PI3K/Akt/mTOR Signaling
PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.
Subcategories of "PI3K/Akt/mTOR Signaling"
- AMPK(158 products)
- ATM/ATR(71 products)
- DNA-PK(51 products)
- EGFR(572 products)
- MELK(7 products)
- PDK(9 products)
- PI3K(242 products)
- S6 Kinase(9 products)
- gsk-3(112 products)
- mTOR(144 products)
Show 2 more subcategories
Found 1038 products of "PI3K/Akt/mTOR Signaling"
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Duvelisib
CAS:<p>Duvelisib (INK1197, IPI-145) is a selective inhibitor of phosphatidylinositol 3-kinase (PI3K) and p100δ.Cost-effective and quality-assured.</p>Formula:C22H17ClN6OPurity:98.87% - 99.74%Color and Shape:SolidMolecular weight:416.86PIK-75
CAS:<p>PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).</p>Formula:C16H14BrN5O4SPurity:98.52% - >99.99%Color and Shape:SolidMolecular weight:452.28PD153035
CAS:<p>PD153035 (NSC-669364) hydrochloride is an effective and selective inhibitor of EGFR (Ki/IC50: 5.2/29 pM, in cell-free assays); little inhibitory against FGFR,</p>Formula:C16H14BrN3O2Purity:98.47% - 99.29%Color and Shape:SolidMolecular weight:360.21Acalisib
CAS:<p>Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.</p>Formula:C21H16FN7OPurity:98.99% - ≥95%Color and Shape:SolidMolecular weight:401.4Nazartinib
CAS:<p>Nazartinib (EGF816) (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (</p>Formula:C26H31ClN6O2Purity:98.63% - ≥95%Color and Shape:Solid PowderMolecular weight:495.02Vacuolin-1
CAS:<p>Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane.</p>Formula:C26H24IN7OPurity:97.20% - 98.45%Color and Shape:SolidMolecular weight:577.42HG-9-91-01
CAS:<p>HG-9-91-01 (SIK inhibitor 1) is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and</p>Formula:C32H37N7O3Purity:96.86% - 99.71%Color and Shape:SolidMolecular weight:567.68CZC24832
CAS:<p>CZC24832 is a selective inhibitor of PI 3-kinase γ.</p>Formula:C15H17FN6O2SPurity:99.08% - 99.12%Color and Shape:SolidMolecular weight:364.4PD-089828
CAS:<p>PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).</p>Formula:C18H18Cl2N6OPurity:97.39%Color and Shape:SolidMolecular weight:405.28Parsaclisib hydrochloride
CAS:<p>Parsaclisib hydrochloride (INCB050465 HCl) is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity.</p>Formula:C20H23Cl2FN6O2Purity:98%Color and Shape:SolidMolecular weight:469.34COH-SR4
CAS:<p>COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation.</p>Formula:C13H8Cl4N2OPurity:98.96%Color and Shape:SolidMolecular weight:350.03RLY-2608
CAS:<p>RLY-2608 is a variant PI3Kalpha inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft model.</p>Formula:C29H14ClF5N6O2Purity:98.62% - 98.7%Color and Shape:SolidMolecular weight:608.91740 Y-P
CAS:<p>740 Y-P (740YPDGFR) is a PI3K activator with cell permeability,binds GST fusion proteins containing the N-and C-terminal SH2 domains of p85. Low-Cost!</p>Formula:C141H222N43O39PS3Purity:98.3% - 99.87%Color and Shape:SolidMolecular weight:3270.7Gefitinib hydrochloride
CAS:<p>Obtustatin triacetate is an integrin derived from the venom of Vipera lebetina obtusa and is an α1β1 integrin and in vivo angiogenesis inhibitor.</p>Formula:C22H25Cl2FN4O3Purity:99.8%Color and Shape:SolidMolecular weight:483.36CHIR 98024
CAS:<p>CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.</p>Formula:C20H17Cl2N9O2Purity:96.74%Color and Shape:SolidMolecular weight:486.31Cavutilide
CAS:<p>Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.</p>Formula:C22H26FN3O3Purity:99.82% - 99.85%Color and Shape:SolidMolecular weight:399.458BMS-690514
CAS:<p>BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.</p>Formula:C19H24N6O2Purity:99.08%Color and Shape:SolidMolecular weight:368.43Naquotinib mesylate
CAS:<p>Naquotinib mesylate (ASP8273 (mesylate)) is an orally available, mutant-selective and irreversible inhibitor of EGFR(iC50s of 8-33 nM and 230 nM for toward EGFR</p>Formula:C31H46N8O6SPurity:98%Color and Shape:SolidMolecular weight:658.81Canertinib dihydrochloride
CAS:<p>Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and</p>Formula:C24H27Cl3FN5O3Purity:99.13% - >99.99%Color and Shape:SolidMolecular weight:558.86Almonertinib hydrochloride
CAS:<p>Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation.</p>Formula:C30H36ClN7O2Purity:98.01% - 98.12%Color and Shape:SolidMolecular weight:562.1Imgatuzumab
CAS:<p>Imgatuzumab (RG 7160) is a humanized anti-EGFR monoclonal antibody and immunomodulator for cancer research.</p>Color and Shape:LiquidMolecular weight:145.0 (kDa)Depatuxizumab
CAS:<p>Depatuxizumab is a humanised monoclonal antibody targeting EGFR with blood-brain barrier (BBB) permeability, inhibit tumor growth,GBM,SCCHN.</p>Purity:95%Color and Shape:LiquidElgemtumab
CAS:<p>Elgemtumab (LJM716) is a fully humanised monoclonal antibody targeting HER3/ERBB3, acting as an antagonist to block HER3/Akt phosphorylation antitumour.</p>Purity:95%Color and Shape:LiquidZalutumumab
