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PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR signaling inhibitors are compounds that target the phosphoinositide 3-kinase (PI3K), Akt kinase, and mammalian target of rapamycin (mTOR) pathways. These pathways are critical regulators of cell growth, survival, metabolism, and autophagy, making them key targets in cancer research and metabolic disorders. Inhibiting these pathways can help to control tumor growth and proliferation, offering potential therapeutic strategies for various cancers and other diseases characterized by dysregulated cell signaling. At CymitQuimica, we offer a comprehensive selection of high-quality PI3K/Akt/mTOR inhibitors to support your research in oncology, cellular signaling, and metabolic diseases.

Subcategories of "PI3K/Akt/mTOR Signaling"

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Found 1032 products of "PI3K/Akt/mTOR Signaling"

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  • PD-161570
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    PD-161570

    CAS:
    PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.
    Formula:C26H35Cl2N7O
    Purity:99.92%
    Color and Shape:Solid
    Molecular weight:532.51

    Ref: TM-T23127

  • NIH-12848
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    NIH-12848

    CAS:
    <p>NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.</p>
    Formula:C20H14F3N3S
    Purity:99.84% - 99.9%
    Color and Shape:Solid
    Molecular weight:385.41

    Ref: TM-T3556

  • GNE-493
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    GNE-493

    CAS:
    GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for
    Formula:C17H20N6O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:372.44

    Ref: TM-T7166

  • Tuxobertinib
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    Tuxobertinib

    CAS:
    <p>Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations. BDTX-189 exhibits anticancer activity.</p>
    Formula:C29H29ClN6O4
    Purity:99.22%
    Color and Shape:Solid
    Molecular weight:561.03

    Ref: TM-T9072

  • SB 216763
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    SB 216763

    CAS:
    SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).
    Formula:C19H12Cl2N2O2
    Purity:98.9% - 99.13%
    Color and Shape:Solid
    Molecular weight:371.22

    Ref: TM-T3077

  • SU5214
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    SU5214

    CAS:
    SU5214 is a modulator of tyrosine kinase signal transduction.
    Formula:C16H13NO2
    Purity:99.45% - 99.55%
    Color and Shape:Solid
    Molecular weight:251.28

    Ref: TM-T3569

  • CC-115 hydrochloride
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    CC-115 hydrochloride

    CAS:
    CC-115 hydrochloride: potent DNA-PK/mTOR inhibitor; IC50s: 13 nM and 21 nM; blocks mTORC1/C2 pathways.
    Formula:C16H17ClN8O
    Color and Shape:Solid
    Molecular weight:372.82

    Ref: TM-T61505

  • Neratinib
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    Neratinib

    CAS:
    Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.
    Formula:C30H29ClN6O3
    Purity:96.17% - 99.85%
    Color and Shape:Solid
    Molecular weight:557.04

    Ref: TM-T2325

  • Idelalisib
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    Idelalisib

    CAS:
    <p>Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).</p>
    Formula:C22H18FN7O
    Purity:98% - 99.39%
    Color and Shape:Solid
    Molecular weight:415.42

    Ref: TM-T1894

  • GSK-3β inhibitor 10
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    GSK-3β inhibitor 10

    CAS:
    GSK-3β inhibitor 10 has skin-whitening, anti-oxidizing and PPAR activities.
    Formula:C12H12N2O3S
    Purity:98.06%
    Color and Shape:Solid
    Molecular weight:264.3

    Ref: TM-T9725

  • KenPaullone
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    KenPaullone

    CAS:
    KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.
    Formula:C16H11BrN2O
    Purity:97.14% - 98.99%
    Color and Shape:Tan Solid
    Molecular weight:327.18

    Ref: TM-T2247

  • AZD8931 diFuMaric acid
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    AZD8931 diFuMaric acid

    CAS:
    <p>AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).</p>
    Formula:C31H33ClFN5O11
    Purity:99.92%
    Color and Shape:Solid
    Molecular weight:706.1

    Ref: TM-T8751

  • TDZD-8
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    TDZD-8

    CAS:
    <p>TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.</p>
    Formula:C10H10N2O2S
    Purity:97.13% - 99.61%
    Color and Shape:White Solid
    Molecular weight:222.26

    Ref: TM-T6187

  • Poziotinib hydrochloride
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    Poziotinib hydrochloride

    CAS:
    <p>Oral poziotinib HCl targets EGFR/HER mutants, inhibiting cancer cell growth.</p>
    Formula:C23H22Cl3FN4O3
    Purity:99.69% - 99.81%
    Color and Shape:Solid
    Molecular weight:527.8

    Ref: TM-T8758

  • ZD-4190
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    ZD-4190

    CAS:
    <p>ZD-4190 blocks VEGFR2 and EGFR, aiding cancer treatment.</p>
    Formula:C19H16BrFN6O2
    Purity:99.12%
    Color and Shape:Solid
    Molecular weight:459.27

    Ref: TM-T5475

  • Leniolisib
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    Leniolisib

    CAS:
    <p>Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).</p>
    Formula:C21H25F3N6O2
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:450.46

    Ref: TM-T5166

  • AG-494
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    AG-494

    CAS:
    <p>AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.</p>
    Formula:C16H12N2O3
    Purity:98.69%
    Color and Shape:Solid
    Molecular weight:280.28

    Ref: TM-T4205

  • HTH-01-015
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    HTH-01-015

    CAS:
    <p>HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).</p>
    Formula:C26H28N8O
    Purity:98.38% - 99.70%
    Color and Shape:Solid
    Molecular weight:468.55

    Ref: TM-T2374

  • MAZ51
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    MAZ51

    CAS:
    MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.
    Formula:C21H18N2O
    Purity:98.53%
    Color and Shape:Solid
    Molecular weight:314.38

    Ref: TM-T8496

  • AG 1406
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    AG 1406

    CAS:
    <p>AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.</p>
    Formula:C16H18N2O
    Purity:98.12%
    Color and Shape:Solid
    Molecular weight:254.33

    Ref: TM-T4554