inhibitory effects on NGP cells, with an IC50 value of 101.5 nM. SK2187 is utilized in studies of MYCN-amplified neuroblastoma.Formula:C45H49ClFN7O11SColor and Shape:SolidMolecular weight:950.43dAurAB2
dAurAB2 is a bifunctional PROTAC capable of effectively degrading Aurora-A and Aurora-B, with DC50 values of 59 nM and 39 nM, respectively. It reduces N-Myc levels in MYCN-amplified IMR32 neuroblastoma cells and is valuable for neuroblastoma research.Color and Shape:Odour SolidPROTAC MPS1 degrader 1
PROTAC MPS1 degrader 1 (Compound 19) acts as a potent degrader of Monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB, with DC50 values of 17.7, 108.7, and 570.3 nM respectively. It is utilized in the study of acute myeloid leukemia. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase)Formula:C41H46N12O7Color and Shape:SolidMolecular weight:818.88PROTAC MPS1 degrader 2
PROTAC MPS1 Degrader 2 (Compound 15) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB with DC50 values of 42.0, 2.1, and 154.0 nM respectively. It is utilized in the research of acute myeloid leukemia.Formula:C41H41N11O8SColor and Shape:SolidMolecular weight:847.90CAM2602
<p>CAM2602 is an inhibitor of Aurora A-TPX2 interaction, demonstrating a binding affinity of 19 nM with Aurora A. This compound has been shown to inhibit the growth of pancreatic cancer cells. In solid tumor xenograft models, CAM2602 increases the proportion of PH3-positive cells while decreasing the ratio of P-Thr288Aurora A-positive cells, ultimately inhibiting tumor growth.</p>Color and Shape:Odour SoliddAURK-4
CAS:dAURK-4, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].Formula:C52H52ClFN8O12Color and Shape:SolidMolecular weight:1035.47Aurora A inhibitor 3
<p>Aurora A Inhibitor 3 (Compound 5h) effectively inhibits Aurora-A kinase, exhibiting an IC50 of 0.78 μM, and demonstrates cytotoxicity against MCF-7 and MDA-MB-</p>Purity:98%Color and Shape:Odour SolidRetreversine
CAS:Retreversine serves as an inactive control counterpart to Reversine, a pioneering class of ATP-competitive Aurora kinase inhibitor.Formula:C21H27N7OColor and Shape:SolidMolecular weight:393.49AKI603
CAS:AKI603: Aurora A kinase blocker; IC50 12.3 nM; targets BCR-ABL-T315I resistance; halts leukemia cell growth.Formula:C19H23N9O2Purity:99.81%Color and Shape:SolidMolecular weight:409.45AURKA against 1
<p>Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.</p>Formula:C28H32FN9O2Color and Shape:SolidMolecular weight:545.61JB170
CAS:JB170 is a specific Aurora A degradator. Alisertib and Thalidomide, induces S-phase arrest in cell growth and inhibits the non-catalytic function.Formula:C48H44ClFN8O11Purity:99.82%Color and Shape:SolidMolecular weight:963.3611α-O-Tigloyl-12β-O-acetyltenacigenin B
CAS:11α-O-Tigloyl-12β-O-acetyltenacigenin B, an ester derivative isolated from Garcinia cambogia (MTC), modulates the antitumor effects of Aurora-A in lymphomaFormula:C28H40O7Purity:98%Color and Shape:SolidMolecular weight:488.61JB300
CAS:JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Formula:C43H45ClFN7O10SColor and Shape:SolidMolecular weight:906.375Barasertib
CAS:AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Formula:C26H31FN7O6PPurity:99.92% - 99.97%Color and Shape:SolidMolecular weight:587.54HLB-0532259
CAS:<p>HLB-0532259 is a PROTAC degrader that targets the degradation of Aurora-A and N-Myc. In non-MYCN amplified MCF-7 cells, it degrades Aurora-A with a DC50 of 20.2 nM, and in MYCN amplified SK-N-BE and Kelly cells, it degrades N-Myc with DC50 values of 179 nM and 229 nM, respectively. HLB-0532259 has demonstrated antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)</p>Formula:C40H44N8O7Color and Shape:SolidMolecular weight:748.827TAS-119