CAS:<p>Zalutumumab is a high-affinity fully human monoclonal antibody ,the extracellular domain of the EGFR squamous cell carcinoma of the head and neck (SCCHN).</p>Purity:95%Color and Shape:LiquidIzalontamab
CAS:<p>Izalontamab (SI-B001) is a bispecific EGFR/HER3 monoclonal antibody that binds to both EGFR×EGFR homodimers and EGFR×HER3 heterodimers.</p>Purity:95%+ - 95%+Color and Shape:LiquidBecotatug
CAS:<p>Becotatug (JMT-101) is an IgG1 antibody that targets EGFR and can be conjugated to Afatinib and Osimertinib, functioning as a synthetic antibody-drug conjugate</p>Purity:95% - 95%Color and Shape:LiquidAnbenitamab
CAS:<p>Anbenitamab (KN-026) is a bispecific HER2 antibody for metastatic breast cancer research, blocking HER2 pathways and mediating ADCC.</p>Color and Shape:LiquidPonezumab
CAS:<p>Ponezumab (PF-04360365), a humanized IgG2 antibody, lowers Aβ in the CNS & boosts mice memory. Used in Alzheimer's research.</p>Color and Shape:LiquidFutuximab
CAS:<p>Futuximab, a chimeric monoclonal antibody, targets distinct epitopes on the epidermal growth factor receptor (EGFR), exhibiting antineoplastic activity [1].</p>Purity:95% - 95%Color and Shape:LiquidZanidatamab
CAS:<p>Zanidatamab (ZW25) is a bispecific, humanized monoclonal antibody that targets two distinct epitopes (ECD2 and ECD4) of the HER2 receptor, exhibiting anti-tumor</p>Color and Shape:LiquidSerclutamab
CAS:<p>Serclutamab, a humanized chimeric monoclonal antibody of the IgG1-κ isotype, selectively targets the epidermal growth factor receptor (EGFR).</p>Purity:98%Color and Shape:Liquid1-Azakenpaullone
CAS:<p>1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.</p>Formula:C15H10BrN3OPurity:99.73%Color and Shape:Tan SolidMolecular weight:328.16Icotinib
CAS:<p>Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.</p>Formula:C22H21N3O4Purity:99.76% - 99.94%Color and Shape:SolidMolecular weight:391.42IGF-1R modulator 1
CAS:<p>IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB). This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and/or other trophic factors, such as Alzheimer's disease.</p>Formula:C22H17N3O4Color and Shape:SolidMolecular weight:387.39lavendustin A
CAS:<p>lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.</p>Formula:C21H19NO6Purity:98%Color and Shape:Off-White SolidMolecular weight:381.38GSK2292767
CAS:<p>GSK2292767 is a potent and selective PI3Kδ inhibitor.</p>Formula:C24H28N6O5SPurity:98%Color and Shape:SolidMolecular weight:512.58ZM323881 hydrochloride
CAS:<p>ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor.</p>Formula:C22H19ClFN3O2Purity:99.43%Color and Shape:SolidMolecular weight:411.86CNX-1351
CAS:<p>CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.</p>Formula:C30H35N7O3SPurity:99.66% - 99.83%Color and Shape:SolidMolecular weight:573.71Icotinib Hydrochloride
CAS:<p>Icotinib Hydrochloride, an oral EGFR inhibitor (BPI-2009H), may halt cancer growth by blocking EGFR signaling.</p>Formula:C22H22ClN3O4Purity:99.89%Color and Shape:SolidMolecular weight:427.88TAK-285
CAS:<p>TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.</p>Formula:C26H25ClF3N5O3Purity:99.73%Color and Shape:SolidMolecular weight:547.96CAL-130
CAS:<p>CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).</p>Formula:C23H22N8OPurity:98%Color and Shape:SolidMolecular weight:426.47TCS 2002
CAS:<p>GSK-3β inhibitor 9b: potent, selective, oral, IC50=35 nM, good pharmacokinetics, BBB-permeable, researched for Alzheimer's.</p>Formula:C18H14N2O3SColor and Shape:SolidMolecular weight:338.38MS 154N
CAS:<p>MS 154N is a negative control for MS 154, binds WT/L858R EGFR tightly (Kd 3-4.3nM), doesn't trigger mutant EGFR degradation.</p>Formula:C47H56ClFN8O8Color and Shape:SolidMolecular weight:915.45PI3K/mTOR Inhibitor-9
CAS:<p>PI3K/mTOR Inhibitor-9 acts on mTOR (38 nM IC50) and PI3Kα/γ (6.6 nM IC50), PI3Kδ (0.8 nM IC50).</p>Formula:C23H27N7O2Color and Shape:SolidMolecular weight:433.51EGFR-IN-16
CAS:<p>EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.</p>Formula:C16H11NO3Purity:98%Color and Shape:SolidMolecular weight:265.26NVP-CLR457
CAS:<p>NVP-CLR457 is an oral pan-class I PI3K inhibitor with dose-dependent antitumor activity.</p>Formula:C18H20F3N7O4Color and Shape:SolidMolecular weight:455.39NU-7163
CAS:<p>NU-7163 is a potent and selective inhibitor of ATP-competitive DNA-PK.</p>Formula:C18H17NO3Purity:98%Color and Shape:SolidMolecular weight:295.33EGA
CAS:<p>EGA blocks the entry of a variety of other acid-dependent bacterial toxins and viruses into mammalian cells and can be used to treat infectious diseases.</p>Formula:C16H16BrN3OPurity:98% - 99.6%Color and Shape:SolidMolecular weight:346.22EGFR-IN-67
CAS:<p>EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].</p>Formula:C18H17N3SColor and Shape:SolidMolecular weight:307.41DS21360717
CAS:<p>DS21360717 is an effective oral tyrosine kinase inhibitor with anticancer activity and IC50 of 0.49 nM.</p>Formula:C21H23N7OPurity:98%Color and Shape:SolidMolecular weight:389.45DNA-PK-IN-1
