PKA
Protein kinase A (PKA) is a key enzyme in the GPCR signaling cascade, activated by cyclic AMP (cAMP) in response to various extracellular signals. PKA regulates a wide range of cellular processes, including metabolism, gene expression, and cell growth. Dysregulation of PKA activity is associated with various diseases, including cancer, metabolic disorders, and cardiovascular conditions. PKA modulators are valuable tools in research aimed at understanding GPCR signaling pathways and developing new therapeutic strategies. At CymitQuimica, we provide a selection of high-quality PKA modulators to support your research in signal transduction, cellular regulation, and disease mechanisms.
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MR-L2
CAS:2374703-19-0
MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).
Formula:
C19H16Cl3FN4O
Purity:
98.09% - 98.94%
Color and Shape:
Solid
Molecular weight:
441.71
Ref: TM-T12103
| 1mg | 143.00 € | ||
| 2mg | 203.00 € | ||
| 5mg | 346.00 € | ||
| 10mg | 519.00 € | ||
| 25mg | 835.00 € | ||
| 50mg | 1,140.00 € | ||
| 100mg | 1,532.00 € | ||
| 500mg | 3,067.00 € | ||
| 1mL*10mM (DMSO) | 375.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Bucladesine sodium
CAS:16980-89-5
Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties.
Formula:
C18H23N5NaO8P
Purity:
96.56% - 99.58%
Color and Shape:
White Powder
Molecular weight:
491.37
Ref: TM-T1418
| 2g | 390.00 € | ||
| 25mg | 36.00 € | ||
| 50mg | 49.00 € | ||
| 100mg | 86.00 € | ||
| 200mg | 114.00 € | ||
| 500mg | 181.00 € | ||
| 1mL*10mM (DMSO) | 50.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
A-3 hydrochloride
CAS:78957-85-4
A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 …
Formula:
C12H14Cl2N2O2S
Purity:
99.32%
Color and Shape:
Solid
Molecular weight:
321.22
Ref: TM-T14069
| 1mg | 35.00 € | ||
| 5mg | 68.00 € | ||
| 10mg | 97.00 € | ||
| 25mg | 172.00 € | ||
| 50mg | 278.00 € | ||
| 100mg | 445.00 € | ||
| 500mg | 920.00 € | ||
| 1mL*10mM (DMSO) | 92.00 € |
Estimated delivery in United States, on Monday 16 Dec 2024
Fasudil
CAS:103745-39-7
Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
Formula:
C14H17N3O2S
Purity:
99.84%
Color and Shape:
Solid
Molecular weight:
291.37
Ref: TM-T1606
| 50mg | 39.00 € | ||
| 100mg | 49.00 € | ||
| 200mg | 67.00 € | ||
| 500mg | 104.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
Protein kinase G inhibitor-1
CAS:354544-70-0
Protein kinase G inhibitor-1 is a potent Protein kinase G inhibitor, IC50= 0.9 uM.
