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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1037 products of "PI3K/Akt/mTOR Signaling"

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  • YB-3-17
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    YB-3-17

    CAS:
    <p>YB-3-17 is a bifunctional molecule that can inhibit mTOR with an IC50 of 0.22 nM or degrade the G1 to S phase transition 1 gene (GSPT1) through the PROTAC mechanism, with a DC50 of 5 nM. It exhibits antiproliferative activity at nanomolar concentrations in various glioblastoma cell lines. Additionally, YB-3-17 shows antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase Cereblon)</p>
    Formula:C38H39N11O6
    Color and Shape:Solid
    Molecular weight:745.786

    Ref: TM-T204111

  • Varlitinib
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    Varlitinib

    CAS:
    <p>Varlitinib (ASLAN001) is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively.</p>
    Formula:C22H19ClN6O2S
    Purity:99.7%
    Color and Shape:Solid
    Molecular weight:466.94

    Ref: TM-T6719

  • HER2-IN-13
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    HER2-IN-13

    CAS:
    <p>HER2-IN-13 (Compound 33) serves as an effective HER2 inhibitor, exhibiting an IC50 value of 8 nM, and additionally demonstrates inhibition of wt-EGFR with an</p>
    Formula:C26H23ClF2N8O3
    Color and Shape:Solid
    Molecular weight:568.96

    Ref: TM-T75164

  • PI3Kγ inhibitor 5
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    PI3Kγ inhibitor 5

    CAS:
    <p>PI3Kγ inhibitor 5 is a potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ), exhibiting an exceptional IC50 value of 34 nM.</p>
    Formula:C28H32F2N6O4
    Color and Shape:Solid
    Molecular weight:554.599

    Ref: TM-T40196

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    JBJ-09-063 TFA

    <p>JBJ-09-063 TFA, an EGFR inhibitor selective for EGFR mutations, IC50s: 0.147-0.396 nM, blocks EGFR/Akt/ERK signaling, for EGFR-mutant lung cancer research.</p>
    Formula:C33H30F4N4O5S
    Color and Shape:Solid
    Molecular weight:670.67

    Ref: TM-T74561

  • GSK-3β inhibitor 24
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    GSK-3β inhibitor 24

    <p>GSK-3β inhibitor24 (Compound 41) is a potent GSK-3β inhibitor with an IC50 of 0.22 nM. It increases GSK-3β phosphorylation at the Ser9 site in a dose-dependent manner and inhibits tau protein hyperphosphorylation by reducing the abundance of p-tau-Ser396. The compound upregulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2), demonstrating significant anti-Alzheimer's disease (AD) activity.</p>
    Formula:C26H18N4O3
    Color and Shape:Solid
    Molecular weight:434.446

    Ref: TM-T204492

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    EGFR-IN-42

    <p>EGFR-IN-42 (17b) is a potent EGFR inhibitor with nanomolar efficacy, merging tamoxifen/endoxifen and gefitinib, exhibiting enhanced anti-cancer action.</p>
    Formula:C49H53ClFN5O5
    Color and Shape:Solid
    Molecular weight:846.43

    Ref: TM-T74457

  • Amdizalisib
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    Amdizalisib

    CAS:
    <p>Amdizalisib is a PI3K inhibitor and used for the research of inflammatory disease, autoimmune disease or cancer.</p>
    Formula:C19H15ClN8
    Color and Shape:Solid
    Molecular weight:390.84

    Ref: TM-T39327

  • PF-06465603
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    PF-06465603

    CAS:
    <p>PF-06465603 is a metabolite of PF-04691502, a highly potent and selective ATP competitive kinase inhibitor of class 1 PI3Ks and mTOR.</p>
    Formula:C22H25N5O5
    Color and Shape:Solid
    Molecular weight:439.46

    Ref: TM-T28373

  • ARUK2001607
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    ARUK2001607

    CAS:
    ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.
    Formula:C14H13N3O2S2
    Purity:99.75%
    Color and Shape:Soild
    Molecular weight:319.40

    Ref: TM-T67845

  • FRATide
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    FRATide

    CAS:
    <p>FRATtide inhibits the phosphorylation of Axin and β-catenin, inhibits GSK-3 binding to Axin, and is a peptide derived from the GSK-3 binding protein.</p>
    Formula:C55H102N2O2
    Color and Shape:Solid
    Molecular weight:823.433

    Ref: TM-T35550

  • 740 Y-P(TFA)
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    740 Y-P(TFA)

    <p>740 Y-P(TFA)(1236188-16-1 free base) (740YPDGFR(TFA)) is a potent and cell-permeable activator of PI3K.</p>
    Formula:C143H223F3N43O41PS3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3384.73

    Ref: TM-TQ0003L

  • Tyrosine Kinase Inhibitor Library
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    Tyrosine Kinase Inhibitor Library

    <p>A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related</p>
    Color and Shape:Odour Solid

    Ref: TM-L2200

  • BI-4732
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    BI-4732

    CAS:
    <p>DL-Homocystine is a mutagen secreted by F. nucleatum.</p>
    Formula:C32H36N10O2
    Purity:98.88%
    Color and Shape:Solid
    Molecular weight:592.69

    Ref: TM-T85354

  • IC 86621
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    IC 86621

    CAS:
    <p>IC 86621: DNA-PK ATP-competitive inhibitor, IC50 120 nM, enhances DSB antitumor effects, EC50 68 µM for repair.</p>
    Formula:C12H15NO3
    Purity:99.68%
    Color and Shape:Solid
    Molecular weight:221.25

    Ref: TM-T9760

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    EGFR/VEGFR2-IN-5

    <p>EGFR/VEGFR2-IN-5 (Compound 14) is an orally active dual inhibitor of EGFR and VEGFR2, exhibiting an IC50 value of 1.15 µM for VEGFR2 and 0.28 µM for EGFRT790M. This compound demonstrates significant anticancer activity.</p>
    Formula:C17H15N7O5S
    Color and Shape:Solid
    Molecular weight:429.41

    Ref: TM-T205483

  • 6-Me-ATP
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    6-Me-ATP

    CAS:
    <p>6-Me-ATP, a modified ATP, binds well to GSK3 and donates phosphate for GSK3β phosphorylation.</p>
    Formula:C11H18N5O13P3
    Color and Shape:Solid
    Molecular weight:521.21

    Ref: TM-T74033

  • (R)-VX-984
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    (R)-VX-984

    CAS:
    <p>(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.</p>
    Formula:C23H21D2N7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:415.49

    Ref: TM-T12648

  • PI3-Kinase α Inhibitor 2 (hydrochloride)
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    PI3-Kinase α Inhibitor 2 (hydrochloride)

    CAS:
    <p>PI3-Kinase α Inhibitor 2 (hydrochloride) is a PI3-Kinase α inhibitor.</p>
    Formula:C16H17Cl2N3O2S
    Color and Shape:Solid
    Molecular weight:386.3

    Ref: TM-T35526

  • PD-149163 hydrochloride
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    PD-149163 hydrochloride

    PD-149163 hydrochloride is a neurokinin B agonist with antipsychotic activity, used for research on neurological diseases.
    Formula:C42H72ClN9O6
    Color and Shape:Solid
    Molecular weight:834.53

    Ref: TM-T70271L