CAS:<p>DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-PK-IN-1 has potential for cancer disease research.</p>Formula:C23H26N8O2Color and Shape:SolidMolecular weight:446.5WR23
CAS:<p>WR23 is a piperidinylquinoxaline derivative and a phosphoinositide 3-kinase α (PI3Kα) inhibitor.</p>Formula:C19H18BrN3O3SPurity:98%Color and Shape:SolidMolecular weight:448.33LTURM-36
CAS:<p>LTURM-36 is a novel inhibitor of PI 3-kinase delta.</p>Formula:C22H18N2O3Purity:98%Color and Shape:SolidMolecular weight:358.39ZDWX-25
CAS:<p>ZDWX-25, a strong GSK-3β & DYRK1A inhibitor, kills SH-SY5Y/HL-7702 cells, may aid Alzheimer's research; IC50: 71 nM for GSK-3β.</p>Formula:C17H15N3O3Color and Shape:SolidMolecular weight:309.32MIPS-9922
CAS:<p>MIPS-9922: potent PI3Kβ inhibitor; prevents αIIbβ3 activation, platelet adhesion, and ADP-triggered aggregation.</p>Formula:C28H31F2N9O2Purity:98%Color and Shape:SolidMolecular weight:563.6NSC81111
CAS:<p>NSC81111 shows anticaner effects which is a potent and orally active inhibitor of EGFR-TK (IC50 = 0.15 nM) [1].</p>Formula:C19H16O4Color and Shape:SolidMolecular weight:308.33Limertinib
CAS:<p>Limertinib (ASK120067) is a EGFR tyrosine kinase inhibitor targeting EGFR T790M, applicable for the study of non-small cell lung cancer.</p>Formula:C29H32ClN7O2Purity:97.44%Color and Shape:SolidMolecular weight:546.06GNE-293
CAS:<p>GNE-293 is a potent and selective PI3Kδ inhibitor.</p>Formula:C28H36N8O4SPurity:98%Color and Shape:SolidMolecular weight:580.7PI-540
CAS:<p>PI-540 is a potent and selective inhibitor of class 1A phosphatidylinositide 3-kinases (PI3K).</p>Formula:C22H27N5O2SColor and Shape:SolidMolecular weight:425.55DNA-PK-IN-3
CAS:<p>DNA-PK-IN-3 is a potent DNA-PK inhibitor, enhancing radio/chemotherapy and reducing tumors with limited side effects.</p>Formula:C19H19N9OColor and Shape:SolidMolecular weight:389.41PI3K-IN-6
CAS:<p>PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively).</p>Formula:C17H14Cl2FN9OPurity:98%Color and Shape:SolidMolecular weight:450.26PI3Kδ/γ-IN-2
CAS:<p>PI3Kδ/γ-IN-2 is a potent, orally bioavailable dual inhibitor of PI3Kδ (IC50: 1 nM) and PI3Kγ (IC50: 4.3 nM) with potential for use in anti-B-cell malignancy</p>Formula:C25H21ClN8OColor and Shape:SolidMolecular weight:484.94GLPG3970
CAS:<p>GLPG3970, a pioneering inhibitor of SIK2/SIK3, is utilized in the investigation of inflammation and autoimmune diseases.</p>Formula:C25H27F3N4O4Purity:99.60% - >99.99%Color and Shape:SolidMolecular weight:504.5EGFR-IN-68
CAS:<p>EGFR-IN-68, an EGFR inhibitor, has an IC50 of 0.33 μM and shows significant anticancer effects.</p>Formula:C24H22N2OColor and Shape:SolidMolecular weight:354.44EAI001
CAS:<p>EAI001 is a potent and selective mutant epidermal growth factor receptor (EGFR) variant inhibitor that inhibits EGFRL858R/T790M with an IC50 value of 24 nM.</p>Formula:C19H15N3O2SPurity:>99.99%Color and Shape:SolidMolecular weight:349.41PI3Kγ inhibitor 4
CAS:<p>PI3Kγ inhibitor 4 is a selective, potent, orally active PI3Kγ inhibitor (IC50: 40 nM).</p>Formula:C20H24N4O4SColor and Shape:SolidMolecular weight:416.49Nimotuzumab
CAS:<p>Nimotuzumab is a humanized therapeutic monoclonal antibody against epidermal growth factor receptor EGFR).</p>Purity:95.00% - 98.5% (SDS-PAGE); 96.4% (SEC-HPLC)Color and Shape:LiquidMRT80
CAS:<p>MRT80 is an inhibitor of GSK-3 in vitro. MRT80 de-stabilizes MDM2 and stabilizes p53 protein and E2F-1.</p>Formula:C15H15N5OPurity:98%Color and Shape:SolidMolecular weight:281.31mTOR inhibitor-2
CAS:<p>mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).</p>Formula:C23H21N7OPurity:98%Color and Shape:SolidMolecular weight:411.46SDZ281-977
CAS:<p>SDZ 281-977 is a derivative of Lavendustin A which is the EGF receptor tyrosine kinase inhibitor.</p>Formula:C18H20O5Purity:99.64%Color and Shape:SolidMolecular weight:316.35(E/Z)-CP-724714
CAS:<p>(E/Z)-CP-724714, comprising racemic mixtures of (E)-CP-724714 and (Z)-CP-724714 isomers, is a potent, selective, and orally active inhibitor of ErbB2 (HER2)[1].</p>Formula:C27H27N5O3Purity:98%Color and Shape:SolidMolecular weight:469.54AG-183
CAS:<p>(Z)-Tyrphostin A51, a Z-isomer of Lanoconazole A51, is a strong PTK inhibitor blocking [3 H]taurine release and tyrosyl phosphorylation.</p>Formula:C13H8N4O3Color and Shape:Brown SolidMolecular weight:268.23PI3Kα-IN-13
CAS:<p>PI3Kα-IN-13 (Compound 18a), a PI3Kα inhibitor with an IC50 of 2.5 nM, effectively induces apoptosis and hampers the proliferation of various cancer cell lines,</p>Formula:C21H19N5O3Purity:98%Color and Shape:SolidMolecular weight:389.41Nemiralisib
CAS:<p>Nemiralisib (GSK-2269557) is an oral PI3Kδ inhibitor (pKi 9.9) for treating respiratory diseases like COPD.</p>Formula:C26H28N6OPurity:99.91%Color and Shape:SolidMolecular weight:440.54PI4KIII β inhibitor 3