Formula:
C14H18N2O2S
Purity:
98.11%
Color and Shape:
Soild
Molecular weight:
278.37
Ref: TM-T67755
| 1mg | 112.00 € | ||
| 5mg | 248.00 € | ||
| 10mg | 365.00 € | ||
| 25mg | 546.00 € | ||
| 50mg | 768.00 € | ||
| 100mg | 1,033.00 € | ||
| 200mg | 1,402.00 € | ||
| 1mL*10mM (DMSO) | 229.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
PKA-IN-1
CAS:179985-52-5
PKA-IN-1 is a selective and potent cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor …
Formula:
C13H11N3O
Purity:
97.52%
Color and Shape:
Liquid
Molecular weight:
225.25
Ref: TM-T39217
| 10mg | 46.00 € | ||
| 25mg | 69.00 € | ||
| 50mg | 95.00 € | ||
| 100mg | 149.00 € | ||
| 1mL*10mM (DMSO) | 75.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
AP-C2
CAS:682793-07-3
AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor …
Formula:
C18H16N4S
Purity:
100%
Color and Shape:
Soild
Molecular weight:
320.41
Ref: TM-T77570
| 1mg | 62.00 € | ||
| 5mg | 131.00 € | ||
| 10mg | 176.00 € | ||
| 25mg | 352.00 € | ||
| 50mg | 610.00 € | ||
| 100mg | 1,054.00 € | ||
| 500mg | 2,126.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
Aplithianines A
Aplithianines A effectively inhibits J-PKAcα with an IC50 value of 1 μM and displays higher …
Purity:
98%
Ref: TM-T82984
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 17 Dec 2024
KT5720
CAS:108068-98-0
KT5720 is a cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase A (PKA) (Ki: 60 …
Formula:
C32H31N3O5
Purity:
98%
Color and Shape:
Solid
Molecular weight:
537.61
Ref: TM-T15669
| 50µg | 188.00 € | ||
| 100µg | 307.00 € | ||
| 250µg | 707.00 € | ||
| 500µg | 1,025.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
Kemptide
CAS:65189-71-1
Kemptide is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK).
Formula:
C32H61N13O9
Purity:
98%
Color and Shape:
Solid
Molecular weight:
771.91
Ref: TM-TP1351
| 1mg | 108.00 € | ||
| 5mg | 332.00 € | ||
| 10mg | 610.00 € | ||
| 25mg | 1,385.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
Gliotoxin
CAS:67-99-2
Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks …
Formula:
C13H14N2O4S2
Purity:
98%
Color and Shape:
Solid
Molecular weight:
326.39
Ref: TM-TN1694
| 1mg | 141.00 € | ||
| 5mg | 601.00 € | ||
| 10mg | 996.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
JAK1/2/3 Inhibitor 1
CAS:16234-14-3
JAK1/2/3 Inhibitor 1 is a potent protein kinase inhibitor.JAK1/2/3 Inhibitor 1 has antitumor activity that …
Formula:
C6H2Cl2N2S
Purity:
99.32%
Color and Shape:
Liquid
Molecular weight:
205.06
Ref: TM-T77504
| 5mg | 54.00 € | ||
| 10mg | 64.00 € | ||
| 25mg | 96.00 € | ||
| 50mg | 123.00 € | ||
| 100mg | 176.00 € | ||
| 500mg | 474.00 € |
Estimated delivery in United States, on Tuesday 17 Dec 2024
H-89
CAS:127243-85-0
H-89 is a PKA inhibitor, a candidate cardioprotectant, induces spatial learning impairment in rats, and …
Formula:
C20H20BrN3O2S
Purity:
98%
Color and Shape:
Off-White Powder
Molecular weight:
446.36
Ref: TM-T11524
| 5mg | 39.00 € | ||
| 10mg | 57.00 € | ||
| 25mg | 110.00 € | ||
| 50mg | 168.00 € | ||
| 100mg | 243.00 € | ||
| 500mg | 599.00 € | ||
| 1mL*10mM (DMSO) | 43.00 € |
Estimated delivery in United States, on Thursday 19 Dec 2024
H-8 hydrochloride