CAS:TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Formula:C23H22Cl2FN5O3Purity:99.65%Color and Shape:SolidMolecular weight:506.36CD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Color and Shape:SolidSP-96
CAS:<p>SP-96: Aurora B inhibitor, IC50=0.316 nM, selectively hinders MDA-MD-468 growth, GI50=107 nM, for triple-negative breast cancer research.</p>Formula:C25H20FN7OPurity:99.54%Color and Shape:SolidMolecular weight:453.47Aurora-A ligand 1
CAS:<p>Aurora-A ligand 1 is a potent and selective inhibitor of Aurora-A, exhibiting a dissociation constant (Kd) of 0.85 nM. It serves as a target protein ligand [PROTAC target protein ligand] in the development of PROTAC Aurora-A degraders with antitumor activity. Additionally, Aurora-A ligand 1 is utilized in the synthesis of HLB-0532259, which exhibits antitumor effects against neuroblastoma.</p>Formula:C21H23N5O3Color and Shape:SolidMolecular weight:393.439MS44
MS44 is a potent degrader of aurora kinase B (AURKBPROTAC) with a degradation concentration (DC50) of 103 nM. It effectively and selectively degrades AURKB in a time- and ubiquitin-proteasome system (UPS)-dependent manner, showing specificity for AURKB over AURKA and AURKC. MS44 inhibits the proliferation of various cancer cell lines and strongly induces G2/M arrest. It is useful for studying AURKB-dependent tumors.Color and Shape:Odour SolidGSK-1070916
CAS:GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM.Formula:C30H33N7OPurity:99.73%Color and Shape:SolidMolecular weight:507.637BIO
CAS:<p>7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.</p>Formula:C16H10BrN3O2Purity:99.67%Color and Shape:SolidMolecular weight:356.17PF 477736
CAS:PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Formula:C22H25N7O2Purity:97.58% - 99.94%Color and Shape:SolidMolecular weight:419.48Phthalazinone pyrazole
CAS:Phthalazinone pyrazole: a potent, selective oral Aurora-A kinase inhibitor, overexpressed in tumors with oncogenic activity.Formula:C18H15N5OPurity:97.03%Color and Shape:SolidMolecular weight:317.34TCS7010
CAS:TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay.Formula:C31H31ClFN7O2Purity:98.49% - 99.62%Color and Shape:SolidMolecular weight:588.07Ilorasertib
CAS:Ilorasertib (ABT-348) inhibits Aurora kinases A/B/C & RET, PDGFRβ, Flt1 (IC50: 1-120 nM).Formula:C25H21FN6O2SPurity:96.17% - 97.49%Color and Shape:SolidMolecular weight:488.54Hesperadin
CAS:Hesperadin(IC50=250 nM) effectively inhibits Aurora B.Formula:C29H32N4O3SPurity:98.04% - 99.44%Color and Shape:SolidMolecular weight:516.65CYC-116
CAS:CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not activeFormula:C18H20N6OSPurity:97.36% - 97.59%Color and Shape:SolidMolecular weight:368.46SP-146
<p>SP-146 is a selective, potent and non-ATP-competitive Aurora B inhibitor(IC50 : 0.316 nM).</p>Formula:C25H20FN7OPurity:97.82%Color and Shape:SolidMolecular weight:453.47MK-8745
CAS:<p>MK-8745 is a potent and selective Aurora A inhibitor.</p>Formula:C20H19ClFN5OSPurity:99.09% - 99.79%Color and Shape:SolidMolecular weight:431.91CCT 137690
CAS:CCT 137690 is a highly specific and oral-available aurora kinase inhibitor, for aurora A(IC50=15 nM ), B(IC50=25 nM) and C(IC50=19 nM).Formula:C26H31BrN8OPurity:98.51% - 99.89%Color and Shape:SolidMolecular weight:551.48SNS-314 Mesylate
CAS:SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor. SNS-314 is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.Formula:C18H15ClN6OS2·CH4O3SPurity:99.44% - 99.92%Color and Shape:SolidMolecular weight:527.04AT9283