CAS:<p>PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).</p>Formula:C22H22N8OSPurity:98%Color and Shape:SolidMolecular weight:446.53TGX-155
CAS:<p>TGX-155 is a selective PI3K inhibitor.</p>Formula:C20H19FN2O3Purity:98%Color and Shape:SolidMolecular weight:354.37FT-1518
CAS:<p>FT-1518 is an orally available, selective and potent mTORC1 and mTORC2 inhibitor with anticancer and antitumor activity for cancer research.</p>Formula:C20H26N8OPurity:98.34% - 98.80%Color and Shape:SolidMolecular weight:394.47Tarlox-TKI
CAS:<p>Tarlox-TKI (Kinase inhibitor-1) is a pan-ErbB inhibitor, the active ingredient of Tarloxotinib, which has antitumor activity.</p>Formula:C19H18BrClN6OPurity:97.03%Color and Shape:SolidMolecular weight:461.74AZD3458
CAS:<p>AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5 , respectively).</p>Formula:C20H23N3O4S2Color and Shape:SolidMolecular weight:433.54RV-1729
CAS:<p>RV-1729, a phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) inhibitor, is used potentially for the treatment of asthma.</p>Formula:C39H39ClN8O5Color and Shape:SolidMolecular weight:735.23BKI-1369
CAS:<p>BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).</p>Formula:C23H27N7OColor and Shape:SolidMolecular weight:417.51RTC-5
CAS:<p>RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties.</p>Formula:C24H22ClF3N2O3SPurity:98.14%Color and Shape:SolidMolecular weight:510.96CAL-130 Hydrochloride
CAS:<p>CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).</p>Formula:C23H23ClN8OColor and Shape:SolidMolecular weight:462.94EGFR-IN-50
CAS:<p>EGFR-IN-50, a potent EGFR blocker, hinders L858R mutation; GI50: 8 nM for TEL-EGFR-L858R, 6.03 μM for T790M-L858R; curbs cancer cell growth.</p>Formula:C24H26BrN3O4S2Color and Shape:SolidMolecular weight:564.51NSC114126
CAS:<p>NSC114126 is a potent, oral EGFR-TK inhibitor with strong antiproliferative effects, promising for cancer research.</p>Formula:C22H20O4Color and Shape:SolidMolecular weight:348.39JBJ-04-125-02
CAS:<p>JBJ-04-125-02: Oral EGFR inhibitor, targets EGFRL858R/T790M with 0.26 nM IC50, halts cancer growth, anti-tumor.</p>Formula:C29H26FN5O3SPurity:98%Color and Shape:SolidMolecular weight:543.61PIKfyve-IN-2
CAS:<p>PIKfyve-IN-2 is a potent inhibitor of the PIKfyve kinase, with potential applications in cancer and autoimmune disorder research [1].</p>Formula:C22H22N8OColor and Shape:SolidMolecular weight:414.46BRD3731
CAS:<p>BRD3731 selectively inhibits GSK3β with IC50 of 15 nM; it's promising for PTSD, psychiatric issues, diabetes, and neurodegeneration.</p>Formula:C24H31N3OColor and Shape:SolidMolecular weight:377.523F8
CAS:<p>3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used in</p>Formula:C15H14N2O4Purity:98.14% - 98.25%Color and Shape:SolidMolecular weight:286.28Epertinib
CAS:<p>Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM).</p>Formula:C30H27ClFN5O3Purity:98%Color and Shape:SolidMolecular weight:560.02EGFR-IN-64
CAS:<p>EGFR-IN-64 inhibits EGFR with 0.33 μM IC50, showing promising anticancer properties.</p>Formula:C20H21N3O3Color and Shape:SolidMolecular weight:351.4(R)-PS210
CAS:<p>(R)-PS210, the R enantiomer of PS210 is a substrate-selective allosteric PDK1 activator with an (AC50 of 1.8 μM).</p>Formula:C19H15F3O5Color and Shape:SolidMolecular weight:380.31GW 583340 dihydrochloride
CAS:<p>GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 inhibitor and inhibits 80% of tumor growth in a mouse xenograft mode.</p>Formula:C28H27Cl3FN5O3S2Purity:98.80%Color and Shape:SolidMolecular weight:671.03FD2056
CAS:<p>FD2056 is a potent, orally active PI3K inhibitor, with IC50 values of 0.30, 0.80, 1.10, and 0.42 nM against PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.</p>Formula:C23H17ClN6O2SPurity:98%Color and Shape:SolidMolecular weight:476.94EGFR-IN-89
CAS:<p>EGFR-IN-89 (compound 13k) is a fourth-generation inhibitor selectively targeting EGFR mutations, exhibiting potent activity with an IC50 of 10.1 nM against</p>Formula:C26H31FN8O2SPurity:98%Color and Shape:SolidMolecular weight:538.64AMPK activator 12
CAS:<p>AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein for cancer research.</p>Formula:C23H24BrNO2Purity:99.55%Color and Shape:SolidMolecular weight:426.35PI5P4Ks-IN-1
CAS:<p>PI5P4Ks-IN-1 (compound 7) is an active compound which engages PI5P4Kγ[1].</p>Formula:C20H17N3SColor and Shape:SolidMolecular weight:331.43Antiproliferative agent-34
CAS:<p>Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.</p>Formula:C27H27N7O5Purity:98%Color and Shape:SolidMolecular weight:529.55PIMPC
CAS:<p>PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibits</p>Formula:C21H19N5OPurity:98%Color and Shape:SolidMolecular weight:357.41PI3Kγ inhibitor 7
CAS:<p>PI3Kγ Inhibitor 7 (compound 2) is a potent, orally active agent that selectively inhibits PI3Kγ with an IC50 of 3.42 nM and demonstrates antitumor activity [1].</p>Formula:C31H25N9O2Purity:98%Color and Shape:SolidMolecular weight:555.59EGFR-IN-73
