DNA/RNA Synthesis

<p>M7G(3'-OMe-5')pppA(2'-OMe) is a cap analogue for mRNA synthesis in vitro.</p>

<p>Carboxy pyridostatin trifluoroacetate salt exhibits higher molecular specificity for RNA over DNA G4s.</p>

<p>RNA Pol II-IN-2 (20iii) strongly inhibits Pol II (Ki=9.5 nM), is more toxic to CHO/HEK293 than α-amanitin.</p>

<p>5'-O-DMT-2'-O-TBDMS-Bz-rC, a modified nucleoside, is utilized in the synthesis of DNA or RNA.</p>

<p>N6-Methyladenine (6-(Methylamino)Purine) is a modified purine commonly found in genomes of prokaryotes, protists, and plants.</p>

<p>5’-O-DMT-rU is a modified nucleoside and can be used to synthesize RNA.</p>

<p>m7Gpppm6AmpG, a trinucleotide mRNA 5’ cap analog, facilitates RNA synthesis in vitro [1].</p>

<p>IBU-DC Phosphoramidite is used for synthesis of oligonucleotides.</p>

<p>MRK-952 is a NUDIX hydrolase inhibitor. NUDIX enzymes play a role in cellular metabolism, homeostasis, and mRNA processing.</p>

<p>5'-O-DMT-ibu-dC can be used in the synthesis of oligodeoxyribonucleotides.</p>

<p>Orotidine 5'-monophosphate trisodium, a pyrimidine nucleotide, is synthesized through the de novo DNA synthesis pathway by various microorganisms, including M.</p>

<p>Compound 19962-37-9, with CAS No. 19962-37-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 19962-37-9 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>DMT-5Me-dC(Bz)-CE Phosphoramidite aids in crafting LNAs for better fluorescent probes.</p>

<p>GS-443902 trisodium, a strong RdRp blocker, inhibits RSV/HCV with IC50 of 1.1/5 μM and is Remdesivir's active form.</p>

<p>AV-153, a 1,4-dihydropyridine, reduces DNA damage, stimulates repair, and has anti-cancer properties.</p>

<p>N1-Methylpseudouridine-5′-triphosphate tetralithium, also known as 1-Methylpseudouridine-5′-triphosphate tetralithium, is a nucleobase-modified nucleotide.</p>

<p>Suricapavir is an effective viral replication inhibitor with antiviral activity.</p>

<p>5’-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.</p>

<p>dGMP is a substrate for DNA synthesis, phosphorylated to dGDP and dGTP, and linked to mitochondrial DNA depletion syndrome in humans.</p>

<p>TS-0022666 is a selective TUT4/7 inhibitor, antiproliferative and anti-leukaemic in vivo and in vitro, cancers with FOCAD deficiency.</p>

<p>TS-002902 is a small molecule inhibitor of TUT4/7, exhibiting antiproliferative activity. It holds potential for use in cancer research.</p>

<p>Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled.UTP is a key in RNA synthesis molecule a substrate for RNA polymerase.</p>

<p>Clofarabine-5'-triphosphate is a metabolite of Clofarabine, produced via phosphorylation by deoxycytidine kinase (dCK). It exhibits cytotoxicity in cancer cells by inhibiting DNA synthesis and DNA repair.</p>

<p>5’-O-DMT-Ri can be used in the synthesis of oligoribonucleotides[1].</p>

<p>5’-O-DMT-PAC-dA can be used in the synthesis of oligoribonucleotides[1].</p>

<p>3'-dUTP trisodium, a nucleotide analogue, inhibits RNA polymerases I/II and UTP integration into RNA (Ki=2.0 μM).</p>

<p>cis-Lomibuvir (cis-VX-222) is a selective HCV NS5B RdRp inhibitor with a Kd of 17 nM and an EC50 of 5.2 nM, targeting thumb pocket 2.</p>

<p>5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.</p>

<p>Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.</p>

<p>ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.</p>

<p>CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 μM). It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis).</p>

<p>3'Ome-m7GpppAmpG is a trinucleotide cap with LNA, boosting translation; useful in mRNA vaccines and gene therapy.</p>

<p>PT-129 is a RPOTAC degrader that targets the G3BP1/2NTF2 domain (protein-RNA interaction site), facilitating the breakdown of intracellular stress granules. It prevents the formation of stress granules in stressed cells and deconstructs existing ones, thereby disrupting ATF4 transmission and inhibiting cancer cell proliferation. Stress granules (SGs) are membraneless cytoplasmic compartments formed under stress, which aid in the transfer of ATF4 from fibroblasts to tumor cells, promoting fibroblast-related tumor growth. G3BP1/2 serve as central proteins in the SG network, and inhibiting them may reduce the stress resilience of cancer cells within the tumor microenvironment. PT-129 consists of a target protein ligand (red part) G3BP1/2-Targeting ligand-1, an E3 ligase ligand (blue part) Thalidomide 4-fluoride, and a PROTAC linker (black part) Amino-PEG3-C2-acid; the E3 ligase ligand and linker form the complex Thalidomide-NH-PEG3-propionic acid.</p>