CAS:<p>AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).</p>Formula:C19H23N7O2Purity:99.83% - 99.98%Color and Shape:SolidMolecular weight:381.43SNS-314
CAS:<p>SNS-314 inhibits Aurora kinases A and B, blocking cell division in AK-overexpressing tumors.</p>Formula:C18H15ClN6OS2Purity:98%Color and Shape:SolidMolecular weight:430.93Reversine
CAS:Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).Formula:C21H27N7OPurity:98% - 99.45%Color and Shape:SolidMolecular weight:393.49BI-847325
CAS:BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.Formula:C29H28N4O2Purity:97.13% - 97.54%Color and Shape:SolidMolecular weight:464.56Aurora kinase inhibitor-2
CAS:Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).Formula:C23H20N4O3Purity:98.66%Color and Shape:SolidMolecular weight:400.43Protein kinase inhibitor 6
CAS:<p>Protein kinase inhibitor 6 is a protein kinase inhibitor.</p>Formula:C13H9FN2SPurity:98.01%Color and Shape:SolidMolecular weight:244.29Alisertib
CAS:Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.Formula:C27H20ClFN4O4Purity:98.31% - >99.99%Color and Shape:SolidMolecular weight:518.92MLN8054
CAS:MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.Formula:C25H15ClF2N4O2Purity:98.07% - 98.26%Color and Shape:SolidMolecular weight:476.86ZM-447439
CAS:ZM 447439 selectively inhibits Aurora A/B (IC50: 110/130 nM); 8x less effective on MEK1, Src, Lck; minimal impact on CDK1/2/4, Plk1, Chk1.Formula:C29H31N5O4Purity:99.11% - 99.59%Color and Shape:Pale Yellow SolidMolecular weight:513.59AT-9283 HCl
CAS:AT-9283, a multi-targeted kinase inhibitor, is used potentially for the treatment of multiple myeloma.Formula:C19H24ClN7O2Color and Shape:SolidMolecular weight:417.89TAK-632
CAS:TAK-632 is a potent pan-Raf inhibitor.Formula:C27H18F4N4O3SPurity:98% - 99.5%Color and Shape:SolidMolecular weight:554.52VX-11e
CAS:VX-11e (TCS ERK 11e) is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.Formula:C24H20Cl2FN5O2Purity:98.92% - ≥98%Color and Shape:SolidMolecular weight:500.35Aurora kinase inhibitor-3
CAS:Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK,Formula:C21H18F3N5OPurity:98.91%Color and Shape:SolidMolecular weight:413.4URMC-099
CAS:URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 – MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.Formula:C27H27N5Purity:99.32% - 99.98%Color and Shape:SolidMolecular weight:421.54MLN8054 sodium
CAS:MLN8054 sodium is an Aurora A inhibitor.Formula:C25H14ClF2N4NaO2Color and Shape:SolidMolecular weight:498.84Danusertib
CAS:<p>Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.</p>Formula:C26H30N6O3Purity:97.88% - 98.79%Color and Shape:White PowderMolecular weight:474.55KW-2449
CAS:<p>KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.</p>Formula:C20H20N4OPurity:98.43% - 99.69%Color and Shape:SolidMolecular weight:332.4JNJ-7706621
CAS:<p>JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.</p>Formula:C15H12F2N6O3SPurity:99.1% - 99.85%Color and Shape:SolidMolecular weight:394.36Palmatine chloride
CAS:Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.Formula:C21H22ClNO4Purity:97.9% - 99.47%Color and Shape:SolidMolecular weight:387.86Palmatine
CAS:<p>Palmatine, also known as Burasaine, inhibits dopamine production and may treat flavivirus, jaundice, dysentery, hypertension, and liver issues.</p>Formula:C21H22NO4Purity:96.28% - 99.49%Color and Shape:SolidMolecular weight:352.4XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Formula:C22H31N9OPurity:99.07%Color and Shape:SolidMolecular weight:437.54Tozasertib
