PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
- AMPK(159 products)
- ATM/ATR(71 products)
- DNA-PK(51 products)
- EGFR(572 products)
- MELK(7 products)
- PDK(9 products)
- PI3K(242 products)
- S6 Kinase(9 products)
- gsk-3(112 products)
- mTOR(144 products)
Show 2 more subcategories
Found 1037 products of "PI3K/Akt/mTOR Signaling"
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Desmethyl-VS-5584
CAS:<p>Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.</p>Formula:C16H20N8OPurity:>99.99%Color and Shape:SolidMolecular weight:340.38CZC-8004
CAS:<p>CZC-8004 (CZC-00008004) is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.</p>Formula:C17H16FN5Purity:99.29%Color and Shape:SolidMolecular weight:309.34LY-294002 hydrochloride
CAS:<p>LY-294002 HCl (NSC 697286) is a stable PI3K inhibitor (IC50: 0.5-0.97 µM) and prevents autophagosome formation.</p>Formula:C19H17NO3·HClPurity:99.95%Color and Shape:SolidMolecular weight:343.81MHY-1685
CAS:<p>MHY-1685 is a mammalian target of rapamycin (mTOR) inhibitor and a senescence inhibitor that can rejuvenate senile hCSCs by modulating autophagy.</p>Formula:C11H8N2O4Purity:99.76%Color and Shape:SolidMolecular weight:232.19GSK 3 Inhibitor IX
CAS:<p>GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex.</p>Formula:C16H10BrN3O2Purity:98% - 99.72%Color and Shape:SolidMolecular weight:356.17(Rac)-JBJ-04-125-02
CAS:<p>(Rac)-JBJ-04-125-02 (JBJ-04-125-02) is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer.</p>Formula:C29H26FN5O3SPurity:97.57%Color and Shape:SolidMolecular weight:543.61TWS119
CAS:<p>TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation</p>Formula:C18H14N4O2Purity:98.14% - 99.63%Color and Shape:SolidMolecular weight:318.33Leptomycin B
CAS:<p>Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.</p>Formula:C33H48O6Purity:97.10% - 99.04%Color and Shape:White Crystalline SolidMolecular weight:540.73GSK3i XIII
CAS:<p>GSK3i XIII (GSK3 inhibitor XIII) is a GSK-3 ATP-binding site inhibitor.</p>Formula:C18H19N5Purity:98.87%Color and Shape:SolidMolecular weight:305.38Pilaralisib
CAS:<p>Pilaralisib (XL-147) is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K).</p>Formula:C25H25ClN6O4SPurity:98.51% - 99.61%Color and Shape:SolidMolecular weight:541.02SF2523
CAS:<p>SF2523 is a highly selective and potent inhibitor.</p>Formula:C19H17NO5SPurity:99.1% - 99.51%Color and Shape:SolidMolecular weight:371.41DS-7423
CAS:<p>DS-7423: a dual PI3K/mTOR inhibitor; IC50s—PI3Kα: 15.6 nM, mTOR: 34.9 nM, PI3Kβ: 1,143 nM, PI3Kγ: 249 nM, PI3Kδ: 262 nM.</p>Formula:C22H27F3N10O2Purity:99.98%Color and Shape:SolidMolecular weight:520.51OTSSP167 hydrochloride
CAS:<p>OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM).</p>Formula:C25H29Cl3N4O2Purity:99.41%Color and Shape:SolidMolecular weight:523.88Gedatolisib
CAS:<p>Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling</p>Formula:C32H41N9O4Purity:98% - 99.36%Color and Shape:SolidMolecular weight:615.73Pelitinib
CAS:<p>Pelitinib (EKB-569) (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).</p>Formula:C24H23ClFN5O2Purity:98.37% - 99.84%Color and Shape:Off-White SolidMolecular weight:467.92CNX-2006
CAS:<p>CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.</p>Formula:C26H27F4N7O2Purity:98.85% - 99.16%Color and Shape:SolidMolecular weight:545.53Sapitinib
CAS:<p>Sapitinib (AZD-8931) , a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib or</p>Formula:C23H25ClFN5O3Purity:98.89% - 99.83%Color and Shape:SolidMolecular weight:473.93Mobocertinib
CAS:<p>Mobocertinib (tak788) is a potent inhibitor of epidermal growth factor receptor (EGFR) and an antineoplastic agent</p>Formula:C32H39N7O4Purity:99.47% - 99.97%Color and Shape:SolidMolecular weight:585.7CUDC-101
CAS:<p>CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively.</p>Formula:C24H26N4O4Purity:95.76% - 99.17%Color and Shape:SolidMolecular weight:434.49Afatinib
CAS:<p>Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.</p>Formula:C24H25ClFN5O3Purity:98.56% - 99.9%Color and Shape:Off-White SolidMolecular weight:485.94