<p>WRN inhibitor 14 (compound S35) is an orally administered WRN inhibitor with anticancer properties. It effectively suppresses tumor growth in the SW48 xenograft model in BALB/c nude mice.</p>

<p>N4-Benzoyl-5’-O-DMTr-2’-O-(N3-trifluoroacetyl) aminopropyl cytidine 3’-CED phosphoramidite is a useful organic compound for research related to life sciences.</p>

<p>Nucleoside Derivatives - Indole nucleosides; Nucleoside Phosphoramidites</p>

<p>DMTr-TNA-5MeU-amidite is a Nucleoside Phosphoramidite.</p>

<p>5'-O-DMTr-N6-Fmoc-dA-phosphoramidite is a Nucleoside Phosphoramidite.</p>

<p>1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine is a bicyclic nucleoside.</p>

<p>Nucleoside Derivatives - LNA-related nucleosides; Nucleoside Phosphoramidites</p>

<p>5'-DMTr-dA(Bz)-Methyl phosphonamidite is a Nucleoside Derivative - phosphonamidite.</p>

<p>5'-O-DMTr-N4-Fmoc-5-Me-dC-phosphoramidite is a Nucleoside Phosphoramidite.</p>

<p>Phosphoramidite (a modified phosphoramidite monomer) is utilized in the synthesis of oligonucleotides.</p>

<p>Nucleoside phosphonamidite</p>

<p>3'-F-3'-dA(Bz)-2'-phosphoramidite is a Nucleoside Phosphoramidite; Nucleoside Derivative - Fluoro-modified nucleoside.</p>

<p>5'-O-DMT-N2-ibu-dG is a deoxynucleoside served as a building block in oligonucleotide synthesis, with protecting groups to prevent unwanted reactions.</p>

<p>N4-Bz-5'-O-DMTr-3'-deoxy-3'-fluoro-beta-D-xylofuranosyl cytidine-2'-CED-phosphoramidite is a useful organic compound for research related to life sciences.</p>

<p>5'-DMTr-T-Methyl phosphonamidite is a Nucleoside Derivative - phosphonamidite.</p>

<p>5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative that finds utility in oligonucleotide synthesis.</p>

<p>APE1-IN-1 is a purine/pyrimidine-free endonuclease 1 inhibitor with potential antitumor activity that enhances the toxicity of alkylating agents on cancer cells</p>

<p>NSC 80467 inhibits survivin, targets DNA synthesis, induces γH2AX, and pKAP1 markers of DNA damage.</p>

<p>Nolatrexed dihydrochloride (Thymitaq) is a soluble, lipophilic cancer drug that inhibits DNA replication, causing cell cycle arrest and apoptosis.</p>

<p>DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.</p>

<p>2’-O-Me-C(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.</p>

<p>Synucleozid hydrochloride inhibits the translation of the intrinsically disordered protein α-synuclein by targeting its structured mRNA.</p>

<p>2'-O-MOE-5MeU-3'-phosphoramidite is a Nucleoside Phosphoramidite.</p>

<p>Bz-rA Phosphoramidite is used for ribonucleotides modification[1].</p>

<p>2'-O-MOE-5-Me-rU is a Nucleoside Derivative - 2'-Modified nucleoside.</p>

<p>Balapiravir (R1626) is a prodrug targeting HCV polymerase, discontinued due to safety concerns like lymphopenia and other serious side effects.</p>

<p>2'-O-MOE-rC is a Nucleoside Phosphoramidite; Nucleoside Derivative - 2'-Modified nucleoside.</p>

<p>5'-DMTr-dC (Ac)-methylphosphonamidite is a Nucleoside Derivative - phosphonamidite.</p>

<p>5'-O-TBDMS-dG, a modified nucleoside, is utilized in the synthesis of deoxyribonucleic acid or nucleic acid.</p>

<p>Nucleoside Derivatives - 7-Deaza-purine nucleosides; 2’,3’-Dideoxy nucleosides</p>

<p>2'-O,4'-C-Methyleneguanosine is a Nucleoside Derivative - LNA-related nucleoside.</p>

<p>Remdesivir impurity, O-desphosphate acetonide, is a byproduct obstructing its antiviral efficacy against COVID-19.</p>

<p>2'-O-MOE-5-Me-rC is a Nucleoside Derivative - 2'-Modified nucleoside.</p>

<p>Maleic hydrazide is a plant germination inhibitor that participates in nucleic acid metabolism pathways ,inhibiting cell division in the apical meristem.</p>

<p>2-Amino-2'-deoxyadenosine is a deoxyribonucleoside used for the oligonucleotide synthesis.</p>