CAS:Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Formula:C23H28N8OSPurity:99.99%Color and Shape:SolidMolecular weight:464.59PHA-680632
CAS:<p>PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.</p>Formula:C28H35N7O2Purity:98.2%Color and Shape:SolidMolecular weight:501.62GW779439X
CAS:GW779439X is an inhibitor of CDK.Formula:C22H21F3N8Purity:97.87%Color and Shape:SolidMolecular weight:454.45AMG 900
CAS:<p>AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.</p>Formula:C28H21N7OSPurity:98.4% - 99.51%Color and Shape:SolidMolecular weight:503.58CCT241736
CAS:CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3Formula:C22H23Cl2N7Purity:96.2% - 99.81%Color and Shape:SolidMolecular weight:456.37ENMD-2076
CAS:ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.Formula:C21H25N7Purity:97.63% - ≥95%Color and Shape:SolidMolecular weight:375.47Barasertib-HQPA
CAS:<p>Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.</p>Formula:C26H30FN7O3Purity:98.43% - 99.29%Color and Shape:SolidMolecular weight:507.56MK-5108
CAS:MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.Formula:C22H21ClFN3O3SPurity:99.22%Color and Shape:SolidMolecular weight:461.94SCH-1473759 hydrochloride
CAS:SCH-1473759 hydrochloride is an inhibitor of aurora(aurora A and B with IC50s of 4 and 13 nM, respectively).Formula:C20H27ClN8OSPurity:98.29%Color and Shape:SolidMolecular weight:463GW843682X
CAS:GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).Formula:C22H18F3N3O4SPurity:99.92%Color and Shape:SolidMolecular weight:477.46BI-831266
CAS:BI-831266 is a potent and selective Aurora kinase B inhibitor.Formula:C27H38ClN7O2Color and Shape:SolidMolecular weight:528.09Aurora kinase inhibitor-9
CAS:Aurora kinase inhibitor-9 (9d) targets AURKA/B with IC50: 0.093 μM for A and 0.09 μM for B, with wide anti-proliferative effects.Formula:C19H17Cl2N3O4SColor and Shape:SolidMolecular weight:454.33Aurora kinase inhibitor-10
CAS:Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects.Formula:C21H19F5N6O4SColor and Shape:SolidMolecular weight:546.47Aurora Kinases-IN-2
CAS:Aurora Kinases-IN-2 (12Aj) hinders Aurora A/B kinases (IC50: 90/152 nM), used in cancer studies.Formula:C22H18ClN5O3Color and Shape:SolidMolecular weight:435.86Aurora A/PKC-IN-1
CAS:Aurora A/PKC-IN-1 inhibits AurA (IC50: 6.9 nM), PKCα (IC50: 16.9 nM), and hinders breast cancer cell growth and spread.Formula:C16H14N6OSe2Color and Shape:SolidMolecular weight:464.24L 888607 Racemate
CAS:L 888607 Racemate blocks DP1 and TP receptors with 132 nM and 17 nM affinity.Formula:C19H15ClFNO2SColor and Shape:SolidMolecular weight:375.84Ilorasertib hydrochloride
CAS:Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:Formula:C25H22ClFN6O2SPurity:98.45%Color and Shape:SolidMolecular weight:525OM-137
CAS:OM137 inhibits Aurora kinases, impedes cell growth at high doses, and enhances low-dose paclitaxel effects.Formula:C13H14N4O3SColor and Shape:SolidMolecular weight:306.34SAR156497
CAS:SAR156497: selective Aurora A/B/C inhibitor; IC50: 0.5 nM (A), 1 nM (B), 3 nM (C); good metabolic stability; anti-tumoral without genetic specificity.Formula:C27H24N4O4Color and Shape:SolidMolecular weight:468.5FAK/aurora kinase-IN-1
CAS:FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].Formula:C23H24ClN7O3Color and Shape:SolidMolecular weight:481.93VE-465
CAS:VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.Formula:C22H28N8OSColor and Shape:SolidMolecular weight:452.58HOI-07
CAS:HOI-07 is a specific Aurora B inhibitor.Formula:C19H13NO4Color and Shape:SolidMolecular weight:319.31Binucleine 2