CAS:<p>EGFR-IN-73 (Compound 3f) effectively inhibits the prevalent EGFR mutation, EGFR Del19, exhibiting an IC50 value of 119 nM [1].</p>Formula:C19H17ClFN3O4Purity:98%Color and Shape:SolidMolecular weight:405.81Selatinib
CAS:<p>Selatinib is an orally active and potent dual inhibitor of EGFR and ErbB2 with anticancer activity that inhibits the growth of NCI-N87 tumor cells.</p>Formula:C29H26ClFN4O3SPurity:98.00%Color and Shape:SolidMolecular weight:565.06CGP52411
CAS:<p>CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM).</p>Formula:C20H15N3O2Purity:99.78%Color and Shape:SolidMolecular weight:329.35PI3K/mTOR Inhibitor-4
CAS:<p>Oral PI3K/mTOR Inhibitor-4 targets PI3Kα, γ, δ, mTOR; IC50s: 0.63, 22, 9.2, 13.85 nM. Used in cancer research.</p>Formula:C27H22FN3O6SColor and Shape:SolidMolecular weight:535.54BRD0209
CAS:<p>BRD0209 is a highly selective and potent GSK3 inhibitor.</p>Formula:C22H25N3OPurity:99.92%Color and Shape:SolidMolecular weight:347.45GSK-3β inhibitor 12
CAS:<p>GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3β</p>Formula:C14H13N3OSPurity:98.58%Color and Shape:SolidMolecular weight:271.34NVS-PI3-4
CAS:<p>NVS-PI3-4: A selective PI3Kγ inhibitor for research in allergies, inflammation, and cancer.</p>Formula:C20H26N4O3SColor and Shape:SolidMolecular weight:402.51TC-G 24
CAS:<p>GSK-3β inhibitor</p>Formula:C15H11ClN4O3Purity:98%Color and Shape:SolidMolecular weight:330.73JNJ28871063 hydrochloride
CAS:<p>ErbB receptor family inhibitor</p>Formula:C24H28Cl2N6O3Purity:98%Color and Shape:SolidMolecular weight:519.42(S)-PI3Kα-IN-4
CAS:<p>(S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM.</p>Formula:C25H23ClFN5O5SColor and Shape:SolidMolecular weight:56018BIOder
CAS:<p>18BIOder is a neuroprotective inhibitor of GSK-3β, highly selectively inhibiting HIV-1. It is the second generation derivative of 6BIO.</p>Formula:C9H7ClN2O2Purity:98%Color and Shape:SolidMolecular weight:210.62Tyrphostin 51
CAS:<p>Tyrphostin 51 is an effective inhibitor of EGFR kinase.</p>Formula:C13H8N4O3Purity:98%Color and Shape:SolidMolecular weight:268.23CHMFL-PI3KD-317
CAS:<p>CHMFL-PI3KD-317: potent PI3Kδ inhibitor, IC50=6 nM, orally active, >10x selective vs. PI3K isoforms, anti-cancer.</p>Formula:C21H24ClN5O3S2Purity:99.16%Color and Shape:SolidMolecular weight:494.03MS 39
CAS:<p>MS 39, a selective EGFR depressant, degrades mutant receptors in lung cancer lines without affecting wild-type. Effective in vitro and in mice.</p>Formula:C55H71ClFN9O7SColor and Shape:SolidMolecular weight:1056.72PI3KD/V-IN-01
CAS:<p>PI3KD/V-IN-01 is a potent ATP-competitive PI3Kδ/Vps34 dual inhibitor.</p>Formula:C21H24ClN5O3S2Purity:98%Color and Shape:SolidMolecular weight:494.03AZ2
CAS:<p>AZ2 is a highly selective, active PI3Kγ inhibitor (pIC50=9.3) for use in inflammatory and immune disorders.</p>Formula:C20H23N3O2SPurity:99.25%Color and Shape:SolidMolecular weight:369.48Gefitinib N-oxide
CAS:<p>Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib N-oxide is the N-oxide derivative of Gefitinib.</p>Formula:C22H24ClFN4O4Purity:98%Color and Shape:SolidMolecular weight:462.9Cazpaullone
CAS:<p>Cazpaullone inhibits GSK-3 and briefly boosts Pax4 mRNA expression.</p>Formula:C16H10N4OColor and Shape:SolidMolecular weight:274.28DBPR112
CAS:<p>DBPR112: oral furanopyrimidine EGFR inhibitor; IC50: 15 nM (EGFRWT), 48 nM (L858R/T790M); blocks ATP site, strong antitumor effects.</p>Formula:C32H31N5O3Purity:99.25%Color and Shape:SolidMolecular weight:533.62AM-0687
CAS:<p>AM-0687: Strong PI3Kδ blocker; pAKT IC50=0.7nM, u(pAKT) IC50=4.6nM; Rat IgG ED50=0.026mg/kg, IgM ED50=0.016mg/kg; Clu=2.3L/hr/kg.</p>Formula:C23H19FN8OPurity:98%Color and Shape:SolidMolecular weight:442.45VP3.15
CAS:<p>VP3.15 is an orally bioavailable and CNS-penetrant dual inhibitor of phosphodiesterase (PDE)7- GSK3 (IC50s: 1.59 μM and 0.88 μM for PDE7 and GSK-3).</p>Formula:C20H22N4OSPurity:98%Color and Shape:SolidMolecular weight:366.48GSK3-IN-2
CAS:<p>GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.</p>Formula:C17H19N3OSPurity:98.8%Color and Shape:SolidMolecular weight:313.423,5-dimethyl PIT-1
CAS:<p>PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as</p>Formula:C16H15N3O4SColor and Shape:SolidMolecular weight:345.37Aloisine B
CAS:<p>Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively.</p>Formula:C15H14ClN3Purity:95.15%Color and Shape:SolidMolecular weight:271.74PI3K/mTOR Inhibitor-2
CAS:<p>Potent PI3K/mTOR Inhibitor-2 targets PI3Kα/β/δ/γ & mTOR (IC50: 3.4, 34, 16,1, 4.7 nM); exhibits antitumor effects.</p>Formula:C20H13ClF2N4O4SPurity:96.16%Color and Shape:SolidMolecular weight:478.86PI3Kdelta inhibitor 1
CAS:<p>PI3Kdelta inhibitor 1 is a potent, selective and orally available inhibitor of PI3Kδ with an IC50 of 1.3 nM.</p>Formula:C27H38N6O5SPurity:98%Color and Shape:SolidMolecular weight:558.69Mutated EGFR-IN-3