CAS:113276-94-1
H-8 hydrochloride is a reversible and ATP-competitive PKA inhibitor. It can be used to study …
Formula:
C12H17Cl2N3O2S
Purity:
99.93%
Color and Shape:
White To Off-White Crystalline Solid
Molecular weight:
338.25
Ref: TM-T22832
| 1mg | 53.00 € | ||
| 5mg | 111.00 € | ||
| 10mg | 169.00 € | ||
| 25mg | 280.00 € | ||
| 50mg | 428.00 € | ||
| 100mg | 616.00 € | ||
| 500mg | 1,273.00 € |
Estimated delivery in United States, on Thursday 19 Dec 2024
Bilobetin
CAS:521-32-4
Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
Formula:
C31H20O10
Purity:
97.74% - 99.73%
Color and Shape:
Solid
Molecular weight:
552.48
Ref: TM-T4S2128
| 1mg | 46.00 € | ||
| 2mg | 69.00 € | ||
| 5mg | 142.00 € | ||
| 10mg | 245.00 € | ||
| 25mg | 416.00 € | ||
| 50mg | 600.00 € | ||
| 100mg | 825.00 € | ||
| 1mL*10mM (DMSO) | 185.00 € |
Estimated delivery in United States, on Monday 23 Dec 2024
AT13148
CAS:1056901-62-2
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
Formula:
C17H16ClN3O
Purity:
98.04% - ≥95%
Color and Shape:
Solid
Molecular weight:
313.78
Ref: TM-T2482
| 1mg | 48.00 € | ||
| 2mg | 67.00 € | ||
| 5mg | 117.00 € | ||
| 10mg | 189.00 € | ||
| 25mg | 329.00 € | ||
| 50mg | 476.00 € | ||
| 1mL*10mM (DMSO) | 126.00 € |
Estimated delivery in United States, on Monday 23 Dec 2024
Staurosporine
CAS:62996-74-1
Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) …
Formula:
C28H26N4O3
Purity:
99.24% - 99.87%
Color and Shape:
Off-White Powder
Molecular weight:
466.53
Ref: TM-T6680
| 1mg | 60.00 € | ||
| 2mg | 85.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 142.00 € | ||
| 25mg | 240.00 € | ||
| 50mg | 392.00 € | ||
| 100mg | 582.00 € | ||
| 500mg | 1,251.00 € | ||
| 1mL*10mM (DMSO) | 107.00 € |
Estimated delivery in United States, on Monday 23 Dec 2024
8-Bromo-cAMP sodium salt
CAS:76939-46-3
8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. 8-Bromo-cAMP is …
Formula:
C10H10BrN5NaO6P
Purity:
98% - 99.94%
Color and Shape:
Off-White Powder
Molecular weight:
430.08
Ref: TM-T6747
| 5mg | 48.00 € | ||
| 10mg | 63.00 € | ||
| 25mg | 84.00 € | ||
| 50mg | 127.00 € | ||
| 100mg | 211.00 € | ||
| 200mg | 322.00 € | ||
| 1mL*10mM (DMSO) | 51.00 € |
Estimated delivery in United States, on Monday 23 Dec 2024
CCG215022
CAS:1813527-81-9
CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 …
Formula:
C26H22FN7O3
Purity:
97.46% - 99.69%
Color and Shape:
Solid
Molecular weight:
499.5
Ref: TM-T3498
| 1mg | 94.00 € | ||
| 2mg | 138.00 € | ||
| 5mg | 231.00 € | ||
| 10mg | 369.00 € | ||
| 25mg | 616.00 € | ||
| 50mg | 877.00 € | ||
| 100mg | 1,196.00 € | ||
| 500mg | 2,385.00 € | ||
| 1mL*10mM (DMSO) | 257.00 € |
Estimated delivery in United States, on Monday 23 Dec 2024
AT7867
CAS:857531-00-1
AT7867 inhibits Akt1/2/3 & p70S6K/PKA (IC50: 32/17/47 nM & 85/20 nM), minimal effect beyond AGC …
Formula:
C20H20ClN3
Purity:
99.63%
Color and Shape:
Solid
Molecular weight:
337.85
Ref: TM-T6304
| 2mg | 43.00 € | ||
| 5mg | 63.00 € | ||
| 10mg | 83.00 € | ||
| 25mg | 130.00 € | ||
| 50mg | 203.00 € | ||
| 100mg | 302.00 € | ||
| 200mg | 436.00 € | ||
| 1mL*10mM (DMSO) | 63.00 € |
Estimated delivery in United States, on Monday 23 Dec 2024