CAS:Binucleine 2: Drosophila Aurora B kinase inhibitor (Ki=0.36μM), dose-dependent, minimal effect on human/X. laevis kinases, disrupts mitosis in fly cells.Formula:C13H11ClFN5Color and Shape:SolidMolecular weight:291.71Aurora Kinases-IN-3
CAS:Aurora Kinases-IN-3 is an oral AURKB inhibitor that disrupts its mitotic localization, not its H3 Ser10 phosphorylation.Formula:C20H16F3N3O4Color and Shape:SolidMolecular weight:419.35RET-IN-19
CAS:<p>RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.</p>Formula:C28H28N6O4SColor and Shape:SolidMolecular weight:544.62Tripolin A
CAS:<p>Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)</p>Formula:C15H11NO3Purity:98%Color and Shape:SolidMolecular weight:253.25Chiauranib
CAS:<p>Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.</p>Formula:C27H21N3O3Purity:99.22%Color and Shape:SolidMolecular weight:435.47GRK6-IN-1
CAS:GRK6-IN-1 (compound 18) is a potent GRK6 blocker, with an IC50 of 120 nM, showing promise for multiple myeloma research.Formula:C22H23ClN6O2Purity:99.37%Color and Shape:SolidMolecular weight:438.91CD532
CAS:CD532: Potent Aurora A inhibitor, IC50=45 nM, blocks kinase activity, degrades MYCN, interacts with AURKA, studies cancer.Formula:C26H25F3N8OPurity:99.99%Color and Shape:SolidMolecular weight:522.52Aurora kinase inhibitor-8
CAS:Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase.Formula:C30H29N7O3Color and Shape:SolidMolecular weight:535.6GW814408X
CAS:GW814408X, a kinase chemical genome group (KCGS) compound, inhibits the AURKC kinase, which is involved in cell cycle progression, checkpoint regulation, and cell division. It exhibits cell line-dependent toxicity, such as cytotoxic effects on HeLa cells, and acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, potentially impacting Fluc reporter assays [1].Formula:C19H16N6OMolecular weight:344.37TC-A 2317 hydrochloride
CAS:<p>TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.</p>Formula:C19H29ClN6OPurity:98%Color and Shape:SolidMolecular weight:392.93Aurora Kinases-IN-4
CAS:<p>Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.</p>Formula:C26H28N8OPurity:98%Color and Shape:SolidMolecular weight:468.55AAPK-25
CAS:AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Formula:C21H13Cl2N3O2SPurity:97.05%Color and Shape:SolidMolecular weight:442.32GRK2 Inhibitor 2
CAS:GRK2 Inhibitor 2 (Compound 8h), with an IC50 of 19 nM for GRK2 and 137 nM for Aurora-A, enhances β-AR-mediated cAMP accumulation in GRK2-overexpressing HEK293Formula:C19H16N4O2Color and Shape:SolidMolecular weight:332.36GSK2646264
CAS:<p>GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.</p>Formula:C24H26N2O2Color and Shape:SolidMolecular weight:374.48LY3295668
CAS:<p>LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.</p>Formula:C24H26ClF2N5O2Purity:99.68%Color and Shape:SolidMolecular weight:489.95CCT129202
CAS:CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.Formula:C23H25ClN8OSPurity:98.14%Color and Shape:SolidMolecular weight:497.02Hesperadin hydrochloride
Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.Formula:C29H33ClN4O3SColor and Shape:SolidMolecular weight:553.12Glycyl H-1152 hydrochloride
CAS:Glycyl-H-1152 is a potent ROCK-II inhibitor (IC50=11.8 nM) with high selectivity over CaMKII, PKG, Aurora A, PKA, and PKC. Better than Y-27632 and HA-1077.Formula:C18H26Cl2N4O3SColor and Shape:SolidMolecular weight:449.39SCH-1473759
CAS:SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).Formula:C20H26N8OSPurity:98%Color and Shape:SolidMolecular weight:426.546K465
CAS:6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.Formula:C26H33ClFN9OPurity:99.78%Color and Shape:SolidMolecular weight:542.05