CAS:<p>Mutated EGFR-IN-3: ATP-competitive, selective dibenzodiazepinone inhibitor for EGFR mutations, IC50 12-13 nM.</p>Formula:C31H29FN4O2Purity:98%Color and Shape:SolidMolecular weight:508.59Nazartinib mesylate
CAS:<p>Nazartinib mesylate is a novel, covalent mutant-selective inhibitor of EGFR (Ki and Kinact: 31 nM and 0.222/min on EGFR(L858R/790M) mutant).</p>Formula:C27H35ClN6O5SPurity:98%Color and Shape:SolidMolecular weight:591.12DNA-PK-IN-4
CAS:<p>DNA-PK-IN-4, an imidazolinone, targets DNA-PKcs to hinder tumor DNA repair and induce apoptosis, showing cancer research potential.</p>Formula:C20H24N6O3Color and Shape:SolidMolecular weight:396.44EGFR/HER2-IN-9
CAS:<p>EGFR/HER2-IN-9, a compound inhibiting both EGFR and HER2, demonstrates potency with IC50 values of 3.2 nM for EGFR, 14 nM for HER2, and 8.3 nM against the EGFR</p>Formula:C25H25ClFN5O4Color and Shape:SolidMolecular weight:513.95Lavendustin C6
CAS:<p>Lavendustin C6 is a effective tyrosine kinase inhibitor.</p>Formula:C20H25NO5Color and Shape:SolidMolecular weight:359.42Leniolisib phosphate
CAS:<p>Leniolisib phosphate is an effective PI3K inhibitor.</p>Formula:C21H28F3N6O6PColor and Shape:SolidMolecular weight:548.45BAY 2476568
CAS:<p>BAY 2476568 is a selective and potent EGFR inhibitor that acts on both wild-type EGFR (IC50 <0.2 nM) and mutant EGFR (IC50 <0.2 nM).</p>Formula:C24H27FN4O4Color and Shape:SolidMolecular weight:454.49EGFR-IN-55
CAS:<p>"EGFR-IN-55 targets EGFRWT (70 nM IC50) & EGFRL858R/T790M (3.9 nM IC50), halts NCI-H1975 cell cycle in G0/G1, showing anticancer properties."</p>Formula:C25H25Cl2N7O2Color and Shape:SolidMolecular weight:526.42PKI-179
CAS:<p>PKI-179: Dual PI3K/mTOR inhibitor, orally active, IC50s: 0.42-77 nM, targets E545K and H1047R, antitumor in vivo.</p>Formula:C25H28N8O3Color and Shape:SolidMolecular weight:488.54EGFR-IN-28
CAS:<p>EGFR-IN-28 is a potent EGFR inhibitor. EGFR-IN-28 has antitumor activity .</p>Formula:C31H39BrN10O3SColor and Shape:SolidMolecular weight:711.68SIKs-IN-1
CAS:<p>SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, functions as an inhibitor of Salt-inducible kinases (SIKs), which play a role in the M1/M2</p>Formula:C27H31F2N7OColor and Shape:SolidMolecular weight:507.58PI3K-IN-36
CAS:<p>PI3K-IN-36 is a potent inhibitor of PI3K, suitable for research applications in follicular lymphoma (FL).</p>Formula:C30H36F2N8OColor and Shape:SolidMolecular weight:562.66PI3Kγ inhibitor 6
CAS:<p>PI3Kγ Inhibitor 6, a specific inhibitor of PI3Kγ, is utilized in the study of inflammatory and autoimmune diseases.</p>Formula:C16H11NO5SColor and Shape:SolidMolecular weight:329.33PKI-179 hydrochloride
CAS:<p>PKI-179: oral PI3K/mTOR inhibitor; IC50: PI3Kα/β/δ/γ (8-74 nM), PI3Kα mutants (11-14 nM), mTOR (0.42 nM); selective; inhibits cancer cell growth.</p>Formula:C25H29ClN8O3Color and Shape:SolidMolecular weight:525PI3K-IN-28
CAS:<p>PI3K-IN-28, a potent PI3K inhibitor with low toxicity in MCF-10a, has IC50 values of 5.8, 2.3, 7.9 μM and high selectivity index of 39.</p>Formula:C26H16F9N3O3S2Color and Shape:SolidMolecular weight:653.54DNA-PK-IN-5
CAS:<p>DNA-PK-IN-5: potent DNA-PK inhibitor, reduces tumor repair, induces apoptosis, enhances radiotherapy, overcomes resistance.</p>Formula:C21H22N8O2Color and Shape:SolidMolecular weight:418.45CAY10717
CAS:<p>CAY10717 inhibits 34/104 kinases at 100 nM, targets EGFR/ABL/B-Raf mutations, kills various cancer cells, and blocks HUVEC growth.</p>Formula:C29H25F3N6O3Color and Shape:SolidMolecular weight:562.54UNC-CA359
CAS:<p>UNC-CA359: potent EGFR inhibitor, IC50=18 nM, strong anti-tumor effect, promising for chordoma.</p>Formula:C18H14ClN3O2Color and Shape:SolidMolecular weight:339.78EGFR-IN-49
CAS:<p>EGFR-IN-49 selectively inhibits EGFR mutations T790M (IC50: 65 nM) & T790M/L858R (IC50: 13.6 nM), triggering apoptosis dose-dependently.</p>Formula:C22H15N5O2SColor and Shape:SolidMolecular weight:413.45EGFR-IN-75
<p>EGFR-IN-75 inhibits EGFR WT/T790M; IC50s: 0.28/5.02 μM. It has anticancer and antioxidant effects.</p>Formula:C10H6N6S2Color and Shape:SolidMolecular weight:274.32PI3Kα-IN-4
CAS:<p>PI3Kα-IN-4 is a potent, selective, and orally active PI3Kα inhibitor, demonstrating an IC50 of 1.8 nM and exhibiting antitumor activity[1].</p>Formula:C25H23ClFN5O5SColor and Shape:SolidMolecular weight:560(E/Z)-AG490
CAS:<p>(E/Z)-AG490 is a racemic mix of (E)- and (Z)-isomers; it inhibits tyrosine kinase, EGFR, Stat-3, and JAK2/3.</p>Formula:C17H14N2O3Color and Shape:SolidMolecular weight:294.3PI3K-IN-2
CAS:<p>PI3K-IN-2 inhibits PI3Kβ/δ (IC50: 7.1, 8.6 nM) with greater selectivity over PI3Kσ/γ (IC50: 13, 190 nM) and is orally active.</p>Formula:C28H29F2N3O5Color and Shape:SolidMolecular weight:525.54PD 173955-Analog1
CAS:<p>PD 173955-Analog1 is a potent c-Src inhibitor known to have activity against a variety of cancers including colon, lung, head and neck carcinoma.</p>Formula:C21H14Cl2N4O3Color and Shape:SolidMolecular weight:441.27NVP-BBD130