<p>3'-Deoxy-3'-fluoroguanosine is a nucleoside phosphorylase inhibitor that inhibits RNA replication by binding replons.</p>

<p>Nucleoside phosphoramidites；Nucleoside Derivatives - Acyclic nucleosides;</p>

<p>2’-OMe-A(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.</p>

<p>2’-OMe-G(ibu) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.</p>

<p>7-TFA-ap-7-Deaza-dA, a modified nucleoside, finds application in the synthesis of deoxyribonucleic acid or nucleic acid.</p>

<p>5’-O-DMT-3’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.</p>

<p>Nucleoside Phosphoramidites; Ready for phosphorylation</p>

<p>DMT-dC(ac) Phosphoramidite is a phosphoramidite monomer that has been modified for use in oligonucleotide synthesis.</p>

<p>DHPS-IN-1, a chemical compound, demonstrates exceptional inhibitory potency against melanoma cells, as evidenced by its IC50 value of 0.014 μM.</p>

<p>3'-Deoxy-3'-alpha-C-methyluridine is a Nucleoside; Used for nucleoside and nucleic acid modifications.</p>

<p>Napropamide is an acetamide herbicide that inhibits root growth to control annual grasses and broadleaf weeds.</p>

<p>N6-Methyl-dA phosphoramidite can be used in the synthesis of oligodeoxyribonucleotides.</p>

<p>DMTr-TNA-U-amidite is a Nucleoside Phosphoramidite.</p>

<p>Antipain dihydrochloride (Antipain 2HCl) is a protease inhibitor derived from Actinomycetes with analgesic activity.</p>

<p>5'-O-DMT-N6-Me-2'-dA is a nucleoside with protective and modification effects.</p>

<p>5’-O-DMT-2’-TBDMS-Uridine is a deoxyribonucleoside used for the oligonucleotide synthesis.</p>

<p>DMTr-MOE-Inosine-3-CED-phosphoramidite is a useful organic compound for research related to life sciences and the catalog number is TNU1574.</p>

<p>BPN-15477 is a splicing modulator compound (SMC) that which restores correct splicing of exon 20 in ELP1 (Elongator complex protein 1).</p>

<p>2'-O-MOE-U is a Nucleoside Phosphoramidite; Nucleoside Derivative - 2'-Modified nucleoside.</p>

<p>DMT-dG(dmf) Phosphoramidite is a phosphinamide monomer employed for oligonucleotide synthesis.</p>

<p>2'-MOE-G(iBu)-3'-phosphoramidite is a Nucleoside Phosphoramidite;Nucleoside Derivative - 2'-Modified nucleoside;.</p>

<p>Nucleoside Phosphoramidites; Nucleoside Derivatives - LNA-related nucleosides</p>

<p>Branaplam hydrochloride (LMI070; NVS-SM1) is an orally active SMN2 splicing modulator (EC50 20 nM) that also inhibits hERG channels (IC50 6.3 μM).</p>

<p>Compound BPP (HDGFRP2/PSIP1-IN-1) is a dual inhibitor targeting the PWWP domains of Hepatoma-derived Growth Factor Related Protein 2 (HDGFRP2) and its homologue PSIP1. This compound effectively hinders the occurrence and progression of Diffuse Intrinsic Pontine Glioma (DIPG). It demonstrates binding affinity with a Kd value of 7 μM for HDGFRP2, indicative of its efficient ligand efficacy at 0.47. Additionally, Compound BPP exhibits a Kd value of 27 μM when binding to the PSIP1 PWWP domain, and a Kd value of 14 μM against HDGFRP3, confirming its potency as an inhibitor within the HDGFRP2 PWWP subfamily.</p>

<p>3'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-fluorouridine-2'-CED-phosphoramidite is a Nucleoside Phosphoramidite.</p>

<p>Uridine 5'-diphosphate sodium, P2Y6 agonist (EC50: 300 nM), P2Y14 antagonist (pEC50: 7.28).</p>

<p>RNase L-IN-1 is an RNase L inhibitor with potential anticancer activity and inhibits viral replication.</p>

<p>Nucleoside Derivatives - LNA-related nucleosides; Nucleoside Phorphoramidites</p>

<p>ML216 (CID-49852229) inhibits BLM helicase (IC50: 1.8 μM), 28-fold selective over RECQ1, RECQ5, and UvrD (IC50s &gt; 50 μM).</p>

<p>Lurbinectedin (PM01183) is a DNA minor groove covalent binder. Lurbinectedin also shows effective anti-tumor activity.</p>

<p>Dasabuvir sodium (ABT-333) inhibits HCV NS5B polymerase, targeting genotypes 1a (EC50: 7.7 nM) and 1b (EC50: 1.8 nM).</p>

<p>TH5427 HCl inhibits NUDT5 with 29 nM IC50; 690x more selective over MTH1; blocks ATP in breast cancer cells, hindering growth.</p>