CAS:<p>NVP-BBD130 is a stable, ATP-competitive, potent, orally active inhibitor of PI3K and mTOR.</p>Formula:C28H21N5OColor and Shape:SolidMolecular weight:443.5EGFR/HER2-IN-3
CAS:<p>EGFR/HER2-IN-3 (Compound ZINC21942954) is a dual EGFR and HER2 inhibitor.</p>Formula:C26H23N5O3Color and Shape:SolidMolecular weight:453.49DNA-PK-IN-7
CAS:<p>DNA-PK-IN-7 is a potent DNA-PK inhibitor (IC50= 1 nM) (WO2021104277A1, compound 5).</p>Formula:C19H21N9O2Color and Shape:SolidMolecular weight:407.43eCF-309
CAS:<p>eCF-309 is a potent mTOR inhibitor with IC50 value of 15 nM.</p>Formula:C18H21N7O3Color and Shape:SolidMolecular weight:383.4EGFR-IN-31
CAS:<p>EGFR-IN-31: Potent EGFR inhibitor, targets mutations & overexpression in NSCLC; potential cancer research compound. (WO2021185298A1, 2)</p>Formula:C32H36FN7O2Color and Shape:SolidMolecular weight:569.67PDZ1i
CAS:<p>PDZ1i: potent MDA-9/Syntenin inhibitor; crosses blood-brain barrier; targets GBM, FAK, EGFRvIII; lowers MMP secretion.</p>Formula:C28H26N8O4Color and Shape:SolidMolecular weight:538.56BIBX 1382 Dihydrochloride
CAS:<p>BIBX 1382 Dihydrochloride blocks Lassa/Ebola entry, aids in studying virus-host interactions, and hints at kinase targets for therapy.</p>Formula:C18H21Cl3FN7Color and Shape:SolidMolecular weight:460.76LDC0496
CAS:<p>LDC0496: Potent EGFR/Her2 exon 20 inhibitor; selective for wild-type EGFR, kinase-specific.</p>Formula:C32H35N5O3Color and Shape:SolidMolecular weight:537.65EGFR-IN-69
CAS:<p>EGFR-IN-69: Potent EGFR inhibitor for NSCLC research; IC50: 4.3-25.6 nM against various EGFR mutations.</p>Formula:C31H37Cl2N7O3SColor and Shape:SolidMolecular weight:658.64PfGSK3/PfPK6-IN-2
CAS:<p>PfGSK3/PfPK6-IN-2 inhibits Plasmodium falciparum GSK3/PK6 (IC50: 172 nM/11 nM) for Malaria research.</p>Formula:C24H25Cl2N5OSColor and Shape:SolidMolecular weight:502.46EGFR-IN-63
CAS:<p>EGFR- IN-63 is an EGFR inhibitor with an IC50 value of 0.096 μM. EGFR- IN-63 exhibited anticancer effects on MCF-7 cells (IC50: 2.49 μM).</p>Formula:C20H12BrN5SColor and Shape:SolidMolecular weight:434.31PI3Kδ-IN-3
CAS:<p>PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function.</p>Formula:C28H24N6O3Purity:98.43%Color and Shape:SolidMolecular weight:492.53EMI48
CAS:<p>EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].</p>Formula:C21H20N2O3Color and Shape:SolidMolecular weight:348.4OXA-01
CAS:<p>OXA-01 is a potent mTORC1 and mTORC2 inhibitor, with IC 50 values of 29 nM and 7 nM, respectively [1]. OXA-01 demonstrates broad anti-tumor activity.</p>Formula:C21H20ClN5O2Color and Shape:SolidMolecular weight:409.87BRD1652
CAS:<p>BRD1652 is a highly selective and potent GSK3 inhibitor.</p>Formula:C20H20F3N3OPurity:98%Color and Shape:SolidMolecular weight:375.39CC260
CAS:<p>CC260 selectively inhibits PI5P4Kα/β (Ki: 40/30 nM), with minimal effect on Plk1/RSK2, useful for metabolic, diabetes, and cancer studies.</p>Formula:C24H29Cl2N5O2Color and Shape:SolidMolecular weight:490.43AS2541019
CAS:<p>AS2541019 is a selective Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibitor.</p>Formula:C26H33F2N7O3Color and Shape:SolidMolecular weight:529.58CHMFL-PI4K-127
CAS:<p>CHMFL-PI4K-127 (15g) selectively inhibits PfPI4K (IC50=0.9 nM), potent against Plasmodium 3D7 (EC50=25.1 nM), with oral anti-malaria activity.</p>Formula:C18H15ClN4O3SColor and Shape:SolidMolecular weight:402.85EGFR-IN-54
CAS:<p>EGFR-IN-54 (Compound 3c) is a potent inhibitor of EGFR (IC50: 1.623 μM) and is toxic to cancer cells.</p>Formula:C17H14N4O4S3Color and Shape:SolidMolecular weight:434.51EGFR-IN-25
CAS:<p>EGFR-IN-25, an efficacious EGFR inhibitor, demonstrates IC50 values of 9 nM for BaF3 cells (EGFR DEL19/T790M/C797S) and 60 nM for A431 cells (WT), respectively.</p>Formula:C34H43N9O2Color and Shape:SolidMolecular weight:609.76EMI56
CAS:<p>EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1].</p>Formula:C21H20N2O3Color and Shape:SolidMolecular weight:348.4EGFR-IN-39
CAS:<p>EGFR-IN-39, an acrylamide, is a potent EGFR inhibitor and antitumor agent targeting NSCLC with low toxicity. See WO2021185348A1 for details.</p>Formula:C24H25ClN6O3Color and Shape:SolidMolecular weight:480.95JBJ-09-063 hydrochloride
<p>JBJ-09-063 hydrochloride: targeted EGFR inhibitor, effective for various mutations and TKI-resistant lung cancer models.</p>Formula:C31H30ClFN4O3SColor and Shape:SolidMolecular weight:593.11EGFR/HER2-IN-2
CAS:<p>EGFR/HER2-IN-2 (Compound ZINC35560729) is a dual EGFR and HER2 inhibitor that acts on both EGFR (IC50: 5.02 μM) and HER2 (IC50: 0.83 μM).</p>Formula:C26H23N5O3Color and Shape:SolidMolecular weight:453.49SIC-19
CAS:<p>SIC-19, a SIK2 inhibitor, functions by promoting the degradation of SIK2 protein via the ubiquitination pathway. It inhibits the growth of cancer cells and sensitizes cells, ovarian cancer organoids, and xenograft models to PARP inhibitors (such as Olaparib).</p>Formula:C29H26N4O5S2Color and Shape:SolidMolecular weight:574.67EGFR-IN-21
CAS:<p>EGFR-IN-21, a potent EGFR inhibitor, exhibits an IC50 of 0.38 nM, demonstrating significant antitumor activity.</p>Formula:C36H44BrN10O2PColor and Shape:SolidMolecular weight:759.68PI3Ka-IN-5
CAS:<p>PI3Ka-IN-5 is a potent PI3Kα/mTOR inhibitor, with an IC 50 of 0.7 nM and 3.3 nM, respectively. PI3Ka-IN-5 can be used for the research of colorectal cancer .</p>Formula:C30H35N9O5Color and Shape:SolidMolecular weight:601.66EGFR mutant-IN-2
CAS:<p>EGFR mutant-IN-2 (Compound D51) is an inhibitor of EGFR mutants, specifically targeting EGFR L858R/T790M/C797S and EGFR del19/T790M/C797S mutants with IC50 values of 14 nM and 62 nM, respectively. This compound exhibits favorable pharmacokinetic (PK) parameters, safety properties, in vivo stability, and demonstrates antitumor activity [1].</p>Formula:C27H27F3N6O2SColor and Shape:SolidMolecular weight:556.6ON 146040
CAS:<p>ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.</p>Formula:C24H23N7O3SPurity:97.39%Color and Shape:SolidMolecular weight:489.55P-2281
CAS:<p>P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cell</p>Formula:C9H8ClN3OPurity:99.95%Color and Shape:SolidMolecular weight:209.63PI3K/mTOR Inhibitor-13
CAS:<p>PI3K/mTOR Inhibitor-13, an oral dual blocker of PI3K and mTOR, may treat sexual diseases, solid tumors, and IPF.</p>Formula:C20H13F2N5O3SColor and Shape:SolidMolecular weight:441.41PI3Kα/mTOR-IN-1
CAS:<p>PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR.</p>Formula:C16H18N6OPurity:99.89%Color and Shape:SolidMolecular weight:310.35EGFR-IN-2
CAS:<p>EGFR-IN-2 is a oral and mutation-selective EGFR inhibito,NSCLC, with high selectivity for resistant single and double mutant T790M.</p>Formula:C26H33N9O3SPurity:98.52% - 99.79%Color and Shape:SolidMolecular weight:551.66Mutated EGFR-IN-2
CAS:<p>Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.</p>Formula:C29H35FN8O3Purity:98%Color and Shape:SolidMolecular weight:562.64PI3K/mTOR Inhibitor-8
CAS:<p>PI3K/mTOR Inhibitor-8: Dual PI3Kα (IC50: 0.46 nM) & mTOR (IC50: 12 nM) inhibitor; blocks G1/S phase & induces apoptosis in HCT-116 cells.</p>Formula:C23H22N8O4SColor and Shape:SolidMolecular weight:506.54PI3K-IN-38
CAS:<p>PI3K-IN-38: oral PI3K inhibitor, IC50 of 0.541 µM, anticancer, anti-inflammatory, halts tumors in vivo.</p>Formula:C20H24N6O2Purity:99.89%Color and Shape:SolidMolecular weight:380.44AMPK activator 4
CAS:<p>Potent, selective AMPK activator 4 enhances glucose tolerance and insulin sensitivity without affecting mitochondrial complex I.</p>Formula:C24H21ClN2O3Purity:99.46% - 99.65%Color and Shape:SolidMolecular weight:420.89Tyrphostin AG 112
CAS:<p>Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.</p>Formula:C13H8N4OPurity:97.01%Color and Shape:SolidMolecular weight:236.23PI3K-IN-9
CAS:<p>PI3K-IN-9 is a potent and selective inhibitor of PI3Kδ(IC50 of 8.9 nM).</p>Formula:C19H23N7OPurity:98%Color and Shape:SolidMolecular weight:365.43EGFR-IN-53
CAS:<p>EGFR-IN-53 (Compound 7) is a potent inhibitor of EGFR (IC50 = 8.264 μM) that exhibits cytotoxic activity against cancer cell lines [1].</p>Formula:C14H13N3O2SColor and Shape:SolidMolecular weight:287.34PI3K-IN-10
CAS:<p>PI3K-IN-10 is a potent inhibitor of pan-PI3K .</p>Formula:C23H19ClN6OPurity:98%Color and Shape:SolidMolecular weight:430.89PI3Kγ inhibitor 1
CAS:<p>PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.</p>Formula:C32H26N8O2SPurity:98%Color and Shape:SolidMolecular weight:586.67EGFR/C797S-IN-1
CAS:<p>EGFR/C797S-IN-1: Potent EGFR-C797S inhibitor, IC50 of 0.128 µM, dose-dependent p-EGFR suppression, anti-tumor properties.</p>Formula:C28H30N4O3Color and Shape:SolidMolecular weight:470.56PI3-Kinase α Inhibitor 2
CAS:<p>Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and</p>Formula:C16H15N3O2SColor and Shape:SolidMolecular weight:313.37EGFR-IN-5
CAS:<p>EGFR-IN-5 inhibits EGFR & mutants; IC50: EGFR 10.4nM, L858R 1.1nM, L858R/T790M 34nM, L858R/T790M/C797S 7.2nM.</p>Formula:C31H38FN9OPurity:98.17%Color and Shape:SolidMolecular weight:571.69PI3Kδ/γ-IN-1
CAS:<p>PI3Kδ/γ-IN-1 is a selective and effective inhibitor of PI3Kδ/γ that can be used in the treatment of hematologic malignancies.</p>Formula:C25H28N6O4SColor and Shape:SolidMolecular weight:508.59PP30
CAS:<p>PP30 is an inhibitor of mTORC1 and mTORC2. It is selective within the PI3K family, inhibiting other PI3Ks only at high concentrations.</p>Formula:C18H19N7OSPurity:98%Color and Shape:SolidMolecular weight:381.45PI3K/mTOR Inhibitor-3
CAS:<p>PI3K/mTOR Inhibitor-3, a potent dual-action anti-cancer imidazoline, targets PI3K and mTOR.</p>Formula:C22H23N5OColor and Shape:SolidMolecular weight:373.45DIF-3
CAS:<p>DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.</p>Formula:C13H17ClO4Purity:99.57%Color and Shape:SolidMolecular weight:272.72EHT 1610
CAS:<p>EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively.</p>Formula:C18H14FN5O2SPurity:98.59%Color and Shape:SolidMolecular weight:383.4
